TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YGR186W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.158 | 2.66E-20 | YKL021C | MAK11 | het | Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats |
0.103 | 2.23E-9 | YKR018C | YKR018C | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication |
0.101 | 3.96E-9 | YPR015C_p | YPR015C_p | hom | Putative protein of unknown function; overexpression causes a cell cycle delay or arrest |
0.098 | 1.21E-8 | YEL061C | CIN8 | hom | Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation |
0.098 | 1.45E-8 | YDL167C | NRP1 | hom | Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis |
0.095 | 3.80E-8 | YDR368W | YPR1 | hom | NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication |
0.090 | 1.68E-7 | YDR361C | BCP1 | het | Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport |
0.089 | 2.37E-7 | YMR244C-A | COA6 | hom | Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress |
0.086 | 6.34E-7 | YDR407C | TRS120 | het | One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic |
0.083 | 1.37E-6 | YML128C | MSC1 | hom | Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated |
0.082 | 1.81E-6 | YML062C | MFT1 | hom | Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance |
0.081 | 2.34E-6 | YMR273C | ZDS1 | hom | Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication |
0.081 | 2.56E-6 | YMR001C-A_p | YMR001C-A_p | hom | Putative protein of unknown function |
0.079 | 4.99E-6 | YMR043W | MCM1 | het | Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes |
0.078 | 6.40E-6 | YDL196W_d | YDL196W_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 |