YGR192C / TDH3

Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; TDH3 has a paralog, TDH2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR192C / TDH3

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:-4.27|P-value:1.34E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:3.63|P-value:1.88E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.29|P-value:1.24E-5 ID:SGTC_224|Compound:benfluorex|FD-Score:3.87|P-value:7.49E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:-3.83|P-value:8.39E-5 ID:SGTC_285|Compound:1486-1325|FD-Score:3.16|P-value:9.78E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:-4.69|P-value:2.03E-6 ID:SGTC_292|Compound:k038-0015|FD-Score:-4.79|P-value:1.24E-6 ID:SGTC_298|Compound:1391-0729|FD-Score:-6.31|P-value:2.84E-10 ID:SGTC_302|Compound:1094-0063|FD-Score:4.48|P-value:5.55E-6 ID:SGTC_305|Compound:1682-2595|FD-Score:-4.18|P-value:2.02E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:4.84|P-value:1.03E-6 ID:SGTC_427|Compound:1354-0053|FD-Score:3.88|P-value:7.11E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.21|P-value:5.63E-10 ID:SGTC_455|Compound:paf C-16|FD-Score:3.37|P-value:4.72E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.46|P-value:3.35E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.92|P-value:6.20E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:3.19|P-value:8.88E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.47|P-value:3.35E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.22|P-value:8.02E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.58|P-value:2.23E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:3.23|P-value:7.73E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.25|P-value:7.24E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.71|P-value:1.37E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.64|P-value:1.74E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:4.46|P-value:6.28E-6 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.30|P-value:6.06E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.63|P-value:1.85E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.94|P-value:5.30E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-5.30|P-value:9.83E-8 ID:SGTC_1915|Compound:st067105|FD-Score:-5.09|P-value:2.87E-7 ID:SGTC_2018|Compound:5133068|FD-Score:3.74|P-value:1.21E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.82|P-value:8.52E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.70|P-value:1.46E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:5.41|P-value:5.65E-8 ID:SGTC_2783|Compound:7738165|FD-Score:5.83|P-value:5.55E-9 ID:SGTC_2787|Compound:5284540|FD-Score:3.54|P-value:2.62E-4 ID:SGTC_2789|Compound:5281112|FD-Score:4.43|P-value:7.15E-6 ID:SGTC_2974|Compound:9094440|FD-Score:-3.30|P-value:5.93E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.62|P-value:1.96E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.56|P-value:2.46E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.77|P-value:1.10E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.94|P-value:5.93E-7 ID:SGTC_3159|Compound:9100096|FD-Score:3.80|P-value:9.78E-5 ID:SGTC_3218|Compound:9131285|FD-Score:4.68|P-value:2.26E-6 ID:SGTC_3341|Compound:9147222|FD-Score:3.41|P-value:4.13E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:-4.27|P-value:1.34E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:3.63|P-value:1.88E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.29|P-value:1.24E-5 ID:SGTC_224|Compound:benfluorex|FD-Score:3.87|P-value:7.49E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:-3.83|P-value:8.39E-5 ID:SGTC_285|Compound:1486-1325|FD-Score:3.16|P-value:9.78E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:-4.69|P-value:2.03E-6 ID:SGTC_292|Compound:k038-0015|FD-Score:-4.79|P-value:1.24E-6 ID:SGTC_298|Compound:1391-0729|FD-Score:-6.31|P-value:2.84E-10 ID:SGTC_302|Compound:1094-0063|FD-Score:4.48|P-value:5.55E-6 ID:SGTC_305|Compound:1682-2595|FD-Score:-4.18|P-value:2.02E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:4.84|P-value:1.03E-6 ID:SGTC_427|Compound:1354-0053|FD-Score:3.88|P-value:7.11E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.21|P-value:5.63E-10 ID:SGTC_455|Compound:paf C-16|FD-Score:3.37|P-value:4.72E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.46|P-value:3.35E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.92|P-value:6.20E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:3.19|P-value:8.88E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.47|P-value:3.35E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.22|P-value:8.02E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.58|P-value:2.23E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:3.23|P-value:7.73E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.25|P-value:7.24E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.71|P-value:1.37E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.64|P-value:1.74E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:4.46|P-value:6.28E-6 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.30|P-value:6.06E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.63|P-value:1.85E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.94|P-value:5.30E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-5.30|P-value:9.83E-8 ID:SGTC_1915|Compound:st067105|FD-Score:-5.09|P-value:2.87E-7 ID:SGTC_2018|Compound:5133068|FD-Score:3.74|P-value:1.21E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.82|P-value:8.52E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.70|P-value:1.46E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:5.41|P-value:5.65E-8 ID:SGTC_2783|Compound:7738165|FD-Score:5.83|P-value:5.55E-9 ID:SGTC_2787|Compound:5284540|FD-Score:3.54|P-value:2.62E-4 ID:SGTC_2789|Compound:5281112|FD-Score:4.43|P-value:7.15E-6 ID:SGTC_2974|Compound:9094440|FD-Score:-3.30|P-value:5.93E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.62|P-value:1.96E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.56|P-value:2.46E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.77|P-value:1.10E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.94|P-value:5.93E-7 ID:SGTC_3159|Compound:9100096|FD-Score:3.80|P-value:9.78E-5 ID:SGTC_3218|Compound:9131285|FD-Score:4.68|P-value:2.26E-6 ID:SGTC_3341|Compound:9147222|FD-Score:3.41|P-value:4.13E-4

Top fitness defect scores for YGR192C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_453 enantio-paf c16 6.21 10.0 µM 5.63E-10 39 2.63E-10
2 SGTC_2783 7738165 5.83 71.4 µM 5.55E-9 7 2.82E-9
3 SGTC_2741 miltefosine 5.41 3.0 µM 5.65E-8 22 3.14E-8
4 SGTC_358 0075-0058 4.84 9.4 µM 1.03E-6 32 6.37E-7
5 SGTC_3218 9131285 4.68 49.5 µM 2.26E-6 endomembrane recycling 24 1.44E-6
6 SGTC_302 1094-0063 4.48 18.9 µM 5.55E-6 4 3.67E-6
7 SGTC_1395 3486-0190 4.46 4.3 µM 6.28E-6 4 4.17E-6
8 SGTC_2789 5281112 4.43 71.4 µM 7.15E-6 22 4.78E-6
9 SGTC_537 1334-0398 3.92 209.0 µM 6.20E-5 26 4.49E-5
10 SGTC_427 1354-0053 3.88 47.3 µM 7.11E-5 23 5.18E-5
11 SGTC_224 benfluorex 3.87 43.9 µM 7.49E-5 5 5.47E-5
12 SGTC_3159 9100096 3.80 49.5 µM 9.78E-5 23 7.21E-5
13 SGTC_3142 9086498 3.77 49.5 µM 1.10E-4 iron homeostasis 44 8.12E-5
14 SGTC_2018 5133068 3.74 143.0 µM 1.21E-4 28 9.03E-5
15 SGTC_1114 scopoletin 3.71 1.7 µM 1.37E-4 21 1.02E-4
16 SGTC_2658 polymyxin b sulfate 3.70 77.0 µM 1.46E-4 NEO1 51 1.09E-4
17 SGTC_1636 st007707 3.63 68.9 µM 1.85E-4 59 1.39E-4
18 SGTC_53 0973-0023 3.63 40.0 µM 1.88E-4 RNA processing & uracil transport 18 1.42E-4
19 SGTC_3058 9093861 3.62 49.5 µM 1.96E-4 27 1.48E-4
20 SGTC_724 3910-0327 3.58 137.0 µM 2.23E-4 ERG2 29 1.69E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 6.30E-14 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.119 4.77E-12 YNL198C_d YNL198C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.116 1.62E-11 YDL188C PPH22 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
0.114 4.14E-11 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.110 1.86E-10 YIL038C NOT3 hom Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
0.106 6.62E-10 YDR414C ERD1 hom Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
0.105 9.62E-10 YNL104C LEU4 hom Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication
0.101 4.27E-9 YHR131C_p YHR131C_p hom Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study
0.099 7.90E-9 YBR110W ALG1 het Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
0.097 1.74E-8 YGL150C INO80 het ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription
0.096 2.70E-8 YOL122C SMF1 hom Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
0.096 3.01E-8 YOR332W VMA4 hom Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress
0.094 4.20E-8 YBL005W PDR3 hom Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.093 7.77E-8 YMR216C SKY1 hom SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1
0.089 2.47E-7 YLR052W IES3 hom Subunit of the INO80 chromatin remodeling complex