YGR179C / OKP1

Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR179C / OKP1

Click on Significant Values for Screen Details ID:SGTC_106|Compound:0092-0003|FD-Score:2.92|P-value:3.03E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.45|P-value:4.50E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:3.73|P-value:6.68E-6 ID:SGTC_216|Compound:k038-0035|FD-Score:2.81|P-value:4.95E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:2.65|P-value:9.31E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:2.86|P-value:3.88E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-2.83|P-value:6.89E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-2.90|P-value:5.15E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-3.44|P-value:4.59E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:3.21|P-value:8.65E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:2.96|P-value:2.64E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:2.82|P-value:4.63E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:2.74|P-value:6.41E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.91|P-value:4.94E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.20|P-value:1.44E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:4.25|P-value:3.56E-7 ID:SGTC_1096|Compound:rimcazole|FD-Score:2.88|P-value:3.57E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.49|P-value:2.21E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:2.85|P-value:4.06E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:-3.10|P-value:2.21E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-2.94|P-value:4.37E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:2.66|P-value:8.78E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.89|P-value:2.79E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.98|P-value:3.33E-9 ID:SGTC_1927|Compound:st060202|FD-Score:3.01|P-value:2.06E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.68|P-value:1.43E-5 ID:SGTC_1998|Compound:st075797|FD-Score:-3.18|P-value:1.58E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-4.34|P-value:3.90E-7 ID:SGTC_2240|Compound:6690706|FD-Score:-3.44|P-value:4.69E-5 ID:SGTC_2246|Compound:7293507|FD-Score:2.91|P-value:3.15E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.15|P-value:1.77E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.17|P-value:1.01E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-3.37|P-value:6.53E-5 ID:SGTC_2313|Compound:7726885|FD-Score:2.88|P-value:3.69E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.13|P-value:1.22E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.56|P-value:2.65E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.89|P-value:4.93E-6 ID:SGTC_2785|Compound:7756463|FD-Score:-2.98|P-value:3.60E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-3.44|P-value:4.69E-5 ID:SGTC_2826|Compound:7992541|FD-Score:-3.34|P-value:7.44E-5 ID:SGTC_2945|Compound:9067681|FD-Score:-3.00|P-value:3.43E-4 ID:SGTC_2951|Compound:9072950|FD-Score:4.56|P-value:5.23E-8 ID:SGTC_2978|Compound:9011784|FD-Score:-3.15|P-value:1.79E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.19|P-value:1.46E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-3.05|P-value:2.68E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.30|P-value:5.50E-5 ID:SGTC_3240|Compound:9133527|FD-Score:3.03|P-value:1.95E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.54|P-value:1.71E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:2.92|P-value:3.03E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.45|P-value:4.50E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:3.73|P-value:6.68E-6 ID:SGTC_216|Compound:k038-0035|FD-Score:2.81|P-value:4.95E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:2.65|P-value:9.31E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:2.86|P-value:3.88E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-2.83|P-value:6.89E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-2.90|P-value:5.15E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-3.44|P-value:4.59E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:3.21|P-value:8.65E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:2.96|P-value:2.64E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:2.82|P-value:4.63E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:2.74|P-value:6.41E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.91|P-value:4.94E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.20|P-value:1.44E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:4.25|P-value:3.56E-7 ID:SGTC_1096|Compound:rimcazole|FD-Score:2.88|P-value:3.57E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.49|P-value:2.21E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:2.85|P-value:4.06E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:-3.10|P-value:2.21E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-2.94|P-value:4.37E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:2.66|P-value:8.78E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.89|P-value:2.79E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.98|P-value:3.33E-9 ID:SGTC_1927|Compound:st060202|FD-Score:3.01|P-value:2.06E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.68|P-value:1.43E-5 ID:SGTC_1998|Compound:st075797|FD-Score:-3.18|P-value:1.58E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-4.34|P-value:3.90E-7 ID:SGTC_2240|Compound:6690706|FD-Score:-3.44|P-value:4.69E-5 ID:SGTC_2246|Compound:7293507|FD-Score:2.91|P-value:3.15E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.15|P-value:1.77E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.17|P-value:1.01E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-3.37|P-value:6.53E-5 ID:SGTC_2313|Compound:7726885|FD-Score:2.88|P-value:3.69E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.13|P-value:1.22E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.56|P-value:2.65E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.89|P-value:4.93E-6 ID:SGTC_2785|Compound:7756463|FD-Score:-2.98|P-value:3.60E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-3.44|P-value:4.69E-5 ID:SGTC_2826|Compound:7992541|FD-Score:-3.34|P-value:7.44E-5 ID:SGTC_2945|Compound:9067681|FD-Score:-3.00|P-value:3.43E-4 ID:SGTC_2951|Compound:9072950|FD-Score:4.56|P-value:5.23E-8 ID:SGTC_2978|Compound:9011784|FD-Score:-3.15|P-value:1.79E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.19|P-value:1.46E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-3.05|P-value:2.68E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.30|P-value:5.50E-5 ID:SGTC_3240|Compound:9133527|FD-Score:3.03|P-value:1.95E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.54|P-value:1.71E-5

Top fitness defect scores for YGR179C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1926 methyl fluorone black 4.98 53.6 µM 3.33E-9 DNA intercalators 17 3.20E-7 0.03
2 SGTC_2951 9072950 4.56 58.1 µM 5.23E-8 ERG2 3 2.54E-6 0.52
3 SGTC_756 0508-1999 4.25 28.3 µM 3.56E-7 RPP1 & pyrimidine depletion 9 1.07E-5 0.42
4 SGTC_1788 fluconazole 3.89 20.0 µM 2.79E-6 azole & statin 9 5.06E-5 0.22
5 SGTC_207 4185-0010 3.73 4.5 µM 6.68E-6 endomembrane recycling 17 9.75E-5 0.10
6 SGTC_3314 9135860 3.54 59.4 µM 1.71E-5 4 1.98E-4 0.02
7 SGTC_1203 3992-3522 3.49 103.0 µM 2.21E-5 19 2.41E-4 0.17
8 SGTC_2999 9069765 3.30 71.4 µM 5.50E-5 amide catabolism 5 4.78E-4 0.04
9 SGTC_439 amiodarone 3.21 34.4 µM 8.65E-5 NEO1-PIK1 15 6.73E-4 0.01
10 SGTC_2288 7946289 3.17 167.3 µM 1.01E-4 12 7.58E-4 0.00
11 SGTC_2592 piperlongumine 3.13 83.3 µM 1.22E-4 TSC3-RPN4 22 8.72E-4 0.08
12 SGTC_3240 9133527 3.03 49.5 µM 1.95E-4 3 0.00124 0.03
13 SGTC_1927 st060202 3.01 13.8 µM 2.06E-4 16 0.00129 0.04
14 SGTC_522 1273-0010 2.96 11.6 µM 2.64E-4 60S ribosome export 19 0.00156 0.02
15 SGTC_106 0092-0003 2.92 11.6 µM 3.03E-4 copper-dependent oxidative stress 14 0.00173 0.21
16 SGTC_2246 7293507 2.91 91.6 µM 3.15E-4 26 0.00179 0.01
17 SGTC_1096 rimcazole 2.88 32.2 µM 3.57E-4 7 0.00196 0.03
18 SGTC_2313 7726885 2.88 200.0 µM 3.69E-4 RPP1 & pyrimidine depletion 24 0.00201 0.02
19 SGTC_357 1325-0123 2.86 420.0 µM 3.88E-4 14 0.00209 0.10
20 SGTC_1271 0832-2808 2.85 169.0 µM 4.06E-4 26 0.00217 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.18E-15 YML116W-A_d YML116W-A_d hom Putative protein of unknown function
0.126 2.14E-13 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.125 3.96E-13 YDL026W_d YDL026W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.125 4.27E-13 YDR275W BSC2 hom Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication
0.115 2.82E-11 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.114 3.00E-11 YMR181C_p YMR181C_p hom Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); not an essential gene; YMR181C has a paralog, YPL229W, that arose from the whole genome duplication
0.109 2.50E-10 YER046W SPO73 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
0.107 4.48E-10 YDR037W KRS1 het Lysyl-tRNA synthetase
0.101 5.01E-9 YPR168W NUT2 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress
0.099 9.95E-9 YKL152C GPM1 het Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
0.095 3.62E-8 YKL072W STB6 hom Protein that binds Sin3p in a two-hybrid assay
0.094 5.12E-8 YKL043W PHD1 hom Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication
0.092 8.95E-8 YCR077C PAT1 hom Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress
0.091 1.30E-7 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.090 1.65E-7 YMR002W MIC17 hom Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress