YGR195W / SKI6

Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR195W / SKI6

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:2.77|P-value:9.87E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:4.50|P-value:2.41E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:3.50|P-value:4.60E-5 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:2.94|P-value:4.98E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:18.20|P-value:3.04E-93 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:5.63|P-value:1.41E-10 ID:SGTC_353|Compound:1988-1175|FD-Score:2.91|P-value:5.59E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:2.78|P-value:9.36E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.20|P-value:1.16E-6 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.49|P-value:4.43E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:11.10|P-value:7.83E-36 ID:SGTC_496|Compound:calpeptin|FD-Score:4.36|P-value:5.19E-7 ID:SGTC_610|Compound:4215-0184|FD-Score:15.80|P-value:6.65E-71 ID:SGTC_617|Compound:3770-0098|FD-Score:12.50|P-value:1.39E-44 ID:SGTC_632|Compound:0781-2353|FD-Score:3.68|P-value:1.92E-5 ID:SGTC_639|Compound:0833-0042|FD-Score:3.34|P-value:9.43E-5 ID:SGTC_644|Compound:1498-1197|FD-Score:3.23|P-value:1.53E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:2.94|P-value:5.14E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.17|P-value:1.95E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.96|P-value:4.70E-6 ID:SGTC_861|Compound:0443-0273|FD-Score:2.79|P-value:8.91E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.17|P-value:1.85E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.88|P-value:7.11E-6 ID:SGTC_994|Compound:3910-0338|FD-Score:4.65|P-value:9.43E-8 ID:SGTC_1002|Compound:4049-0206|FD-Score:-2.98|P-value:4.06E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:18.70|P-value:2.46E-98 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:10.80|P-value:2.97E-34 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.31|P-value:6.36E-7 ID:SGTC_1285|Compound:0929-0069|FD-Score:-3.39|P-value:6.92E-5 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.02|P-value:3.68E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:-3.38|P-value:7.13E-5 ID:SGTC_1547|Compound:harmine|FD-Score:-3.06|P-value:2.92E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-3.24|P-value:1.34E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.25|P-value:1.39E-4 ID:SGTC_1667|Compound:st014849|FD-Score:3.00|P-value:3.95E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.34|P-value:9.48E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:13.10|P-value:7.83E-49 ID:SGTC_1701|Compound:st028638|FD-Score:3.05|P-value:3.27E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.57|P-value:3.24E-5 ID:SGTC_1737|Compound:st035557|FD-Score:3.25|P-value:1.36E-4 ID:SGTC_1744|Compound:st037937|FD-Score:-3.07|P-value:2.73E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.79|P-value:1.10E-5 ID:SGTC_1998|Compound:st075797|FD-Score:-2.89|P-value:5.64E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.55|P-value:3.30E-5 ID:SGTC_2290|Compound:7904846|FD-Score:-2.84|P-value:7.10E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.24|P-value:1.46E-4 ID:SGTC_2361|Compound:9034121|FD-Score:2.98|P-value:4.24E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.19|P-value:1.81E-4 ID:SGTC_2397|Compound:5161689|FD-Score:-3.87|P-value:6.90E-6 ID:SGTC_2450|Compound:5739737|FD-Score:-2.83|P-value:7.30E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.29|P-value:1.06E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-2.87|P-value:6.14E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.56|P-value:3.42E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:2.86|P-value:6.92E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.42|P-value:6.48E-5 ID:SGTC_2848|Compound:9016370|FD-Score:3.45|P-value:5.56E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-3.20|P-value:1.62E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-5.71|P-value:6.97E-11 ID:SGTC_3216|Compound:9129716|FD-Score:-3.52|P-value:3.71E-5 ID:SGTC_3337|Compound:9144342|FD-Score:5.95|P-value:1.36E-11 ID:SGTC_3340|Compound:9146634|FD-Score:2.86|P-value:6.78E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.43|P-value:6.16E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:2.77|P-value:9.87E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:4.50|P-value:2.41E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:3.50|P-value:4.60E-5 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:2.94|P-value:4.98E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:18.20|P-value:3.04E-93 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:5.63|P-value:1.41E-10 ID:SGTC_353|Compound:1988-1175|FD-Score:2.91|P-value:5.59E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:2.78|P-value:9.36E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.20|P-value:1.16E-6 ID:SGTC_419|Compound:nsc-638432|FD-Score:-3.49|P-value:4.43E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:11.10|P-value:7.83E-36 ID:SGTC_496|Compound:calpeptin|FD-Score:4.36|P-value:5.19E-7 ID:SGTC_610|Compound:4215-0184|FD-Score:15.80|P-value:6.65E-71 ID:SGTC_617|Compound:3770-0098|FD-Score:12.50|P-value:1.39E-44 ID:SGTC_632|Compound:0781-2353|FD-Score:3.68|P-value:1.92E-5 ID:SGTC_639|Compound:0833-0042|FD-Score:3.34|P-value:9.43E-5 ID:SGTC_644|Compound:1498-1197|FD-Score:3.23|P-value:1.53E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:2.94|P-value:5.14E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.17|P-value:1.95E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.96|P-value:4.70E-6 ID:SGTC_861|Compound:0443-0273|FD-Score:2.79|P-value:8.91E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.17|P-value:1.85E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.88|P-value:7.11E-6 ID:SGTC_994|Compound:3910-0338|FD-Score:4.65|P-value:9.43E-8 ID:SGTC_1002|Compound:4049-0206|FD-Score:-2.98|P-value:4.06E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:18.70|P-value:2.46E-98 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:10.80|P-value:2.97E-34 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.31|P-value:6.36E-7 ID:SGTC_1285|Compound:0929-0069|FD-Score:-3.39|P-value:6.92E-5 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.02|P-value:3.68E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:-3.38|P-value:7.13E-5 ID:SGTC_1547|Compound:harmine|FD-Score:-3.06|P-value:2.92E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-3.24|P-value:1.34E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.25|P-value:1.39E-4 ID:SGTC_1667|Compound:st014849|FD-Score:3.00|P-value:3.95E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.34|P-value:9.48E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:13.10|P-value:7.83E-49 ID:SGTC_1701|Compound:st028638|FD-Score:3.05|P-value:3.27E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.57|P-value:3.24E-5 ID:SGTC_1737|Compound:st035557|FD-Score:3.25|P-value:1.36E-4 ID:SGTC_1744|Compound:st037937|FD-Score:-3.07|P-value:2.73E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.79|P-value:1.10E-5 ID:SGTC_1998|Compound:st075797|FD-Score:-2.89|P-value:5.64E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.55|P-value:3.30E-5 ID:SGTC_2290|Compound:7904846|FD-Score:-2.84|P-value:7.10E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.24|P-value:1.46E-4 ID:SGTC_2361|Compound:9034121|FD-Score:2.98|P-value:4.24E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.19|P-value:1.81E-4 ID:SGTC_2397|Compound:5161689|FD-Score:-3.87|P-value:6.90E-6 ID:SGTC_2450|Compound:5739737|FD-Score:-2.83|P-value:7.30E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.29|P-value:1.06E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-2.87|P-value:6.14E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.56|P-value:3.42E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:2.86|P-value:6.92E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.42|P-value:6.48E-5 ID:SGTC_2848|Compound:9016370|FD-Score:3.45|P-value:5.56E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-3.20|P-value:1.62E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-5.71|P-value:6.97E-11 ID:SGTC_3216|Compound:9129716|FD-Score:-3.52|P-value:3.71E-5 ID:SGTC_3337|Compound:9144342|FD-Score:5.95|P-value:1.36E-11 ID:SGTC_3340|Compound:9146634|FD-Score:2.86|P-value:6.78E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.43|P-value:6.16E-5

Top fitness defect scores for YGR195W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1074 carmofur 18.70 3.8 µM 2.46E-98 exosome 1 1.09E-78 2.88
2 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 18.20 4.6 µM 3.04E-93 heat shock/prefoldin 2 1.23E-74 5.16
3 SGTC_610 4215-0184 15.80 155.0 µM 6.65E-71 exosome 1 7.39E-57 2.92
4 SGTC_1698 5-fluorocytosine 13.10 1.1 µM 7.83E-49 exosome 2 2.75E-39 3.55
5 SGTC_617 3770-0098 12.50 35.0 µM 1.39E-44 exosome 4 6.68E-36 1.09
6 SGTC_423 5-fluorouracil 11.10 457.0 µM 7.83E-36 exosome 5 6.24E-29 2.32
7 SGTC_1077 5-fluorocytosine 10.80 377.0 nM 2.97E-34 exosome 5 1.13E-27 1.07
8 SGTC_3337 9144342 5.95 33.5 µM 1.36E-11 7 1.36E-9 1.40
9 SGTC_261 5-fluorouridine 5.63 15.4 µM 1.41E-10 exosome 4 8.88E-9 0.43
10 SGTC_994 3910-0338 4.65 138.0 µM 9.43E-8 calcium & mitochondrial duress 8 1.63E-6 0.38
11 SGTC_75 0159-0059 4.50 199.0 µM 2.41E-7 fatty acid desaturase (OLE1) 4 3.46E-6 0.27
12 SGTC_496 calpeptin 4.36 138.0 µM 5.19E-7 3 6.41E-6 0.53
13 SGTC_774 k060-0086 3.96 136.0 µM 4.70E-6 4 3.77E-5 0.07
14 SGTC_932 2857-0803 3.88 154.0 µM 7.11E-6 6 5.26E-5 0.04
15 SGTC_1868 st057644 3.79 42.7 µM 1.10E-5 8 7.50E-5 0.11
16 SGTC_632 0781-2353 3.68 4.7 µM 1.92E-5 Golgi 22 1.17E-4 0.15
17 SGTC_1722 st034304 3.57 3.6 µM 3.24E-5 mitochondrial processes 12 1.78E-4 0.02
18 SGTC_2553 4-methylesculetin 3.56 85.1 µM 3.42E-5 6 1.87E-4 0.04
19 SGTC_118 0083-0097 3.50 135.3 µM 4.60E-5 translation 28 2.37E-4 0.04
20 SGTC_2848 9016370 3.45 26.0 µM 5.56E-5 8 2.76E-4 0.30

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.633 0 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.599 0 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.589 7.87E-313 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.485 3.15E-197 YDR280W RRP45 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.471 1.58E-184 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.464 9.46E-179 YPL043W NOP4 het Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.461 3.55E-176 YPR142C_d YPR142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing
0.417 2.79E-141 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.380 2.19E-115 YPR143W RRP15 het Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
0.357 1.72E-101 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.324 7.05E-83 YNL232W CSL4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)
0.290 3.96E-66 YNL002C RLP7 het Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs
0.277 3.11E-60 YNL061W NOP2 het Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
0.245 5.23E-47 YDR060W MAK21 het Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
0.237 4.07E-44 YKL021C MAK11 het Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats