YGR167W / CLC1

Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR167W / CLC1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.76|P-value:7.05E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:3.71|P-value:8.11E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:9.07|P-value:6.32E-15 ID:SGTC_53|Compound:0973-0023|FD-Score:5.16|P-value:5.78E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:4.87|P-value:1.73E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:5.75|P-value:5.22E-7 ID:SGTC_93|Compound:0109-0045|FD-Score:7.58|P-value:5.99E-11 ID:SGTC_98|Compound:0074-0023|FD-Score:7.84|P-value:1.32E-11 ID:SGTC_119|Compound:0121-0043|FD-Score:5.36|P-value:2.63E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:5.39|P-value:2.28E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:6.84|P-value:3.07E-9 ID:SGTC_150|Compound:3970-0969|FD-Score:7.14|P-value:6.51E-10 ID:SGTC_188|Compound:3229-0966|FD-Score:4.18|P-value:1.92E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:-4.01|P-value:3.12E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:-4.36|P-value:1.01E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:6.22|P-value:6.10E-8 ID:SGTC_214|Compound:4373-3496|FD-Score:7.87|P-value:1.12E-11 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.03|P-value:1.15E-9 ID:SGTC_278|Compound:4092-0821|FD-Score:-3.69|P-value:8.31E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.55|P-value:5.20E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:-4.79|P-value:2.26E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:5.07|P-value:8.25E-6 ID:SGTC_376|Compound:3970-0862|FD-Score:5.00|P-value:1.07E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:6.03|P-value:1.47E-7 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.44|P-value:8.20E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.31|P-value:3.21E-6 ID:SGTC_459|Compound:nigericin|FD-Score:6.19|P-value:7.25E-8 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.99|P-value:3.50E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.89|P-value:1.60E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-4.20|P-value:1.72E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:5.88|P-value:2.91E-7 ID:SGTC_585|Compound:0kpi-0023|FD-Score:4.83|P-value:2.05E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:5.02|P-value:1.01E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:5.32|P-value:3.04E-6 ID:SGTC_717|Compound:1532-0246|FD-Score:4.73|P-value:2.90E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:9.84|P-value:2.86E-17 ID:SGTC_767|Compound:0929-0023|FD-Score:6.18|P-value:7.60E-8 ID:SGTC_800|Compound:3448-7362|FD-Score:5.52|P-value:1.36E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:4.27|P-value:1.42E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:4.18|P-value:1.94E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:6.36|P-value:3.30E-8 ID:SGTC_832|Compound:4083-0019|FD-Score:4.60|P-value:4.57E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:10.80|P-value:1.83E-20 ID:SGTC_897|Compound:1000-0139|FD-Score:4.94|P-value:1.37E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:7.57|P-value:6.03E-11 ID:SGTC_917|Compound:harmaline|FD-Score:-4.34|P-value:1.08E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:-4.13|P-value:2.18E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.96|P-value:3.90E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:4.51|P-value:6.30E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:5.20|P-value:5.00E-6 ID:SGTC_987|Compound:1497-1013|FD-Score:7.71|P-value:2.77E-11 ID:SGTC_1034|Compound:k072-0165|FD-Score:5.52|P-value:1.34E-6 ID:SGTC_1104|Compound:tacrolimus|FD-Score:4.92|P-value:1.46E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.83|P-value:5.79E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:6.92|P-value:2.06E-9 ID:SGTC_1228|Compound:0124-0032|FD-Score:5.47|P-value:1.64E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.04|P-value:3.03E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.53|P-value:1.44E-8 ID:SGTC_1690|Compound:st023502|FD-Score:5.22|P-value:4.66E-6 ID:SGTC_1723|Compound:st034307|FD-Score:7.38|P-value:1.76E-10 ID:SGTC_1797|Compound:st048695|FD-Score:-3.65|P-value:9.44E-4 ID:SGTC_1838|Compound:st055369|FD-Score:4.31|P-value:1.25E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.68|P-value:3.31E-11 ID:SGTC_2007|Compound:4011539|FD-Score:4.28|P-value:1.38E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.95|P-value:1.30E-5 ID:SGTC_2094|Compound:5332512|FD-Score:4.38|P-value:9.82E-5 ID:SGTC_2128|Compound:5255449|FD-Score:4.97|P-value:1.20E-5 ID:SGTC_2157|Compound:5649910|FD-Score:-4.28|P-value:1.31E-4 ID:SGTC_2179|Compound:6298986|FD-Score:6.38|P-value:2.89E-8 ID:SGTC_2182|Compound:6325192|FD-Score:7.94|P-value:7.29E-12 ID:SGTC_2186|Compound:6124449|FD-Score:3.82|P-value:5.91E-4 ID:SGTC_2200|Compound:6600604|FD-Score:6.77|P-value:4.39E-9 ID:SGTC_2300|Compound:7976697|FD-Score:-4.38|P-value:9.46E-5 ID:SGTC_2303|Compound:7774051|FD-Score:-4.55|P-value:5.32E-5 ID:SGTC_2350|Compound:9023895|FD-Score:-4.59|P-value:4.65E-5 ID:SGTC_2399|Compound:5884133|FD-Score:4.11|P-value:2.44E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:5.72|P-value:5.90E-7 ID:SGTC_2443|Compound:5493264|FD-Score:4.07|P-value:2.75E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.86|P-value:5.03E-4 ID:SGTC_2472|Compound:5377652|FD-Score:5.71|P-value:6.11E-7 ID:SGTC_2488|Compound:5268135|FD-Score:4.55|P-value:5.48E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:11.70|P-value:1.21E-23 ID:SGTC_2526|Compound:patulin|FD-Score:7.32|P-value:2.45E-10 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.06|P-value:8.51E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:8.60|P-value:1.32E-13 ID:SGTC_2679|Compound:rapamycin|FD-Score:8.12|P-value:2.58E-12 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.40|P-value:2.20E-6 ID:SGTC_2782|Compound:7736369|FD-Score:3.88|P-value:4.98E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-3.91|P-value:4.36E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.69|P-value:3.33E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-4.18|P-value:1.86E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-5.41|P-value:2.04E-6 ID:SGTC_2948|Compound:9070189|FD-Score:-4.37|P-value:9.90E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-10.70|P-value:2.99E-20 ID:SGTC_2993|Compound:9054257|FD-Score:-6.96|P-value:1.53E-9 ID:SGTC_3012|Compound:9080433|FD-Score:4.03|P-value:3.10E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-6.01|P-value:1.56E-7 ID:SGTC_3126|Compound:9127922|FD-Score:-5.17|P-value:5.39E-6 ID:SGTC_3166|Compound:9102297|FD-Score:3.95|P-value:3.90E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.66|P-value:9.42E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-6.15|P-value:8.02E-8 ID:SGTC_10|Compound:0279-0212|FD-Score:3.76|P-value:7.05E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:3.71|P-value:8.11E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:9.07|P-value:6.32E-15 ID:SGTC_53|Compound:0973-0023|FD-Score:5.16|P-value:5.78E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:4.87|P-value:1.73E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:5.75|P-value:5.22E-7 ID:SGTC_93|Compound:0109-0045|FD-Score:7.58|P-value:5.99E-11 ID:SGTC_98|Compound:0074-0023|FD-Score:7.84|P-value:1.32E-11 ID:SGTC_119|Compound:0121-0043|FD-Score:5.36|P-value:2.63E-6 ID:SGTC_124|Compound:0136-0217|FD-Score:5.39|P-value:2.28E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:6.84|P-value:3.07E-9 ID:SGTC_150|Compound:3970-0969|FD-Score:7.14|P-value:6.51E-10 ID:SGTC_188|Compound:3229-0966|FD-Score:4.18|P-value:1.92E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:-4.01|P-value:3.12E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:-4.36|P-value:1.01E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:6.22|P-value:6.10E-8 ID:SGTC_214|Compound:4373-3496|FD-Score:7.87|P-value:1.12E-11 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.03|P-value:1.15E-9 ID:SGTC_278|Compound:4092-0821|FD-Score:-3.69|P-value:8.31E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.55|P-value:5.20E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:-4.79|P-value:2.26E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:5.07|P-value:8.25E-6 ID:SGTC_376|Compound:3970-0862|FD-Score:5.00|P-value:1.07E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:6.03|P-value:1.47E-7 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.44|P-value:8.20E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.31|P-value:3.21E-6 ID:SGTC_459|Compound:nigericin|FD-Score:6.19|P-value:7.25E-8 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.99|P-value:3.50E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.89|P-value:1.60E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-4.20|P-value:1.72E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:5.88|P-value:2.91E-7 ID:SGTC_585|Compound:0kpi-0023|FD-Score:4.83|P-value:2.05E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:5.02|P-value:1.01E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:5.32|P-value:3.04E-6 ID:SGTC_717|Compound:1532-0246|FD-Score:4.73|P-value:2.90E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:9.84|P-value:2.86E-17 ID:SGTC_767|Compound:0929-0023|FD-Score:6.18|P-value:7.60E-8 ID:SGTC_800|Compound:3448-7362|FD-Score:5.52|P-value:1.36E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:4.27|P-value:1.42E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:4.18|P-value:1.94E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:6.36|P-value:3.30E-8 ID:SGTC_832|Compound:4083-0019|FD-Score:4.60|P-value:4.57E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:10.80|P-value:1.83E-20 ID:SGTC_897|Compound:1000-0139|FD-Score:4.94|P-value:1.37E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:7.57|P-value:6.03E-11 ID:SGTC_917|Compound:harmaline|FD-Score:-4.34|P-value:1.08E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:-4.13|P-value:2.18E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.96|P-value:3.90E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:4.51|P-value:6.30E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:5.20|P-value:5.00E-6 ID:SGTC_987|Compound:1497-1013|FD-Score:7.71|P-value:2.77E-11 ID:SGTC_1034|Compound:k072-0165|FD-Score:5.52|P-value:1.34E-6 ID:SGTC_1104|Compound:tacrolimus|FD-Score:4.92|P-value:1.46E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.83|P-value:5.79E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:6.92|P-value:2.06E-9 ID:SGTC_1228|Compound:0124-0032|FD-Score:5.47|P-value:1.64E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.04|P-value:3.03E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.53|P-value:1.44E-8 ID:SGTC_1690|Compound:st023502|FD-Score:5.22|P-value:4.66E-6 ID:SGTC_1723|Compound:st034307|FD-Score:7.38|P-value:1.76E-10 ID:SGTC_1797|Compound:st048695|FD-Score:-3.65|P-value:9.44E-4 ID:SGTC_1838|Compound:st055369|FD-Score:4.31|P-value:1.25E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.68|P-value:3.31E-11 ID:SGTC_2007|Compound:4011539|FD-Score:4.28|P-value:1.38E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.95|P-value:1.30E-5 ID:SGTC_2094|Compound:5332512|FD-Score:4.38|P-value:9.82E-5 ID:SGTC_2128|Compound:5255449|FD-Score:4.97|P-value:1.20E-5 ID:SGTC_2157|Compound:5649910|FD-Score:-4.28|P-value:1.31E-4 ID:SGTC_2179|Compound:6298986|FD-Score:6.38|P-value:2.89E-8 ID:SGTC_2182|Compound:6325192|FD-Score:7.94|P-value:7.29E-12 ID:SGTC_2186|Compound:6124449|FD-Score:3.82|P-value:5.91E-4 ID:SGTC_2200|Compound:6600604|FD-Score:6.77|P-value:4.39E-9 ID:SGTC_2300|Compound:7976697|FD-Score:-4.38|P-value:9.46E-5 ID:SGTC_2303|Compound:7774051|FD-Score:-4.55|P-value:5.32E-5 ID:SGTC_2350|Compound:9023895|FD-Score:-4.59|P-value:4.65E-5 ID:SGTC_2399|Compound:5884133|FD-Score:4.11|P-value:2.44E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:5.72|P-value:5.90E-7 ID:SGTC_2443|Compound:5493264|FD-Score:4.07|P-value:2.75E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.86|P-value:5.03E-4 ID:SGTC_2472|Compound:5377652|FD-Score:5.71|P-value:6.11E-7 ID:SGTC_2488|Compound:5268135|FD-Score:4.55|P-value:5.48E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:11.70|P-value:1.21E-23 ID:SGTC_2526|Compound:patulin|FD-Score:7.32|P-value:2.45E-10 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.06|P-value:8.51E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:8.60|P-value:1.32E-13 ID:SGTC_2679|Compound:rapamycin|FD-Score:8.12|P-value:2.58E-12 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.40|P-value:2.20E-6 ID:SGTC_2782|Compound:7736369|FD-Score:3.88|P-value:4.98E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-3.91|P-value:4.36E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.69|P-value:3.33E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-4.18|P-value:1.86E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-5.41|P-value:2.04E-6 ID:SGTC_2948|Compound:9070189|FD-Score:-4.37|P-value:9.90E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-10.70|P-value:2.99E-20 ID:SGTC_2993|Compound:9054257|FD-Score:-6.96|P-value:1.53E-9 ID:SGTC_3012|Compound:9080433|FD-Score:4.03|P-value:3.10E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-6.01|P-value:1.56E-7 ID:SGTC_3126|Compound:9127922|FD-Score:-5.17|P-value:5.39E-6 ID:SGTC_3166|Compound:9102297|FD-Score:3.95|P-value:3.90E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.66|P-value:9.42E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-6.15|P-value:8.02E-8

Top fitness defect scores for YGR167W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2514 salinomycin 11.70 42.7 µM 1.21E-23 4 5.98E-32
2 SGTC_841 0251-0215 10.80 91.2 µM 1.83E-20 11 1.43E-27
3 SGTC_748 0136-0228 9.84 77.9 µM 2.86E-17 redox potentiating 11 3.60E-23
4 SGTC_50 0929-0078 9.07 56.4 µM 6.32E-15 12 6.09E-20
5 SGTC_2615 purpurogallin-4-carboxylic acid 8.60 100.0 µM 1.32E-13 redox potentiating 13 3.99E-18
6 SGTC_2679 rapamycin 8.12 1.0 nM 2.58E-12 42 2.38E-16
7 SGTC_2182 6325192 7.94 200.0 µM 7.29E-12 Golgi 1 9.92E-16
8 SGTC_214 4373-3496 7.87 70.0 µM 1.12E-11 5 1.80E-15
9 SGTC_98 0074-0023 7.84 107.7 µM 1.32E-11 Golgi 6 2.26E-15
10 SGTC_987 1497-1013 7.71 404.0 µM 2.77E-11 2 6.21E-15
11 SGTC_1844 rapamycin 7.68 4.0 nM 3.31E-11 62 7.94E-15
12 SGTC_93 0109-0045 7.58 59.2 µM 5.99E-11 DNA damage response 2 1.79E-14
13 SGTC_908 3448-7491 7.57 47.7 µM 6.03E-11 mitochondrial stress 21 1.81E-14
14 SGTC_1723 st034307 7.38 2.5 µM 1.76E-10 mitochondrial processes 2 7.88E-14
15 SGTC_2526 patulin 7.32 37.6 µM 2.45E-10 19 1.25E-13
16 SGTC_150 3970-0969 7.14 77.2 µM 6.51E-10 12 4.76E-13
17 SGTC_275 trichlorophene 7.03 5.7 µM 1.15E-9 mitochondrial stress 92 1.03E-12
18 SGTC_1213 1315-0166 6.92 115.0 µM 2.06E-9 8 2.31E-12
19 SGTC_149 3970-0822 6.84 46.1 µM 3.07E-9 tubulin folding & SWR complex 23 4.00E-12
20 SGTC_2200 6600604 6.77 21.9 µM 4.39E-9 tubulin folding & SWR complex 21 6.54E-12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.337 4.43E-90 YDR320C SWA2 hom Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
0.267 1.25E-55 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.266 3.07E-55 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.243 3.40E-46 YDR137W RGP1 hom Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
0.241 1.58E-45 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.240 5.03E-45 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.234 9.00E-43 YDR080W VPS41 hom Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
0.220 7.24E-38 YGL012W ERG4 hom C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
0.216 9.96E-37 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.216 1.65E-36 YDR129C SAC6 hom Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.215 3.21E-36 YFL025C BST1 hom GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
0.214 6.40E-36 YDR136C_d VPS61_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect
0.211 4.03E-35 YLR262C YPT6 hom Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
0.205 3.53E-33 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.202 4.22E-32 YNR006W VPS27 hom Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)