YGR187C / HGH1

Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR187C / HGH1

Click on Significant Values for Screen Details ID:SGTC_188|Compound:3229-0966|FD-Score:3.06|P-value:8.67E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.84|P-value:4.17E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:4.63|P-value:1.05E-6 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.16|P-value:6.09E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.15|P-value:6.37E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.60|P-value:1.15E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.32|P-value:3.36E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.09|P-value:7.88E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.93|P-value:5.59E-10 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.27|P-value:3.43E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.12|P-value:7.14E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:4.76|P-value:5.29E-7 ID:SGTC_815|Compound:1582-0027|FD-Score:3.43|P-value:2.19E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.25|P-value:4.38E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.34|P-value:3.20E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.52|P-value:1.27E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.93|P-value:2.86E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.41|P-value:2.40E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.45|P-value:2.07E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.04|P-value:1.71E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-4.21|P-value:6.22E-6 ID:SGTC_1737|Compound:st035557|FD-Score:-3.45|P-value:1.72E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.91|P-value:2.39E-7 ID:SGTC_1749|Compound:st037932|FD-Score:3.55|P-value:1.38E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:4.64|P-value:9.75E-7 ID:SGTC_1889|Compound:st059080|FD-Score:3.48|P-value:1.83E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.03|P-value:1.85E-5 ID:SGTC_1961|Compound:st076550|FD-Score:-3.70|P-value:6.17E-5 ID:SGTC_1995|Compound:st072814|FD-Score:3.96|P-value:2.46E-5 ID:SGTC_2044|Compound:5102272|FD-Score:3.41|P-value:2.43E-4 ID:SGTC_2306|Compound:7482397|FD-Score:3.80|P-value:4.94E-5 ID:SGTC_2307|Compound:7538926|FD-Score:6.37|P-value:3.02E-11 ID:SGTC_2311|Compound:7694451|FD-Score:-6.33|P-value:2.84E-11 ID:SGTC_2312|Compound:7706453|FD-Score:3.35|P-value:3.07E-4 ID:SGTC_2323|Compound:6148992|FD-Score:4.12|P-value:1.23E-5 ID:SGTC_2403|Compound:6032726|FD-Score:-3.23|P-value:3.89E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.27|P-value:4.03E-4 ID:SGTC_2440|Compound:5628896|FD-Score:4.23|P-value:7.36E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.60|P-value:1.15E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.02|P-value:9.93E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.11|P-value:6.20E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.30|P-value:2.73E-8 ID:SGTC_2686|Compound:alizarin|FD-Score:5.72|P-value:2.21E-9 ID:SGTC_2691|Compound:st077356|FD-Score:5.25|P-value:3.53E-8 ID:SGTC_2692|Compound:st077426|FD-Score:-2.99|P-value:9.56E-4 ID:SGTC_2702|Compound:st077768|FD-Score:4.58|P-value:1.33E-6 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.10|P-value:7.63E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-6.94|P-value:3.54E-13 ID:SGTC_2835|Compound:9006588|FD-Score:5.01|P-value:1.34E-7 ID:SGTC_3127|Compound:9126946|FD-Score:-3.10|P-value:6.32E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.14|P-value:6.51E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.30|P-value:3.65E-4 ID:SGTC_3194|Compound:9111903|FD-Score:4.76|P-value:5.34E-7 ID:SGTC_3196|Compound:9111891|FD-Score:4.43|P-value:2.82E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:3.06|P-value:8.67E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.84|P-value:4.17E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:4.63|P-value:1.05E-6 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.16|P-value:6.09E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.15|P-value:6.37E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.60|P-value:1.15E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.32|P-value:3.36E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.09|P-value:7.88E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.93|P-value:5.59E-10 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.27|P-value:3.43E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.12|P-value:7.14E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:4.76|P-value:5.29E-7 ID:SGTC_815|Compound:1582-0027|FD-Score:3.43|P-value:2.19E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.25|P-value:4.38E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.34|P-value:3.20E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.52|P-value:1.27E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.93|P-value:2.86E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.41|P-value:2.40E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.45|P-value:2.07E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.04|P-value:1.71E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-4.21|P-value:6.22E-6 ID:SGTC_1737|Compound:st035557|FD-Score:-3.45|P-value:1.72E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.91|P-value:2.39E-7 ID:SGTC_1749|Compound:st037932|FD-Score:3.55|P-value:1.38E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:4.64|P-value:9.75E-7 ID:SGTC_1889|Compound:st059080|FD-Score:3.48|P-value:1.83E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.03|P-value:1.85E-5 ID:SGTC_1961|Compound:st076550|FD-Score:-3.70|P-value:6.17E-5 ID:SGTC_1995|Compound:st072814|FD-Score:3.96|P-value:2.46E-5 ID:SGTC_2044|Compound:5102272|FD-Score:3.41|P-value:2.43E-4 ID:SGTC_2306|Compound:7482397|FD-Score:3.80|P-value:4.94E-5 ID:SGTC_2307|Compound:7538926|FD-Score:6.37|P-value:3.02E-11 ID:SGTC_2311|Compound:7694451|FD-Score:-6.33|P-value:2.84E-11 ID:SGTC_2312|Compound:7706453|FD-Score:3.35|P-value:3.07E-4 ID:SGTC_2323|Compound:6148992|FD-Score:4.12|P-value:1.23E-5 ID:SGTC_2403|Compound:6032726|FD-Score:-3.23|P-value:3.89E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.27|P-value:4.03E-4 ID:SGTC_2440|Compound:5628896|FD-Score:4.23|P-value:7.36E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.60|P-value:1.15E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.02|P-value:9.93E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.11|P-value:6.20E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.30|P-value:2.73E-8 ID:SGTC_2686|Compound:alizarin|FD-Score:5.72|P-value:2.21E-9 ID:SGTC_2691|Compound:st077356|FD-Score:5.25|P-value:3.53E-8 ID:SGTC_2692|Compound:st077426|FD-Score:-2.99|P-value:9.56E-4 ID:SGTC_2702|Compound:st077768|FD-Score:4.58|P-value:1.33E-6 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.10|P-value:7.63E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-6.94|P-value:3.54E-13 ID:SGTC_2835|Compound:9006588|FD-Score:5.01|P-value:1.34E-7 ID:SGTC_3127|Compound:9126946|FD-Score:-3.10|P-value:6.32E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.14|P-value:6.51E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.30|P-value:3.65E-4 ID:SGTC_3194|Compound:9111903|FD-Score:4.76|P-value:5.34E-7 ID:SGTC_3196|Compound:9111891|FD-Score:4.43|P-value:2.82E-6

Top fitness defect scores for YGR187C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2307 7538926 6.37 6.3 µM 3.02E-11 8 9.41E-11
2 SGTC_513 4245-1575 5.93 41.7 µM 5.59E-10 unfolded protein response 48 1.49E-9
3 SGTC_2686 alizarin 5.72 95.4 µM 2.21E-9 RPP1 & pyrimidine depletion 8 5.44E-9
4 SGTC_2651 1327-0036 5.30 5.0 µM 2.73E-8 96 5.88E-8
5 SGTC_2691 st077356 5.25 60.2 µM 3.53E-8 11 7.50E-8
6 SGTC_2835 9006588 5.01 71.4 µM 1.34E-7 19 2.65E-7
7 SGTC_1745 st081495 4.91 74.0 µM 2.39E-7 RNA processing & uracil transport 40 4.60E-7
8 SGTC_806 3966-4455 4.76 5.9 µM 5.29E-7 8 9.74E-7
9 SGTC_3194 9111903 4.76 49.5 µM 5.34E-7 10 9.83E-7
10 SGTC_1888 azatryptophan 4.64 97.5 µM 9.75E-7 8 1.74E-6
11 SGTC_214 4373-3496 4.63 70.0 µM 1.05E-6 39 1.87E-6
12 SGTC_2702 st077768 4.58 96.8 µM 1.33E-6 9 2.33E-6
13 SGTC_3196 9111891 4.43 49.5 µM 2.82E-6 mitochondrial processes 11 4.76E-6
14 SGTC_2440 5628896 4.23 157.8 µM 7.36E-6 21 1.18E-5
15 SGTC_2323 6148992 4.12 148.3 µM 1.23E-5 29 1.93E-5
16 SGTC_1428 4049-0204 4.04 61.7 µM 1.71E-5 11 2.63E-5
17 SGTC_1942 st076330 4.03 65.2 µM 1.85E-5 27 2.84E-5
18 SGTC_1995 st072814 3.96 61.1 µM 2.46E-5 14 3.71E-5
19 SGTC_1042 0350-0096 3.93 82.0 µM 2.86E-5 TSC3-RPN4 27 4.29E-5
20 SGTC_212 3807-4682 3.84 38.8 µM 4.17E-5 tubulin folding & SWR complex 73 6.13E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 1.09E-19 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.145 3.40E-17 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.143 7.99E-17 YNL182C IPI3 het Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene
0.139 6.89E-16 YDR504C SPG3 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.132 2.07E-14 YDR385W EFT2 hom Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication
0.129 7.10E-14 YDR056C_p YDR056C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein
0.123 1.04E-12 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.115 2.29E-11 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.114 3.25E-11 YIL003W CFD1 het Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol
0.110 1.44E-10 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.107 4.53E-10 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.106 6.66E-10 YKL191W DPH2 hom Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p
0.105 9.82E-10 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.105 1.13E-9 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.101 5.16E-9 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress