YGR198W / YPP1

Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR198W / YPP1

Click on Significant Values for Screen Details ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:2.86|P-value:9.92E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:2.90|P-value:8.46E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:2.94|P-value:7.32E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:-3.15|P-value:2.79E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.58|P-value:5.18E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.18|P-value:2.47E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:8.67|P-value:2.11E-21 ID:SGTC_1037|Compound:k284-1091|FD-Score:-4.39|P-value:7.89E-7 ID:SGTC_1039|Compound:k821-0043|FD-Score:4.89|P-value:5.47E-8 ID:SGTC_1040|Compound:k898-0338|FD-Score:6.21|P-value:7.81E-12 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.53|P-value:5.69E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:-4.66|P-value:1.72E-7 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.48|P-value:7.03E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:2.95|P-value:7.02E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.47|P-value:8.50E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:-3.78|P-value:1.78E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:-4.38|P-value:8.56E-7 ID:SGTC_1317|Compound:1273-0028|FD-Score:2.99|P-value:6.09E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.85|P-value:8.98E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.64|P-value:3.95E-5 ID:SGTC_1660|Compound:st012960|FD-Score:2.98|P-value:6.32E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.19|P-value:2.75E-6 ID:SGTC_1712|Compound:st032288|FD-Score:5.25|P-value:6.01E-9 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-2.82|P-value:9.96E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.03|P-value:5.15E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.07|P-value:4.38E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.15|P-value:3.18E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.15|P-value:3.15E-4 ID:SGTC_2301|Compound:7769476|FD-Score:2.93|P-value:7.50E-4 ID:SGTC_2328|Compound:6201408|FD-Score:3.78|P-value:2.09E-5 ID:SGTC_2330|Compound:7979373|FD-Score:2.91|P-value:8.04E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.27|P-value:1.94E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.55|P-value:5.87E-5 ID:SGTC_2385|Compound:9074692|FD-Score:3.04|P-value:4.93E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.20|P-value:2.58E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.13|P-value:3.44E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.71|P-value:2.43E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-2.90|P-value:7.34E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-2.86|P-value:8.74E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-4.86|P-value:5.46E-8 ID:SGTC_2909|Compound:7941780|FD-Score:3.27|P-value:2.01E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.62|P-value:4.36E-5 ID:SGTC_2980|Compound:9014342|FD-Score:4.77|P-value:1.15E-7 ID:SGTC_2987|Compound:9018338|FD-Score:2.93|P-value:7.67E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-2.83|P-value:9.69E-4 ID:SGTC_3007|Compound:9078383|FD-Score:-3.09|P-value:3.51E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-2.86|P-value:8.64E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-7.02|P-value:8.94E-15 ID:SGTC_3135|Compound:9127742|FD-Score:3.74|P-value:2.51E-5 ID:SGTC_3216|Compound:9129716|FD-Score:3.20|P-value:2.67E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.15|P-value:2.83E-4 ID:SGTC_3298|Compound:9116858|FD-Score:-2.83|P-value:9.76E-4 ID:SGTC_3304|Compound:9125678|FD-Score:6.47|P-value:1.07E-12 ID:SGTC_3308|Compound:9128332|FD-Score:3.49|P-value:7.91E-5 ID:SGTC_3309|Compound:9129340|FD-Score:2.95|P-value:6.99E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:2.86|P-value:9.92E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:2.90|P-value:8.46E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:2.94|P-value:7.32E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:-3.15|P-value:2.79E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.58|P-value:5.18E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.18|P-value:2.47E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:8.67|P-value:2.11E-21 ID:SGTC_1037|Compound:k284-1091|FD-Score:-4.39|P-value:7.89E-7 ID:SGTC_1039|Compound:k821-0043|FD-Score:4.89|P-value:5.47E-8 ID:SGTC_1040|Compound:k898-0338|FD-Score:6.21|P-value:7.81E-12 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.53|P-value:5.69E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:-4.66|P-value:1.72E-7 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.48|P-value:7.03E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:2.95|P-value:7.02E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.47|P-value:8.50E-5 ID:SGTC_1227|Compound:3909-8010|FD-Score:-3.78|P-value:1.78E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:-4.38|P-value:8.56E-7 ID:SGTC_1317|Compound:1273-0028|FD-Score:2.99|P-value:6.09E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.85|P-value:8.98E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.64|P-value:3.95E-5 ID:SGTC_1660|Compound:st012960|FD-Score:2.98|P-value:6.32E-4 ID:SGTC_1673|Compound:st016611|FD-Score:4.19|P-value:2.75E-6 ID:SGTC_1712|Compound:st032288|FD-Score:5.25|P-value:6.01E-9 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-2.82|P-value:9.96E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.03|P-value:5.15E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.07|P-value:4.38E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.15|P-value:3.18E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.15|P-value:3.15E-4 ID:SGTC_2301|Compound:7769476|FD-Score:2.93|P-value:7.50E-4 ID:SGTC_2328|Compound:6201408|FD-Score:3.78|P-value:2.09E-5 ID:SGTC_2330|Compound:7979373|FD-Score:2.91|P-value:8.04E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.27|P-value:1.94E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.55|P-value:5.87E-5 ID:SGTC_2385|Compound:9074692|FD-Score:3.04|P-value:4.93E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.20|P-value:2.58E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.13|P-value:3.44E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.71|P-value:2.43E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-2.90|P-value:7.34E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-2.86|P-value:8.74E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-4.86|P-value:5.46E-8 ID:SGTC_2909|Compound:7941780|FD-Score:3.27|P-value:2.01E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.62|P-value:4.36E-5 ID:SGTC_2980|Compound:9014342|FD-Score:4.77|P-value:1.15E-7 ID:SGTC_2987|Compound:9018338|FD-Score:2.93|P-value:7.67E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-2.83|P-value:9.69E-4 ID:SGTC_3007|Compound:9078383|FD-Score:-3.09|P-value:3.51E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-2.86|P-value:8.64E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-7.02|P-value:8.94E-15 ID:SGTC_3135|Compound:9127742|FD-Score:3.74|P-value:2.51E-5 ID:SGTC_3216|Compound:9129716|FD-Score:3.20|P-value:2.67E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.15|P-value:2.83E-4 ID:SGTC_3298|Compound:9116858|FD-Score:-2.83|P-value:9.76E-4 ID:SGTC_3304|Compound:9125678|FD-Score:6.47|P-value:1.07E-12 ID:SGTC_3308|Compound:9128332|FD-Score:3.49|P-value:7.91E-5 ID:SGTC_3309|Compound:9129340|FD-Score:2.95|P-value:6.99E-4

Top fitness defect scores for YGR198W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1035 k081-0041 8.67 55.2 µM 2.11E-21 Golgi 1 2.13E-18 2.46
2 SGTC_3304 9125678 6.47 46.1 µM 1.07E-12 19 5.01E-11 0.39
3 SGTC_1040 k898-0338 6.21 155.0 µM 7.81E-12 1 2.71E-10 2.00
4 SGTC_1712 st032288 5.25 53.4 µM 6.01E-9 calcium & mitochondrial duress 21 7.63E-8 0.04
5 SGTC_1039 k821-0043 4.89 94.0 µM 5.47E-8 Golgi 2 4.98E-7 1.07
6 SGTC_2980 9014342 4.77 25.3 µM 1.15E-7 12 9.40E-7 0.03
7 SGTC_1673 st016611 4.19 27.3 µM 2.75E-6 6 1.40E-5 0.38
8 SGTC_2328 6201408 3.78 200.0 µM 2.09E-5 12 7.90E-5 0.12
9 SGTC_3135 9127742 3.74 49.5 µM 2.51E-5 2 9.22E-5 0.26
10 SGTC_1503 4585-0012 3.64 61.3 µM 3.95E-5 8 1.36E-4 0.05
11 SGTC_2976 9009005 3.62 19.5 µM 4.36E-5 9 1.48E-4 0.08
12 SGTC_773 4358-1457 3.58 44.6 µM 5.18E-5 12 1.71E-4 0.14
13 SGTC_2338 7999974 3.55 200.0 µM 5.87E-5 13 1.91E-4 0.15
14 SGTC_3308 9128332 3.49 17.6 µM 7.91E-5 plasma membrane duress 13 2.46E-4 0.06
15 SGTC_1219 1469-0211 3.47 33.1 µM 8.50E-5 6 2.62E-4 0.00
16 SGTC_2332 7982454 3.27 138.9 µM 1.94E-4 18 5.29E-4 0.05
17 SGTC_2909 7941780 3.27 10.5 µM 2.01E-4 11 5.47E-4 0.12
18 SGTC_2427 5545055 3.20 42.8 µM 2.58E-4 14 6.75E-4 0.02
19 SGTC_3216 9129716 3.20 49.5 µM 2.67E-4 RPP1 & pyrimidine depletion 10 6.97E-4 0.09
20 SGTC_2299 7976368 3.15 114.9 µM 3.15E-4 14 8.03E-4 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.213 1.44E-35 YKL083W_d YKL083W_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14
0.176 1.36E-24 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.173 4.92E-24 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.159 2.45E-20 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.156 1.01E-19 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.147 1.52E-17 YLR153C ACS2 het Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.129 7.03E-14 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.127 1.38E-13 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.126 2.42E-13 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.122 1.29E-12 YKL088W CAB3 het Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC
0.117 1.04E-11 YDL182W LYS20 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication
0.112 8.74E-11 YKL146W AVT3 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.110 1.72E-10 YBR241C_p YBR241C_p hom Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
0.110 2.05E-10 YMR187C_p YMR187C_p hom Putative protein of unknown function; YMR187C is not an essential gene
0.108 3.81E-10 YDR357C_p CNL1_p hom Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm