YGR197C / SNG1

Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR197C / SNG1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.19|P-value:3.16E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.02|P-value:6.11E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.01|P-value:8.62E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:7.00|P-value:3.28E-14 ID:SGTC_128|Compound:0906-2981|FD-Score:-4.93|P-value:6.43E-8 ID:SGTC_132|Compound:0417-1715|FD-Score:-5.25|P-value:9.21E-9 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.05|P-value:7.22E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.32|P-value:1.83E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.36|P-value:1.63E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:2.93|P-value:8.49E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.72|P-value:3.41E-5 ID:SGTC_211|Compound:3455-0679|FD-Score:-2.92|P-value:8.98E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.26|P-value:2.41E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:-2.89|P-value:9.70E-4 ID:SGTC_251|Compound:melphalan|FD-Score:2.93|P-value:8.51E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.77|P-value:2.65E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:3.17|P-value:3.38E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:-2.95|P-value:7.90E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.04|P-value:5.72E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:-4.28|P-value:2.23E-6 ID:SGTC_554|Compound:4483-2211|FD-Score:4.51|P-value:6.90E-7 ID:SGTC_555|Compound:4296-0685|FD-Score:-3.05|P-value:5.47E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:3.32|P-value:1.84E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-2.99|P-value:6.91E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.40|P-value:1.22E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-2.96|P-value:7.49E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:2.97|P-value:7.31E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:2.94|P-value:8.24E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.66|P-value:4.37E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:2.94|P-value:8.14E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.37|P-value:1.54E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.04|P-value:5.66E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.51|P-value:6.59E-7 ID:SGTC_1743|Compound:st037606|FD-Score:-3.98|P-value:1.02E-5 ID:SGTC_1887|Compound:st057648|FD-Score:3.29|P-value:2.11E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:4.10|P-value:5.64E-6 ID:SGTC_1988|Compound:st071872|FD-Score:2.96|P-value:7.66E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-3.08|P-value:4.79E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.70|P-value:3.74E-5 ID:SGTC_2052|Compound:5265182|FD-Score:5.69|P-value:5.31E-10 ID:SGTC_2056|Compound:5235370|FD-Score:2.94|P-value:8.09E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.50|P-value:8.98E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-2.94|P-value:8.10E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-6.07|P-value:3.89E-11 ID:SGTC_2607|Compound:solasodine|FD-Score:-7.14|P-value:9.96E-15 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:17.30|P-value:4.77E-77 ID:SGTC_2657|Compound:nystatin|FD-Score:3.11|P-value:4.34E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-5.02|P-value:3.72E-8 ID:SGTC_2810|Compound:7959871|FD-Score:-2.92|P-value:8.92E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.19|P-value:3.16E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.02|P-value:6.11E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.01|P-value:8.62E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:7.00|P-value:3.28E-14 ID:SGTC_128|Compound:0906-2981|FD-Score:-4.93|P-value:6.43E-8 ID:SGTC_132|Compound:0417-1715|FD-Score:-5.25|P-value:9.21E-9 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.05|P-value:7.22E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.32|P-value:1.83E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.36|P-value:1.63E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:2.93|P-value:8.49E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.72|P-value:3.41E-5 ID:SGTC_211|Compound:3455-0679|FD-Score:-2.92|P-value:8.98E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.26|P-value:2.41E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:-2.89|P-value:9.70E-4 ID:SGTC_251|Compound:melphalan|FD-Score:2.93|P-value:8.51E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.77|P-value:2.65E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:3.17|P-value:3.38E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:-2.95|P-value:7.90E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.04|P-value:5.72E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:-4.28|P-value:2.23E-6 ID:SGTC_554|Compound:4483-2211|FD-Score:4.51|P-value:6.90E-7 ID:SGTC_555|Compound:4296-0685|FD-Score:-3.05|P-value:5.47E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:3.32|P-value:1.84E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-2.99|P-value:6.91E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.40|P-value:1.22E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-2.96|P-value:7.49E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:2.97|P-value:7.31E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:2.94|P-value:8.24E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.66|P-value:4.37E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:2.94|P-value:8.14E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.37|P-value:1.54E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.04|P-value:5.66E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.51|P-value:6.59E-7 ID:SGTC_1743|Compound:st037606|FD-Score:-3.98|P-value:1.02E-5 ID:SGTC_1887|Compound:st057648|FD-Score:3.29|P-value:2.11E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:4.10|P-value:5.64E-6 ID:SGTC_1988|Compound:st071872|FD-Score:2.96|P-value:7.66E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-3.08|P-value:4.79E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.70|P-value:3.74E-5 ID:SGTC_2052|Compound:5265182|FD-Score:5.69|P-value:5.31E-10 ID:SGTC_2056|Compound:5235370|FD-Score:2.94|P-value:8.09E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.50|P-value:8.98E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-2.94|P-value:8.10E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-6.07|P-value:3.89E-11 ID:SGTC_2607|Compound:solasodine|FD-Score:-7.14|P-value:9.96E-15 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:17.30|P-value:4.77E-77 ID:SGTC_2657|Compound:nystatin|FD-Score:3.11|P-value:4.34E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-5.02|P-value:3.72E-8 ID:SGTC_2810|Compound:7959871|FD-Score:-2.92|P-value:8.92E-4

Top fitness defect scores for YGR197C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2615 purpurogallin-4-carboxylic acid 17.30 100.0 µM 4.77E-77 redox potentiating 2 2.05E-67
2 SGTC_127 0180-0333 7.00 59.1 µM 3.28E-14 mitochondrial response to ROS 4 1.31E-12
3 SGTC_2052 5265182 5.69 7.1 µM 5.31E-10 5 6.23E-9
4 SGTC_1589 2',5'-dimethoxyflavone 4.51 47.2 µM 6.59E-7 7 3.17E-6
5 SGTC_554 4483-2211 4.51 187.0 µM 6.90E-7 11 3.31E-6
6 SGTC_767 0929-0023 4.40 86.0 µM 1.22E-6 TRP & mitochondrial translation 52 5.46E-6
7 SGTC_1894 3',6'-dihydroxyflavone 4.10 78.7 µM 5.64E-6 10 2.08E-5
8 SGTC_255 tunicamycin 3.77 200.5 nM 2.65E-5 unfolded protein response 83 8.08E-5
9 SGTC_1084 voriconazole 3.66 435.0 nM 4.37E-5 azole & statin 38 1.25E-4
10 SGTC_2181 6316240 3.50 54.3 µM 8.98E-5 34 2.36E-4
11 SGTC_1230 0170-0365 3.37 3.8 µM 1.54E-4 endomembrane recycling 104 3.79E-4
12 SGTC_575 k072-0246 3.32 11.9 µM 1.84E-4 43 4.42E-4
13 SGTC_1887 st057648 3.29 70.8 µM 2.11E-4 34 5.00E-4
14 SGTC_230 MPP+ 3.26 141.7 µM 2.41E-4 42 5.62E-4
15 SGTC_10 0279-0212 3.19 42.6 µM 3.16E-4 TRP & mitochondrial translation 183 7.13E-4
16 SGTC_258 haloperidol 3.17 50.8 µM 3.38E-4 fatty acid desaturase (OLE1) 61 7.57E-4
17 SGTC_2657 nystatin 3.11 74.4 µM 4.34E-4 41 9.42E-4
18 SGTC_1252 0493-0875 3.04 34.8 µM 5.66E-4 73 0.00119
19 SGTC_288 1315-0019 3.04 35.1 µM 5.72E-4 RSC & ERG11 65 0.00120
20 SGTC_22 0964-0034 3.02 14.5 µM 6.11E-4 unfolded protein response 89 0.00127

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.267 9.98E-56 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.226 2.88E-40 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.216 8.85E-37 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.201 6.81E-32 YBR157C ICS2 hom Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
0.196 2.18E-30 YBL059W_p YBL059W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication
0.163 1.76E-21 YBR051W_d YBR051W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
0.156 9.77E-20 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.141 2.52E-16 YDR173C ARG82 hom Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
0.134 7.17E-15 YGL180W ATG1 hom Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p
0.133 1.28E-14 YPL222W_p FMP40_p hom Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.124 4.95E-13 YBR151W APD1 hom Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
0.117 1.16E-11 YMR279C YMR279C hom Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication
0.117 1.32E-11 YLR304C ACO1 hom Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
0.115 2.19E-11 YJL138C TIF2 hom Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF2 has a paralog, TIF1, that arose from the whole genome duplication
0.114 3.48E-11 YPR174C YPR174C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication