YGR169C-A_p

Putative protein of unknown function; YGR169C-A has a paralog, YJR005C-A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR169C-A / YGR169C-A

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.91|P-value:2.74E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:4.61|P-value:9.65E-7 ID:SGTC_87|Compound:0100-0052|FD-Score:3.61|P-value:9.80E-5 ID:SGTC_109|Compound:0132-0036|FD-Score:3.60|P-value:1.04E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:-4.62|P-value:7.87E-7 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.93|P-value:2.20E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:5.55|P-value:4.89E-9 ID:SGTC_136|Compound:0097-0015|FD-Score:3.33|P-value:2.98E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.49|P-value:1.62E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.19|P-value:4.97E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.47|P-value:1.52E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:-3.16|P-value:5.09E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.87|P-value:3.20E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.27|P-value:3.36E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:7.53|P-value:3.61E-15 ID:SGTC_729|Compound:4092-0585|FD-Score:3.26|P-value:3.84E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:4.95|P-value:1.59E-7 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.07|P-value:7.86E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:-4.06|P-value:1.19E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:-3.23|P-value:3.91E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:4.57|P-value:1.19E-6 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.12|P-value:5.71E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:-4.82|P-value:2.72E-7 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.04|P-value:8.67E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-4.25|P-value:4.93E-6 ID:SGTC_1345|Compound:1488-0192|FD-Score:4.41|P-value:2.61E-6 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.01|P-value:9.67E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:4.13|P-value:1.02E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.64|P-value:8.71E-5 ID:SGTC_1553|Compound:gossypol|FD-Score:-3.13|P-value:5.62E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.35|P-value:2.71E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-3.62|P-value:8.35E-5 ID:SGTC_1715|Compound:st032160|FD-Score:3.06|P-value:8.14E-4 ID:SGTC_1719|Compound:st032227|FD-Score:-3.03|P-value:8.00E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-2.97|P-value:9.96E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.10|P-value:1.17E-5 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.40|P-value:2.24E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.08|P-value:7.62E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.06|P-value:8.01E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-3.12|P-value:5.85E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.17|P-value:5.37E-4 ID:SGTC_2030|Compound:5175110|FD-Score:5.43|P-value:1.01E-8 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.33|P-value:3.03E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.12|P-value:6.61E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.15|P-value:5.86E-4 ID:SGTC_2352|Compound:9027995|FD-Score:4.40|P-value:2.75E-6 ID:SGTC_2354|Compound:9060492|FD-Score:3.58|P-value:1.09E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.36|P-value:2.63E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.02|P-value:8.45E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.25|P-value:4.05E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.76|P-value:4.46E-7 ID:SGTC_2821|Compound:7996764|FD-Score:-4.60|P-value:8.67E-7 ID:SGTC_2824|Compound:7998404|FD-Score:-3.02|P-value:8.43E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.98|P-value:1.75E-5 ID:SGTC_3026|Compound:9090633|FD-Score:4.20|P-value:7.46E-6 ID:SGTC_3126|Compound:9127922|FD-Score:3.03|P-value:9.01E-4 ID:SGTC_3177|Compound:9107506|FD-Score:3.15|P-value:5.80E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.95|P-value:2.29E-5 ID:SGTC_3232|Compound:9132874|FD-Score:3.10|P-value:7.02E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.91|P-value:2.74E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:4.61|P-value:9.65E-7 ID:SGTC_87|Compound:0100-0052|FD-Score:3.61|P-value:9.80E-5 ID:SGTC_109|Compound:0132-0036|FD-Score:3.60|P-value:1.04E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:-4.62|P-value:7.87E-7 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.93|P-value:2.20E-5 ID:SGTC_127|Compound:0180-0333|FD-Score:5.55|P-value:4.89E-9 ID:SGTC_136|Compound:0097-0015|FD-Score:3.33|P-value:2.98E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.49|P-value:1.62E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.19|P-value:4.97E-4 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.47|P-value:1.52E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:-3.16|P-value:5.09E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.87|P-value:3.20E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.27|P-value:3.36E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:7.53|P-value:3.61E-15 ID:SGTC_729|Compound:4092-0585|FD-Score:3.26|P-value:3.84E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:4.95|P-value:1.59E-7 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.07|P-value:7.86E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:-4.06|P-value:1.19E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:-3.23|P-value:3.91E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:4.57|P-value:1.19E-6 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.12|P-value:5.71E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:-4.82|P-value:2.72E-7 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.04|P-value:8.67E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-4.25|P-value:4.93E-6 ID:SGTC_1345|Compound:1488-0192|FD-Score:4.41|P-value:2.61E-6 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.01|P-value:9.67E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:4.13|P-value:1.02E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.64|P-value:8.71E-5 ID:SGTC_1553|Compound:gossypol|FD-Score:-3.13|P-value:5.62E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.35|P-value:2.71E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-3.62|P-value:8.35E-5 ID:SGTC_1715|Compound:st032160|FD-Score:3.06|P-value:8.14E-4 ID:SGTC_1719|Compound:st032227|FD-Score:-3.03|P-value:8.00E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-2.97|P-value:9.96E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.10|P-value:1.17E-5 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.40|P-value:2.24E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.08|P-value:7.62E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.06|P-value:8.01E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-3.12|P-value:5.85E-4 ID:SGTC_1999|Compound:st074831|FD-Score:3.17|P-value:5.37E-4 ID:SGTC_2030|Compound:5175110|FD-Score:5.43|P-value:1.01E-8 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.33|P-value:3.03E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.12|P-value:6.61E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.15|P-value:5.86E-4 ID:SGTC_2352|Compound:9027995|FD-Score:4.40|P-value:2.75E-6 ID:SGTC_2354|Compound:9060492|FD-Score:3.58|P-value:1.09E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.36|P-value:2.63E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.02|P-value:8.45E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.25|P-value:4.05E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.76|P-value:4.46E-7 ID:SGTC_2821|Compound:7996764|FD-Score:-4.60|P-value:8.67E-7 ID:SGTC_2824|Compound:7998404|FD-Score:-3.02|P-value:8.43E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.98|P-value:1.75E-5 ID:SGTC_3026|Compound:9090633|FD-Score:4.20|P-value:7.46E-6 ID:SGTC_3126|Compound:9127922|FD-Score:3.03|P-value:9.01E-4 ID:SGTC_3177|Compound:9107506|FD-Score:3.15|P-value:5.80E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.95|P-value:2.29E-5 ID:SGTC_3232|Compound:9132874|FD-Score:3.10|P-value:7.02E-4

Top fitness defect scores for YGR169C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_685 1278-0033 7.53 54.9 µM 3.61E-15 60S ribosome export 1 2.60E-14
2 SGTC_127 0180-0333 5.55 59.1 µM 4.89E-9 mitochondrial response to ROS 9 1.41E-8
3 SGTC_2030 5175110 5.43 200.0 µM 1.01E-8 Golgi 9 2.78E-8
4 SGTC_936 3005-4620 4.95 401.0 µM 1.59E-7 11 3.69E-7
5 SGTC_2802 7925815 4.76 54.5 µM 4.46E-7 22 9.70E-7
6 SGTC_19 0279-0214 4.61 38.4 µM 9.65E-7 TRP & mitochondrial translation 27 2.00E-6
7 SGTC_1181 1222-0449 4.57 220.0 µM 1.19E-6 16 2.44E-6
8 SGTC_1345 1488-0192 4.41 31.4 µM 2.61E-6 11 5.08E-6
9 SGTC_2352 9027995 4.40 87.8 µM 2.75E-6 tubulin folding & SWR complex 26 5.33E-6
10 SGTC_3026 9090633 4.20 49.5 µM 7.46E-6 16 1.36E-5
11 SGTC_1472 k841-0093 4.13 193.0 µM 1.02E-5 15 1.82E-5
12 SGTC_1868 st057644 4.10 42.7 µM 1.17E-5 30 2.07E-5
13 SGTC_3217 9129673 3.95 49.5 µM 2.29E-5 38 3.89E-5
14 SGTC_7 0192-1582 3.91 4.2 µM 2.74E-5 57 4.62E-5
15 SGTC_675 1309-0189 3.87 238.0 µM 3.20E-5 15 5.34E-5
16 SGTC_1552 6-methylflavone 3.64 10.6 µM 8.71E-5 superoxide 23 1.37E-4
17 SGTC_87 0100-0052 3.61 35.5 µM 9.80E-5 137 1.53E-4
18 SGTC_109 0132-0036 3.60 33.7 µM 1.04E-4 34 1.62E-4
19 SGTC_2354 9060492 3.58 162.0 µM 1.09E-4 28 1.69E-4
20 SGTC_436 n,n-dimethylsphingosine 3.49 3.3 µM 1.62E-4 41 2.44E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.095 3.42E-8 YDR352W YPQ2 hom Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter
0.085 7.33E-7 YER118C SHO1 hom Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
0.080 3.77E-6 YGR203W YCH1 hom Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.079 5.18E-6 YMR304W UBP15 hom Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p
0.078 6.75E-6 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.077 8.72E-6 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.074 1.78E-5 YOR371C GPB1 hom Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication
0.073 2.23E-5 YNL044W YIP3 hom Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p
0.072 3.05E-5 YPL151C PRP46 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
0.071 3.58E-5 YMR194W RPL36A hom Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication
0.071 3.59E-5 YER086W ILV1 hom Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
0.070 4.89E-5 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.069 6.19E-5 YPR038W_d IRC16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci
0.069 6.28E-5 YFR032C-B_p YFR032C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.067 1.09E-4 YDR175C RSM24 hom Mitochondrial ribosomal protein of the small subunit