HIPHOP chemogenomics database
YGR164W_d 
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YGR164W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.446 | 5.66E-164 | YLR204W | QRI5 | hom | Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA |
| 0.442 | 1.27E-160 | YDR120C | TRM1 | hom | tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments |
| 0.409 | 3.30E-135 | YLR087C | CSF1 | hom | Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| 0.403 | 9.04E-131 | YMR031W-A_d | YMR031W-A_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C |
| 0.375 | 1.78E-112 | YNL237W | YTP1 | hom | Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins |
| 0.372 | 2.12E-110 | YBL079W | NUP170 | hom | Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication |
| 0.359 | 2.25E-102 | YIL170W | HXT12 | hom | Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family |
| 0.328 | 3.16E-85 | YDR392W | SPT3 | hom | Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters |
| 0.324 | 1.22E-82 | YDR475C | JIP4 | hom | Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence |
| 0.319 | 3.59E-80 | YLR055C | SPT8 | hom | Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters |
| 0.301 | 4.69E-71 | YPR070W | MED1 | hom | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation |
| 0.298 | 6.18E-70 | YJR074W | MOG1 | hom | Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p |
| 0.298 | 6.40E-70 | YDR093W | DNF2 | hom | Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase |
| 0.284 | 1.60E-63 | YGL013C | PDR1 | hom | Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication |
| 0.265 | 3.18E-55 | YJL164C | TPK1 | hom | cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication |