YGR170W / PSD2

Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR170W / PSD2

Click on Significant Values for Screen Details ID:SGTC_146|Compound:3448-8650|FD-Score:3.77|P-value:7.89E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:4.76|P-value:8.72E-7 ID:SGTC_363|Compound:0455-0021|FD-Score:14.20|P-value:1.74E-46 ID:SGTC_424|Compound:splitomicin|FD-Score:3.47|P-value:2.51E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-5.63|P-value:6.77E-9 ID:SGTC_428|Compound:3448-4153|FD-Score:-4.25|P-value:8.81E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:4.00|P-value:2.97E-5 ID:SGTC_526|Compound:4469-0568|FD-Score:4.30|P-value:8.03E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:7.83|P-value:1.84E-15 ID:SGTC_580|Compound:1123-0028|FD-Score:-3.19|P-value:6.40E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:-4.27|P-value:8.06E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:-4.85|P-value:4.92E-7 ID:SGTC_762|Compound:1165-0429|FD-Score:3.80|P-value:6.81E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.61|P-value:1.45E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.75|P-value:8.37E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:3.99|P-value:3.09E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:4.09|P-value:2.07E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:4.29|P-value:8.29E-6 ID:SGTC_947|Compound:3447-0010|FD-Score:-4.17|P-value:1.28E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.21|P-value:5.86E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.89|P-value:4.21E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.14|P-value:7.55E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.38|P-value:3.53E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.72|P-value:9.62E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.63|P-value:1.36E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.69|P-value:1.07E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.21|P-value:6.45E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.36|P-value:3.71E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:-3.37|P-value:3.25E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.18|P-value:7.15E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.17|P-value:7.43E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.38|P-value:3.36E-8 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.31|P-value:7.77E-6 ID:SGTC_1800|Compound:st050079|FD-Score:-3.54|P-value:1.75E-4 ID:SGTC_1803|Compound:st050068|FD-Score:-3.75|P-value:7.47E-5 ID:SGTC_1895|Compound:st058434|FD-Score:3.31|P-value:4.53E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.76|P-value:7.31E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.23|P-value:6.02E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.40|P-value:2.93E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.55|P-value:1.24E-8 ID:SGTC_2693|Compound:st077581|FD-Score:3.89|P-value:4.71E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.87|P-value:5.14E-5 ID:SGTC_2798|Compound:7813637|FD-Score:3.70|P-value:1.05E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.95|P-value:3.30E-7 ID:SGTC_2847|Compound:9005661|FD-Score:3.43|P-value:2.89E-4 ID:SGTC_2860|Compound:9025725|FD-Score:-3.08|P-value:9.32E-4 ID:SGTC_2896|Compound:9052656|FD-Score:6.15|P-value:3.35E-10 ID:SGTC_2925|Compound:9010536|FD-Score:4.08|P-value:2.12E-5 ID:SGTC_2978|Compound:9011784|FD-Score:3.89|P-value:4.76E-5 ID:SGTC_3192|Compound:9110362|FD-Score:-3.57|P-value:1.58E-4 ID:SGTC_3198|Compound:9112019|FD-Score:-3.07|P-value:9.46E-4 ID:SGTC_3308|Compound:9128332|FD-Score:5.34|P-value:4.13E-8 ID:SGTC_146|Compound:3448-8650|FD-Score:3.77|P-value:7.89E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:4.76|P-value:8.72E-7 ID:SGTC_363|Compound:0455-0021|FD-Score:14.20|P-value:1.74E-46 ID:SGTC_424|Compound:splitomicin|FD-Score:3.47|P-value:2.51E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-5.63|P-value:6.77E-9 ID:SGTC_428|Compound:3448-4153|FD-Score:-4.25|P-value:8.81E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:4.00|P-value:2.97E-5 ID:SGTC_526|Compound:4469-0568|FD-Score:4.30|P-value:8.03E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:7.83|P-value:1.84E-15 ID:SGTC_580|Compound:1123-0028|FD-Score:-3.19|P-value:6.40E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:-4.27|P-value:8.06E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:-4.85|P-value:4.92E-7 ID:SGTC_762|Compound:1165-0429|FD-Score:3.80|P-value:6.81E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.61|P-value:1.45E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.75|P-value:8.37E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:3.99|P-value:3.09E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:4.09|P-value:2.07E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:4.29|P-value:8.29E-6 ID:SGTC_947|Compound:3447-0010|FD-Score:-4.17|P-value:1.28E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.21|P-value:5.86E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.89|P-value:4.21E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.14|P-value:7.55E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.38|P-value:3.53E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.72|P-value:9.62E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.63|P-value:1.36E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.69|P-value:1.07E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.21|P-value:6.45E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.36|P-value:3.71E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:-3.37|P-value:3.25E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.18|P-value:7.15E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.17|P-value:7.43E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.38|P-value:3.36E-8 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.31|P-value:7.77E-6 ID:SGTC_1800|Compound:st050079|FD-Score:-3.54|P-value:1.75E-4 ID:SGTC_1803|Compound:st050068|FD-Score:-3.75|P-value:7.47E-5 ID:SGTC_1895|Compound:st058434|FD-Score:3.31|P-value:4.53E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.76|P-value:7.31E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.23|P-value:6.02E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.40|P-value:2.93E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.55|P-value:1.24E-8 ID:SGTC_2693|Compound:st077581|FD-Score:3.89|P-value:4.71E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.87|P-value:5.14E-5 ID:SGTC_2798|Compound:7813637|FD-Score:3.70|P-value:1.05E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.95|P-value:3.30E-7 ID:SGTC_2847|Compound:9005661|FD-Score:3.43|P-value:2.89E-4 ID:SGTC_2860|Compound:9025725|FD-Score:-3.08|P-value:9.32E-4 ID:SGTC_2896|Compound:9052656|FD-Score:6.15|P-value:3.35E-10 ID:SGTC_2925|Compound:9010536|FD-Score:4.08|P-value:2.12E-5 ID:SGTC_2978|Compound:9011784|FD-Score:3.89|P-value:4.76E-5 ID:SGTC_3192|Compound:9110362|FD-Score:-3.57|P-value:1.58E-4 ID:SGTC_3198|Compound:9112019|FD-Score:-3.07|P-value:9.46E-4 ID:SGTC_3308|Compound:9128332|FD-Score:5.34|P-value:4.13E-8

Top fitness defect scores for YGR170W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_363 0455-0021 14.20 3.1 µM 1.74E-46 azole & statin 4 5.45E-46
2 SGTC_528 3492-0019 7.83 172.0 µM 1.84E-15 calcium & mitochondrial duress 76 2.50E-15
3 SGTC_2896 9052656 6.15 71.4 µM 3.35E-10 endomembrane recycling 38 3.98E-10
4 SGTC_2688 kanamycin b 5.55 96.7 µM 1.24E-8 calcium & mitochondrial duress 191 1.42E-8
5 SGTC_1712 st032288 5.38 53.4 µM 3.36E-8 calcium & mitochondrial duress 96 3.80E-8
6 SGTC_3308 9128332 5.34 17.6 µM 4.13E-8 plasma membrane duress 45 4.66E-8
7 SGTC_2816 7982706 4.95 58.4 µM 3.30E-7 azole & statin 29 3.64E-7
8 SGTC_159 3970-0959 4.76 50.0 µM 8.72E-7 46 9.54E-7
9 SGTC_1788 fluconazole 4.31 20.0 µM 7.77E-6 azole & statin 55 8.32E-6
10 SGTC_526 4469-0568 4.30 170.0 µM 8.03E-6 azole & statin 30 8.59E-6
11 SGTC_943 3253-1379 4.29 105.0 µM 8.29E-6 22 8.87E-6
12 SGTC_940 3232-1287 4.09 54.8 µM 2.07E-5 NEO1 32 2.19E-5
13 SGTC_2925 9010536 4.08 32.5 µM 2.12E-5 azole & statin 41 2.25E-5
14 SGTC_513 4245-1575 4.00 41.7 µM 2.97E-5 unfolded protein response 114 3.14E-5
15 SGTC_916 4466-0038 3.99 42.0 nM 3.09E-5 cell wall 69 3.26E-5
16 SGTC_2693 st077581 3.89 40.7 µM 4.71E-5 35 4.96E-5
17 SGTC_2978 9011784 3.89 43.0 µM 4.76E-5 31 5.01E-5
18 SGTC_2776 terbinafine 3.87 19.9 µM 5.14E-5 cell wall signaling 54 5.40E-5
19 SGTC_762 1165-0429 3.80 115.0 µM 6.81E-5 TSC3-RPN4 23 7.14E-5
20 SGTC_146 3448-8650 3.77 53.1 µM 7.89E-5 NEO1-PIK1 151 8.26E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.278 1.34E-60 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.274 1.10E-58 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.270 2.58E-57 YNL264C PDR17 hom Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
0.258 5.78E-52 YNL288W CAF40 hom Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
0.255 5.72E-51 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.243 2.54E-46 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.216 1.22E-36 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.213 1.11E-35 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.212 2.13E-35 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.200 1.09E-31 YDL133W SRF1 hom Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
0.194 9.03E-30 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.188 4.93E-28 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.181 3.35E-26 YGR004W PEX31 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p
0.181 5.32E-26 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.180 6.63E-26 YOL016C CMK2 hom Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication