YGR182C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR182C / YGR182C

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:2.65|P-value:9.87E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:2.87|P-value:3.91E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:2.69|P-value:8.31E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:-2.78|P-value:5.70E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-2.72|P-value:7.42E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.47|P-value:2.52E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.51|P-value:2.04E-5 ID:SGTC_499|Compound:genistein|FD-Score:-3.10|P-value:1.45E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:2.92|P-value:3.20E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:5.72|P-value:1.13E-11 ID:SGTC_719|Compound:2810-4230|FD-Score:-2.88|P-value:3.79E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:3.33|P-value:4.96E-5 ID:SGTC_732|Compound:3970-1727|FD-Score:2.95|P-value:2.85E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:2.70|P-value:7.88E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.72|P-value:6.71E-6 ID:SGTC_809|Compound:3998-0021|FD-Score:2.81|P-value:5.04E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:-2.97|P-value:2.57E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:2.92|P-value:3.18E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:2.70|P-value:7.88E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.36|P-value:4.38E-5 ID:SGTC_1499|Compound:4480-0877|FD-Score:2.78|P-value:5.73E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.19|P-value:9.82E-5 ID:SGTC_1699|Compound:st031318|FD-Score:2.68|P-value:8.64E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.24|P-value:7.66E-5 ID:SGTC_1739|Compound:st037196|FD-Score:2.83|P-value:4.64E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-2.71|P-value:7.67E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-3.34|P-value:4.72E-5 ID:SGTC_2354|Compound:9060492|FD-Score:3.17|P-value:1.04E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-2.67|P-value:8.88E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-2.86|P-value:4.17E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.68|P-value:8.60E-6 ID:SGTC_2487|Compound:5918373|FD-Score:3.40|P-value:3.52E-5 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.42|P-value:3.24E-5 ID:SGTC_2491|Compound:paeonol|FD-Score:3.61|P-value:1.24E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.93|P-value:3.08E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.34|P-value:4.63E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-2.77|P-value:6.03E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-2.94|P-value:2.96E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-2.75|P-value:6.53E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.77|P-value:5.21E-6 ID:SGTC_2797|Compound:7859098|FD-Score:6.53|P-value:1.19E-14 ID:SGTC_2834|Compound:9001755|FD-Score:2.83|P-value:4.64E-4 ID:SGTC_2843|Compound:9000894|FD-Score:2.66|P-value:9.34E-4 ID:SGTC_2|Compound:0422-0095|FD-Score:2.65|P-value:9.87E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:2.87|P-value:3.91E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:2.69|P-value:8.31E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:-2.78|P-value:5.70E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-2.72|P-value:7.42E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.47|P-value:2.52E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.51|P-value:2.04E-5 ID:SGTC_499|Compound:genistein|FD-Score:-3.10|P-value:1.45E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:2.92|P-value:3.20E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:5.72|P-value:1.13E-11 ID:SGTC_719|Compound:2810-4230|FD-Score:-2.88|P-value:3.79E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:3.33|P-value:4.96E-5 ID:SGTC_732|Compound:3970-1727|FD-Score:2.95|P-value:2.85E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:2.70|P-value:7.88E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.72|P-value:6.71E-6 ID:SGTC_809|Compound:3998-0021|FD-Score:2.81|P-value:5.04E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:-2.97|P-value:2.57E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:2.92|P-value:3.18E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:2.70|P-value:7.88E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.36|P-value:4.38E-5 ID:SGTC_1499|Compound:4480-0877|FD-Score:2.78|P-value:5.73E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.19|P-value:9.82E-5 ID:SGTC_1699|Compound:st031318|FD-Score:2.68|P-value:8.64E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.24|P-value:7.66E-5 ID:SGTC_1739|Compound:st037196|FD-Score:2.83|P-value:4.64E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-2.71|P-value:7.67E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-3.34|P-value:4.72E-5 ID:SGTC_2354|Compound:9060492|FD-Score:3.17|P-value:1.04E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-2.67|P-value:8.88E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-2.86|P-value:4.17E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.68|P-value:8.60E-6 ID:SGTC_2487|Compound:5918373|FD-Score:3.40|P-value:3.52E-5 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.42|P-value:3.24E-5 ID:SGTC_2491|Compound:paeonol|FD-Score:3.61|P-value:1.24E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:2.93|P-value:3.08E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.34|P-value:4.63E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-2.77|P-value:6.03E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-2.94|P-value:2.96E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-2.75|P-value:6.53E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.77|P-value:5.21E-6 ID:SGTC_2797|Compound:7859098|FD-Score:6.53|P-value:1.19E-14 ID:SGTC_2834|Compound:9001755|FD-Score:2.83|P-value:4.64E-4 ID:SGTC_2843|Compound:9000894|FD-Score:2.66|P-value:9.34E-4

Top fitness defect scores for YGR182C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2797 7859098 6.53 81.8 µM 1.19E-14 4 3.38E-11
2 SGTC_716 1683-5115 5.72 658.0 µM 1.13E-11 4 5.28E-9
3 SGTC_2794 7785382 3.77 27.3 µM 5.21E-6 42 8.13E-5
4 SGTC_808 0711-0032 3.72 135.0 µM 6.71E-6 17 9.81E-5
5 SGTC_2491 paeonol 3.61 100.0 µM 1.24E-5 11 1.55E-4
6 SGTC_373 0844-0104 3.51 25.9 µM 2.04E-5 ERAD & cell cycle 67 2.24E-4
7 SGTC_352 k048-0007 3.47 5.1 µM 2.52E-5 ERAD & cell cycle 98 2.62E-4
8 SGTC_2490 carminic acid 3.42 95.4 µM 3.24E-5 11 3.16E-4
9 SGTC_2487 5918373 3.40 44.0 µM 3.52E-5 34 3.36E-4
10 SGTC_1230 0170-0365 3.36 3.8 µM 4.38E-5 endomembrane recycling 105 3.96E-4
11 SGTC_2493 resveratrol 3.34 26.1 µM 4.63E-5 19 4.13E-4
12 SGTC_725 1497-0963 3.33 19.0 µM 4.96E-5 copper-dependent oxidative stress 38 4.35E-4
13 SGTC_1525 8-methoxypsoralen 3.19 92.5 µM 9.82E-5 DNA damage response 70 7.23E-4
14 SGTC_2354 9060492 3.17 162.0 µM 1.04E-4 49 7.57E-4
15 SGTC_732 3970-1727 2.95 52.7 µM 2.85E-4 36 0.00160
16 SGTC_2492 derrusnin 2.93 100.0 µM 3.08E-4 30 0.00170
17 SGTC_882 0843-0131 2.92 351.0 µM 3.18E-4 60 0.00174
18 SGTC_713 1488-1073 2.92 324.0 µM 3.20E-4 ERG2 44 0.00175
19 SGTC_156 3474-0145 2.87 5.6 µM 3.91E-4 endomembrane recycling 112 0.00203
20 SGTC_1739 st037196 2.83 92.5 µM 4.64E-4 80 0.00231

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.182 1.89E-26 YDR131C_p YDR131C_p hom F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
0.176 1.22E-24 YOL160W_d YOL160W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.168 1.79E-22 YHR131C_p YHR131C_p hom Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study
0.167 2.59E-22 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.161 6.94E-21 YER109C FLO8 hom Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
0.152 7.03E-19 YDR501W PLM2 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication
0.143 9.19E-17 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.143 1.14E-16 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.142 1.20E-16 YGL051W MST27 hom Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
0.138 9.09E-16 YJL157C FAR1 hom Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.129 6.04E-14 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.127 1.33E-13 YDR134C YDR134C hom Hypothetical protein; YDR134C has a paralog, CCW12, that arose from the whole genome duplication
0.126 2.02E-13 YKL018W SWD2 het Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination
0.126 2.42E-13 YLR356W ATG33 hom Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes
0.118 5.98E-12 YGR181W TIM13 hom Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane