YGR163W / GTR2

Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR163W / GTR2

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:5.13|P-value:1.09E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:4.96|P-value:1.98E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:5.24|P-value:7.25E-6 ID:SGTC_42|Compound:0133-0086|FD-Score:3.83|P-value:7.63E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:9.59|P-value:8.93E-16 ID:SGTC_138|Compound:0850-0259|FD-Score:10.60|P-value:5.36E-19 ID:SGTC_166|Compound:k072-0058|FD-Score:7.50|P-value:2.57E-10 ID:SGTC_180|Compound:1486-1293|FD-Score:4.40|P-value:1.35E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:6.73|P-value:1.19E-8 ID:SGTC_228|Compound:caffeine|FD-Score:6.34|P-value:7.48E-8 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.14|P-value:3.02E-4 ID:SGTC_276|Compound:colchicine|FD-Score:4.63|P-value:6.37E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.17|P-value:8.42E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:5.21|P-value:8.08E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.86|P-value:5.65E-9 ID:SGTC_311|Compound:1315-0136|FD-Score:4.45|P-value:1.16E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:5.75|P-value:9.44E-7 ID:SGTC_359|Compound:0081-0058|FD-Score:4.42|P-value:1.26E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.97|P-value:5.04E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.87|P-value:6.34E-4 ID:SGTC_398|Compound:bronopol|FD-Score:4.86|P-value:2.83E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:4.23|P-value:2.34E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:4.68|P-value:5.40E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:4.48|P-value:1.05E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:7.84|P-value:4.02E-11 ID:SGTC_717|Compound:1532-0246|FD-Score:4.17|P-value:2.82E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:-3.96|P-value:4.88E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.93|P-value:5.70E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:7.10|P-value:2.03E-9 ID:SGTC_952|Compound:1185-0122|FD-Score:4.50|P-value:9.75E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:3.92|P-value:5.96E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:5.08|P-value:1.31E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.60|P-value:6.94E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:5.63|P-value:1.56E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:5.51|P-value:2.50E-6 ID:SGTC_1084|Compound:voriconazole|FD-Score:-3.77|P-value:8.40E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:3.78|P-value:8.84E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:5.90|P-value:5.13E-7 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.41|P-value:1.32E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:6.49|P-value:3.80E-8 ID:SGTC_1395|Compound:3486-0190|FD-Score:4.13|P-value:3.17E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.84|P-value:6.84E-4 ID:SGTC_1606|Compound:st000094|FD-Score:-4.13|P-value:2.95E-4 ID:SGTC_1607|Compound:st000305|FD-Score:-3.72|P-value:9.68E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.86|P-value:6.96E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.90|P-value:6.20E-4 ID:SGTC_1754|Compound:st042065|FD-Score:8.74|P-value:2.20E-13 ID:SGTC_1781|Compound:st038725|FD-Score:6.70|P-value:1.41E-8 ID:SGTC_1800|Compound:st050079|FD-Score:7.88|P-value:3.29E-11 ID:SGTC_1801|Compound:st050089|FD-Score:3.77|P-value:9.02E-4 ID:SGTC_1803|Compound:st050068|FD-Score:6.20|P-value:1.42E-7 ID:SGTC_1818|Compound:st052136|FD-Score:6.13|P-value:1.92E-7 ID:SGTC_1829|Compound:berberine|FD-Score:-3.86|P-value:6.52E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:29.60|P-value:1.08E-133 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.02|P-value:3.04E-7 ID:SGTC_1877|Compound:wortmannin|FD-Score:8.43|P-value:1.38E-12 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.79|P-value:7.95E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.10|P-value:3.22E-4 ID:SGTC_2026|Compound:5148700|FD-Score:4.26|P-value:2.09E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-4.26|P-value:1.92E-4 ID:SGTC_2090|Compound:5301565|FD-Score:5.66|P-value:1.39E-6 ID:SGTC_2120|Compound:5538279|FD-Score:5.76|P-value:9.28E-7 ID:SGTC_2127|Compound:5253358|FD-Score:9.02|P-value:3.72E-14 ID:SGTC_2177|Compound:5811945|FD-Score:11.30|P-value:5.09E-21 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.62|P-value:2.02E-8 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.18|P-value:2.71E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:3.86|P-value:6.98E-4 ID:SGTC_2323|Compound:6148992|FD-Score:4.28|P-value:1.99E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-3.99|P-value:4.50E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-5.16|P-value:8.79E-6 ID:SGTC_2344|Compound:7990960|FD-Score:5.79|P-value:8.22E-7 ID:SGTC_2393|Compound:9031399|FD-Score:-3.79|P-value:7.96E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.91|P-value:6.01E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:5.04|P-value:1.51E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.45|P-value:1.06E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:10.30|P-value:8.07E-18 ID:SGTC_2679|Compound:rapamycin|FD-Score:13.00|P-value:1.90E-27 ID:SGTC_2858|Compound:9025781|FD-Score:-6.42|P-value:4.71E-8 ID:SGTC_2896|Compound:9052656|FD-Score:-4.20|P-value:2.33E-4 ID:SGTC_2912|Compound:7964298|FD-Score:5.75|P-value:9.52E-7 ID:SGTC_2950|Compound:9072895|FD-Score:-3.94|P-value:5.10E-4 ID:SGTC_3035|Compound:9091303|FD-Score:4.72|P-value:4.66E-5 ID:SGTC_3037|Compound:9091026|FD-Score:4.28|P-value:1.96E-4 ID:SGTC_3052|Compound:9092717|FD-Score:-4.10|P-value:3.17E-4 ID:SGTC_3148|Compound:9097893|FD-Score:8.93|P-value:6.59E-14 ID:SGTC_3173|Compound:9105693|FD-Score:6.15|P-value:1.75E-7 ID:SGTC_3178|Compound:9107506|FD-Score:4.44|P-value:1.19E-4 ID:SGTC_3213|Compound:9129884|FD-Score:5.00|P-value:1.70E-5 ID:SGTC_3285|Compound:9112818|FD-Score:3.82|P-value:7.90E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-4.41|P-value:1.19E-4 ID:SGTC_3311|Compound:9131146|FD-Score:5.68|P-value:1.24E-6 ID:SGTC_3350|Compound:9150499|FD-Score:4.37|P-value:1.49E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:5.13|P-value:1.09E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:4.96|P-value:1.98E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:5.24|P-value:7.25E-6 ID:SGTC_42|Compound:0133-0086|FD-Score:3.83|P-value:7.63E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:9.59|P-value:8.93E-16 ID:SGTC_138|Compound:0850-0259|FD-Score:10.60|P-value:5.36E-19 ID:SGTC_166|Compound:k072-0058|FD-Score:7.50|P-value:2.57E-10 ID:SGTC_180|Compound:1486-1293|FD-Score:4.40|P-value:1.35E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:6.73|P-value:1.19E-8 ID:SGTC_228|Compound:caffeine|FD-Score:6.34|P-value:7.48E-8 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.14|P-value:3.02E-4 ID:SGTC_276|Compound:colchicine|FD-Score:4.63|P-value:6.37E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.17|P-value:8.42E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:5.21|P-value:8.08E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.86|P-value:5.65E-9 ID:SGTC_311|Compound:1315-0136|FD-Score:4.45|P-value:1.16E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:5.75|P-value:9.44E-7 ID:SGTC_359|Compound:0081-0058|FD-Score:4.42|P-value:1.26E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.97|P-value:5.04E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.87|P-value:6.34E-4 ID:SGTC_398|Compound:bronopol|FD-Score:4.86|P-value:2.83E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:4.23|P-value:2.34E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:4.68|P-value:5.40E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:4.48|P-value:1.05E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:7.84|P-value:4.02E-11 ID:SGTC_717|Compound:1532-0246|FD-Score:4.17|P-value:2.82E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:-3.96|P-value:4.88E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.93|P-value:5.70E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:7.10|P-value:2.03E-9 ID:SGTC_952|Compound:1185-0122|FD-Score:4.50|P-value:9.75E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:3.92|P-value:5.96E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:5.08|P-value:1.31E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.60|P-value:6.94E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:5.63|P-value:1.56E-6 ID:SGTC_1081|Compound:sertraline|FD-Score:5.51|P-value:2.50E-6 ID:SGTC_1084|Compound:voriconazole|FD-Score:-3.77|P-value:8.40E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:3.78|P-value:8.84E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:5.90|P-value:5.13E-7 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.41|P-value:1.32E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:6.49|P-value:3.80E-8 ID:SGTC_1395|Compound:3486-0190|FD-Score:4.13|P-value:3.17E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.84|P-value:6.84E-4 ID:SGTC_1606|Compound:st000094|FD-Score:-4.13|P-value:2.95E-4 ID:SGTC_1607|Compound:st000305|FD-Score:-3.72|P-value:9.68E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.86|P-value:6.96E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.90|P-value:6.20E-4 ID:SGTC_1754|Compound:st042065|FD-Score:8.74|P-value:2.20E-13 ID:SGTC_1781|Compound:st038725|FD-Score:6.70|P-value:1.41E-8 ID:SGTC_1800|Compound:st050079|FD-Score:7.88|P-value:3.29E-11 ID:SGTC_1801|Compound:st050089|FD-Score:3.77|P-value:9.02E-4 ID:SGTC_1803|Compound:st050068|FD-Score:6.20|P-value:1.42E-7 ID:SGTC_1818|Compound:st052136|FD-Score:6.13|P-value:1.92E-7 ID:SGTC_1829|Compound:berberine|FD-Score:-3.86|P-value:6.52E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:29.60|P-value:1.08E-133 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.02|P-value:3.04E-7 ID:SGTC_1877|Compound:wortmannin|FD-Score:8.43|P-value:1.38E-12 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.79|P-value:7.95E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.10|P-value:3.22E-4 ID:SGTC_2026|Compound:5148700|FD-Score:4.26|P-value:2.09E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-4.26|P-value:1.92E-4 ID:SGTC_2090|Compound:5301565|FD-Score:5.66|P-value:1.39E-6 ID:SGTC_2120|Compound:5538279|FD-Score:5.76|P-value:9.28E-7 ID:SGTC_2127|Compound:5253358|FD-Score:9.02|P-value:3.72E-14 ID:SGTC_2177|Compound:5811945|FD-Score:11.30|P-value:5.09E-21 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.62|P-value:2.02E-8 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.18|P-value:2.71E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:3.86|P-value:6.98E-4 ID:SGTC_2323|Compound:6148992|FD-Score:4.28|P-value:1.99E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-3.99|P-value:4.50E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-5.16|P-value:8.79E-6 ID:SGTC_2344|Compound:7990960|FD-Score:5.79|P-value:8.22E-7 ID:SGTC_2393|Compound:9031399|FD-Score:-3.79|P-value:7.96E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.91|P-value:6.01E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:5.04|P-value:1.51E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.45|P-value:1.06E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:10.30|P-value:8.07E-18 ID:SGTC_2679|Compound:rapamycin|FD-Score:13.00|P-value:1.90E-27 ID:SGTC_2858|Compound:9025781|FD-Score:-6.42|P-value:4.71E-8 ID:SGTC_2896|Compound:9052656|FD-Score:-4.20|P-value:2.33E-4 ID:SGTC_2912|Compound:7964298|FD-Score:5.75|P-value:9.52E-7 ID:SGTC_2950|Compound:9072895|FD-Score:-3.94|P-value:5.10E-4 ID:SGTC_3035|Compound:9091303|FD-Score:4.72|P-value:4.66E-5 ID:SGTC_3037|Compound:9091026|FD-Score:4.28|P-value:1.96E-4 ID:SGTC_3052|Compound:9092717|FD-Score:-4.10|P-value:3.17E-4 ID:SGTC_3148|Compound:9097893|FD-Score:8.93|P-value:6.59E-14 ID:SGTC_3173|Compound:9105693|FD-Score:6.15|P-value:1.75E-7 ID:SGTC_3178|Compound:9107506|FD-Score:4.44|P-value:1.19E-4 ID:SGTC_3213|Compound:9129884|FD-Score:5.00|P-value:1.70E-5 ID:SGTC_3285|Compound:9112818|FD-Score:3.82|P-value:7.90E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-4.41|P-value:1.19E-4 ID:SGTC_3311|Compound:9131146|FD-Score:5.68|P-value:1.24E-6 ID:SGTC_3350|Compound:9150499|FD-Score:4.37|P-value:1.49E-4

Top fitness defect scores for YGR163W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1844 rapamycin 29.60 4.0 nM 1.08E-133 2 4.92E-193
2 SGTC_2679 rapamycin 13.00 1.0 nM 1.90E-27 9 5.45E-39
3 SGTC_2177 5811945 11.30 192.0 µM 5.09E-21 2 1.10E-29
4 SGTC_138 0850-0259 10.60 40.9 µM 5.36E-19 cell wall 37 9.28E-27
5 SGTC_2651 1327-0036 10.30 5.0 µM 8.07E-18 22 4.69E-25
6 SGTC_56 0957-0365 9.59 83.2 µM 8.93E-16 Golgi 7 4.24E-22
7 SGTC_2127 5253358 9.02 187.9 µM 3.72E-14 1 9.30E-20
8 SGTC_3148 9097893 8.93 49.5 µM 6.59E-14 3 2.12E-19
9 SGTC_1754 st042065 8.74 16.1 µM 2.20E-13 NEO1-PIK1 43 1.21E-18
10 SGTC_1877 wortmannin 8.43 25.0 µM 1.38E-12 21 1.72E-17
11 SGTC_1800 st050079 7.88 29.1 µM 3.29E-11 NEO1-PIK1 12 1.67E-15
12 SGTC_666 0272-0154 7.84 136.0 µM 4.02E-11 cell wall 10 2.24E-15
13 SGTC_166 k072-0058 7.50 166.4 µM 2.57E-10 DNA intercalators 3 3.25E-14
14 SGTC_916 4466-0038 7.10 42.0 nM 2.03E-9 cell wall 16 6.38E-13
15 SGTC_210 3551-0445 6.73 56.8 µM 1.19E-8 20 8.20E-12
16 SGTC_1781 st038725 6.70 66.3 µM 1.41E-8 NEO1 45 1.05E-11
17 SGTC_2232 chlorophetanol 6.62 41.5 µM 2.02E-8 TRP & mitochondrial translation 31 1.75E-11
18 SGTC_1361 1608-0041 6.49 5.6 µM 3.80E-8 RPP1 & pyrimidine depletion 3 4.34E-11
19 SGTC_228 caffeine 6.34 993.1 µM 7.48E-8 4 1.15E-10
20 SGTC_1803 st050068 6.20 52.4 µM 1.42E-7 NEO1-PIK1 76 2.91E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.633 0 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.516 8.47E-227 YBR077C SLM4 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
0.461 1.02E-175 YKR007W MEH1 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
0.418 1.80E-142 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.375 1.06E-112 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.371 9.52E-110 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.370 1.17E-109 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.353 7.23E-99 YPL180W TCO89 hom Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin
0.351 6.10E-98 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.309 2.90E-75 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.305 5.34E-73 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.264 1.15E-54 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.264 1.04E-54 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.253 5.18E-50 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.251 2.77E-49 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex