YGR224W / AZR1

Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR224W / AZR1

Click on Significant Values for Screen Details ID:SGTC_19|Compound:0279-0214|FD-Score:3.30|P-value:2.52E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.28|P-value:2.74E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:2.96|P-value:8.83E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:3.66|P-value:5.92E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.95|P-value:1.61E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:3.13|P-value:4.90E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:2.93|P-value:9.88E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.22|P-value:3.47E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:2.98|P-value:8.28E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.94|P-value:1.07E-7 ID:SGTC_458|Compound:nppb|FD-Score:3.06|P-value:6.21E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:6.25|P-value:2.95E-11 ID:SGTC_547|Compound:1120-0019|FD-Score:3.49|P-value:1.18E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.09|P-value:5.52E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.34|P-value:2.19E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.13|P-value:4.86E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.88|P-value:2.23E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:5.29|P-value:1.43E-8 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.30|P-value:3.50E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.81|P-value:3.03E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.12|P-value:7.39E-6 ID:SGTC_1011|Compound:4112-3381|FD-Score:-3.23|P-value:4.41E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.33|P-value:2.24E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:4.30|P-value:3.18E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:3.12|P-value:4.93E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:-3.10|P-value:7.14E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.74|P-value:5.95E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.59|P-value:7.74E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:2.98|P-value:8.29E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.34|P-value:2.14E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.35|P-value:2.81E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:5.18|P-value:2.76E-8 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.24|P-value:3.15E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:4.70|P-value:4.09E-7 ID:SGTC_1770|Compound:st043884|FD-Score:3.23|P-value:3.29E-4 ID:SGTC_1772|Compound:st048439|FD-Score:4.21|P-value:4.76E-6 ID:SGTC_1779|Compound:st039427|FD-Score:2.99|P-value:7.92E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.24|P-value:3.18E-4 ID:SGTC_2030|Compound:5175110|FD-Score:4.52|P-value:1.05E-6 ID:SGTC_2184|Compound:6075246|FD-Score:3.14|P-value:4.63E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.02|P-value:1.18E-5 ID:SGTC_2799|Compound:7812892|FD-Score:6.15|P-value:5.81E-11 ID:SGTC_2857|Compound:9024691|FD-Score:4.14|P-value:6.79E-6 ID:SGTC_2884|Compound:9058502|FD-Score:4.77|P-value:2.69E-7 ID:SGTC_2889|Compound:9059656|FD-Score:-3.30|P-value:3.37E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-4.02|P-value:1.68E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:3.30|P-value:2.52E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.28|P-value:2.74E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:2.96|P-value:8.83E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:3.66|P-value:5.92E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:3.95|P-value:1.61E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:3.13|P-value:4.90E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:2.93|P-value:9.88E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.22|P-value:3.47E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:2.98|P-value:8.28E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.94|P-value:1.07E-7 ID:SGTC_458|Compound:nppb|FD-Score:3.06|P-value:6.21E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:6.25|P-value:2.95E-11 ID:SGTC_547|Compound:1120-0019|FD-Score:3.49|P-value:1.18E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.09|P-value:5.52E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.34|P-value:2.19E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.13|P-value:4.86E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:3.88|P-value:2.23E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:5.29|P-value:1.43E-8 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.30|P-value:3.50E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.81|P-value:3.03E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.12|P-value:7.39E-6 ID:SGTC_1011|Compound:4112-3381|FD-Score:-3.23|P-value:4.41E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.33|P-value:2.24E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:4.30|P-value:3.18E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:3.12|P-value:4.93E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:-3.10|P-value:7.14E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.74|P-value:5.95E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.59|P-value:7.74E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:2.98|P-value:8.29E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.34|P-value:2.14E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.35|P-value:2.81E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:5.18|P-value:2.76E-8 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.24|P-value:3.15E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:4.70|P-value:4.09E-7 ID:SGTC_1770|Compound:st043884|FD-Score:3.23|P-value:3.29E-4 ID:SGTC_1772|Compound:st048439|FD-Score:4.21|P-value:4.76E-6 ID:SGTC_1779|Compound:st039427|FD-Score:2.99|P-value:7.92E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.24|P-value:3.18E-4 ID:SGTC_2030|Compound:5175110|FD-Score:4.52|P-value:1.05E-6 ID:SGTC_2184|Compound:6075246|FD-Score:3.14|P-value:4.63E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.02|P-value:1.18E-5 ID:SGTC_2799|Compound:7812892|FD-Score:6.15|P-value:5.81E-11 ID:SGTC_2857|Compound:9024691|FD-Score:4.14|P-value:6.79E-6 ID:SGTC_2884|Compound:9058502|FD-Score:4.77|P-value:2.69E-7 ID:SGTC_2889|Compound:9059656|FD-Score:-3.30|P-value:3.37E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-4.02|P-value:1.68E-5

Top fitness defect scores for YGR224W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_474 dl-dihydrosphingosine 6.25 5.0 µM 2.95E-11 10 2.10E-10
2 SGTC_2799 7812892 6.15 81.8 µM 5.81E-11 superoxide 9 3.90E-10
3 SGTC_884 0851-0618 5.29 334.0 µM 1.43E-8 2 6.11E-8
4 SGTC_1506 4226-2149 5.18 212.0 µM 2.76E-8 13 1.12E-7
5 SGTC_430 0958-0115 4.94 16.4 µM 1.07E-7 10 3.88E-7
6 SGTC_2884 9058502 4.77 52.0 µM 2.69E-7 14 9.05E-7
7 SGTC_1693 xanthone 4.70 101.9 µM 4.09E-7 DNA damage response 10 1.33E-6
8 SGTC_2030 5175110 4.52 200.0 µM 1.05E-6 Golgi 18 3.15E-6
9 SGTC_1074 carmofur 4.30 3.8 µM 3.18E-6 exosome 13 8.73E-6
10 SGTC_1772 st048439 4.21 82.2 µM 4.76E-6 29 1.26E-5
11 SGTC_2857 9024691 4.14 58.4 µM 6.79E-6 20 1.75E-5
12 SGTC_1002 4049-0206 4.12 172.0 µM 7.39E-6 26 1.89E-5
13 SGTC_2309 7664088 4.02 163.9 µM 1.18E-5 25 2.91E-5
14 SGTC_142 0335-0849 3.95 62.7 µM 1.61E-5 ubiquinone biosynthesis & proteasome 127 3.87E-5
15 SGTC_637 1181-0519 3.88 7.3 µM 2.23E-5 fatty acid desaturase (OLE1) 108 5.22E-5
16 SGTC_987 1497-1013 3.81 404.0 µM 3.03E-5 15 6.89E-5
17 SGTC_79 0052-0007 3.66 94.1 µM 5.92E-5 49 1.28E-4
18 SGTC_1212 0520-0165 3.59 585.0 µM 7.74E-5 46 1.63E-4
19 SGTC_547 1120-0019 3.49 610.0 nM 1.18E-4 azole & statin 43 2.39E-4
20 SGTC_1403 3909-7815 3.34 62.9 µM 2.14E-4 30 4.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.16E-10 YNL245C CWC25 het Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p
0.102 2.84E-9 YNR074C AIF1 hom Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase
0.095 3.21E-8 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.092 9.11E-8 YLR292C SEC72 hom Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.090 1.89E-7 YMR056C AAC1 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.088 2.89E-7 YPR013C_p CMR3_p hom Putative zinc finger protein; YPR013C is not an essential gene
0.084 1.09E-6 YNL181W_p YNL181W_p het Putative oxidoreductase; required for cell viability
0.084 1.16E-6 YHR202W_p YHR202W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization
0.083 1.34E-6 YLR276C DBP9 het DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain
0.081 2.69E-6 YDL224C WHI4 hom Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication
0.081 2.91E-6 YDR201W SPC19 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
0.078 5.46E-6 YOL066C RIB2 het Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs
0.078 6.60E-6 YNL083W SAL1 hom ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains
0.078 6.90E-6 YNL272C SEC2 het Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles
0.076 1.06E-5 YOR311C DGK1 hom Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain