YGR204C-A_p

Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR204C-A / YGR204C-A

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:3.47|P-value:9.88E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:4.05|P-value:6.81E-6 ID:SGTC_264|Compound:promethazine|FD-Score:3.70|P-value:3.52E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:3.95|P-value:1.12E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:3.26|P-value:2.37E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.30|P-value:1.97E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.88|P-value:1.56E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.10|P-value:4.22E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:5.72|P-value:3.86E-10 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.08|P-value:4.47E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.42|P-value:1.20E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.31|P-value:1.85E-6 ID:SGTC_773|Compound:4358-1457|FD-Score:3.32|P-value:1.84E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:-2.88|P-value:9.34E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.22|P-value:2.75E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-3.56|P-value:6.14E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.63|P-value:4.57E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.13|P-value:3.68E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:2.91|P-value:9.07E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.17|P-value:3.28E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.65|P-value:2.91E-7 ID:SGTC_1258|Compound:0671-0043|FD-Score:2.90|P-value:9.31E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:-3.18|P-value:3.00E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.40|P-value:1.31E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.84|P-value:1.83E-5 ID:SGTC_1938|Compound:st074717|FD-Score:4.00|P-value:8.91E-6 ID:SGTC_1974|Compound:st069448|FD-Score:2.92|P-value:8.49E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.42|P-value:1.19E-4 ID:SGTC_2044|Compound:5102272|FD-Score:4.02|P-value:8.02E-6 ID:SGTC_2050|Compound:5263056|FD-Score:3.14|P-value:3.79E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.58|P-value:5.81E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.39|P-value:1.26E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.62|P-value:4.97E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.43|P-value:1.15E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.39|P-value:1.38E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-2.87|P-value:9.92E-4 ID:SGTC_2859|Compound:9028643|FD-Score:2.95|P-value:7.78E-4 ID:SGTC_2932|Compound:9016711|FD-Score:2.98|P-value:6.98E-4 ID:SGTC_3195|Compound:9113082|FD-Score:4.90|P-value:6.97E-8 ID:SGTC_3197|Compound:9113331|FD-Score:3.61|P-value:5.33E-5 ID:SGTC_3200|Compound:9114385|FD-Score:3.47|P-value:9.87E-5 ID:SGTC_3328|Compound:9140624|FD-Score:3.82|P-value:2.01E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:3.47|P-value:9.88E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:4.05|P-value:6.81E-6 ID:SGTC_264|Compound:promethazine|FD-Score:3.70|P-value:3.52E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:3.95|P-value:1.12E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:3.26|P-value:2.37E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.30|P-value:1.97E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.88|P-value:1.56E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.10|P-value:4.22E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:5.72|P-value:3.86E-10 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.08|P-value:4.47E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.42|P-value:1.20E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.31|P-value:1.85E-6 ID:SGTC_773|Compound:4358-1457|FD-Score:3.32|P-value:1.84E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:-2.88|P-value:9.34E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.22|P-value:2.75E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-3.56|P-value:6.14E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.63|P-value:4.57E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.13|P-value:3.68E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:2.91|P-value:9.07E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.17|P-value:3.28E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.65|P-value:2.91E-7 ID:SGTC_1258|Compound:0671-0043|FD-Score:2.90|P-value:9.31E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:-3.18|P-value:3.00E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.40|P-value:1.31E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.84|P-value:1.83E-5 ID:SGTC_1938|Compound:st074717|FD-Score:4.00|P-value:8.91E-6 ID:SGTC_1974|Compound:st069448|FD-Score:2.92|P-value:8.49E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.42|P-value:1.19E-4 ID:SGTC_2044|Compound:5102272|FD-Score:4.02|P-value:8.02E-6 ID:SGTC_2050|Compound:5263056|FD-Score:3.14|P-value:3.79E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.58|P-value:5.81E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.39|P-value:1.26E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.62|P-value:4.97E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.43|P-value:1.15E-4 ID:SGTC_2643|Compound:anethole|FD-Score:3.39|P-value:1.38E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-2.87|P-value:9.92E-4 ID:SGTC_2859|Compound:9028643|FD-Score:2.95|P-value:7.78E-4 ID:SGTC_2932|Compound:9016711|FD-Score:2.98|P-value:6.98E-4 ID:SGTC_3195|Compound:9113082|FD-Score:4.90|P-value:6.97E-8 ID:SGTC_3197|Compound:9113331|FD-Score:3.61|P-value:5.33E-5 ID:SGTC_3200|Compound:9114385|FD-Score:3.47|P-value:9.87E-5 ID:SGTC_3328|Compound:9140624|FD-Score:3.82|P-value:2.01E-5

Top fitness defect scores for YGR204C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_659 k018-0002 5.72 107.0 µM 3.86E-10 3 5.21E-9
2 SGTC_3195 9113082 4.90 49.5 µM 6.97E-8 8 4.75E-7
3 SGTC_1255 0566-0045 4.65 221.0 µM 2.91E-7 excess fatty acid 15 1.64E-6
4 SGTC_673 1082-0474 4.31 110.0 µM 1.85E-6 RSC complex & mRNA processing 53 8.24E-6
5 SGTC_135 0933-0004 4.05 26.4 µM 6.81E-6 60S ribosome export 22 2.56E-5
6 SGTC_2044 5102272 4.02 200.0 µM 8.02E-6 9 2.95E-5
7 SGTC_1938 st074717 4.00 56.4 µM 8.91E-6 10 3.23E-5
8 SGTC_362 0310-0100 3.95 9.0 µM 1.12E-5 RPP1 & pyrimidine depletion 32 3.96E-5
9 SGTC_602 3130-1533 3.88 38.1 µM 1.56E-5 18 5.28E-5
10 SGTC_1916 st067606 3.84 49.2 µM 1.83E-5 42 6.06E-5
11 SGTC_3328 9140624 3.82 29.0 µM 2.01E-5 24 6.56E-5
12 SGTC_264 promethazine 3.70 12.5 mM 3.52E-5 DNA intercalators 61 1.07E-4
13 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 3.62 100.0 µM 4.97E-5 41 1.45E-4
14 SGTC_3197 9113331 3.61 49.5 µM 5.33E-5 43 1.54E-4
15 SGTC_3200 9114385 3.47 49.5 µM 9.87E-5 55 2.63E-4
16 SGTC_50 0929-0078 3.47 56.4 µM 9.88E-5 68 2.64E-4
17 SGTC_2613 3',4'-dimethoxydalbergione 3.43 24.6 µM 1.15E-4 42 3.01E-4
18 SGTC_2015 5119600 3.42 184.0 µM 1.19E-4 43 3.09E-4
19 SGTC_667 1498-1044 3.42 59.0 µM 1.20E-4 RPP1 & pyrimidine depletion 37 3.13E-4
20 SGTC_1762 st045503 3.40 25.5 µM 1.31E-4 44 3.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 8.29E-12 YOR347C PYK2 hom Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication
0.101 5.50E-9 YPR033C HTS1 het Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome
0.097 1.98E-8 YKL151C YKL151C hom NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.096 2.67E-8 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.091 1.35E-7 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.088 3.37E-7 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.086 6.20E-7 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.086 7.07E-7 YJR001W AVT1 hom Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.084 1.17E-6 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.079 4.72E-6 YMR094W CTF13 het Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
0.079 4.97E-6 YKL168C KKQ8 hom Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication
0.079 5.29E-6 YMR176W ECM5 hom Non-essential protein of unknown function; contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress
0.077 6.99E-6 YDR523C SPS1 hom Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis
0.077 7.16E-6 YBR196C-B_p YBR196C-B_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.077 8.84E-6 YOR316C-A_p YOR316C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR