YGR194C / XKS1

Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR194C / XKS1

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:3.18|P-value:1.56E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:2.94|P-value:4.30E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:2.85|P-value:6.28E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.57|P-value:2.66E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:-2.95|P-value:4.19E-4 ID:SGTC_714|Compound:4296-0578|FD-Score:3.42|P-value:5.20E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:3.55|P-value:2.89E-5 ID:SGTC_728|Compound:3030-5151|FD-Score:-2.81|P-value:7.38E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:-2.89|P-value:5.31E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-4.89|P-value:1.60E-8 ID:SGTC_923|Compound:1900-2434|FD-Score:-4.38|P-value:3.53E-7 ID:SGTC_1390|Compound:3413-2614|FD-Score:2.91|P-value:4.97E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.94|P-value:4.09E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.49|P-value:1.90E-7 ID:SGTC_1531|Compound:st059297|FD-Score:3.67|P-value:1.58E-5 ID:SGTC_1706|Compound:st031321|FD-Score:3.12|P-value:2.04E-4 ID:SGTC_1751|Compound:st044839|FD-Score:2.81|P-value:7.18E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-3.80|P-value:8.58E-6 ID:SGTC_1902|Compound:st060212|FD-Score:-3.35|P-value:7.62E-5 ID:SGTC_1961|Compound:st076550|FD-Score:-4.19|P-value:1.07E-6 ID:SGTC_1975|Compound:st070967|FD-Score:5.28|P-value:1.10E-9 ID:SGTC_1976|Compound:st070609|FD-Score:3.83|P-value:7.27E-6 ID:SGTC_2119|Compound:5528445|FD-Score:3.57|P-value:2.67E-5 ID:SGTC_2162|Compound:5663267|FD-Score:2.73|P-value:9.70E-4 ID:SGTC_2164|Compound:5685496|FD-Score:2.82|P-value:7.03E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-2.90|P-value:5.10E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-2.74|P-value:9.73E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:2.75|P-value:9.11E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.20|P-value:1.00E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:2.76|P-value:8.95E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.57|P-value:2.70E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.19|P-value:1.53E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-2.93|P-value:4.57E-4 ID:SGTC_2941|Compound:9056145|FD-Score:4.15|P-value:1.32E-6 ID:SGTC_2989|Compound:9073649|FD-Score:4.21|P-value:9.39E-7 ID:SGTC_2991|Compound:9074669|FD-Score:2.88|P-value:5.58E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.24|P-value:1.22E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.18|P-value:1.56E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:2.94|P-value:4.30E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:2.85|P-value:6.28E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.57|P-value:2.66E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:-2.95|P-value:4.19E-4 ID:SGTC_714|Compound:4296-0578|FD-Score:3.42|P-value:5.20E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:3.55|P-value:2.89E-5 ID:SGTC_728|Compound:3030-5151|FD-Score:-2.81|P-value:7.38E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:-2.89|P-value:5.31E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-4.89|P-value:1.60E-8 ID:SGTC_923|Compound:1900-2434|FD-Score:-4.38|P-value:3.53E-7 ID:SGTC_1390|Compound:3413-2614|FD-Score:2.91|P-value:4.97E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.94|P-value:4.09E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.49|P-value:1.90E-7 ID:SGTC_1531|Compound:st059297|FD-Score:3.67|P-value:1.58E-5 ID:SGTC_1706|Compound:st031321|FD-Score:3.12|P-value:2.04E-4 ID:SGTC_1751|Compound:st044839|FD-Score:2.81|P-value:7.18E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-3.80|P-value:8.58E-6 ID:SGTC_1902|Compound:st060212|FD-Score:-3.35|P-value:7.62E-5 ID:SGTC_1961|Compound:st076550|FD-Score:-4.19|P-value:1.07E-6 ID:SGTC_1975|Compound:st070967|FD-Score:5.28|P-value:1.10E-9 ID:SGTC_1976|Compound:st070609|FD-Score:3.83|P-value:7.27E-6 ID:SGTC_2119|Compound:5528445|FD-Score:3.57|P-value:2.67E-5 ID:SGTC_2162|Compound:5663267|FD-Score:2.73|P-value:9.70E-4 ID:SGTC_2164|Compound:5685496|FD-Score:2.82|P-value:7.03E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-2.90|P-value:5.10E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-2.74|P-value:9.73E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:2.75|P-value:9.11E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.20|P-value:1.00E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:2.76|P-value:8.95E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.57|P-value:2.70E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.19|P-value:1.53E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-2.93|P-value:4.57E-4 ID:SGTC_2941|Compound:9056145|FD-Score:4.15|P-value:1.32E-6 ID:SGTC_2989|Compound:9073649|FD-Score:4.21|P-value:9.39E-7 ID:SGTC_2991|Compound:9074669|FD-Score:2.88|P-value:5.58E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.24|P-value:1.22E-4

Top fitness defect scores for YGR194C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1975 st070967 5.28 30.8 µM 1.10E-9 14 6.40E-8
2 SGTC_2989 9073649 4.21 71.4 µM 9.39E-7 27 1.29E-5
3 SGTC_2941 9056145 4.15 11.2 µM 1.32E-6 15 1.70E-5
4 SGTC_1976 st070609 3.83 63.5 µM 7.27E-6 14 6.50E-5
5 SGTC_1531 st059297 3.67 52.4 µM 1.58E-5 25 1.20E-4
6 SGTC_515 4092-1064 3.57 102.0 µM 2.66E-5 plasma membrane duress 72 1.81E-4
7 SGTC_2119 5528445 3.57 120.6 µM 2.67E-5 35 1.82E-4
8 SGTC_716 1683-5115 3.55 658.0 µM 2.89E-5 38 1.93E-4
9 SGTC_714 4296-0578 3.42 26.1 µM 5.20E-5 5 3.07E-4
10 SGTC_3193 9111931 3.24 49.5 µM 1.22E-4 52 6.04E-4
11 SGTC_46 0329-0187a 3.18 2.2 µM 1.56E-4 114 7.31E-4
12 SGTC_1706 st031321 3.12 10.0 µM 2.04E-4 TSC3-RPN4 34 9.07E-4
13 SGTC_180 1486-1293 2.94 102.8 µM 4.30E-4 92 0.00164
14 SGTC_1390 3413-2614 2.91 145.0 µM 4.97E-4 fatty acid desaturase (OLE1) 73 0.00184
15 SGTC_2991 9074669 2.88 71.4 µM 5.58E-4 azole & statin 129 0.00201
16 SGTC_514 4466-0038 2.85 2.6 nM 6.28E-4 cell wall 239 0.00221
17 SGTC_2164 5685496 2.82 200.0 µM 7.03E-4 68 0.00242
18 SGTC_1751 st044839 2.81 27.2 µM 7.18E-4 Golgi 46 0.00246
19 SGTC_2586 curcumin 2.76 80.0 µM 8.95E-4 iron homeostasis 142 0.00293
20 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 2.75 63.6 µM 9.11E-4 117 0.00297

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.313 3.35E-77 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.302 1.41E-71 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.250 7.60E-49 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.241 1.57E-45 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.223 3.44E-39 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.219 1.21E-37 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.218 1.99E-37 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.211 4.04E-35 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.203 2.16E-32 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family
0.201 1.29E-31 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.197 1.12E-30 YDR497C ITR1 hom Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress
0.195 4.67E-30 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.189 2.11E-28 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.189 4.36E-28 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.188 5.98E-28 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies