YGR196C / FYV8

Protein of unknown function, required for survival upon exposure to K1 killer toxin

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR196C / FYV8

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.20|P-value:6.59E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.80|P-value:6.75E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:4.47|P-value:3.56E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:17.80|P-value:1.41E-71 ID:SGTC_63|Compound:0099-0242|FD-Score:4.95|P-value:3.35E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.08|P-value:9.72E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.96|P-value:3.50E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:3.46|P-value:2.60E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:28.40|P-value:7.65E-179 ID:SGTC_263|Compound:alizarin|FD-Score:3.65|P-value:1.27E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-5.53|P-value:1.39E-8 ID:SGTC_272|Compound:doxorubicin|FD-Score:-3.18|P-value:6.92E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.27|P-value:5.19E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.60|P-value:1.53E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:7.63|P-value:9.11E-15 ID:SGTC_304|Compound:1310-0298|FD-Score:4.53|P-value:2.72E-6 ID:SGTC_353|Compound:1988-1175|FD-Score:5.22|P-value:8.10E-8 ID:SGTC_422|Compound:cantharidin|FD-Score:3.18|P-value:7.07E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.87|P-value:5.08E-7 ID:SGTC_500|Compound:h-89|FD-Score:5.03|P-value:2.19E-7 ID:SGTC_504|Compound:lovastatin|FD-Score:3.37|P-value:3.66E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:6.37|P-value:7.89E-11 ID:SGTC_549|Compound:1661-1316|FD-Score:3.16|P-value:7.72E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.80|P-value:6.99E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.10|P-value:9.17E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:20.50|P-value:2.94E-94 ID:SGTC_825|Compound:1988-2224|FD-Score:3.34|P-value:4.04E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:3.93|P-value:4.04E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:3.66|P-value:1.20E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-5.62|P-value:8.02E-9 ID:SGTC_950|Compound:1165-0508|FD-Score:-5.79|P-value:2.96E-9 ID:SGTC_952|Compound:1185-0122|FD-Score:-8.41|P-value:1.38E-17 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.58|P-value:1.67E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:-3.18|P-value:6.91E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.34|P-value:4.07E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-5.04|P-value:2.02E-7 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-4.17|P-value:1.41E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.68|P-value:1.12E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.54|P-value:1.85E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.29|P-value:4.60E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:4.22|P-value:1.16E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.33|P-value:4.02E-4 ID:SGTC_1614|Compound:st002383|FD-Score:3.61|P-value:1.45E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.11|P-value:8.92E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.58|P-value:1.64E-4 ID:SGTC_2007|Compound:4011539|FD-Score:19.80|P-value:6.42E-88 ID:SGTC_2009|Compound:4012297|FD-Score:25.00|P-value:4.22E-139 ID:SGTC_2028|Compound:5153890|FD-Score:5.52|P-value:1.55E-8 ID:SGTC_2055|Compound:5235184|FD-Score:6.44|P-value:4.97E-11 ID:SGTC_2149|Compound:5554786|FD-Score:5.79|P-value:3.17E-9 ID:SGTC_2215|Compound:7188065|FD-Score:3.19|P-value:6.97E-4 ID:SGTC_2272|Compound:7805186|FD-Score:5.87|P-value:1.93E-9 ID:SGTC_2286|Compound:7945697|FD-Score:4.84|P-value:5.94E-7 ID:SGTC_2289|Compound:7946404|FD-Score:7.17|P-value:3.12E-13 ID:SGTC_2304|Compound:7443016|FD-Score:3.70|P-value:1.02E-4 ID:SGTC_2399|Compound:5884133|FD-Score:13.50|P-value:2.58E-42 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.89|P-value:4.75E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.25|P-value:5.67E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:13.10|P-value:7.87E-40 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.64|P-value:1.32E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.70|P-value:1.03E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.31|P-value:4.28E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.22|P-value:8.29E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.09|P-value:9.32E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.01|P-value:2.87E-5 ID:SGTC_2806|Compound:7952793|FD-Score:3.25|P-value:5.65E-4 ID:SGTC_2895|Compound:9054447|FD-Score:3.25|P-value:5.56E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-3.42|P-value:2.94E-4 ID:SGTC_2953|Compound:9074162|FD-Score:-4.20|P-value:1.22E-5 ID:SGTC_2961|Compound:9083290|FD-Score:3.46|P-value:2.55E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.21|P-value:6.46E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.09|P-value:9.31E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.56|P-value:1.80E-4 ID:SGTC_3092|Compound:9117248|FD-Score:3.60|P-value:1.52E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-4.20|P-value:1.22E-5 ID:SGTC_3221|Compound:9128209|FD-Score:3.09|P-value:9.86E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-3.96|P-value:3.40E-5 ID:SGTC_3324|Compound:9138759|FD-Score:3.15|P-value:7.97E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:3.20|P-value:6.59E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.80|P-value:6.75E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:4.47|P-value:3.56E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:17.80|P-value:1.41E-71 ID:SGTC_63|Compound:0099-0242|FD-Score:4.95|P-value:3.35E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.08|P-value:9.72E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.96|P-value:3.50E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:3.46|P-value:2.60E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:28.40|P-value:7.65E-179 ID:SGTC_263|Compound:alizarin|FD-Score:3.65|P-value:1.27E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-5.53|P-value:1.39E-8 ID:SGTC_272|Compound:doxorubicin|FD-Score:-3.18|P-value:6.92E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.27|P-value:5.19E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.60|P-value:1.53E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:7.63|P-value:9.11E-15 ID:SGTC_304|Compound:1310-0298|FD-Score:4.53|P-value:2.72E-6 ID:SGTC_353|Compound:1988-1175|FD-Score:5.22|P-value:8.10E-8 ID:SGTC_422|Compound:cantharidin|FD-Score:3.18|P-value:7.07E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.87|P-value:5.08E-7 ID:SGTC_500|Compound:h-89|FD-Score:5.03|P-value:2.19E-7 ID:SGTC_504|Compound:lovastatin|FD-Score:3.37|P-value:3.66E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:6.37|P-value:7.89E-11 ID:SGTC_549|Compound:1661-1316|FD-Score:3.16|P-value:7.72E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.80|P-value:6.99E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.10|P-value:9.17E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:20.50|P-value:2.94E-94 ID:SGTC_825|Compound:1988-2224|FD-Score:3.34|P-value:4.04E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:3.93|P-value:4.04E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:3.66|P-value:1.20E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-5.62|P-value:8.02E-9 ID:SGTC_950|Compound:1165-0508|FD-Score:-5.79|P-value:2.96E-9 ID:SGTC_952|Compound:1185-0122|FD-Score:-8.41|P-value:1.38E-17 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.58|P-value:1.67E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:-3.18|P-value:6.91E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.34|P-value:4.07E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-5.04|P-value:2.02E-7 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-4.17|P-value:1.41E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.68|P-value:1.12E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.54|P-value:1.85E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.29|P-value:4.60E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:4.22|P-value:1.16E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.33|P-value:4.02E-4 ID:SGTC_1614|Compound:st002383|FD-Score:3.61|P-value:1.45E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.11|P-value:8.92E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.58|P-value:1.64E-4 ID:SGTC_2007|Compound:4011539|FD-Score:19.80|P-value:6.42E-88 ID:SGTC_2009|Compound:4012297|FD-Score:25.00|P-value:4.22E-139 ID:SGTC_2028|Compound:5153890|FD-Score:5.52|P-value:1.55E-8 ID:SGTC_2055|Compound:5235184|FD-Score:6.44|P-value:4.97E-11 ID:SGTC_2149|Compound:5554786|FD-Score:5.79|P-value:3.17E-9 ID:SGTC_2215|Compound:7188065|FD-Score:3.19|P-value:6.97E-4 ID:SGTC_2272|Compound:7805186|FD-Score:5.87|P-value:1.93E-9 ID:SGTC_2286|Compound:7945697|FD-Score:4.84|P-value:5.94E-7 ID:SGTC_2289|Compound:7946404|FD-Score:7.17|P-value:3.12E-13 ID:SGTC_2304|Compound:7443016|FD-Score:3.70|P-value:1.02E-4 ID:SGTC_2399|Compound:5884133|FD-Score:13.50|P-value:2.58E-42 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.89|P-value:4.75E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.25|P-value:5.67E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:13.10|P-value:7.87E-40 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.64|P-value:1.32E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.70|P-value:1.03E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.31|P-value:4.28E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.22|P-value:8.29E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.09|P-value:9.32E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.01|P-value:2.87E-5 ID:SGTC_2806|Compound:7952793|FD-Score:3.25|P-value:5.65E-4 ID:SGTC_2895|Compound:9054447|FD-Score:3.25|P-value:5.56E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-3.42|P-value:2.94E-4 ID:SGTC_2953|Compound:9074162|FD-Score:-4.20|P-value:1.22E-5 ID:SGTC_2961|Compound:9083290|FD-Score:3.46|P-value:2.55E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.21|P-value:6.46E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.09|P-value:9.31E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.56|P-value:1.80E-4 ID:SGTC_3092|Compound:9117248|FD-Score:3.60|P-value:1.52E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-4.20|P-value:1.22E-5 ID:SGTC_3221|Compound:9128209|FD-Score:3.09|P-value:9.86E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-3.96|P-value:3.40E-5 ID:SGTC_3324|Compound:9138759|FD-Score:3.15|P-value:7.97E-4

Top fitness defect scores for YGR196C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_255 tunicamycin 28.40 200.5 nM 7.65E-179 unfolded protein response 1 2.35E-177
2 SGTC_2009 4012297 25.00 12.1 µM 4.22E-139 cell wall signaling 2 5.92E-138
3 SGTC_663 1486-0733 20.50 13.9 µM 2.94E-94 cell wall signaling 4 1.71E-93
4 SGTC_2007 4011539 19.80 71.8 µM 6.42E-88 cell wall signaling 4 3.30E-87
5 SGTC_58 0957-0393 17.80 9.0 µM 1.41E-71 cell wall 19 5.28E-71
6 SGTC_2399 5884133 13.50 200.0 µM 2.58E-42 cell wall signaling 7 5.47E-42
7 SGTC_2582 agaric acid 13.10 100.0 µM 7.87E-40 redox potentiating 26 1.59E-39
8 SGTC_299 1273-0059 7.63 1.4 µM 9.11E-15 3 1.14E-14
9 SGTC_2289 7946404 7.17 165.1 µM 3.12E-13 26 3.81E-13
10 SGTC_2055 5235184 6.44 200.0 µM 4.97E-11 ERG2 5 5.82E-11
11 SGTC_531 3788-1495 6.37 174.0 µM 7.89E-11 unfolded protein response 6 9.20E-11
12 SGTC_2272 7805186 5.87 180.0 µM 1.93E-9 cell wall signaling 7 2.20E-9
13 SGTC_2149 5554786 5.79 194.8 µM 3.17E-9 cell wall signaling 10 3.59E-9
14 SGTC_2028 5153890 5.52 36.4 µM 1.55E-8 cell wall signaling 14 1.73E-8
15 SGTC_353 1988-1175 5.22 58.3 µM 8.10E-8 unfolded protein response 10 8.95E-8
16 SGTC_2619 obliquin 5.22 87.9 µM 8.29E-8 cell wall 94 9.16E-8
17 SGTC_500 h-89 5.03 112.0 µM 2.19E-7 cell wall signaling 18 2.40E-7
18 SGTC_63 0099-0242 4.95 26.7 µM 3.35E-7 mitochondrial stress 58 3.66E-7
19 SGTC_457 grayanotoxin iii 4.87 135.0 µM 5.08E-7 31 5.54E-7
20 SGTC_2286 7945697 4.84 125.0 µM 5.94E-7 30 6.46E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.656 0 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.527 3.14E-239 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.459 4.14E-174 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.456 3.27E-172 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.434 5.69E-154 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.375 1.75E-112 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.363 6.57E-105 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.355 2.57E-100 YAL056C-A_d YAL056C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.316 1.79E-78 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.311 5.18E-76 YJL095W BCK1 hom Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.307 1.40E-73 YHR030C SLT2 hom Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
0.302 1.25E-71 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.281 5.75E-62 YOR008C SLG1 hom Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response
0.281 9.92E-62 YNL084C END3 hom EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
0.273 2.36E-58 YMR200W ROT1 het Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation