YGR190C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR190C / YGR190C

Click on Significant Values for Screen Details ID:SGTC_88|Compound:0180-0332|FD-Score:3.73|P-value:3.58E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.72|P-value:3.06E-5 ID:SGTC_228|Compound:caffeine|FD-Score:3.12|P-value:4.57E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.36|P-value:1.81E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:6.77|P-value:2.58E-13 ID:SGTC_363|Compound:0455-0021|FD-Score:3.52|P-value:8.96E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:3.45|P-value:1.21E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:18.20|P-value:2.00E-84 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.02|P-value:5.46E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:2.93|P-value:9.29E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:-3.65|P-value:4.19E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:4.25|P-value:3.07E-6 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.06|P-value:4.74E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.67|P-value:4.72E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.16|P-value:4.00E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.29|P-value:2.36E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.82|P-value:2.44E-5 ID:SGTC_1519|Compound:esterone|FD-Score:4.55|P-value:6.34E-7 ID:SGTC_1529|Compound:apigenin|FD-Score:-4.20|P-value:2.96E-6 ID:SGTC_1670|Compound:st016595|FD-Score:2.92|P-value:9.84E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.39|P-value:1.55E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.50|P-value:9.76E-5 ID:SGTC_1908|Compound:st060353|FD-Score:6.53|P-value:1.65E-12 ID:SGTC_2108|Compound:5365811|FD-Score:-3.11|P-value:3.87E-4 ID:SGTC_2277|Compound:7947813|FD-Score:-3.90|P-value:1.29E-5 ID:SGTC_2287|Compound:7945887|FD-Score:3.51|P-value:9.60E-5 ID:SGTC_2318|Compound:6029776|FD-Score:3.24|P-value:2.92E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.38|P-value:1.31E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-4.36|P-value:1.32E-6 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.36|P-value:1.79E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-2.96|P-value:6.87E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-4.85|P-value:8.96E-8 ID:SGTC_2808|Compound:7946468|FD-Score:-3.27|P-value:2.06E-4 ID:SGTC_2885|Compound:9057732|FD-Score:2.98|P-value:7.93E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.93|P-value:1.43E-5 ID:SGTC_2913|Compound:7966556|FD-Score:3.08|P-value:5.30E-4 ID:SGTC_2936|Compound:9038235|FD-Score:4.00|P-value:1.06E-5 ID:SGTC_2964|Compound:9083345|FD-Score:-3.25|P-value:2.25E-4 ID:SGTC_3011|Compound:9081274|FD-Score:2.99|P-value:7.39E-4 ID:SGTC_3055|Compound:9094636|FD-Score:-2.88|P-value:9.10E-4 ID:SGTC_3112|Compound:9123419|FD-Score:-5.18|P-value:1.25E-8 ID:SGTC_3209|Compound:9113616|FD-Score:4.02|P-value:9.51E-6 ID:SGTC_3253|Compound:9135987|FD-Score:3.13|P-value:4.50E-4 ID:SGTC_3290|Compound:9121031|FD-Score:3.18|P-value:3.59E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.46|P-value:1.18E-4 ID:SGTC_3347|Compound:9188721|FD-Score:11.10|P-value:7.24E-33 ID:SGTC_88|Compound:0180-0332|FD-Score:3.73|P-value:3.58E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.72|P-value:3.06E-5 ID:SGTC_228|Compound:caffeine|FD-Score:3.12|P-value:4.57E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.36|P-value:1.81E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:6.77|P-value:2.58E-13 ID:SGTC_363|Compound:0455-0021|FD-Score:3.52|P-value:8.96E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:3.45|P-value:1.21E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:18.20|P-value:2.00E-84 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.02|P-value:5.46E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:2.93|P-value:9.29E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:-3.65|P-value:4.19E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:4.25|P-value:3.07E-6 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.06|P-value:4.74E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.67|P-value:4.72E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.16|P-value:4.00E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.29|P-value:2.36E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.82|P-value:2.44E-5 ID:SGTC_1519|Compound:esterone|FD-Score:4.55|P-value:6.34E-7 ID:SGTC_1529|Compound:apigenin|FD-Score:-4.20|P-value:2.96E-6 ID:SGTC_1670|Compound:st016595|FD-Score:2.92|P-value:9.84E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.39|P-value:1.55E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.50|P-value:9.76E-5 ID:SGTC_1908|Compound:st060353|FD-Score:6.53|P-value:1.65E-12 ID:SGTC_2108|Compound:5365811|FD-Score:-3.11|P-value:3.87E-4 ID:SGTC_2277|Compound:7947813|FD-Score:-3.90|P-value:1.29E-5 ID:SGTC_2287|Compound:7945887|FD-Score:3.51|P-value:9.60E-5 ID:SGTC_2318|Compound:6029776|FD-Score:3.24|P-value:2.92E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.38|P-value:1.31E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-4.36|P-value:1.32E-6 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.36|P-value:1.79E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-2.96|P-value:6.87E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-4.85|P-value:8.96E-8 ID:SGTC_2808|Compound:7946468|FD-Score:-3.27|P-value:2.06E-4 ID:SGTC_2885|Compound:9057732|FD-Score:2.98|P-value:7.93E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.93|P-value:1.43E-5 ID:SGTC_2913|Compound:7966556|FD-Score:3.08|P-value:5.30E-4 ID:SGTC_2936|Compound:9038235|FD-Score:4.00|P-value:1.06E-5 ID:SGTC_2964|Compound:9083345|FD-Score:-3.25|P-value:2.25E-4 ID:SGTC_3011|Compound:9081274|FD-Score:2.99|P-value:7.39E-4 ID:SGTC_3055|Compound:9094636|FD-Score:-2.88|P-value:9.10E-4 ID:SGTC_3112|Compound:9123419|FD-Score:-5.18|P-value:1.25E-8 ID:SGTC_3209|Compound:9113616|FD-Score:4.02|P-value:9.51E-6 ID:SGTC_3253|Compound:9135987|FD-Score:3.13|P-value:4.50E-4 ID:SGTC_3290|Compound:9121031|FD-Score:3.18|P-value:3.59E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.46|P-value:1.18E-4 ID:SGTC_3347|Compound:9188721|FD-Score:11.10|P-value:7.24E-33

Top fitness defect scores for YGR190C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_690 glyoxal 18.20 20.3 µM 2.00E-84 1 4.44E-74 4.87
2 SGTC_3347 9188721 11.10 44.7 µM 7.24E-33 3 4.97E-29 1.34
3 SGTC_249 wiskostatin 6.77 11.2 µM 2.58E-13 1 6.52E-12 1.68
4 SGTC_1908 st060353 6.53 56.5 µM 1.65E-12 RPP1 & pyrimidine depletion 2 3.32E-11 0.19
5 SGTC_1519 esterone 4.55 74.0 µM 6.34E-7 DNA intercalators 3 2.69E-6 0.17
6 SGTC_1269 0831-0796 4.25 3.0 µM 3.07E-6 60S ribosome export 4 1.08E-5 0.28
7 SGTC_3209 9113616 4.02 49.5 µM 9.51E-6 3 2.93E-5 0.11
8 SGTC_2936 9038235 4.00 15.6 µM 1.06E-5 6 3.22E-5 0.13
9 SGTC_2906 7926292 3.93 26.4 µM 1.43E-5 5 4.20E-5 0.08
10 SGTC_1505 k297-0037 3.82 20.6 µM 2.44E-5 5 6.71E-5 0.09
11 SGTC_88 0180-0332 3.73 8.7 µM 3.58E-5 9 9.43E-5 0.12
12 SGTC_1353 1498-1206 3.67 8.1 µM 4.72E-5 mitochondrial response to ROS 8 1.20E-4 0.22
13 SGTC_363 0455-0021 3.52 3.1 µM 8.96E-5 azole & statin 23 2.12E-4 0.02
14 SGTC_2287 7945887 3.51 168.8 µM 9.60E-5 3 2.26E-4 0.26
15 SGTC_1886 st057356 3.50 49.9 µM 9.76E-5 60S ribosome export 10 2.29E-4 0.00
16 SGTC_3312 9133330 3.46 71.4 µM 1.18E-4 9 2.71E-4 0.31
17 SGTC_386 1509-0011 3.45 3.1 µM 1.21E-4 10 2.76E-4 0.04
18 SGTC_1820 st053765 3.39 18.6 µM 1.55E-4 RPP1 & pyrimidine depletion 9 3.44E-4 0.03
19 SGTC_2682 pyrogallin 3.36 40.0 µM 1.79E-4 copper-dependent oxidative stress 6 3.91E-4 0.06
20 SGTC_229 benomyl 3.36 22.9 µM 1.81E-4 tubulin folding & SWR complex 17 3.95E-4 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.427 2.36E-148 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.302 1.64E-71 YGR191W HIP1 het High-affinity histidine permease, also involved in the transport of manganese ions
0.278 1.23E-60 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.265 3.62E-55 YNR031C SSK2 hom MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress
0.263 3.28E-54 YOR364W_d YOR364W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C
0.249 1.14E-48 YNL307C MCK1 hom Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family
0.247 1.41E-47 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
0.225 6.57E-40 YLR113W HOG1 hom Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress
0.202 4.17E-32 YBL024W NCL1 hom S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120
0.199 3.33E-31 YJL110C GZF3 hom GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication
0.196 2.07E-30 YML113W DAT1 hom DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability
0.187 1.02E-27 YKL152C GPM1 het Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
0.185 3.95E-27 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.172 8.54E-24 YGL133W ITC1 hom Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex
0.170 4.19E-23 YJR139C HOM6 hom Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions