HIPHOP chemogenomics database

YGR215W / RSM27

Mitochondrial ribosomal protein of the small subunit

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR215W / RSM27

Click on Significant Values for Screen Details

Top fitness defect scores for YGR215W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	13.80	5.3 µM	4.55E-40		121	1.90E-43
2	SGTC_310	1273-0058	10.80	1.1 µM	1.72E-25	mitochondrial stress	32	1.42E-27
3	SGTC_173	1273-0061	8.83	2.7 µM	1.33E-17	mitochondrial stress	53	5.47E-19
4	SGTC_275	trichlorophene	8.35	5.7 µM	5.85E-16	mitochondrial stress	66	3.35E-17
5	SGTC_601	0986-0029	8.16	62.9 µM	2.55E-15	calcium & mitochondrial duress	4	1.66E-16
6	SGTC_1882	5615643	6.88	20.0 µM	2.15E-11	TRP & mitochondrial translation	13	3.08E-12
7	SGTC_2688	kanamycin b	6.68	96.7 µM	7.57E-11	calcium & mitochondrial duress	119	1.21E-11
8	SGTC_70	0141-0289	6.18	43.3 µM	1.55E-9	mitochondrial stress	76	3.22E-10
9	SGTC_1883	5-benzylidenerhodanine	6.07	20.0 µM	2.93E-9	TRP & mitochondrial translation	18	6.44E-10
10	SGTC_2232	chlorophetanol	5.53	41.5 µM	5.72E-8	TRP & mitochondrial translation	53	1.63E-8
11	SGTC_2526	patulin	5.52	37.6 µM	6.05E-8		34	1.73E-8
12	SGTC_767	0929-0023	5.23	86.0 µM	2.56E-7	TRP & mitochondrial translation	29	8.26E-8
13	SGTC_1623	st003709	5.13	20.3 µM	4.20E-7	calcium & mitochondrial duress	26	1.42E-7
14	SGTC_1624	st003710	4.87	6.2 µM	1.46E-6	calcium & mitochondrial duress	24	5.48E-7
15	SGTC_10	0279-0212	4.66	42.6 µM	3.94E-6	TRP & mitochondrial translation	78	1.61E-6
16	SGTC_28	pentachloropyridine N-oxide	4.49	1.6 µM	8.17E-6	TSC3-RPN4	46	3.54E-6
17	SGTC_2942	9052777	4.48	62.2 µM	8.75E-6		21	3.82E-6
18	SGTC_1353	1498-1206	4.44	8.1 µM	1.03E-5	mitochondrial response to ROS	40	4.55E-6
19	SGTC_68	0986-0284	4.30	82.8 µM	1.84E-5		51	8.55E-6
20	SGTC_2826	7992541	4.29	19.5 µM	1.92E-5		15	8.96E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.522	7.44E-234	YDR194C	MSS116	hom	DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.516	3.85E-227	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.516	2.38E-227	YMR228W	MTF1	hom	Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.502	4.39E-214	YLR069C	MEF1	hom	Mitochondrial elongation factor involved in translational elongation
0.498	5.48E-210	YNL184C_p	YNL184C_p	hom	Protein of unknown function; expressed at both mRNA and protein levels
0.497	6.44E-209	YPL040C	ISM1	hom	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.491	3.65E-203	YPR100W	MRPL51	hom	Mitochondrial ribosomal protein of the large subunit
0.487	1.96E-199	YER050C	RSM18	hom	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.483	8.01E-196	YER087W	AIM10	hom	Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.474	4.96E-188	YMR072W	ABF2	hom	Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.474	1.41E-187	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.474	3.33E-187	YMR193W	MRPL24	hom	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.473	7.94E-187	YMR282C	AEP2	hom	Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
0.470	2.13E-184	YNL177C	MRPL22	hom	Mitochondrial ribosomal protein of the large subunit
0.470	3.91E-184	YPR166C	MRP2	hom	Mitochondrial ribosomal protein of the small subunit