HIPHOP chemogenomics database

YGR176W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR176W / YGR176W

Click on Significant Values for Screen Details

Top fitness defect scores for YGR176W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2776	terbinafine	11.00	19.9 µM	6.59E-34	cell wall signaling	10	2.23E-28
2	SGTC_358	0075-0058	6.01	9.4 µM	1.93E-11		18	9.15E-10
3	SGTC_217	ketoconazole	5.52	989.0 nM	6.55E-10	ergosterol depletion effects on membrane	10	1.71E-8
4	SGTC_374	0880-0231	4.81	82.3 µM	6.39E-8	iron homeostasis	10	7.70E-7
5	SGTC_3066	9117245	4.57	49.5 µM	2.62E-7		7	2.49E-6
6	SGTC_3300	9124615	4.50	50.5 µM	3.85E-7		12	3.43E-6
7	SGTC_2736	butenafine	4.46	14.7 µM	4.63E-7		19	4.01E-6
8	SGTC_2848	9016370	4.19	26.0 µM	2.04E-6		18	1.38E-5
9	SGTC_558	k064-0027	3.94	21.3 µM	7.35E-6	DNA damage response	25	4.01E-5
10	SGTC_3012	9080433	3.91	71.4 µM	8.66E-6		13	4.60E-5
11	SGTC_3103	9120822	3.83	49.5 µM	1.27E-5		18	6.33E-5
12	SGTC_383	2324-0395	3.78	7.4 µM	1.60E-5	azole & statin	41	7.69E-5
13	SGTC_2581	avocatin a	3.71	64.0 µM	2.32E-5	sphingolipid biosynthesis & PDR1	62	1.05E-4
14	SGTC_3305	9127027	3.59	53.8 µM	4.06E-5		26	1.67E-4
15	SGTC_65	0798-0905	3.56	35.0 µM	4.68E-5	calcium & mitochondrial duress	109	1.88E-4
16	SGTC_2123	5259487	3.40	200.0 µM	9.58E-5		32	3.43E-4
17	SGTC_2816	7982706	3.36	58.4 µM	1.09E-4	azole & statin	80	3.83E-4
18	SGTC_3223	9129970	3.08	49.5 µM	3.61E-4		55	0.00104
19	SGTC_246	cycloheximide	3.08	667.0 µM	3.62E-4		40	0.00104
20	SGTC_381	3461-2219	3.08	42.7 µM	3.65E-4	copper-dependent oxidative stress	54	0.00105

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.339	8.82E-91	YGR175C	ERG1	het	Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
0.149	4.94E-18	YBL019W	APN2	hom	Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII
0.138	1.13E-15	YBR169C	SSE2	hom	Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.137	1.96E-15	YOL071W	EMI5	hom	Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
0.125	3.24E-13	YIL010W	DOT5	hom	Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.122	1.31E-12	YMR322C_p	SNO4_p	hom	Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.120	2.94E-12	YDR420W	HKR1	hom	Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection
0.118	5.88E-12	YLR179C	YLR179C	hom	Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.116	1.60E-11	YER083C	GET2	hom	Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division
0.114	4.48E-11	YJR115W_p	YJR115W_p	hom	Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
0.113	5.10E-11	YLR237W	THI7	hom	Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.112	7.30E-11	YHR045W_p	YHR045W_p	hom	Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.112	8.96E-11	YHR030C	SLT2	hom	Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
0.109	2.21E-10	YHL007C	STE20	hom	Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p
0.107	4.88E-10	YKL026C	GPX1	hom	Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress