YGR173W / RBG2

Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR173W / RBG2

Click on Significant Values for Screen Details ID:SGTC_127|Compound:0180-0333|FD-Score:3.74|P-value:8.10E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:3.38|P-value:3.36E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.59|P-value:1.65E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.52|P-value:1.99E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:4.87|P-value:4.65E-7 ID:SGTC_904|Compound:1141-0088|FD-Score:3.13|P-value:7.96E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.93|P-value:4.13E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-9.31|P-value:4.75E-21 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.44|P-value:2.64E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.72|P-value:9.04E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.79|P-value:7.28E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.24|P-value:5.41E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.55|P-value:1.74E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.46|P-value:2.66E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.35|P-value:3.70E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.54|P-value:1.81E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.93|P-value:3.85E-5 ID:SGTC_1731|Compound:st035964|FD-Score:3.44|P-value:2.61E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.12|P-value:8.21E-4 ID:SGTC_2298|Compound:7976326|FD-Score:3.14|P-value:7.66E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-4.52|P-value:2.93E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.33|P-value:4.28E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-3.68|P-value:1.14E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.10|P-value:8.97E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.61|P-value:1.39E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.47|P-value:2.35E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-3.68|P-value:1.15E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.65|P-value:1.28E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-3.54|P-value:1.97E-4 ID:SGTC_2923|Compound:7992654|FD-Score:3.30|P-value:4.46E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-4.42|P-value:4.86E-6 ID:SGTC_2978|Compound:9011784|FD-Score:-6.78|P-value:5.27E-12 ID:SGTC_2980|Compound:9014342|FD-Score:-4.84|P-value:6.26E-7 ID:SGTC_3006|Compound:9075424|FD-Score:-5.21|P-value:8.99E-8 ID:SGTC_3049|Compound:9092223|FD-Score:-3.51|P-value:2.17E-4 ID:SGTC_3168|Compound:9103419|FD-Score:-3.13|P-value:8.67E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.74|P-value:8.10E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:3.38|P-value:3.36E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.59|P-value:1.65E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.52|P-value:1.99E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:4.87|P-value:4.65E-7 ID:SGTC_904|Compound:1141-0088|FD-Score:3.13|P-value:7.96E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.93|P-value:4.13E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-9.31|P-value:4.75E-21 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.44|P-value:2.64E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.72|P-value:9.04E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.79|P-value:7.28E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.24|P-value:5.41E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.55|P-value:1.74E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.46|P-value:2.66E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.35|P-value:3.70E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.54|P-value:1.81E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.93|P-value:3.85E-5 ID:SGTC_1731|Compound:st035964|FD-Score:3.44|P-value:2.61E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.12|P-value:8.21E-4 ID:SGTC_2298|Compound:7976326|FD-Score:3.14|P-value:7.66E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-4.52|P-value:2.93E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.33|P-value:4.28E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-3.68|P-value:1.14E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.10|P-value:8.97E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.61|P-value:1.39E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.47|P-value:2.35E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-3.68|P-value:1.15E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.65|P-value:1.28E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-3.54|P-value:1.97E-4 ID:SGTC_2923|Compound:7992654|FD-Score:3.30|P-value:4.46E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-4.42|P-value:4.86E-6 ID:SGTC_2978|Compound:9011784|FD-Score:-6.78|P-value:5.27E-12 ID:SGTC_2980|Compound:9014342|FD-Score:-4.84|P-value:6.26E-7 ID:SGTC_3006|Compound:9075424|FD-Score:-5.21|P-value:8.99E-8 ID:SGTC_3049|Compound:9092223|FD-Score:-3.51|P-value:2.17E-4 ID:SGTC_3168|Compound:9103419|FD-Score:-3.13|P-value:8.67E-4

Top fitness defect scores for YGR173W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_861 0443-0273 4.87 110.0 µM 4.65E-7 3 5.49E-7
2 SGTC_1653 st012112 3.93 65.0 µM 3.85E-5 12 4.33E-5
3 SGTC_127 0180-0333 3.74 59.1 µM 8.10E-5 mitochondrial response to ROS 56 9.04E-5
4 SGTC_1117 retinoic acid 3.72 1.1 µM 9.04E-5 23 1.01E-4
5 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.61 70.0 µM 1.39E-4 redox potentiating 88 1.55E-4
6 SGTC_1411 3909-8223 3.55 150.0 µM 1.74E-4 16 1.93E-4
7 SGTC_1637 st007924 3.54 17.4 µM 1.81E-4 40 2.01E-4
8 SGTC_650 1328-0195 3.52 38.0 µM 1.99E-4 30 2.19E-4
9 SGTC_2611 pyromycin 3.47 23.9 µM 2.35E-4 53 2.59E-4
10 SGTC_1731 st035964 3.44 63.0 µM 2.61E-4 50 2.88E-4
11 SGTC_1113 artemisinin 3.44 1.2 µM 2.64E-4 heme biosynthesis & mitochondrial translocase 27 2.91E-4
12 SGTC_135 0933-0004 3.38 26.4 µM 3.36E-4 60S ribosome export 43 3.69E-4
13 SGTC_1625 st003711 3.35 30.1 µM 3.70E-4 calcium & mitochondrial duress 62 4.06E-4
14 SGTC_2923 7992654 3.30 58.1 µM 4.46E-4 Golgi 54 4.89E-4
15 SGTC_1409 3909-8004 3.24 61.9 µM 5.41E-4 51 5.92E-4
16 SGTC_2298 7976326 3.14 193.8 µM 7.66E-4 27 8.35E-4
17 SGTC_904 1141-0088 3.13 396.0 µM 7.96E-4 48 8.67E-4
18 SGTC_1942 st076330 3.12 65.2 µM 8.21E-4 61 8.94E-4
19 SGTC_2600 tangeritin 3.10 88.0 µM 8.97E-4 69 9.75E-4
20 SGTC_1730 st033808 3.06 45.1 µM 0.00102 94 0.00111

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 3.11E-19 YGL091C NBP35 het Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases
0.137 1.30E-15 YIL024C_p YIL024C_p hom Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
0.130 4.76E-14 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.120 3.38E-12 YPR033C HTS1 het Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome
0.116 1.48E-11 YGR121C MEP1 hom Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
0.113 5.29E-11 YMR028W TAP42 het Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits
0.106 7.88E-10 YDR055W PST1 hom Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
0.105 1.07E-9 YOL067C RTG1 hom Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus
0.104 1.57E-9 YLR072W_p YLR072W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene
0.103 1.87E-9 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.098 1.44E-8 YMR184W ADD37 hom Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress
0.095 3.12E-8 YDR285W ZIP1 hom Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate
0.094 5.66E-8 YOL038C-A_p YOL038C-A_p hom Putative protein of unknown function; identified by SAGE analysis
0.093 7.08E-8 YKL040C NFU1 hom Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria
0.091 1.20E-7 YFL028C CAF16 hom Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator