HIPHOP chemogenomics database
YGR171C / MSM1 
Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YGR171C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.470 | 1.12E-183 | YPL078C | ATP4 | hom | Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated |
| 0.466 | 6.12E-181 | YDR462W | MRPL28 | hom | Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress |
| 0.466 | 1.56E-179 | YMR287C | DSS1 | hom | 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs |
| 0.464 | 5.36E-179 | YJL023C | PET130 | hom | Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| 0.463 | 9.37E-178 | YNL252C | MRPL17 | hom | Mitochondrial ribosomal protein of the large subunit |
| 0.454 | 1.11E-170 | YNL184C_p | YNL184C_p | hom | Protein of unknown function; expressed at both mRNA and protein levels |
| 0.447 | 3.16E-164 | YGR215W | RSM27 | hom | Mitochondrial ribosomal protein of the small subunit |
| 0.440 | 6.62E-159 | YMR228W | MTF1 | hom | Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation |
| 0.439 | 1.79E-158 | YGR220C | MRPL9 | hom | Mitochondrial ribosomal protein of the large subunit |
| 0.437 | 1.83E-156 | YDR518W | EUG1 | hom | Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER |
| 0.436 | 3.54E-156 | YLL033W | IRC19 | hom | Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci |
| 0.433 | 7.86E-154 | YMR072W | ABF2 | hom | Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation |
| 0.432 | 6.96E-153 | YDR079W | PET100 | hom | Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme |
| 0.431 | 1.44E-151 | YMR293C | HER2 | hom | Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase |
| 0.427 | 1.49E-148 | YDR237W | MRPL7 | hom | Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein |