YGR211W / ZPR1

Essential protein with two zinc fingers; present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p); relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR211W / ZPR1

Click on Significant Values for Screen Details ID:SGTC_178|Compound:4092-0806|FD-Score:-2.88|P-value:7.99E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-2.85|P-value:8.90E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.91|P-value:9.42E-6 ID:SGTC_369|Compound:0957-0393|FD-Score:3.30|P-value:1.66E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.32|P-value:1.59E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-5.37|P-value:2.27E-9 ID:SGTC_514|Compound:4466-0038|FD-Score:8.63|P-value:2.79E-21 ID:SGTC_522|Compound:1273-0010|FD-Score:3.86|P-value:1.34E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:4.03|P-value:5.83E-6 ID:SGTC_766|Compound:1391-0721|FD-Score:3.91|P-value:1.08E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:3.53|P-value:6.29E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-2.96|P-value:5.91E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.15|P-value:3.25E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.52|P-value:5.90E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.33|P-value:1.47E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.13|P-value:3.35E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-5.21|P-value:6.36E-9 ID:SGTC_1249|Compound:0481-0015|FD-Score:-2.96|P-value:5.94E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-2.92|P-value:6.89E-4 ID:SGTC_1675|Compound:st018485|FD-Score:2.87|P-value:9.08E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:2.96|P-value:6.51E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.61|P-value:4.48E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-5.31|P-value:3.36E-9 ID:SGTC_2051|Compound:5263410|FD-Score:-4.79|P-value:8.24E-8 ID:SGTC_2113|Compound:5491891|FD-Score:-2.96|P-value:6.07E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.85|P-value:1.46E-5 ID:SGTC_2120|Compound:5538279|FD-Score:-3.92|P-value:9.19E-6 ID:SGTC_2121|Compound:5257820|FD-Score:4.55|P-value:3.84E-7 ID:SGTC_2163|Compound:5671233|FD-Score:-4.10|P-value:3.68E-6 ID:SGTC_2246|Compound:7293507|FD-Score:3.83|P-value:1.56E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.21|P-value:2.19E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-6.32|P-value:2.53E-12 ID:SGTC_2445|Compound:5742597|FD-Score:-3.48|P-value:6.95E-5 ID:SGTC_2814|Compound:7977482|FD-Score:2.86|P-value:9.36E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-2.98|P-value:5.49E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.04|P-value:4.88E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-2.99|P-value:5.39E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-2.88|P-value:7.99E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-2.85|P-value:8.90E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.91|P-value:9.42E-6 ID:SGTC_369|Compound:0957-0393|FD-Score:3.30|P-value:1.66E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.32|P-value:1.59E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-5.37|P-value:2.27E-9 ID:SGTC_514|Compound:4466-0038|FD-Score:8.63|P-value:2.79E-21 ID:SGTC_522|Compound:1273-0010|FD-Score:3.86|P-value:1.34E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:4.03|P-value:5.83E-6 ID:SGTC_766|Compound:1391-0721|FD-Score:3.91|P-value:1.08E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:3.53|P-value:6.29E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-2.96|P-value:5.91E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.15|P-value:3.25E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.52|P-value:5.90E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.33|P-value:1.47E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.13|P-value:3.35E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:-5.21|P-value:6.36E-9 ID:SGTC_1249|Compound:0481-0015|FD-Score:-2.96|P-value:5.94E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-2.92|P-value:6.89E-4 ID:SGTC_1675|Compound:st018485|FD-Score:2.87|P-value:9.08E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:2.96|P-value:6.51E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.61|P-value:4.48E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-5.31|P-value:3.36E-9 ID:SGTC_2051|Compound:5263410|FD-Score:-4.79|P-value:8.24E-8 ID:SGTC_2113|Compound:5491891|FD-Score:-2.96|P-value:6.07E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.85|P-value:1.46E-5 ID:SGTC_2120|Compound:5538279|FD-Score:-3.92|P-value:9.19E-6 ID:SGTC_2121|Compound:5257820|FD-Score:4.55|P-value:3.84E-7 ID:SGTC_2163|Compound:5671233|FD-Score:-4.10|P-value:3.68E-6 ID:SGTC_2246|Compound:7293507|FD-Score:3.83|P-value:1.56E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.21|P-value:2.19E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-6.32|P-value:2.53E-12 ID:SGTC_2445|Compound:5742597|FD-Score:-3.48|P-value:6.95E-5 ID:SGTC_2814|Compound:7977482|FD-Score:2.86|P-value:9.36E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-2.98|P-value:5.49E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.04|P-value:4.88E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-2.99|P-value:5.39E-4

Top fitness defect scores for YGR211W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_514 4466-0038 8.63 2.6 nM 2.79E-21 cell wall 5 3.00E-18 0.37
2 SGTC_2121 5257820 4.55 149.6 µM 3.84E-7 4 2.73E-6 0.07
3 SGTC_916 4466-0038 4.15 42.0 nM 3.25E-6 cell wall 25 1.68E-5 0.07
4 SGTC_763 3453-1109 4.03 128.0 µM 5.83E-6 3 2.75E-5 0.02
5 SGTC_766 1391-0721 3.91 126.0 µM 1.08E-5 3 4.63E-5 0.28
6 SGTC_522 1273-0010 3.86 11.6 µM 1.34E-5 60S ribosome export 3 5.60E-5 0.07
7 SGTC_2115 tiliquinol 3.85 12.8 µM 1.46E-5 4 5.99E-5 0.27
8 SGTC_2246 7293507 3.83 91.6 µM 1.56E-5 10 6.36E-5 0.02
9 SGTC_1718 roemerine 3.61 11.9 µM 4.48E-5 redox potentiating 20 1.56E-4 0.10
10 SGTC_807 1315-0151 3.53 48.0 µM 6.29E-5 12 2.08E-4 0.03
11 SGTC_1083 didemethylchlorpromazine sulfoxide 3.33 707.4 nM 1.47E-4 redox potentiating 32 4.30E-4 0.10
12 SGTC_425 3825-7017 3.32 13.1 µM 1.59E-4 19 4.58E-4 0.19
13 SGTC_369 0957-0393 3.30 4.5 µM 1.66E-4 cell wall signaling 14 4.78E-4 0.04
14 SGTC_1219 1469-0211 3.13 33.1 µM 3.35E-4 11 8.68E-4 0.11
15 SGTC_3219 9131112 3.04 49.5 µM 4.88E-4 Golgi 31 0.00120 6.37E-4
16 SGTC_1679 4130-1276 2.96 6.7 µM 6.51E-4 Golgi 40 0.00153 1.36E-4
17 SGTC_1675 st018485 2.87 24.5 µM 9.08E-4 60S ribosome export 26 0.00203 0.09
18 SGTC_2814 7977482 2.86 43.0 µM 9.36E-4 29 0.00209 0.06
19 SGTC_3344 9148862 2.83 3.9 µM 0.00106 14 0.00231 0.11
20 SGTC_1525 8-methoxypsoralen 2.82 92.5 µM 0.00112 DNA damage response 42 0.00243 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.246 3.29E-47 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.244 1.02E-46 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.218 2.87E-37 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.210 1.19E-34 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.206 1.51E-33 YKL116C PRR1 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
0.192 2.81E-29 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.184 6.60E-27 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.181 3.81E-26 YML119W_p YML119W_p hom Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate
0.180 9.23E-26 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.172 1.55E-23 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.170 3.23E-23 YOR015W_d YOR015W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.170 4.28E-23 YPR061C JID1 hom Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
0.164 1.35E-21 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.159 2.33E-20 YKL053W_d YKL053W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1
0.158 3.95E-20 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus