YGR214W / RPS0A

Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR214W / RPS0A

Click on Significant Values for Screen Details ID:SGTC_355|Compound:1311-2252|FD-Score:3.46|P-value:2.09E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.57|P-value:1.35E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.02|P-value:9.57E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.19|P-value:5.68E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.15|P-value:6.50E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.45|P-value:2.77E-6 ID:SGTC_641|Compound:4092-0595|FD-Score:3.56|P-value:1.40E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.12|P-value:1.32E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:5.43|P-value:1.43E-8 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.26|P-value:3.96E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:4.47|P-value:2.54E-6 ID:SGTC_940|Compound:3232-1287|FD-Score:3.56|P-value:1.40E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.64|P-value:9.24E-5 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.00|P-value:9.92E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.81|P-value:5.13E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.08|P-value:8.34E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.95|P-value:2.44E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.60|P-value:1.21E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.29|P-value:5.22E-6 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.35|P-value:2.82E-4 ID:SGTC_1677|Compound:st019204|FD-Score:-3.11|P-value:6.92E-4 ID:SGTC_1716|Compound:st033144|FD-Score:4.42|P-value:3.22E-6 ID:SGTC_1797|Compound:st048695|FD-Score:4.49|P-value:2.28E-6 ID:SGTC_1841|Compound:st054148|FD-Score:-3.57|P-value:1.20E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.27|P-value:4.18E-4 ID:SGTC_2306|Compound:7482397|FD-Score:4.59|P-value:1.37E-6 ID:SGTC_2322|Compound:7413319|FD-Score:3.30|P-value:3.82E-4 ID:SGTC_2341|Compound:7987486|FD-Score:-4.95|P-value:1.79E-7 ID:SGTC_2352|Compound:9027995|FD-Score:-3.78|P-value:5.13E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.23|P-value:5.00E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.71|P-value:7.35E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.28|P-value:2.90E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.25|P-value:4.20E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.58|P-value:5.78E-9 ID:SGTC_2806|Compound:7952793|FD-Score:3.33|P-value:3.37E-4 ID:SGTC_2811|Compound:7967822|FD-Score:4.35|P-value:4.54E-6 ID:SGTC_2854|Compound:9024559|FD-Score:3.25|P-value:4.65E-4 ID:SGTC_2902|Compound:5787006|FD-Score:-3.12|P-value:6.69E-4 ID:SGTC_3087|Compound:9117406|FD-Score:4.77|P-value:5.45E-7 ID:SGTC_3179|Compound:9107801|FD-Score:-3.91|P-value:2.95E-5 ID:SGTC_3232|Compound:9132874|FD-Score:-3.38|P-value:2.57E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.72|P-value:6.61E-5 ID:SGTC_3289|Compound:9119912|FD-Score:-3.23|P-value:4.40E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.46|P-value:2.09E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.57|P-value:1.35E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.02|P-value:9.57E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.19|P-value:5.68E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.15|P-value:6.50E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.45|P-value:2.77E-6 ID:SGTC_641|Compound:4092-0595|FD-Score:3.56|P-value:1.40E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.12|P-value:1.32E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:5.43|P-value:1.43E-8 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.26|P-value:3.96E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:4.47|P-value:2.54E-6 ID:SGTC_940|Compound:3232-1287|FD-Score:3.56|P-value:1.40E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.64|P-value:9.24E-5 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.00|P-value:9.92E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.81|P-value:5.13E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.08|P-value:8.34E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:-3.95|P-value:2.44E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.60|P-value:1.21E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.29|P-value:5.22E-6 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.35|P-value:2.82E-4 ID:SGTC_1677|Compound:st019204|FD-Score:-3.11|P-value:6.92E-4 ID:SGTC_1716|Compound:st033144|FD-Score:4.42|P-value:3.22E-6 ID:SGTC_1797|Compound:st048695|FD-Score:4.49|P-value:2.28E-6 ID:SGTC_1841|Compound:st054148|FD-Score:-3.57|P-value:1.20E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.27|P-value:4.18E-4 ID:SGTC_2306|Compound:7482397|FD-Score:4.59|P-value:1.37E-6 ID:SGTC_2322|Compound:7413319|FD-Score:3.30|P-value:3.82E-4 ID:SGTC_2341|Compound:7987486|FD-Score:-4.95|P-value:1.79E-7 ID:SGTC_2352|Compound:9027995|FD-Score:-3.78|P-value:5.13E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.23|P-value:5.00E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.71|P-value:7.35E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.28|P-value:2.90E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.25|P-value:4.20E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.58|P-value:5.78E-9 ID:SGTC_2806|Compound:7952793|FD-Score:3.33|P-value:3.37E-4 ID:SGTC_2811|Compound:7967822|FD-Score:4.35|P-value:4.54E-6 ID:SGTC_2854|Compound:9024559|FD-Score:3.25|P-value:4.65E-4 ID:SGTC_2902|Compound:5787006|FD-Score:-3.12|P-value:6.69E-4 ID:SGTC_3087|Compound:9117406|FD-Score:4.77|P-value:5.45E-7 ID:SGTC_3179|Compound:9107801|FD-Score:-3.91|P-value:2.95E-5 ID:SGTC_3232|Compound:9132874|FD-Score:-3.38|P-value:2.57E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.72|P-value:6.61E-5 ID:SGTC_3289|Compound:9119912|FD-Score:-3.23|P-value:4.40E-4

Top fitness defect scores for YGR214W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 5.58 96.7 µM 5.78E-9 calcium & mitochondrial duress 189 1.17E-8
2 SGTC_832 4083-0019 5.43 164.0 µM 1.43E-8 translation 27 2.79E-8
3 SGTC_3087 9117406 4.77 49.5 µM 5.45E-7 4 9.10E-7
4 SGTC_2572 astragaloside iv 4.71 100.0 µM 7.35E-7 11 1.21E-6
5 SGTC_2306 7482397 4.59 179.5 µM 1.37E-6 RPP1 & pyrimidine depletion 13 2.19E-6
6 SGTC_1797 st048695 4.49 56.8 µM 2.28E-6 NEO1 62 3.58E-6
7 SGTC_909 3448-9333 4.47 149.0 µM 2.54E-6 10 3.97E-6
8 SGTC_625 k213-0058 4.45 121.0 µM 2.77E-6 translation 74 4.32E-6
9 SGTC_1716 st033144 4.42 30.6 µM 3.22E-6 14 4.99E-6
10 SGTC_2811 7967822 4.35 32.5 µM 4.54E-6 14 6.93E-6
11 SGTC_800 3448-7362 4.12 155.0 µM 1.32E-5 translation 148 1.93E-5
12 SGTC_1360 1598-0022 3.81 39.8 µM 5.13E-5 ERG2 35 7.07E-5
13 SGTC_1394 3474-0001 3.60 65.7 µM 1.21E-4 endomembrane recycling 49 1.61E-4
14 SGTC_364 0083-0097 3.57 67.7 µM 1.35E-4 38 1.79E-4
15 SGTC_940 3232-1287 3.56 54.8 µM 1.40E-4 NEO1 52 1.85E-4
16 SGTC_641 4092-0595 3.56 30.0 µM 1.40E-4 20 1.85E-4
17 SGTC_355 1311-2252 3.46 105.0 µM 2.09E-4 35 2.72E-4
18 SGTC_2806 7952793 3.33 58.4 µM 3.37E-4 47 4.30E-4
19 SGTC_2322 7413319 3.30 38.2 µM 3.82E-4 ERAD & cell cycle 204 4.85E-4
20 SGTC_2002 4023503 3.27 131.0 µM 4.18E-4 mitochondrial processes 64 5.29E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.223 4.90E-39 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.221 2.67E-38 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.182 2.93E-26 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.174 2.59E-24 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.173 4.55E-24 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.163 2.34E-21 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.148 7.03E-18 YBR048W RPS11B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication
0.146 2.19E-17 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.145 3.55E-17 YGL236C MTO1 hom Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
0.144 4.64E-17 YDR398W UTP5 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.141 2.06E-16 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.136 2.38E-15 YDL081C RPP1A hom Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
0.131 2.27E-14 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.131 2.94E-14 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.130 4.58E-14 YOR295W UAF30 hom Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication