YGR222W / PET54

Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR222W / PET54

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:4.18|P-value:4.23E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.77|P-value:1.96E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.31|P-value:9.11E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.34|P-value:2.57E-7 ID:SGTC_186|Compound:3455-3465|FD-Score:3.74|P-value:2.14E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:16.60|P-value:4.20E-55 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.60|P-value:3.32E-16 ID:SGTC_310|Compound:1273-0058|FD-Score:10.90|P-value:8.92E-25 ID:SGTC_314|Compound:1671-0008|FD-Score:5.26|P-value:3.90E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:5.48|P-value:1.33E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.02|P-value:1.37E-6 ID:SGTC_444|Compound:curcumin|FD-Score:-3.86|P-value:1.60E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.98|P-value:1.67E-6 ID:SGTC_456|Compound:gingerol|FD-Score:3.72|P-value:2.30E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.67|P-value:6.42E-6 ID:SGTC_723|Compound:4182-0001|FD-Score:5.02|P-value:1.18E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:4.05|P-value:6.97E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:5.29|P-value:3.25E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:4.17|P-value:4.38E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:-3.41|P-value:7.39E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.77|P-value:1.93E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.35|P-value:8.13E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.51|P-value:4.81E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.89|P-value:2.15E-6 ID:SGTC_1289|Compound:0976-0073|FD-Score:4.34|P-value:2.20E-5 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.35|P-value:8.14E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.53|P-value:4.97E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:5.16|P-value:6.02E-7 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.61|P-value:3.42E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.70|P-value:2.50E-4 ID:SGTC_1621|Compound:st003705|FD-Score:3.50|P-value:4.85E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.45|P-value:6.48E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.35|P-value:8.85E-4 ID:SGTC_1741|Compound:st038134|FD-Score:-4.95|P-value:1.92E-6 ID:SGTC_1760|Compound:st045453|FD-Score:-3.62|P-value:3.62E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.40|P-value:6.92E-4 ID:SGTC_1847|Compound:st056231|FD-Score:4.06|P-value:6.58E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.78|P-value:1.86E-4 ID:SGTC_1904|Compound:st060225|FD-Score:3.79|P-value:1.80E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-4.74|P-value:4.91E-6 ID:SGTC_1943|Compound:st076331|FD-Score:4.10|P-value:5.74E-5 ID:SGTC_1947|Compound:st076332|FD-Score:-3.53|P-value:5.01E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-7.47|P-value:1.41E-12 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.56|P-value:4.54E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-4.55|P-value:1.10E-5 ID:SGTC_2138|Compound:5575593|FD-Score:3.84|P-value:1.50E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.29|P-value:9.82E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.30|P-value:3.08E-7 ID:SGTC_2254|Compound:7938975|FD-Score:3.39|P-value:7.10E-4 ID:SGTC_2325|Compound:6158266|FD-Score:4.60|P-value:7.67E-6 ID:SGTC_2327|Compound:6189656|FD-Score:4.83|P-value:2.75E-6 ID:SGTC_2328|Compound:6201408|FD-Score:-3.37|P-value:8.26E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-4.11|P-value:6.15E-5 ID:SGTC_2449|Compound:5812982|FD-Score:-3.67|P-value:3.09E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:5.67|P-value:4.85E-8 ID:SGTC_2484|Compound:5809818|FD-Score:5.19|P-value:5.28E-7 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.46|P-value:5.55E-4 ID:SGTC_2671|Compound:danthron|FD-Score:-3.59|P-value:4.03E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:4.71|P-value:4.76E-6 ID:SGTC_2736|Compound:butenafine|FD-Score:-3.55|P-value:4.70E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:-3.67|P-value:3.14E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.24|P-value:3.74E-5 ID:SGTC_2817|Compound:7995342|FD-Score:5.10|P-value:8.23E-7 ID:SGTC_2835|Compound:9006588|FD-Score:4.08|P-value:6.24E-5 ID:SGTC_2851|Compound:9015922|FD-Score:3.76|P-value:2.01E-4 ID:SGTC_2852|Compound:9023854|FD-Score:5.09|P-value:8.57E-7 ID:SGTC_2855|Compound:9016525|FD-Score:-3.55|P-value:4.72E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-5.84|P-value:2.48E-8 ID:SGTC_2896|Compound:9052656|FD-Score:-7.08|P-value:1.84E-11 ID:SGTC_2998|Compound:9066762|FD-Score:3.63|P-value:3.18E-4 ID:SGTC_3174|Compound:9107204|FD-Score:-4.96|P-value:1.84E-6 ID:SGTC_3207|Compound:9114163|FD-Score:-3.93|P-value:1.24E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-3.64|P-value:3.43E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.18|P-value:4.23E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.77|P-value:1.96E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.31|P-value:9.11E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.34|P-value:2.57E-7 ID:SGTC_186|Compound:3455-3465|FD-Score:3.74|P-value:2.14E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:16.60|P-value:4.20E-55 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.60|P-value:3.32E-16 ID:SGTC_310|Compound:1273-0058|FD-Score:10.90|P-value:8.92E-25 ID:SGTC_314|Compound:1671-0008|FD-Score:5.26|P-value:3.90E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:5.48|P-value:1.33E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.02|P-value:1.37E-6 ID:SGTC_444|Compound:curcumin|FD-Score:-3.86|P-value:1.60E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.98|P-value:1.67E-6 ID:SGTC_456|Compound:gingerol|FD-Score:3.72|P-value:2.30E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.67|P-value:6.42E-6 ID:SGTC_723|Compound:4182-0001|FD-Score:5.02|P-value:1.18E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:4.05|P-value:6.97E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:5.29|P-value:3.25E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:4.17|P-value:4.38E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:-3.41|P-value:7.39E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.77|P-value:1.93E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.35|P-value:8.13E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.51|P-value:4.81E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:4.89|P-value:2.15E-6 ID:SGTC_1289|Compound:0976-0073|FD-Score:4.34|P-value:2.20E-5 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.35|P-value:8.14E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.53|P-value:4.97E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:5.16|P-value:6.02E-7 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.61|P-value:3.42E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.70|P-value:2.50E-4 ID:SGTC_1621|Compound:st003705|FD-Score:3.50|P-value:4.85E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.45|P-value:6.48E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.35|P-value:8.85E-4 ID:SGTC_1741|Compound:st038134|FD-Score:-4.95|P-value:1.92E-6 ID:SGTC_1760|Compound:st045453|FD-Score:-3.62|P-value:3.62E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.40|P-value:6.92E-4 ID:SGTC_1847|Compound:st056231|FD-Score:4.06|P-value:6.58E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.78|P-value:1.86E-4 ID:SGTC_1904|Compound:st060225|FD-Score:3.79|P-value:1.80E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-4.74|P-value:4.91E-6 ID:SGTC_1943|Compound:st076331|FD-Score:4.10|P-value:5.74E-5 ID:SGTC_1947|Compound:st076332|FD-Score:-3.53|P-value:5.01E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-7.47|P-value:1.41E-12 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.56|P-value:4.54E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-4.55|P-value:1.10E-5 ID:SGTC_2138|Compound:5575593|FD-Score:3.84|P-value:1.50E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.29|P-value:9.82E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.30|P-value:3.08E-7 ID:SGTC_2254|Compound:7938975|FD-Score:3.39|P-value:7.10E-4 ID:SGTC_2325|Compound:6158266|FD-Score:4.60|P-value:7.67E-6 ID:SGTC_2327|Compound:6189656|FD-Score:4.83|P-value:2.75E-6 ID:SGTC_2328|Compound:6201408|FD-Score:-3.37|P-value:8.26E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-4.11|P-value:6.15E-5 ID:SGTC_2449|Compound:5812982|FD-Score:-3.67|P-value:3.09E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:5.67|P-value:4.85E-8 ID:SGTC_2484|Compound:5809818|FD-Score:5.19|P-value:5.28E-7 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.46|P-value:5.55E-4 ID:SGTC_2671|Compound:danthron|FD-Score:-3.59|P-value:4.03E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:4.71|P-value:4.76E-6 ID:SGTC_2736|Compound:butenafine|FD-Score:-3.55|P-value:4.70E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:-3.67|P-value:3.14E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.24|P-value:3.74E-5 ID:SGTC_2817|Compound:7995342|FD-Score:5.10|P-value:8.23E-7 ID:SGTC_2835|Compound:9006588|FD-Score:4.08|P-value:6.24E-5 ID:SGTC_2851|Compound:9015922|FD-Score:3.76|P-value:2.01E-4 ID:SGTC_2852|Compound:9023854|FD-Score:5.09|P-value:8.57E-7 ID:SGTC_2855|Compound:9016525|FD-Score:-3.55|P-value:4.72E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-5.84|P-value:2.48E-8 ID:SGTC_2896|Compound:9052656|FD-Score:-7.08|P-value:1.84E-11 ID:SGTC_2998|Compound:9066762|FD-Score:3.63|P-value:3.18E-4 ID:SGTC_3174|Compound:9107204|FD-Score:-4.96|P-value:1.84E-6 ID:SGTC_3207|Compound:9114163|FD-Score:-3.93|P-value:1.24E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-3.64|P-value:3.43E-4

Top fitness defect scores for YGR222W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 16.60 5.3 µM 4.20E-55 82 2.38E-62
2 SGTC_310 1273-0058 10.90 1.1 µM 8.92E-25 mitochondrial stress 30 7.15E-28
3 SGTC_275 trichlorophene 8.60 5.7 µM 3.32E-16 mitochondrial stress 61 3.87E-18
4 SGTC_2454 5-benzylidenerhodanine 5.67 10.4 µM 4.85E-8 TRP & mitochondrial translation 15 6.97E-9
5 SGTC_386 1509-0011 5.48 3.1 µM 1.33E-7 97 2.18E-8
6 SGTC_173 1273-0061 5.34 2.7 µM 2.57E-7 mitochondrial stress 134 4.60E-8
7 SGTC_2232 chlorophetanol 5.30 41.5 µM 3.08E-7 TRP & mitochondrial translation 66 5.64E-8
8 SGTC_778 3456-2434 5.29 196.0 µM 3.25E-7 mitochondrial response to ROS 36 5.99E-8
9 SGTC_314 1671-0008 5.26 2.7 µM 3.90E-7 16 7.36E-8
10 SGTC_2484 5809818 5.19 12.0 µM 5.28E-7 7 1.04E-7
11 SGTC_1462 k081-0014 5.16 26.5 µM 6.02E-7 4 1.20E-7
12 SGTC_2817 7995342 5.10 71.4 µM 8.23E-7 11 1.71E-7
13 SGTC_2852 9023854 5.09 52.0 µM 8.57E-7 17 1.79E-7
14 SGTC_723 4182-0001 5.02 115.0 µM 1.18E-6 16 2.57E-7
15 SGTC_1183 1254-0324 4.89 198.0 µM 2.15E-6 7 5.07E-7
16 SGTC_2327 6189656 4.83 200.0 µM 2.75E-6 9 6.71E-7
17 SGTC_2727 riluzole 4.71 51.8 µM 4.76E-6 mitochondrial processes 6 1.25E-6
18 SGTC_2325 6158266 4.60 200.0 µM 7.67E-6 15 2.14E-6
19 SGTC_1289 0976-0073 4.34 69.1 µM 2.20E-5 7 7.01E-6
20 SGTC_116 0155-0182 4.18 31.8 µM 4.23E-5 mitochondrial response to ROS 67 1.47E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.444 6.81E-162 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.437 1.68E-155 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.429 5.38E-150 YMR064W AEP1 hom Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase
0.421 3.54E-144 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.413 3.97E-138 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.408 4.53E-135 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.404 1.60E-131 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.403 4.14E-131 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.400 5.08E-129 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.400 1.04E-128 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.399 7.85E-128 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.393 3.80E-124 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.392 7.67E-124 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.391 1.17E-122 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.387 3.51E-120 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth