YGR168C_p

Putative protein of unknown function; YGR168C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR168C / YGR168C

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:-3.77|P-value:4.55E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.58|P-value:8.25E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.80|P-value:1.27E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:4.91|P-value:9.90E-6 ID:SGTC_792|Compound:4534-1957|FD-Score:4.09|P-value:1.92E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.58|P-value:3.50E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:5.96|P-value:1.08E-7 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.26|P-value:1.07E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.48|P-value:5.07E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.38|P-value:7.14E-5 ID:SGTC_1629|Compound:st005085|FD-Score:3.69|P-value:6.79E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:6.13|P-value:4.77E-8 ID:SGTC_1632|Compound:st005650|FD-Score:5.74|P-value:2.95E-7 ID:SGTC_1712|Compound:st032288|FD-Score:3.73|P-value:6.11E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.27|P-value:1.03E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.01|P-value:6.77E-6 ID:SGTC_1839|Compound:st053978|FD-Score:4.06|P-value:2.10E-4 ID:SGTC_1901|Compound:st060216|FD-Score:5.46|P-value:1.03E-6 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:4.14|P-value:1.64E-4 ID:SGTC_2240|Compound:6690706|FD-Score:5.83|P-value:1.98E-7 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.37|P-value:7.30E-5 ID:SGTC_2260|Compound:7964312|FD-Score:4.89|P-value:1.07E-5 ID:SGTC_2304|Compound:7443016|FD-Score:3.85|P-value:4.14E-4 ID:SGTC_2334|Compound:9017922|FD-Score:4.90|P-value:1.04E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.64|P-value:8.01E-4 ID:SGTC_2816|Compound:7982706|FD-Score:5.31|P-value:1.96E-6 ID:SGTC_2855|Compound:9016525|FD-Score:4.00|P-value:2.57E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.44|P-value:5.83E-5 ID:SGTC_2908|Compound:7930301|FD-Score:4.25|P-value:1.13E-4 ID:SGTC_2947|Compound:9072639|FD-Score:4.40|P-value:6.65E-5 ID:SGTC_2973|Compound:9094665|FD-Score:-3.72|P-value:5.37E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.49|P-value:4.83E-5 ID:SGTC_3255|Compound:9139072|FD-Score:4.93|P-value:9.21E-6 ID:SGTC_33|Compound:0986-0033|FD-Score:-3.77|P-value:4.55E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.58|P-value:8.25E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.80|P-value:1.27E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:4.91|P-value:9.90E-6 ID:SGTC_792|Compound:4534-1957|FD-Score:4.09|P-value:1.92E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.58|P-value:3.50E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:5.96|P-value:1.08E-7 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.26|P-value:1.07E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.48|P-value:5.07E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.38|P-value:7.14E-5 ID:SGTC_1629|Compound:st005085|FD-Score:3.69|P-value:6.79E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:6.13|P-value:4.77E-8 ID:SGTC_1632|Compound:st005650|FD-Score:5.74|P-value:2.95E-7 ID:SGTC_1712|Compound:st032288|FD-Score:3.73|P-value:6.11E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.27|P-value:1.03E-4 ID:SGTC_1800|Compound:st050079|FD-Score:5.01|P-value:6.77E-6 ID:SGTC_1839|Compound:st053978|FD-Score:4.06|P-value:2.10E-4 ID:SGTC_1901|Compound:st060216|FD-Score:5.46|P-value:1.03E-6 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:4.14|P-value:1.64E-4 ID:SGTC_2240|Compound:6690706|FD-Score:5.83|P-value:1.98E-7 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.37|P-value:7.30E-5 ID:SGTC_2260|Compound:7964312|FD-Score:4.89|P-value:1.07E-5 ID:SGTC_2304|Compound:7443016|FD-Score:3.85|P-value:4.14E-4 ID:SGTC_2334|Compound:9017922|FD-Score:4.90|P-value:1.04E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.64|P-value:8.01E-4 ID:SGTC_2816|Compound:7982706|FD-Score:5.31|P-value:1.96E-6 ID:SGTC_2855|Compound:9016525|FD-Score:4.00|P-value:2.57E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.44|P-value:5.83E-5 ID:SGTC_2908|Compound:7930301|FD-Score:4.25|P-value:1.13E-4 ID:SGTC_2947|Compound:9072639|FD-Score:4.40|P-value:6.65E-5 ID:SGTC_2973|Compound:9094665|FD-Score:-3.72|P-value:5.37E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.49|P-value:4.83E-5 ID:SGTC_3255|Compound:9139072|FD-Score:4.93|P-value:9.21E-6

Top fitness defect scores for YGR168C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1631 benzylvanillin 6.13 81.9 µM 4.77E-8 Golgi 5 4.28E-10
2 SGTC_954 1189-0853 5.96 2.9 µM 1.08E-7 endomembrane recycling 12 1.25E-9
3 SGTC_2240 6690706 5.83 185.9 µM 1.98E-7 4 2.76E-9
4 SGTC_1632 st005650 5.74 90.0 µM 2.95E-7 4 4.62E-9
5 SGTC_1901 st060216 5.46 58.6 µM 1.03E-6 11 2.38E-8
6 SGTC_2816 7982706 5.31 58.4 µM 1.96E-6 azole & statin 24 5.50E-8
7 SGTC_1800 st050079 5.01 29.1 µM 6.77E-6 NEO1-PIK1 74 2.76E-7
8 SGTC_3255 9139072 4.93 49.5 µM 9.21E-6 5 4.13E-7
9 SGTC_122 0236-0016 4.91 402.4 µM 9.90E-6 RNA processing & uracil transport 18 4.53E-7
10 SGTC_2334 9017922 4.90 200.0 µM 1.04E-5 7 4.81E-7
11 SGTC_2260 7964312 4.89 200.0 µM 1.07E-5 4 5.05E-7
12 SGTC_953 1188-0045 4.58 9.7 µM 3.50E-5 60S ribosome export 14 2.34E-6
13 SGTC_2975 9084847 4.49 53.7 µM 4.83E-5 14 3.57E-6
14 SGTC_1041 0206-0046 4.48 107.0 µM 5.07E-5 24 3.81E-6
15 SGTC_2858 9025781 4.44 9.0 µM 5.83E-5 sphingolipid biosynthesis & PDR1 78 4.56E-6
16 SGTC_2947 9072639 4.40 7.7 µM 6.65E-5 tubulin folding & SWR complex 30 5.41E-6
17 SGTC_1110 3-hydroxy-3'-methoxyflavone 4.38 1.2 µM 7.14E-5 iron homeostasis 34 5.94E-6
18 SGTC_2251 lansoprazole 4.37 556.0 µM 7.30E-5 14 6.12E-6
19 SGTC_1718 roemerine 4.27 11.9 µM 1.03E-4 redox potentiating 41 9.59E-6
20 SGTC_1028 k015-0029 4.26 4.8 µM 1.07E-4 16 1.00E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 1.07E-14 YDR492W IZH1 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
0.096 2.59E-8 YDR520C_p URC2_p hom Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism
0.096 2.93E-8 YBR213W MET8 hom Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.095 3.20E-8 YGR178C PBP1 hom Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.091 1.38E-7 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.090 1.91E-7 YAR042W SWH1 hom Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction
0.087 4.58E-7 YDL015C TSC13 het Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress
0.087 5.12E-7 YPR092W_d YPR092W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.086 5.98E-7 YDR491C_d YDR491C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 1.86E-6 YHR148W IMP3 het Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
0.082 1.91E-6 YGR206W MVB12 hom ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.081 2.67E-6 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.081 2.85E-6 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.079 4.86E-6 YKL191W DPH2 hom Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p
0.078 6.14E-6 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress