YGR172C / YIP1

Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF4

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR172C / YIP1

Click on Significant Values for Screen Details ID:SGTC_81|Compound:0411-0046|FD-Score:-3.14|P-value:4.43E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:-3.56|P-value:7.93E-5 ID:SGTC_94|Compound:0334-0113|FD-Score:-4.59|P-value:5.34E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:3.82|P-value:1.64E-5 ID:SGTC_325|Compound:2810-4341|FD-Score:2.84|P-value:9.55E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.11|P-value:3.52E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-3.41|P-value:1.50E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.81|P-value:2.58E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:-3.06|P-value:6.04E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.05|P-value:6.17E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:4.31|P-value:1.42E-6 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.45|P-value:1.30E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:2.93|P-value:7.02E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.12|P-value:4.84E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.13|P-value:3.21E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.08|P-value:4.67E-6 ID:SGTC_1212|Compound:0520-0165|FD-Score:-3.43|P-value:1.36E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:2.89|P-value:8.18E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-2.97|P-value:8.26E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.17|P-value:3.01E-6 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.31|P-value:1.55E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:-3.08|P-value:5.56E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.03|P-value:4.71E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.14|P-value:3.09E-4 ID:SGTC_1920|Compound:st075728|FD-Score:2.99|P-value:5.60E-4 ID:SGTC_1927|Compound:st060202|FD-Score:2.96|P-value:6.18E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.85|P-value:1.46E-5 ID:SGTC_2060|Compound:5238662|FD-Score:2.91|P-value:7.56E-4 ID:SGTC_2064|Compound:5220758|FD-Score:2.83|P-value:9.98E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.23|P-value:2.16E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.51|P-value:6.68E-5 ID:SGTC_2279|Compound:7948423|FD-Score:-2.96|P-value:8.84E-4 ID:SGTC_2403|Compound:6032726|FD-Score:-5.18|P-value:1.69E-8 ID:SGTC_2444|Compound:5485484|FD-Score:3.09|P-value:3.79E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:2.92|P-value:7.30E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:2.99|P-value:5.49E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-4.42|P-value:1.32E-6 ID:SGTC_2809|Compound:7964133|FD-Score:5.82|P-value:1.53E-10 ID:SGTC_2849|Compound:9019321|FD-Score:-4.30|P-value:2.44E-6 ID:SGTC_2859|Compound:9028643|FD-Score:2.99|P-value:5.61E-4 ID:SGTC_3311|Compound:9131146|FD-Score:-2.99|P-value:7.70E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:-3.14|P-value:4.43E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:-3.56|P-value:7.93E-5 ID:SGTC_94|Compound:0334-0113|FD-Score:-4.59|P-value:5.34E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:3.82|P-value:1.64E-5 ID:SGTC_325|Compound:2810-4341|FD-Score:2.84|P-value:9.55E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.11|P-value:3.52E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-3.41|P-value:1.50E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.81|P-value:2.58E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:-3.06|P-value:6.04E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.05|P-value:6.17E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:4.31|P-value:1.42E-6 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.45|P-value:1.30E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:2.93|P-value:7.02E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.12|P-value:4.84E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.13|P-value:3.21E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.08|P-value:4.67E-6 ID:SGTC_1212|Compound:0520-0165|FD-Score:-3.43|P-value:1.36E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:2.89|P-value:8.18E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-2.97|P-value:8.26E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.17|P-value:3.01E-6 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.31|P-value:1.55E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:-3.08|P-value:5.56E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.03|P-value:4.71E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.14|P-value:3.09E-4 ID:SGTC_1920|Compound:st075728|FD-Score:2.99|P-value:5.60E-4 ID:SGTC_1927|Compound:st060202|FD-Score:2.96|P-value:6.18E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.85|P-value:1.46E-5 ID:SGTC_2060|Compound:5238662|FD-Score:2.91|P-value:7.56E-4 ID:SGTC_2064|Compound:5220758|FD-Score:2.83|P-value:9.98E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.23|P-value:2.16E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.51|P-value:6.68E-5 ID:SGTC_2279|Compound:7948423|FD-Score:-2.96|P-value:8.84E-4 ID:SGTC_2403|Compound:6032726|FD-Score:-5.18|P-value:1.69E-8 ID:SGTC_2444|Compound:5485484|FD-Score:3.09|P-value:3.79E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:2.92|P-value:7.30E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:2.99|P-value:5.49E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-4.42|P-value:1.32E-6 ID:SGTC_2809|Compound:7964133|FD-Score:5.82|P-value:1.53E-10 ID:SGTC_2849|Compound:9019321|FD-Score:-4.30|P-value:2.44E-6 ID:SGTC_2859|Compound:9028643|FD-Score:2.99|P-value:5.61E-4 ID:SGTC_3311|Compound:9131146|FD-Score:-2.99|P-value:7.70E-4

Top fitness defect scores for YGR172C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2809 7964133 5.82 13.0 µM 1.53E-10 60S ribosome export 3 3.01E-9 0.01
2 SGTC_864 0469-0573 4.31 172.0 µM 1.42E-6 2 8.02E-6 0.28
3 SGTC_1266 0828-0227 4.17 32.9 µM 3.01E-6 9 1.54E-5 0.24
4 SGTC_1203 3992-3522 4.08 103.0 µM 4.67E-6 11 2.24E-5 0.05
5 SGTC_1988 st071872 3.85 53.4 µM 1.46E-5 1 6.00E-5 0.77
6 SGTC_142 0335-0849 3.82 62.7 µM 1.64E-5 ubiquinone biosynthesis & proteasome 20 6.64E-5 0.18
7 SGTC_2196 6573537 3.51 42.7 µM 6.68E-5 copper-dependent oxidative stress 4 2.23E-4 0.04
8 SGTC_1445 4239-0156 3.31 97.7 µM 1.55E-4 7 4.61E-4 0.17
9 SGTC_2107 5363541 3.23 170.2 µM 2.16E-4 16 6.15E-4 0.03
10 SGTC_1895 st058434 3.14 18.3 µM 3.09E-4 11 8.37E-4 0.06
11 SGTC_1079 idarubicin 3.13 2.4 µM 3.21E-4 DNA damage response 12 8.65E-4 0.04
12 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 3.11 8.0 µM 3.52E-4 21 9.37E-4 0.16
13 SGTC_2444 5485484 3.09 36.4 µM 3.79E-4 18 9.98E-4 0.02
14 SGTC_1891 st059073 3.03 26.2 µM 4.71E-4 TSC3-RPN4 13 0.00121 0.13
15 SGTC_2531 methyl deoxycholate 2.99 70.1 µM 5.49E-4 18 0.00138 0.18
16 SGTC_1920 st075728 2.99 45.7 µM 5.60E-4 14 0.00140 0.06
17 SGTC_2859 9028643 2.99 45.5 µM 5.61E-4 6 0.00140 0.02
18 SGTC_1927 st060202 2.96 13.8 µM 6.18E-4 18 0.00153 0.01
19 SGTC_875 0709-0210 2.93 25.7 µM 7.02E-4 fatty acid desaturase (OLE1) 23 0.00170 0.04
20 SGTC_2504 purpurogallin 2.92 52.3 µM 7.30E-4 RPP1 & pyrimidine depletion 12 0.00176 0.13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 3.62E-14 YER046W SPO73 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
0.121 2.38E-12 YDL210W UGA4 hom Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
0.109 2.86E-10 YJL125C GCD14 het Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
0.108 4.21E-10 YDL234C GYP7 hom GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking
0.099 9.07E-9 YMR059W SEN15 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
0.098 1.19E-8 YOR269W PAC1 hom Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly
0.093 6.32E-8 YDL134C PPH21 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication
0.091 1.36E-7 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.090 1.94E-7 YKL167C MRP49 hom Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
0.088 3.90E-7 YGL085W_p LCL3_p hom Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS
0.086 6.31E-7 YMR182C RGM1 hom Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication
0.084 1.20E-6 YNL289W PCL1 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth
0.083 1.42E-6 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.082 1.81E-6 YJL090C DPB11 het DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress
0.082 2.09E-6 YJL130C URA2 hom Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP