YGR164W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR164W / YGR164W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-6.17|P-value:2.77E-10 ID:SGTC_103|Compound:0844-0104|FD-Score:3.09|P-value:9.43E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.47|P-value:2.44E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:4.49|P-value:3.11E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.25|P-value:9.52E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.46|P-value:3.63E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.27|P-value:1.50E-10 ID:SGTC_358|Compound:0075-0058|FD-Score:6.38|P-value:6.88E-11 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.67|P-value:1.14E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.94|P-value:3.79E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-3.33|P-value:4.15E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.57|P-value:2.17E-6 ID:SGTC_505|Compound:gw-5074|FD-Score:3.79|P-value:6.90E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.82|P-value:6.26E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.68|P-value:1.08E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:17.00|P-value:1.19E-65 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.63|P-value:1.33E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.98|P-value:3.12E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:15.10|P-value:4.99E-52 ID:SGTC_683|Compound:panaxydol|FD-Score:5.11|P-value:1.42E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:4.17|P-value:1.40E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:4.88|P-value:4.74E-7 ID:SGTC_759|Compound:3486-0358|FD-Score:3.25|P-value:5.44E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:9.28|P-value:5.21E-21 ID:SGTC_805|Compound:3852-0218|FD-Score:5.13|P-value:1.26E-7 ID:SGTC_828|Compound:2074-0507|FD-Score:3.33|P-value:4.06E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.27|P-value:5.03E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.35|P-value:3.77E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.16|P-value:1.43E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.21|P-value:6.28E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.90|P-value:4.34E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.56|P-value:1.74E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.74|P-value:8.33E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:6.39|P-value:6.69E-11 ID:SGTC_1450|Compound:4112-4260|FD-Score:4.08|P-value:2.09E-5 ID:SGTC_1464|Compound:k208-0027|FD-Score:4.09|P-value:1.96E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:-3.23|P-value:5.83E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.20|P-value:6.53E-4 ID:SGTC_1687|Compound:st020778|FD-Score:11.30|P-value:2.48E-30 ID:SGTC_1712|Compound:st032288|FD-Score:4.99|P-value:2.57E-7 ID:SGTC_1754|Compound:st042065|FD-Score:3.78|P-value:7.26E-5 ID:SGTC_1760|Compound:st045453|FD-Score:4.97|P-value:2.96E-7 ID:SGTC_1800|Compound:st050079|FD-Score:5.33|P-value:4.25E-8 ID:SGTC_1801|Compound:st050089|FD-Score:7.20|P-value:2.33E-13 ID:SGTC_1803|Compound:st050068|FD-Score:3.98|P-value:3.21E-5 ID:SGTC_1818|Compound:st052136|FD-Score:3.13|P-value:8.18E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.33|P-value:4.14E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.85|P-value:2.76E-12 ID:SGTC_1877|Compound:wortmannin|FD-Score:7.01|P-value:8.95E-13 ID:SGTC_1934|Compound:st074720|FD-Score:7.45|P-value:3.38E-14 ID:SGTC_1941|Compound:st076221|FD-Score:11.00|P-value:7.87E-29 ID:SGTC_1991|Compound:st073000|FD-Score:3.92|P-value:4.02E-5 ID:SGTC_1994|Compound:st072947|FD-Score:4.32|P-value:7.18E-6 ID:SGTC_2083|Compound:5306046|FD-Score:-3.95|P-value:3.56E-5 ID:SGTC_2086|Compound:5274770|FD-Score:-4.63|P-value:1.60E-6 ID:SGTC_2138|Compound:5575593|FD-Score:3.41|P-value:3.02E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.74|P-value:8.52E-5 ID:SGTC_2223|Compound:6903751|FD-Score:4.35|P-value:6.23E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.70|P-value:1.18E-6 ID:SGTC_2275|Compound:7947463|FD-Score:4.08|P-value:2.07E-5 ID:SGTC_2322|Compound:7413319|FD-Score:11.20|P-value:6.27E-30 ID:SGTC_2401|Compound:5128683|FD-Score:3.43|P-value:2.86E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.81|P-value:6.52E-5 ID:SGTC_2472|Compound:5377652|FD-Score:4.30|P-value:7.67E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.86|P-value:5.23E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.19|P-value:6.76E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-3.99|P-value:3.04E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.98|P-value:3.21E-5 ID:SGTC_2624|Compound:nerol|FD-Score:-5.56|P-value:1.12E-8 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.59|P-value:1.51E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-5.19|P-value:8.93E-8 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.31|P-value:7.47E-6 ID:SGTC_2811|Compound:7967822|FD-Score:-4.09|P-value:1.96E-5 ID:SGTC_2858|Compound:9025781|FD-Score:10.80|P-value:1.08E-27 ID:SGTC_2880|Compound:9042983|FD-Score:3.50|P-value:2.20E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.62|P-value:1.39E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.17|P-value:7.20E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.13|P-value:8.15E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.59|P-value:1.96E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.17|P-value:2.77E-10 ID:SGTC_103|Compound:0844-0104|FD-Score:3.09|P-value:9.43E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.47|P-value:2.44E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:4.49|P-value:3.11E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.25|P-value:9.52E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.46|P-value:3.63E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.27|P-value:1.50E-10 ID:SGTC_358|Compound:0075-0058|FD-Score:6.38|P-value:6.88E-11 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.67|P-value:1.14E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.94|P-value:3.79E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-3.33|P-value:4.15E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.57|P-value:2.17E-6 ID:SGTC_505|Compound:gw-5074|FD-Score:3.79|P-value:6.90E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.82|P-value:6.26E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.68|P-value:1.08E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:17.00|P-value:1.19E-65 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.63|P-value:1.33E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.98|P-value:3.12E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:15.10|P-value:4.99E-52 ID:SGTC_683|Compound:panaxydol|FD-Score:5.11|P-value:1.42E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:4.17|P-value:1.40E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:4.88|P-value:4.74E-7 ID:SGTC_759|Compound:3486-0358|FD-Score:3.25|P-value:5.44E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:9.28|P-value:5.21E-21 ID:SGTC_805|Compound:3852-0218|FD-Score:5.13|P-value:1.26E-7 ID:SGTC_828|Compound:2074-0507|FD-Score:3.33|P-value:4.06E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.27|P-value:5.03E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.35|P-value:3.77E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.16|P-value:1.43E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.21|P-value:6.28E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.90|P-value:4.34E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.56|P-value:1.74E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.74|P-value:8.33E-5 ID:SGTC_1287|Compound:0971-0001|FD-Score:6.39|P-value:6.69E-11 ID:SGTC_1450|Compound:4112-4260|FD-Score:4.08|P-value:2.09E-5 ID:SGTC_1464|Compound:k208-0027|FD-Score:4.09|P-value:1.96E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:-3.23|P-value:5.83E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.20|P-value:6.53E-4 ID:SGTC_1687|Compound:st020778|FD-Score:11.30|P-value:2.48E-30 ID:SGTC_1712|Compound:st032288|FD-Score:4.99|P-value:2.57E-7 ID:SGTC_1754|Compound:st042065|FD-Score:3.78|P-value:7.26E-5 ID:SGTC_1760|Compound:st045453|FD-Score:4.97|P-value:2.96E-7 ID:SGTC_1800|Compound:st050079|FD-Score:5.33|P-value:4.25E-8 ID:SGTC_1801|Compound:st050089|FD-Score:7.20|P-value:2.33E-13 ID:SGTC_1803|Compound:st050068|FD-Score:3.98|P-value:3.21E-5 ID:SGTC_1818|Compound:st052136|FD-Score:3.13|P-value:8.18E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.33|P-value:4.14E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.85|P-value:2.76E-12 ID:SGTC_1877|Compound:wortmannin|FD-Score:7.01|P-value:8.95E-13 ID:SGTC_1934|Compound:st074720|FD-Score:7.45|P-value:3.38E-14 ID:SGTC_1941|Compound:st076221|FD-Score:11.00|P-value:7.87E-29 ID:SGTC_1991|Compound:st073000|FD-Score:3.92|P-value:4.02E-5 ID:SGTC_1994|Compound:st072947|FD-Score:4.32|P-value:7.18E-6 ID:SGTC_2083|Compound:5306046|FD-Score:-3.95|P-value:3.56E-5 ID:SGTC_2086|Compound:5274770|FD-Score:-4.63|P-value:1.60E-6 ID:SGTC_2138|Compound:5575593|FD-Score:3.41|P-value:3.02E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.74|P-value:8.52E-5 ID:SGTC_2223|Compound:6903751|FD-Score:4.35|P-value:6.23E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.70|P-value:1.18E-6 ID:SGTC_2275|Compound:7947463|FD-Score:4.08|P-value:2.07E-5 ID:SGTC_2322|Compound:7413319|FD-Score:11.20|P-value:6.27E-30 ID:SGTC_2401|Compound:5128683|FD-Score:3.43|P-value:2.86E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.81|P-value:6.52E-5 ID:SGTC_2472|Compound:5377652|FD-Score:4.30|P-value:7.67E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.86|P-value:5.23E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.19|P-value:6.76E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-3.99|P-value:3.04E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.98|P-value:3.21E-5 ID:SGTC_2624|Compound:nerol|FD-Score:-5.56|P-value:1.12E-8 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.59|P-value:1.51E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-5.19|P-value:8.93E-8 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.31|P-value:7.47E-6 ID:SGTC_2811|Compound:7967822|FD-Score:-4.09|P-value:1.96E-5 ID:SGTC_2858|Compound:9025781|FD-Score:10.80|P-value:1.08E-27 ID:SGTC_2880|Compound:9042983|FD-Score:3.50|P-value:2.20E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.62|P-value:1.39E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.17|P-value:7.20E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.13|P-value:8.15E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.59|P-value:1.96E-6

Top fitness defect scores for YGR164W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_528 3492-0019 17.00 172.0 µM 1.19E-65 calcium & mitochondrial duress 5 5.63E-65
2 SGTC_682 0kpi-0099 15.10 17.0 µM 4.99E-52 1 1.70E-51
3 SGTC_1687 st020778 11.30 55.4 µM 2.48E-30 42 4.97E-30
4 SGTC_2322 7413319 11.20 38.2 µM 6.27E-30 ERAD & cell cycle 12 1.24E-29
5 SGTC_1941 st076221 11.00 61.8 µM 7.87E-29 sphingolipid biosynthesis & PDR1 12 1.52E-28
6 SGTC_2858 9025781 10.80 9.0 µM 1.08E-27 sphingolipid biosynthesis & PDR1 17 2.03E-27
7 SGTC_804 1595-0054 9.28 20.9 µM 5.21E-21 sphingolipid biosynthesis & PDR1 3 8.32E-21
8 SGTC_1934 st074720 7.45 32.6 µM 3.38E-14 10 4.58E-14
9 SGTC_1801 st050089 7.20 28.4 µM 2.33E-13 NEO1-PIK1 36 3.09E-13
10 SGTC_1877 wortmannin 7.01 25.0 µM 8.95E-13 32 1.17E-12
11 SGTC_1875 nocodazole 6.85 6.0 µM 2.76E-12 tubulin folding & SWR complex 20 3.58E-12
12 SGTC_1287 0971-0001 6.39 34.6 µM 6.69E-11 sphingolipid biosynthesis & PDR1 19 8.38E-11
13 SGTC_358 0075-0058 6.38 9.4 µM 6.88E-11 15 8.61E-11
14 SGTC_1800 st050079 5.33 29.1 µM 4.25E-8 NEO1-PIK1 65 4.98E-8
15 SGTC_805 3852-0218 5.13 479.0 µM 1.26E-7 ERAD & cell cycle 34 1.46E-7
16 SGTC_683 panaxydol 5.11 45.0 µM 1.42E-7 sphingolipid biosynthesis & PDR1 18 1.64E-7
17 SGTC_1712 st032288 4.99 53.4 µM 2.57E-7 calcium & mitochondrial duress 119 2.95E-7
18 SGTC_1760 st045453 4.97 10.4 µM 2.96E-7 NEO1-PIK1 110 3.39E-7
19 SGTC_743 1275-0778 4.88 158.0 µM 4.74E-7 excess fatty acid 19 5.41E-7
20 SGTC_488 nitrendipine 4.57 139.0 µM 2.17E-6 30 2.44E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.446 5.66E-164 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.442 1.27E-160 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.409 3.30E-135 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.403 9.04E-131 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.375 1.78E-112 YNL237W YTP1 hom Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
0.372 2.12E-110 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.359 2.25E-102 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.328 3.16E-85 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.324 1.22E-82 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.319 3.59E-80 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.301 4.69E-71 YPR070W MED1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.298 6.18E-70 YJR074W MOG1 hom Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
0.298 6.40E-70 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.284 1.60E-63 YGL013C PDR1 hom Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
0.265 3.18E-55 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication