YGR223C / HSV2

Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR223C / HSV2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:9.85|P-value:5.94E-22 ID:SGTC_138|Compound:0850-0259|FD-Score:3.92|P-value:7.00E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:-5.26|P-value:1.71E-7 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.54|P-value:2.99E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.28|P-value:7.19E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.62|P-value:2.20E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.03|P-value:4.54E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.33|P-value:6.18E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.99|P-value:5.47E-5 ID:SGTC_607|Compound:4491-0986|FD-Score:4.06|P-value:4.05E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:3.97|P-value:5.77E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:5.73|P-value:1.37E-8 ID:SGTC_663|Compound:1486-0733|FD-Score:3.57|P-value:2.65E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:5.70|P-value:1.62E-8 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.29|P-value:7.07E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.47|P-value:3.74E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:4.42|P-value:8.76E-6 ID:SGTC_961|Compound:1252-1571|FD-Score:5.52|P-value:4.23E-8 ID:SGTC_994|Compound:3910-0338|FD-Score:3.48|P-value:3.69E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.42|P-value:4.49E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.73|P-value:1.49E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:4.67|P-value:2.87E-6 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.44|P-value:4.27E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.41|P-value:4.80E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.49|P-value:3.58E-4 ID:SGTC_1672|Compound:st016598|FD-Score:3.42|P-value:4.49E-4 ID:SGTC_1707|Compound:st032323|FD-Score:4.37|P-value:1.09E-5 ID:SGTC_1754|Compound:st042065|FD-Score:4.05|P-value:4.30E-5 ID:SGTC_1760|Compound:st045453|FD-Score:4.14|P-value:2.96E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.41|P-value:4.67E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.42|P-value:4.50E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.84|P-value:9.68E-5 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.29|P-value:6.92E-4 ID:SGTC_1934|Compound:st074720|FD-Score:7.72|P-value:3.32E-14 ID:SGTC_2022|Compound:5136654|FD-Score:3.63|P-value:2.16E-4 ID:SGTC_2023|Compound:5144124|FD-Score:3.32|P-value:6.37E-4 ID:SGTC_2152|Compound:5568786|FD-Score:-3.40|P-value:4.83E-4 ID:SGTC_2181|Compound:6316240|FD-Score:-3.56|P-value:2.81E-4 ID:SGTC_2192|Compound:5915882|FD-Score:3.58|P-value:2.60E-4 ID:SGTC_2254|Compound:7938975|FD-Score:6.22|P-value:8.09E-10 ID:SGTC_2272|Compound:7805186|FD-Score:3.75|P-value:1.37E-4 ID:SGTC_2275|Compound:7947463|FD-Score:7.26|P-value:9.02E-13 ID:SGTC_2277|Compound:7947813|FD-Score:5.25|P-value:1.76E-7 ID:SGTC_2321|Compound:7390090|FD-Score:4.59|P-value:4.13E-6 ID:SGTC_2395|Compound:5646831|FD-Score:3.31|P-value:6.47E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:-3.59|P-value:2.48E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.30|P-value:1.51E-5 ID:SGTC_2855|Compound:9016525|FD-Score:4.96|P-value:7.25E-7 ID:SGTC_2856|Compound:9022925|FD-Score:4.42|P-value:9.05E-6 ID:SGTC_2912|Compound:7964298|FD-Score:3.30|P-value:6.86E-4 ID:SGTC_2968|Compound:9090663|FD-Score:5.93|P-value:4.31E-9 ID:SGTC_3046|Compound:9092212|FD-Score:3.32|P-value:6.30E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-6.69|P-value:4.48E-11 ID:SGTC_3196|Compound:9111891|FD-Score:-3.83|P-value:1.01E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-5.98|P-value:3.34E-9 ID:SGTC_3223|Compound:9129970|FD-Score:3.59|P-value:2.49E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.21|P-value:9.30E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:9.85|P-value:5.94E-22 ID:SGTC_138|Compound:0850-0259|FD-Score:3.92|P-value:7.00E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:-5.26|P-value:1.71E-7 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.54|P-value:2.99E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.28|P-value:7.19E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.62|P-value:2.20E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.03|P-value:4.54E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.33|P-value:6.18E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.99|P-value:5.47E-5 ID:SGTC_607|Compound:4491-0986|FD-Score:4.06|P-value:4.05E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:3.97|P-value:5.77E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:5.73|P-value:1.37E-8 ID:SGTC_663|Compound:1486-0733|FD-Score:3.57|P-value:2.65E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:5.70|P-value:1.62E-8 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.29|P-value:7.07E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.47|P-value:3.74E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:4.42|P-value:8.76E-6 ID:SGTC_961|Compound:1252-1571|FD-Score:5.52|P-value:4.23E-8 ID:SGTC_994|Compound:3910-0338|FD-Score:3.48|P-value:3.69E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.42|P-value:4.49E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.73|P-value:1.49E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:4.67|P-value:2.87E-6 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.44|P-value:4.27E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.41|P-value:4.80E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.49|P-value:3.58E-4 ID:SGTC_1672|Compound:st016598|FD-Score:3.42|P-value:4.49E-4 ID:SGTC_1707|Compound:st032323|FD-Score:4.37|P-value:1.09E-5 ID:SGTC_1754|Compound:st042065|FD-Score:4.05|P-value:4.30E-5 ID:SGTC_1760|Compound:st045453|FD-Score:4.14|P-value:2.96E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.41|P-value:4.67E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.42|P-value:4.50E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.84|P-value:9.68E-5 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.29|P-value:6.92E-4 ID:SGTC_1934|Compound:st074720|FD-Score:7.72|P-value:3.32E-14 ID:SGTC_2022|Compound:5136654|FD-Score:3.63|P-value:2.16E-4 ID:SGTC_2023|Compound:5144124|FD-Score:3.32|P-value:6.37E-4 ID:SGTC_2152|Compound:5568786|FD-Score:-3.40|P-value:4.83E-4 ID:SGTC_2181|Compound:6316240|FD-Score:-3.56|P-value:2.81E-4 ID:SGTC_2192|Compound:5915882|FD-Score:3.58|P-value:2.60E-4 ID:SGTC_2254|Compound:7938975|FD-Score:6.22|P-value:8.09E-10 ID:SGTC_2272|Compound:7805186|FD-Score:3.75|P-value:1.37E-4 ID:SGTC_2275|Compound:7947463|FD-Score:7.26|P-value:9.02E-13 ID:SGTC_2277|Compound:7947813|FD-Score:5.25|P-value:1.76E-7 ID:SGTC_2321|Compound:7390090|FD-Score:4.59|P-value:4.13E-6 ID:SGTC_2395|Compound:5646831|FD-Score:3.31|P-value:6.47E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:-3.59|P-value:2.48E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.30|P-value:1.51E-5 ID:SGTC_2855|Compound:9016525|FD-Score:4.96|P-value:7.25E-7 ID:SGTC_2856|Compound:9022925|FD-Score:4.42|P-value:9.05E-6 ID:SGTC_2912|Compound:7964298|FD-Score:3.30|P-value:6.86E-4 ID:SGTC_2968|Compound:9090663|FD-Score:5.93|P-value:4.31E-9 ID:SGTC_3046|Compound:9092212|FD-Score:3.32|P-value:6.30E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-6.69|P-value:4.48E-11 ID:SGTC_3196|Compound:9111891|FD-Score:-3.83|P-value:1.01E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-5.98|P-value:3.34E-9 ID:SGTC_3223|Compound:9129970|FD-Score:3.59|P-value:2.49E-4 ID:SGTC_3279|Compound:9140807|FD-Score:3.21|P-value:9.30E-4

Top fitness defect scores for YGR223C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 9.85 9.0 µM 5.94E-22 cell wall 80 3.36E-23
2 SGTC_1934 st074720 7.72 32.6 µM 3.32E-14 8 5.64E-15
3 SGTC_2275 7947463 7.26 200.0 µM 9.02E-13 iron homeostasis 8 1.87E-13
4 SGTC_2254 7938975 6.22 95.2 µM 8.09E-10 21 2.55E-10
5 SGTC_2968 9090663 5.93 33.4 µM 4.31E-9 8 1.50E-9
6 SGTC_654 1124-0271 5.73 80.9 µM 1.37E-8 3 5.12E-9
7 SGTC_666 0272-0154 5.70 136.0 µM 1.62E-8 cell wall 21 6.10E-9
8 SGTC_961 1252-1571 5.52 372.0 µM 4.23E-8 12 1.69E-8
9 SGTC_2277 7947813 5.25 106.9 µM 1.76E-7 RSC complex & mRNA processing 10 7.67E-8
10 SGTC_2855 9016525 4.96 58.4 µM 7.25E-7 7 3.44E-7
11 SGTC_1105 epirubicin 4.67 18.1 µM 2.87E-6 anthracycline transcription coupled DNA repair 7 1.48E-6
12 SGTC_2321 7390090 4.59 138.8 µM 4.13E-6 16 2.18E-6
13 SGTC_948 3448-0295 4.42 75.3 µM 8.76E-6 15 4.82E-6
14 SGTC_2856 9022925 4.42 19.5 µM 9.05E-6 11 4.99E-6
15 SGTC_1707 st032323 4.37 6.3 µM 1.09E-5 DNA damage response 47 6.07E-6
16 SGTC_2538 3',7'-epoxycaryophyllan-6-one 4.30 100.0 µM 1.51E-5 19 8.62E-6
17 SGTC_1760 st045453 4.14 10.4 µM 2.96E-5 NEO1-PIK1 137 1.75E-5
18 SGTC_607 4491-0986 4.06 66.8 µM 4.05E-5 heme requiring 27 2.44E-5
19 SGTC_1754 st042065 4.05 16.1 µM 4.30E-5 NEO1-PIK1 170 2.60E-5
20 SGTC_431 k089-0097 4.03 107.0 µM 4.54E-5 iron homeostasis 39 2.76E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.244 1.31E-46 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.230 1.43E-41 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.215 1.97E-36 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.207 1.01E-33 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.201 6.33E-32 YMR294W JNM1 hom Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B
0.201 8.53E-32 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.201 9.09E-32 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.197 9.80E-31 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.194 1.04E-29 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.193 1.93E-29 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.187 1.15E-27 YBL026W LSM2 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.186 1.65E-27 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.183 9.09E-27 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.178 3.42E-25 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.177 4.52E-25 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase