YGR171C / MSM1

Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR171C / MSM1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.27|P-value:8.27E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.33|P-value:6.80E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:8.39|P-value:3.36E-16 ID:SGTC_68|Compound:0986-0284|FD-Score:5.50|P-value:6.09E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:4.11|P-value:3.89E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:4.83|P-value:1.70E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:18.00|P-value:1.34E-67 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.85|P-value:8.11E-18 ID:SGTC_310|Compound:1273-0058|FD-Score:11.80|P-value:4.93E-30 ID:SGTC_314|Compound:1671-0008|FD-Score:5.04|P-value:6.24E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.24|P-value:9.06E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.89|P-value:9.12E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:4.46|P-value:8.85E-6 ID:SGTC_608|Compound:k048-0125|FD-Score:-4.32|P-value:1.59E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:4.03|P-value:5.21E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:3.95|P-value:7.33E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:-4.39|P-value:1.18E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:5.45|P-value:7.77E-8 ID:SGTC_767|Compound:0929-0023|FD-Score:6.44|P-value:2.80E-10 ID:SGTC_778|Compound:3456-2434|FD-Score:3.52|P-value:3.57E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.24|P-value:9.17E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:6.52|P-value:1.76E-10 ID:SGTC_903|Compound:1134-0042|FD-Score:8.58|P-value:7.31E-17 ID:SGTC_908|Compound:3448-7491|FD-Score:4.08|P-value:4.37E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:4.10|P-value:3.93E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:3.98|P-value:6.52E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:-3.28|P-value:7.95E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.23|P-value:9.40E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:-3.29|P-value:7.69E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:-4.06|P-value:4.68E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.63|P-value:2.38E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:5.91|P-value:6.46E-9 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.39|P-value:1.21E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.78|P-value:1.38E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.23|P-value:9.27E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.30|P-value:1.73E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:-3.33|P-value:6.77E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.65|P-value:2.23E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.48|P-value:4.13E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.14|P-value:3.81E-7 ID:SGTC_1917|Compound:st066507|FD-Score:-3.27|P-value:8.23E-4 ID:SGTC_2086|Compound:5274770|FD-Score:5.11|P-value:4.34E-7 ID:SGTC_2092|Compound:5303694|FD-Score:4.24|P-value:2.27E-5 ID:SGTC_2140|Compound:5586273|FD-Score:-3.37|P-value:5.84E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.30|P-value:7.46E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.61|P-value:2.59E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.26|P-value:8.61E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.61|P-value:2.58E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.44|P-value:9.78E-6 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.80|P-value:1.28E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.80|P-value:1.28E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.13|P-value:3.50E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-4.00|P-value:5.76E-5 ID:SGTC_2879|Compound:9041815|FD-Score:4.05|P-value:4.83E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.66|P-value:2.11E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-7.07|P-value:5.08E-12 ID:SGTC_2921|Compound:7974240|FD-Score:11.00|P-value:2.35E-26 ID:SGTC_2923|Compound:7992654|FD-Score:-6.79|P-value:3.16E-11 ID:SGTC_2928|Compound:9011484|FD-Score:5.91|P-value:6.30E-9 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.67|P-value:3.52E-6 ID:SGTC_3204|Compound:9114183|FD-Score:-3.40|P-value:5.31E-4 ID:SGTC_3277|Compound:9138724|FD-Score:3.84|P-value:1.12E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.27|P-value:8.27E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.33|P-value:6.80E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:8.39|P-value:3.36E-16 ID:SGTC_68|Compound:0986-0284|FD-Score:5.50|P-value:6.09E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:4.11|P-value:3.89E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:4.83|P-value:1.70E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:18.00|P-value:1.34E-67 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.85|P-value:8.11E-18 ID:SGTC_310|Compound:1273-0058|FD-Score:11.80|P-value:4.93E-30 ID:SGTC_314|Compound:1671-0008|FD-Score:5.04|P-value:6.24E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.24|P-value:9.06E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.89|P-value:9.12E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:4.46|P-value:8.85E-6 ID:SGTC_608|Compound:k048-0125|FD-Score:-4.32|P-value:1.59E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:4.03|P-value:5.21E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:3.95|P-value:7.33E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:-4.39|P-value:1.18E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:5.45|P-value:7.77E-8 ID:SGTC_767|Compound:0929-0023|FD-Score:6.44|P-value:2.80E-10 ID:SGTC_778|Compound:3456-2434|FD-Score:3.52|P-value:3.57E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.24|P-value:9.17E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:6.52|P-value:1.76E-10 ID:SGTC_903|Compound:1134-0042|FD-Score:8.58|P-value:7.31E-17 ID:SGTC_908|Compound:3448-7491|FD-Score:4.08|P-value:4.37E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:4.10|P-value:3.93E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:3.98|P-value:6.52E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:-3.28|P-value:7.95E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.23|P-value:9.40E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:-3.29|P-value:7.69E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:-4.06|P-value:4.68E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.63|P-value:2.38E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:5.91|P-value:6.46E-9 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.39|P-value:1.21E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.78|P-value:1.38E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.23|P-value:9.27E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.30|P-value:1.73E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:-3.33|P-value:6.77E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.65|P-value:2.23E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.48|P-value:4.13E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.14|P-value:3.81E-7 ID:SGTC_1917|Compound:st066507|FD-Score:-3.27|P-value:8.23E-4 ID:SGTC_2086|Compound:5274770|FD-Score:5.11|P-value:4.34E-7 ID:SGTC_2092|Compound:5303694|FD-Score:4.24|P-value:2.27E-5 ID:SGTC_2140|Compound:5586273|FD-Score:-3.37|P-value:5.84E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.30|P-value:7.46E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.61|P-value:2.59E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.26|P-value:8.61E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.61|P-value:2.58E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.44|P-value:9.78E-6 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.80|P-value:1.28E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.80|P-value:1.28E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.13|P-value:3.50E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-4.00|P-value:5.76E-5 ID:SGTC_2879|Compound:9041815|FD-Score:4.05|P-value:4.83E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.66|P-value:2.11E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-7.07|P-value:5.08E-12 ID:SGTC_2921|Compound:7974240|FD-Score:11.00|P-value:2.35E-26 ID:SGTC_2923|Compound:7992654|FD-Score:-6.79|P-value:3.16E-11 ID:SGTC_2928|Compound:9011484|FD-Score:5.91|P-value:6.30E-9 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.67|P-value:3.52E-6 ID:SGTC_3204|Compound:9114183|FD-Score:-3.40|P-value:5.31E-4 ID:SGTC_3277|Compound:9138724|FD-Score:3.84|P-value:1.12E-4

Top fitness defect scores for YGR171C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 18.00 5.3 µM 1.34E-67 70 8.53E-73
2 SGTC_310 1273-0058 11.80 1.1 µM 4.93E-30 mitochondrial stress 25 2.90E-32
3 SGTC_2921 7974240 11.00 10.7 µM 2.35E-26 2 2.69E-28
4 SGTC_275 trichlorophene 8.85 5.7 µM 8.11E-18 mitochondrial stress 59 4.35E-19
5 SGTC_903 1134-0042 8.58 114.0 µM 7.31E-17 2 4.66E-18
6 SGTC_63 0099-0242 8.39 26.7 µM 3.36E-16 mitochondrial stress 5 2.41E-17
7 SGTC_892 0929-0076 6.52 29.0 µM 1.76E-10 TRP & mitochondrial translation 5 3.53E-11
8 SGTC_767 0929-0023 6.44 86.0 µM 2.80E-10 TRP & mitochondrial translation 17 5.81E-11
9 SGTC_2928 9011484 5.91 9.8 µM 6.30E-9 heme biosynthesis & mitochondrial translocase 8 1.67E-9
10 SGTC_1153 4055-0057 5.91 267.0 µM 6.46E-9 3 1.71E-9
11 SGTC_68 0986-0284 5.50 82.8 µM 6.09E-8 24 1.92E-8
12 SGTC_614 0462-0418 5.45 107.0 µM 7.77E-8 9 2.50E-8
13 SGTC_2086 5274770 5.11 176.6 µM 4.34E-7 7 1.59E-7
14 SGTC_314 1671-0008 5.04 2.7 µM 6.24E-7 21 2.35E-7
15 SGTC_173 1273-0061 4.83 2.7 µM 1.70E-6 mitochondrial stress 157 6.92E-7
16 SGTC_596 1155-0152 4.46 116.0 µM 8.85E-6 TRP & mitochondrial translation 26 4.09E-6
17 SGTC_2497 7-hydroxyflavone 4.44 100.0 µM 9.78E-6 12 4.55E-6
18 SGTC_1188 1403-0014 4.39 4.6 µM 1.21E-5 mitochondrial stress 38 5.73E-6
19 SGTC_1319 1306-0155 4.30 43.7 µM 1.73E-5 15 8.42E-6
20 SGTC_2092 5303694 4.24 80.7 µM 2.27E-5 TSC3-RPN4 35 1.13E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.470 1.12E-183 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
0.466 6.12E-181 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.466 1.56E-179 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.464 5.36E-179 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.463 9.37E-178 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.454 1.11E-170 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.447 3.16E-164 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.440 6.62E-159 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.439 1.79E-158 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.437 1.83E-156 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.436 3.54E-156 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.433 7.86E-154 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.432 6.96E-153 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.431 1.44E-151 YMR293C HER2 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase
0.427 1.49E-148 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein