YGR218W / CRM1

Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR218W / CRM1

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:-3.87|P-value:5.89E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:4.12|P-value:1.64E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.27|P-value:5.63E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.71|P-value:9.42E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:3.30|P-value:4.43E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.36|P-value:3.47E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.58|P-value:1.01E-8 ID:SGTC_369|Compound:0957-0393|FD-Score:-4.73|P-value:1.21E-6 ID:SGTC_430|Compound:0958-0115|FD-Score:3.41|P-value:2.91E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.65|P-value:6.74E-9 ID:SGTC_514|Compound:4466-0038|FD-Score:5.77|P-value:3.34E-9 ID:SGTC_525|Compound:k781-2675|FD-Score:3.75|P-value:7.99E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.59|P-value:1.78E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.33|P-value:3.87E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.73|P-value:9.69E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.53|P-value:2.20E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.93|P-value:3.81E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:4.28|P-value:8.02E-6 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.33|P-value:4.52E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:-4.16|P-value:1.71E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.82|P-value:5.96E-5 ID:SGTC_1516|Compound:st013856|FD-Score:3.29|P-value:4.47E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.70|P-value:9.66E-5 ID:SGTC_1961|Compound:st076550|FD-Score:-3.57|P-value:1.92E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.65|P-value:1.18E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-3.25|P-value:6.11E-4 ID:SGTC_2097|Compound:5376186|FD-Score:-3.46|P-value:2.87E-4 ID:SGTC_2133|Compound:5320837|FD-Score:4.04|P-value:2.37E-5 ID:SGTC_2135|Compound:5326629|FD-Score:3.71|P-value:9.14E-5 ID:SGTC_2174|Compound:5790901|FD-Score:-3.20|P-value:7.23E-4 ID:SGTC_2180|Compound:6301957|FD-Score:3.25|P-value:5.14E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.36|P-value:5.68E-6 ID:SGTC_2534|Compound:helenine|FD-Score:4.08|P-value:1.96E-5 ID:SGTC_2537|Compound:larixol|FD-Score:3.20|P-value:6.34E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.13|P-value:7.98E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.24|P-value:6.40E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.66|P-value:1.36E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.16|P-value:7.29E-4 ID:SGTC_2931|Compound:9014674|FD-Score:4.49|P-value:3.13E-6 ID:SGTC_2980|Compound:9014342|FD-Score:3.27|P-value:4.94E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.76|P-value:8.88E-5 ID:SGTC_3194|Compound:9111903|FD-Score:3.14|P-value:7.66E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.71|P-value:9.15E-5 ID:SGTC_3263|Compound:9137018|FD-Score:-4.81|P-value:8.00E-7 ID:SGTC_3272|Compound:9137413|FD-Score:3.91|P-value:4.14E-5 ID:SGTC_3273|Compound:9137859|FD-Score:3.16|P-value:7.20E-4 ID:SGTC_3275|Compound:9138069|FD-Score:-3.36|P-value:4.08E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.56|P-value:1.69E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.13|P-value:8.06E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-3.87|P-value:5.89E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:4.12|P-value:1.64E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.27|P-value:5.63E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.71|P-value:9.42E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:3.30|P-value:4.43E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.36|P-value:3.47E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.58|P-value:1.01E-8 ID:SGTC_369|Compound:0957-0393|FD-Score:-4.73|P-value:1.21E-6 ID:SGTC_430|Compound:0958-0115|FD-Score:3.41|P-value:2.91E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.65|P-value:6.74E-9 ID:SGTC_514|Compound:4466-0038|FD-Score:5.77|P-value:3.34E-9 ID:SGTC_525|Compound:k781-2675|FD-Score:3.75|P-value:7.99E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.59|P-value:1.78E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.33|P-value:3.87E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.73|P-value:9.69E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.53|P-value:2.20E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.93|P-value:3.81E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:4.28|P-value:8.02E-6 ID:SGTC_1286|Compound:0929-0070|FD-Score:-3.33|P-value:4.52E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:-4.16|P-value:1.71E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.82|P-value:5.96E-5 ID:SGTC_1516|Compound:st013856|FD-Score:3.29|P-value:4.47E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.70|P-value:9.66E-5 ID:SGTC_1961|Compound:st076550|FD-Score:-3.57|P-value:1.92E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.65|P-value:1.18E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-3.25|P-value:6.11E-4 ID:SGTC_2097|Compound:5376186|FD-Score:-3.46|P-value:2.87E-4 ID:SGTC_2133|Compound:5320837|FD-Score:4.04|P-value:2.37E-5 ID:SGTC_2135|Compound:5326629|FD-Score:3.71|P-value:9.14E-5 ID:SGTC_2174|Compound:5790901|FD-Score:-3.20|P-value:7.23E-4 ID:SGTC_2180|Compound:6301957|FD-Score:3.25|P-value:5.14E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.36|P-value:5.68E-6 ID:SGTC_2534|Compound:helenine|FD-Score:4.08|P-value:1.96E-5 ID:SGTC_2537|Compound:larixol|FD-Score:3.20|P-value:6.34E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.13|P-value:7.98E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.24|P-value:6.40E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.66|P-value:1.36E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.16|P-value:7.29E-4 ID:SGTC_2931|Compound:9014674|FD-Score:4.49|P-value:3.13E-6 ID:SGTC_2980|Compound:9014342|FD-Score:3.27|P-value:4.94E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.76|P-value:8.88E-5 ID:SGTC_3194|Compound:9111903|FD-Score:3.14|P-value:7.66E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.71|P-value:9.15E-5 ID:SGTC_3263|Compound:9137018|FD-Score:-4.81|P-value:8.00E-7 ID:SGTC_3272|Compound:9137413|FD-Score:3.91|P-value:4.14E-5 ID:SGTC_3273|Compound:9137859|FD-Score:3.16|P-value:7.20E-4 ID:SGTC_3275|Compound:9138069|FD-Score:-3.36|P-value:4.08E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.56|P-value:1.69E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.13|P-value:8.06E-4

Top fitness defect scores for YGR218W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_514 4466-0038 5.77 2.6 nM 3.34E-9 cell wall 18 4.06E-9 0.04
2 SGTC_513 4245-1575 5.65 41.7 µM 6.74E-9 unfolded protein response 12 8.14E-9 0.23
3 SGTC_365 0121-0052 5.58 13.6 µM 1.01E-8 mitochondrial response to ROS 2 1.21E-8 0.68
4 SGTC_669 0108-0021 4.73 26.2 µM 9.69E-7 fatty acid desaturase (OLE1) 8 1.13E-6 0.30
5 SGTC_2931 9014674 4.49 55.7 µM 3.13E-6 4 3.61E-6 0.32
6 SGTC_2336 9001819 4.36 198.7 µM 5.68E-6 heme biosynthesis & mitochondrial translocase 33 6.51E-6 0.18
7 SGTC_944 3370-0224 4.28 231.0 µM 8.02E-6 2 9.17E-6 0.32
8 SGTC_152 4469-0003 4.12 551.2 µM 1.64E-5 11 1.86E-5 0.05
9 SGTC_2534 helenine 4.08 20.1 µM 1.96E-5 RSC complex & mRNA processing 19 2.23E-5 0.06
10 SGTC_2133 5320837 4.04 200.0 µM 2.37E-5 ERG2 5 2.69E-5 0.29
11 SGTC_916 4466-0038 3.93 42.0 nM 3.81E-5 cell wall 29 4.30E-5 0.17
12 SGTC_3272 9137413 3.91 49.5 µM 4.14E-5 5 4.67E-5 0.04
13 SGTC_1368 1852-0141 3.82 284.0 µM 5.96E-5 ERG2 4 6.70E-5 0.10
14 SGTC_525 k781-2675 3.75 26.7 µM 7.99E-5 redox potentiating 43 8.96E-5 0.08
15 SGTC_2135 5326629 3.71 150.4 µM 9.14E-5 RPP1 & pyrimidine depletion 7 1.02E-4 0.02
16 SGTC_3225 9130819 3.71 49.5 µM 9.15E-5 amide catabolism 11 1.03E-4 0.08
17 SGTC_195 4234-0266 3.71 16.6 µM 9.42E-5 18 1.06E-4 0.11
18 SGTC_1638 st008370 3.70 60.6 µM 9.66E-5 ergosterol biosynthesis 17 1.08E-4 0.10
19 SGTC_2057 5236571 3.65 38.3 µM 1.18E-4 RPP1 & pyrimidine depletion 16 1.32E-4 0.24
20 SGTC_3296 9122258 3.56 64.0 µM 1.69E-4 redox potentiating 9 1.88E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 8.13E-20 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.135 3.70E-15 YGL074C_d YGL074C_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor
0.129 5.66E-14 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.124 5.41E-13 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.121 1.94E-12 YPR061C JID1 hom Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
0.117 1.17E-11 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.114 3.22E-11 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.108 3.73E-10 YOR091W TMA46 hom Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p
0.100 7.64E-9 YEL061C CIN8 hom Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation
0.098 1.18E-8 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.096 2.31E-8 YDR389W SAC7 hom GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate
0.096 2.86E-8 YGL073W HSF1 het Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated
0.096 2.97E-8 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.095 3.06E-8 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.095 3.42E-8 YDR053W_d YDR053W_d het Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex