YGR213C / RTA1

Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR213C / RTA1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-4.21|P-value:1.94E-6 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.26|P-value:1.45E-6 ID:SGTC_155|Compound:k072-0202|FD-Score:2.77|P-value:0.00100 ID:SGTC_266|Compound:formosanin C|FD-Score:3.89|P-value:7.49E-6 ID:SGTC_279|Compound:1273-0055|FD-Score:3.03|P-value:3.55E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:2.79|P-value:9.19E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.92|P-value:6.20E-6 ID:SGTC_381|Compound:3461-2219|FD-Score:3.32|P-value:1.05E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.79|P-value:1.19E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.18|P-value:1.97E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:2.87|P-value:6.84E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.22|P-value:1.65E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.47|P-value:7.23E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:-2.98|P-value:5.65E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.03|P-value:4.54E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-3.21|P-value:2.17E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.83|P-value:5.70E-8 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.26|P-value:1.79E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.51|P-value:2.65E-7 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.22|P-value:2.12E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.45|P-value:5.97E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.18|P-value:2.44E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.33|P-value:2.27E-9 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.32|P-value:1.08E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.23|P-value:1.55E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:10.90|P-value:8.20E-34 ID:SGTC_1915|Compound:st067105|FD-Score:-3.20|P-value:2.27E-4 ID:SGTC_2002|Compound:4023503|FD-Score:8.18|P-value:5.72E-20 ID:SGTC_2004|Compound:4023728|FD-Score:4.90|P-value:2.48E-8 ID:SGTC_2005|Compound:4024620|FD-Score:-6.11|P-value:9.19E-12 ID:SGTC_2011|Compound:4012611|FD-Score:-6.58|P-value:2.20E-13 ID:SGTC_2110|Compound:5483698|FD-Score:-2.92|P-value:6.97E-4 ID:SGTC_2124|Compound:5246320|FD-Score:-3.26|P-value:1.76E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.87|P-value:6.66E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.40|P-value:7.55E-5 ID:SGTC_2345|Compound:9052315|FD-Score:-3.29|P-value:1.59E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.77|P-value:1.33E-5 ID:SGTC_2463|Compound:5473429|FD-Score:3.29|P-value:1.22E-4 ID:SGTC_2702|Compound:st077768|FD-Score:-4.22|P-value:1.79E-6 ID:SGTC_2715|Compound:st079500|FD-Score:-3.64|P-value:3.34E-5 ID:SGTC_2798|Compound:7813637|FD-Score:3.56|P-value:3.59E-5 ID:SGTC_2803|Compound:7707263|FD-Score:-3.02|P-value:4.78E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.51|P-value:4.47E-5 ID:SGTC_3051|Compound:9093778|FD-Score:-2.88|P-value:8.25E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:2.79|P-value:9.11E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.85|P-value:8.78E-6 ID:SGTC_3134|Compound:9127454|FD-Score:-3.84|P-value:1.26E-5 ID:SGTC_3170|Compound:9103054|FD-Score:-2.97|P-value:5.84E-4 ID:SGTC_3230|Compound:9131665|FD-Score:3.49|P-value:5.03E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:-4.21|P-value:1.94E-6 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.26|P-value:1.45E-6 ID:SGTC_155|Compound:k072-0202|FD-Score:2.77|P-value:0.00100 ID:SGTC_266|Compound:formosanin C|FD-Score:3.89|P-value:7.49E-6 ID:SGTC_279|Compound:1273-0055|FD-Score:3.03|P-value:3.55E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:2.79|P-value:9.19E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:3.92|P-value:6.20E-6 ID:SGTC_381|Compound:3461-2219|FD-Score:3.32|P-value:1.05E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.79|P-value:1.19E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.18|P-value:1.97E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:2.87|P-value:6.84E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.22|P-value:1.65E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.47|P-value:7.23E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:-2.98|P-value:5.65E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.03|P-value:4.54E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:-3.21|P-value:2.17E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.83|P-value:5.70E-8 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.26|P-value:1.79E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.51|P-value:2.65E-7 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.22|P-value:2.12E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.45|P-value:5.97E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.18|P-value:2.44E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.33|P-value:2.27E-9 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.32|P-value:1.08E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.23|P-value:1.55E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:10.90|P-value:8.20E-34 ID:SGTC_1915|Compound:st067105|FD-Score:-3.20|P-value:2.27E-4 ID:SGTC_2002|Compound:4023503|FD-Score:8.18|P-value:5.72E-20 ID:SGTC_2004|Compound:4023728|FD-Score:4.90|P-value:2.48E-8 ID:SGTC_2005|Compound:4024620|FD-Score:-6.11|P-value:9.19E-12 ID:SGTC_2011|Compound:4012611|FD-Score:-6.58|P-value:2.20E-13 ID:SGTC_2110|Compound:5483698|FD-Score:-2.92|P-value:6.97E-4 ID:SGTC_2124|Compound:5246320|FD-Score:-3.26|P-value:1.76E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.87|P-value:6.66E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.40|P-value:7.55E-5 ID:SGTC_2345|Compound:9052315|FD-Score:-3.29|P-value:1.59E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.77|P-value:1.33E-5 ID:SGTC_2463|Compound:5473429|FD-Score:3.29|P-value:1.22E-4 ID:SGTC_2702|Compound:st077768|FD-Score:-4.22|P-value:1.79E-6 ID:SGTC_2715|Compound:st079500|FD-Score:-3.64|P-value:3.34E-5 ID:SGTC_2798|Compound:7813637|FD-Score:3.56|P-value:3.59E-5 ID:SGTC_2803|Compound:7707263|FD-Score:-3.02|P-value:4.78E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.51|P-value:4.47E-5 ID:SGTC_3051|Compound:9093778|FD-Score:-2.88|P-value:8.25E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:2.79|P-value:9.11E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.85|P-value:8.78E-6 ID:SGTC_3134|Compound:9127454|FD-Score:-3.84|P-value:1.26E-5 ID:SGTC_3170|Compound:9103054|FD-Score:-2.97|P-value:5.84E-4 ID:SGTC_3230|Compound:9131665|FD-Score:3.49|P-value:5.03E-5

Top fitness defect scores for YGR213C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1876 myriocin 10.90 605.0 nM 8.20E-34 6 6.88E-28
2 SGTC_2002 4023503 8.18 131.0 µM 5.72E-20 mitochondrial processes 2 1.43E-16
3 SGTC_2004 4023728 4.90 41.9 µM 2.48E-8 13 4.72E-7
4 SGTC_1230 0170-0365 4.51 3.8 µM 2.65E-7 endomembrane recycling 45 3.29E-6
5 SGTC_284 0988-0104 3.92 32.6 µM 6.20E-6 heme requiring 12 4.36E-5
6 SGTC_266 formosanin C 3.89 406.0 nM 7.49E-6 sphingolipid biosynthesis & PDR1 70 5.09E-5
7 SGTC_3125 9127534 3.85 49.5 µM 8.78E-6 13 5.80E-5
8 SGTC_383 2324-0395 3.79 7.4 µM 1.19E-5 azole & statin 39 7.42E-5
9 SGTC_2435 5706476 3.77 10.6 µM 1.33E-5 31 8.16E-5
10 SGTC_2798 7813637 3.56 45.5 µM 3.59E-5 47 1.84E-4
11 SGTC_3042 9091578 3.51 49.5 µM 4.47E-5 ERG2 6 2.21E-4
12 SGTC_3230 9131665 3.49 49.5 µM 5.03E-5 2 2.43E-4
13 SGTC_1370 2001-0092 3.45 44.6 µM 5.97E-5 56 2.80E-4
14 SGTC_2182 6325192 3.40 200.0 µM 7.55E-5 Golgi 27 3.39E-4
15 SGTC_381 3461-2219 3.32 42.7 µM 1.05E-4 copper-dependent oxidative stress 40 4.43E-4
16 SGTC_1499 4480-0877 3.32 67.3 µM 1.08E-4 19 4.57E-4
17 SGTC_2463 5473429 3.29 200.0 µM 1.22E-4 ERG2 37 5.04E-4
18 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 3.23 67.5 µM 1.55E-4 75 6.11E-4
19 SGTC_932 2857-0803 3.22 154.0 µM 1.65E-4 58 6.45E-4
20 SGTC_656 4090-1979 3.18 187.0 µM 1.97E-4 46 7.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.366 1.01E-106 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.234 4.31E-43 YMR296C LCB1 het Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.211 3.86E-35 YBR125C PTC4 hom Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
0.204 6.93E-33 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.201 8.71E-32 YDR071C PAA1 hom Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication
0.195 4.96E-30 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.176 1.09E-24 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.143 7.20E-17 YML058W SML1 hom Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
0.135 3.28E-15 YDR258C HSP78 hom Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates
0.132 1.95E-14 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.130 4.96E-14 YGR072W UPF3 hom Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
0.129 5.16E-14 YPL110C GDE1 hom Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes
0.127 1.80E-13 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.124 5.30E-13 YDR133C_d YDR133C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
0.117 1.23E-11 YGR042W YGR042W hom Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress