YGR177C / ATF2

Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR177C / ATF2

Click on Significant Values for Screen Details ID:SGTC_148|Compound:3253-0744|FD-Score:-3.60|P-value:4.20E-5 ID:SGTC_233|Compound:rapamycin|FD-Score:-3.90|P-value:1.01E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:3.46|P-value:8.33E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:-4.59|P-value:2.69E-7 ID:SGTC_380|Compound:3970-0968|FD-Score:-4.66|P-value:1.80E-7 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-2.97|P-value:5.83E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:-3.97|P-value:7.17E-6 ID:SGTC_730|Compound:1436-0052|FD-Score:-2.96|P-value:6.12E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:-3.19|P-value:2.44E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.39|P-value:1.12E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.56|P-value:4.90E-5 ID:SGTC_1111|Compound:tnp00062|FD-Score:4.00|P-value:6.54E-6 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.67|P-value:3.28E-5 ID:SGTC_1114|Compound:scopoletin|FD-Score:2.94|P-value:7.04E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.06|P-value:4.39E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.63|P-value:3.63E-5 ID:SGTC_1273|Compound:0849-0096|FD-Score:2.91|P-value:7.79E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.05|P-value:5.13E-6 ID:SGTC_1633|Compound:st005664|FD-Score:-3.09|P-value:3.60E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-5.51|P-value:8.84E-10 ID:SGTC_2347|Compound:9049783|FD-Score:3.29|P-value:1.71E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.09|P-value:3.83E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.02|P-value:4.86E-4 ID:SGTC_2450|Compound:5739737|FD-Score:2.86|P-value:9.32E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:2.89|P-value:8.33E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.27|P-value:1.89E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.78|P-value:1.82E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.53|P-value:6.10E-5 ID:SGTC_2723|Compound:salbutamol|FD-Score:2.91|P-value:7.80E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.67|P-value:3.29E-5 ID:SGTC_2831|Compound:7999036|FD-Score:-4.37|P-value:9.00E-7 ID:SGTC_2833|Compound:9001315|FD-Score:3.29|P-value:1.75E-4 ID:SGTC_2942|Compound:9052777|FD-Score:2.84|P-value:9.99E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.08|P-value:3.85E-4 ID:SGTC_3090|Compound:9117696|FD-Score:-3.54|P-value:5.51E-5 ID:SGTC_3095|Compound:9117207|FD-Score:-3.25|P-value:1.94E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.18|P-value:2.57E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.90|P-value:4.71E-8 ID:SGTC_3145|Compound:9085516|FD-Score:3.04|P-value:4.65E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-3.33|P-value:1.38E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-3.06|P-value:4.09E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.60|P-value:4.20E-5 ID:SGTC_233|Compound:rapamycin|FD-Score:-3.90|P-value:1.01E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:3.46|P-value:8.33E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:-4.59|P-value:2.69E-7 ID:SGTC_380|Compound:3970-0968|FD-Score:-4.66|P-value:1.80E-7 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-2.97|P-value:5.83E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:-3.97|P-value:7.17E-6 ID:SGTC_730|Compound:1436-0052|FD-Score:-2.96|P-value:6.12E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:-3.19|P-value:2.44E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.39|P-value:1.12E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.56|P-value:4.90E-5 ID:SGTC_1111|Compound:tnp00062|FD-Score:4.00|P-value:6.54E-6 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.67|P-value:3.28E-5 ID:SGTC_1114|Compound:scopoletin|FD-Score:2.94|P-value:7.04E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.06|P-value:4.39E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.63|P-value:3.63E-5 ID:SGTC_1273|Compound:0849-0096|FD-Score:2.91|P-value:7.79E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.05|P-value:5.13E-6 ID:SGTC_1633|Compound:st005664|FD-Score:-3.09|P-value:3.60E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-5.51|P-value:8.84E-10 ID:SGTC_2347|Compound:9049783|FD-Score:3.29|P-value:1.71E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.09|P-value:3.83E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.02|P-value:4.86E-4 ID:SGTC_2450|Compound:5739737|FD-Score:2.86|P-value:9.32E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:2.89|P-value:8.33E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.27|P-value:1.89E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.78|P-value:1.82E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.53|P-value:6.10E-5 ID:SGTC_2723|Compound:salbutamol|FD-Score:2.91|P-value:7.80E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.67|P-value:3.29E-5 ID:SGTC_2831|Compound:7999036|FD-Score:-4.37|P-value:9.00E-7 ID:SGTC_2833|Compound:9001315|FD-Score:3.29|P-value:1.75E-4 ID:SGTC_2942|Compound:9052777|FD-Score:2.84|P-value:9.99E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.08|P-value:3.85E-4 ID:SGTC_3090|Compound:9117696|FD-Score:-3.54|P-value:5.51E-5 ID:SGTC_3095|Compound:9117207|FD-Score:-3.25|P-value:1.94E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.18|P-value:2.57E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.90|P-value:4.71E-8 ID:SGTC_3145|Compound:9085516|FD-Score:3.04|P-value:4.65E-4 ID:SGTC_3166|Compound:9102297|FD-Score:-3.33|P-value:1.38E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-3.06|P-value:4.09E-4

Top fitness defect scores for YGR177C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3141 9094609 4.90 49.5 µM 4.71E-8 iron homeostasis 21 4.75E-7
2 SGTC_1369 1866-0067 4.05 208.0 µM 5.13E-6 RPP1 & pyrimidine depletion 34 2.53E-5
3 SGTC_1111 tnp00062 4.00 510.7 nM 6.54E-6 8 3.11E-5
4 SGTC_1113 artemisinin 3.67 1.2 µM 3.28E-5 heme biosynthesis & mitochondrial translocase 20 1.22E-4
5 SGTC_2757 clomiphene 3.67 4.2 µM 3.29E-5 fatty acid desaturase (OLE1) 50 1.23E-4
6 SGTC_2621 lithochol-11-enic acid 3.53 100.0 µM 6.10E-5 41 2.07E-4
7 SGTC_374 0880-0231 3.46 82.3 µM 8.33E-5 iron homeostasis 41 2.70E-4
8 SGTC_990 3985-0011 3.39 41.3 µM 1.12E-4 amide catabolism 35 3.47E-4
9 SGTC_2347 9049783 3.29 174.8 µM 1.71E-4 53 4.98E-4
10 SGTC_2833 9001315 3.29 45.5 µM 1.75E-4 amide catabolism 85 5.07E-4
11 SGTC_2568 diosmetin 3.27 100.0 µM 1.89E-4 52 5.43E-4
12 SGTC_2397 5161689 3.09 200.0 µM 3.83E-4 76 9.91E-4
13 SGTC_1207 2099-0101 3.06 141.0 µM 4.39E-4 64 0.00111
14 SGTC_3145 9085516 3.04 49.5 µM 4.65E-4 fatty acid desaturase (OLE1) 72 0.00117
15 SGTC_1114 scopoletin 2.94 1.7 µM 7.04E-4 47 0.00166
16 SGTC_1273 0849-0096 2.91 14.1 µM 7.79E-4 RPP1 & pyrimidine depletion 62 0.00182
17 SGTC_2723 salbutamol 2.91 83.6 µM 7.80E-4 23 0.00182
18 SGTC_2564 betulinic acid 2.89 100.0 µM 8.33E-4 92 0.00192
19 SGTC_2450 5739737 2.86 12.9 µM 9.32E-4 73 0.00211
20 SGTC_2942 9052777 2.84 62.2 µM 9.99E-4 100 0.00225

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 8.79E-13 YFR014C CMK1 hom Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication
0.113 5.70E-11 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.109 2.19E-10 YGL230C_p YGL230C_p hom Putative protein of unknown function; non-essential gene
0.109 2.38E-10 YER101C AST2 hom Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication
0.109 2.60E-10 YJL106W IME2 hom Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
0.106 7.08E-10 YKR032W_d YKR032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.105 1.03E-9 YDR279W RNH202 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome
0.105 1.08E-9 YGL111W NSA1 het Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
0.103 2.00E-9 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.094 4.95E-8 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.093 6.06E-8 YGR248W SOL4 hom 6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication
0.093 6.41E-8 YNL338W_d YNL338W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
0.093 8.02E-8 YLR211C_p YLR211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron
0.086 5.75E-7 YGR205W TDA10 hom ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele
0.086 6.45E-7 YNL087W TCB2 hom ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud