YGR176W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR176W / YGR176W

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.56|P-value:4.68E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:2.84|P-value:9.04E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:5.52|P-value:6.55E-10 ID:SGTC_234|Compound:nsc-17383|FD-Score:2.94|P-value:6.29E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.08|P-value:3.62E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.05|P-value:4.01E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:6.01|P-value:1.93E-11 ID:SGTC_361|Compound:000s-0510|FD-Score:3.02|P-value:4.55E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.57|P-value:4.27E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:4.81|P-value:6.39E-8 ID:SGTC_381|Compound:3461-2219|FD-Score:3.08|P-value:3.65E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.78|P-value:1.60E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:3.94|P-value:7.35E-6 ID:SGTC_652|Compound:0437-0092|FD-Score:-2.96|P-value:5.54E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:2.82|P-value:9.89E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.44|P-value:7.53E-5 ID:SGTC_1498|Compound:4478-3555|FD-Score:2.95|P-value:6.03E-4 ID:SGTC_1734|Compound:st037168|FD-Score:2.86|P-value:8.47E-4 ID:SGTC_2035|Compound:5154463|FD-Score:2.92|P-value:6.68E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-3.13|P-value:2.82E-4 ID:SGTC_2117|Compound:5521686|FD-Score:-4.40|P-value:6.28E-7 ID:SGTC_2123|Compound:5259487|FD-Score:3.40|P-value:9.58E-5 ID:SGTC_2424|Compound:5537928|FD-Score:-3.38|P-value:9.63E-5 ID:SGTC_2440|Compound:5628896|FD-Score:-3.28|P-value:1.50E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-4.87|P-value:3.95E-8 ID:SGTC_2451|Compound:5856223|FD-Score:-3.28|P-value:1.51E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.71|P-value:2.32E-5 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-3.20|P-value:2.09E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:4.46|P-value:4.63E-7 ID:SGTC_2776|Compound:terbinafine|FD-Score:11.00|P-value:6.59E-34 ID:SGTC_2802|Compound:7925815|FD-Score:-3.16|P-value:2.51E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.36|P-value:1.09E-4 ID:SGTC_2820|Compound:7989630|FD-Score:2.94|P-value:6.12E-4 ID:SGTC_2830|Compound:7992007|FD-Score:3.03|P-value:4.31E-4 ID:SGTC_2848|Compound:9016370|FD-Score:4.19|P-value:2.04E-6 ID:SGTC_2957|Compound:9076800|FD-Score:-2.83|P-value:9.01E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.91|P-value:8.66E-6 ID:SGTC_3033|Compound:9090887|FD-Score:-4.02|P-value:4.73E-6 ID:SGTC_3066|Compound:9117245|FD-Score:4.57|P-value:2.62E-7 ID:SGTC_3103|Compound:9120822|FD-Score:3.83|P-value:1.27E-5 ID:SGTC_3130|Compound:9127414|FD-Score:2.98|P-value:5.37E-4 ID:SGTC_3223|Compound:9129970|FD-Score:3.08|P-value:3.61E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-2.83|P-value:8.99E-4 ID:SGTC_3300|Compound:9124615|FD-Score:4.50|P-value:3.85E-7 ID:SGTC_3305|Compound:9127027|FD-Score:3.59|P-value:4.06E-5 ID:SGTC_3308|Compound:9128332|FD-Score:3.02|P-value:4.52E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.48|P-value:6.17E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:3.56|P-value:4.68E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:2.84|P-value:9.04E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:5.52|P-value:6.55E-10 ID:SGTC_234|Compound:nsc-17383|FD-Score:2.94|P-value:6.29E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.08|P-value:3.62E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.05|P-value:4.01E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:6.01|P-value:1.93E-11 ID:SGTC_361|Compound:000s-0510|FD-Score:3.02|P-value:4.55E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.57|P-value:4.27E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:4.81|P-value:6.39E-8 ID:SGTC_381|Compound:3461-2219|FD-Score:3.08|P-value:3.65E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.78|P-value:1.60E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:3.94|P-value:7.35E-6 ID:SGTC_652|Compound:0437-0092|FD-Score:-2.96|P-value:5.54E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:2.82|P-value:9.89E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.44|P-value:7.53E-5 ID:SGTC_1498|Compound:4478-3555|FD-Score:2.95|P-value:6.03E-4 ID:SGTC_1734|Compound:st037168|FD-Score:2.86|P-value:8.47E-4 ID:SGTC_2035|Compound:5154463|FD-Score:2.92|P-value:6.68E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-3.13|P-value:2.82E-4 ID:SGTC_2117|Compound:5521686|FD-Score:-4.40|P-value:6.28E-7 ID:SGTC_2123|Compound:5259487|FD-Score:3.40|P-value:9.58E-5 ID:SGTC_2424|Compound:5537928|FD-Score:-3.38|P-value:9.63E-5 ID:SGTC_2440|Compound:5628896|FD-Score:-3.28|P-value:1.50E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-4.87|P-value:3.95E-8 ID:SGTC_2451|Compound:5856223|FD-Score:-3.28|P-value:1.51E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.71|P-value:2.32E-5 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-3.20|P-value:2.09E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:4.46|P-value:4.63E-7 ID:SGTC_2776|Compound:terbinafine|FD-Score:11.00|P-value:6.59E-34 ID:SGTC_2802|Compound:7925815|FD-Score:-3.16|P-value:2.51E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.36|P-value:1.09E-4 ID:SGTC_2820|Compound:7989630|FD-Score:2.94|P-value:6.12E-4 ID:SGTC_2830|Compound:7992007|FD-Score:3.03|P-value:4.31E-4 ID:SGTC_2848|Compound:9016370|FD-Score:4.19|P-value:2.04E-6 ID:SGTC_2957|Compound:9076800|FD-Score:-2.83|P-value:9.01E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.91|P-value:8.66E-6 ID:SGTC_3033|Compound:9090887|FD-Score:-4.02|P-value:4.73E-6 ID:SGTC_3066|Compound:9117245|FD-Score:4.57|P-value:2.62E-7 ID:SGTC_3103|Compound:9120822|FD-Score:3.83|P-value:1.27E-5 ID:SGTC_3130|Compound:9127414|FD-Score:2.98|P-value:5.37E-4 ID:SGTC_3223|Compound:9129970|FD-Score:3.08|P-value:3.61E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-2.83|P-value:8.99E-4 ID:SGTC_3300|Compound:9124615|FD-Score:4.50|P-value:3.85E-7 ID:SGTC_3305|Compound:9127027|FD-Score:3.59|P-value:4.06E-5 ID:SGTC_3308|Compound:9128332|FD-Score:3.02|P-value:4.52E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.48|P-value:6.17E-5

Top fitness defect scores for YGR176W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2776 terbinafine 11.00 19.9 µM 6.59E-34 cell wall signaling 10 2.23E-28
2 SGTC_358 0075-0058 6.01 9.4 µM 1.93E-11 18 9.15E-10
3 SGTC_217 ketoconazole 5.52 989.0 nM 6.55E-10 ergosterol depletion effects on membrane 10 1.71E-8
4 SGTC_374 0880-0231 4.81 82.3 µM 6.39E-8 iron homeostasis 10 7.70E-7
5 SGTC_3066 9117245 4.57 49.5 µM 2.62E-7 7 2.49E-6
6 SGTC_3300 9124615 4.50 50.5 µM 3.85E-7 12 3.43E-6
7 SGTC_2736 butenafine 4.46 14.7 µM 4.63E-7 19 4.01E-6
8 SGTC_2848 9016370 4.19 26.0 µM 2.04E-6 18 1.38E-5
9 SGTC_558 k064-0027 3.94 21.3 µM 7.35E-6 DNA damage response 25 4.01E-5
10 SGTC_3012 9080433 3.91 71.4 µM 8.66E-6 13 4.60E-5
11 SGTC_3103 9120822 3.83 49.5 µM 1.27E-5 18 6.33E-5
12 SGTC_383 2324-0395 3.78 7.4 µM 1.60E-5 azole & statin 41 7.69E-5
13 SGTC_2581 avocatin a 3.71 64.0 µM 2.32E-5 sphingolipid biosynthesis & PDR1 62 1.05E-4
14 SGTC_3305 9127027 3.59 53.8 µM 4.06E-5 26 1.67E-4
15 SGTC_65 0798-0905 3.56 35.0 µM 4.68E-5 calcium & mitochondrial duress 109 1.88E-4
16 SGTC_2123 5259487 3.40 200.0 µM 9.58E-5 32 3.43E-4
17 SGTC_2816 7982706 3.36 58.4 µM 1.09E-4 azole & statin 80 3.83E-4
18 SGTC_3223 9129970 3.08 49.5 µM 3.61E-4 55 0.00104
19 SGTC_246 cycloheximide 3.08 667.0 µM 3.62E-4 40 0.00104
20 SGTC_381 3461-2219 3.08 42.7 µM 3.65E-4 copper-dependent oxidative stress 54 0.00105

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.339 8.82E-91 YGR175C ERG1 het Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
0.149 4.94E-18 YBL019W APN2 hom Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII
0.138 1.13E-15 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.137 1.96E-15 YOL071W EMI5 hom Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
0.125 3.24E-13 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.122 1.31E-12 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.120 2.94E-12 YDR420W HKR1 hom Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection
0.118 5.88E-12 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.116 1.60E-11 YER083C GET2 hom Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division
0.114 4.48E-11 YJR115W_p YJR115W_p hom Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
0.113 5.10E-11 YLR237W THI7 hom Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.112 7.30E-11 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.112 8.96E-11 YHR030C SLT2 hom Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
0.109 2.21E-10 YHL007C STE20 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p
0.107 4.88E-10 YKL026C GPX1 hom Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress