YGR226C_d

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR226C / YGR226C

Click on Significant Values for Screen Details ID:SGTC_256|Compound:clotrimazole|FD-Score:3.25|P-value:6.98E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.95|P-value:5.03E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.55|P-value:2.28E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-4.03|P-value:3.42E-5 ID:SGTC_779|Compound:1360-0071|FD-Score:3.62|P-value:1.83E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-3.30|P-value:5.54E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.56|P-value:2.21E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:5.15|P-value:2.03E-7 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.83|P-value:8.04E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.81|P-value:8.84E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.23|P-value:7.32E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.20|P-value:1.75E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.33|P-value:5.18E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:-3.21|P-value:7.62E-4 ID:SGTC_1628|Compound:st004252|FD-Score:5.38|P-value:5.86E-8 ID:SGTC_1731|Compound:st035964|FD-Score:7.63|P-value:2.81E-14 ID:SGTC_1733|Compound:st037357|FD-Score:4.04|P-value:3.56E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-3.97|P-value:4.49E-5 ID:SGTC_1943|Compound:st076331|FD-Score:3.37|P-value:4.63E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.98|P-value:4.68E-7 ID:SGTC_2287|Compound:7945887|FD-Score:4.51|P-value:4.56E-6 ID:SGTC_2368|Compound:9071271|FD-Score:-3.19|P-value:8.30E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.64|P-value:1.70E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.22|P-value:1.37E-7 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.21|P-value:7.67E-4 ID:SGTC_2505|Compound:galangin|FD-Score:-4.04|P-value:3.28E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.87|P-value:6.71E-5 ID:SGTC_2784|Compound:7567673|FD-Score:3.21|P-value:7.84E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.25|P-value:6.98E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.95|P-value:5.03E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.55|P-value:2.28E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-4.03|P-value:3.42E-5 ID:SGTC_779|Compound:1360-0071|FD-Score:3.62|P-value:1.83E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-3.30|P-value:5.54E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.56|P-value:2.21E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:5.15|P-value:2.03E-7 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.83|P-value:8.04E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.81|P-value:8.84E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.23|P-value:7.32E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.20|P-value:1.75E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.33|P-value:5.18E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:-3.21|P-value:7.62E-4 ID:SGTC_1628|Compound:st004252|FD-Score:5.38|P-value:5.86E-8 ID:SGTC_1731|Compound:st035964|FD-Score:7.63|P-value:2.81E-14 ID:SGTC_1733|Compound:st037357|FD-Score:4.04|P-value:3.56E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-3.97|P-value:4.49E-5 ID:SGTC_1943|Compound:st076331|FD-Score:3.37|P-value:4.63E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.98|P-value:4.68E-7 ID:SGTC_2287|Compound:7945887|FD-Score:4.51|P-value:4.56E-6 ID:SGTC_2368|Compound:9071271|FD-Score:-3.19|P-value:8.30E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.64|P-value:1.70E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.22|P-value:1.37E-7 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-3.21|P-value:7.67E-4 ID:SGTC_2505|Compound:galangin|FD-Score:-4.04|P-value:3.28E-5 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-3.87|P-value:6.71E-5 ID:SGTC_2784|Compound:7567673|FD-Score:3.21|P-value:7.84E-4

Top fitness defect scores for YGR226C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1731 st035964 7.63 63.0 µM 2.81E-14 3 1.15E-14
2 SGTC_1628 st004252 5.38 77.7 µM 5.86E-8 5 3.71E-8
3 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 5.22 3.7 µM 1.37E-7 26 8.88E-8
4 SGTC_1121 fusaric acid 5.15 630.5 nM 2.03E-7 17 1.33E-7
5 SGTC_1951 sophoraflavanone G 4.98 9.2 µM 4.68E-7 RNA processing & uracil transport 6 3.14E-7
6 SGTC_2287 7945887 4.51 168.8 µM 4.56E-6 5 3.27E-6
7 SGTC_1373 2887-0003 4.20 58.5 µM 1.75E-5 Golgi 17 1.31E-5
8 SGTC_1733 st037357 4.04 54.9 µM 3.56E-5 60S ribosome export 23 2.72E-5
9 SGTC_350 k064-0020 3.95 19.8 µM 5.03E-5 heme requiring 28 3.88E-5
10 SGTC_1149 3909-7961 3.83 23.3 µM 8.04E-5 22 6.29E-5
11 SGTC_1280 0880-0253 3.81 10.1 µM 8.84E-5 21 6.93E-5
12 SGTC_2408 sulbentine 3.64 18.4 µM 1.70E-4 59 1.36E-4
13 SGTC_779 1360-0071 3.62 233.0 µM 1.83E-4 fatty acid desaturase (OLE1) 44 1.47E-4
14 SGTC_1943 st076331 3.37 65.2 µM 4.63E-4 32 3.81E-4
15 SGTC_1378 2093-0007 3.33 380.0 nM 5.18E-4 45 4.28E-4
16 SGTC_256 clotrimazole 3.25 625.0 nM 6.98E-4 ergosterol depletion effects on membrane 56 5.81E-4
17 SGTC_1320 1313-0481 3.23 95.3 µM 7.32E-4 42 6.10E-4
18 SGTC_2784 7567673 3.21 72.7 µM 7.84E-4 iron homeostasis 61 6.55E-4
19 SGTC_1131 3454-3128 3.12 32.3 µM 0.00107 89 8.98E-4
20 SGTC_3192 9110362 3.11 49.5 µM 0.00110 mitochondrial processes 33 9.27E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.185 4.03E-27 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.166 3.22E-22 YPL004C LSP1 hom Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family
0.155 1.71E-19 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.142 1.74E-16 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.134 5.66E-15 YLR421C RPN13 hom Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress
0.131 2.42E-14 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.123 9.27E-13 YKL222C YKL222C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
0.121 1.64E-12 YDR100W TVP15 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p
0.120 3.34E-12 YBR211C AME1 het Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress
0.119 4.49E-12 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.117 1.27E-11 YGR242W_d YGR242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
0.112 6.92E-11 YPR031W NTO1 hom Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3
0.111 1.08E-10 YDL037C BSC1 hom Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.107 4.41E-10 YPL228W CET1 het Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.100 6.87E-9 YMR080C NAM7 hom ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress