YGR228W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR228W / YGR228W

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:4.64|P-value:3.88E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:3.77|P-value:6.47E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:8.50|P-value:2.92E-13 ID:SGTC_75|Compound:0159-0059|FD-Score:3.97|P-value:3.53E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:4.23|P-value:1.57E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-4.55|P-value:7.02E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:6.02|P-value:1.59E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:4.56|P-value:5.24E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:6.83|P-value:3.28E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.06|P-value:3.52E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:5.40|P-value:2.24E-6 ID:SGTC_553|Compound:k007-0256|FD-Score:3.67|P-value:8.65E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.75|P-value:6.97E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:4.77|P-value:2.43E-5 ID:SGTC_595|Compound:3909-8003|FD-Score:4.75|P-value:2.63E-5 ID:SGTC_645|Compound:0845-0943|FD-Score:4.02|P-value:3.01E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.57|P-value:4.96E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:3.83|P-value:5.37E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:4.10|P-value:2.34E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.69|P-value:3.26E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:-5.47|P-value:2.33E-6 ID:SGTC_923|Compound:1900-2434|FD-Score:3.83|P-value:5.51E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:4.36|P-value:1.03E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:5.99|P-value:1.82E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:6.51|P-value:1.62E-8 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.19|P-value:1.75E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.06|P-value:2.71E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.62|P-value:9.88E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.68|P-value:8.50E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.66|P-value:8.98E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:4.50|P-value:6.37E-5 ID:SGTC_1407|Compound:3909-7909|FD-Score:4.08|P-value:2.51E-4 ID:SGTC_1760|Compound:st045453|FD-Score:3.69|P-value:8.18E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.80|P-value:5.92E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.70|P-value:3.17E-5 ID:SGTC_1927|Compound:st060202|FD-Score:3.78|P-value:6.26E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.57|P-value:5.00E-5 ID:SGTC_1943|Compound:st076331|FD-Score:3.84|P-value:5.29E-4 ID:SGTC_1996|Compound:st072960|FD-Score:9.59|P-value:2.18E-16 ID:SGTC_2054|Compound:5233173|FD-Score:4.06|P-value:2.69E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.28|P-value:1.32E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.85|P-value:5.07E-4 ID:SGTC_2177|Compound:5811945|FD-Score:-6.04|P-value:2.08E-7 ID:SGTC_2178|Compound:5812956|FD-Score:5.58|P-value:1.05E-6 ID:SGTC_2254|Compound:7938975|FD-Score:5.28|P-value:3.62E-6 ID:SGTC_2260|Compound:7964312|FD-Score:3.73|P-value:7.36E-4 ID:SGTC_2289|Compound:7946404|FD-Score:6.13|P-value:9.56E-8 ID:SGTC_2302|Compound:7771753|FD-Score:3.69|P-value:8.17E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.90|P-value:4.45E-4 ID:SGTC_2413|Compound:inermin|FD-Score:5.36|P-value:2.57E-6 ID:SGTC_2476|Compound:5806916|FD-Score:4.10|P-value:2.34E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.61|P-value:4.38E-5 ID:SGTC_2785|Compound:7756463|FD-Score:6.19|P-value:7.38E-8 ID:SGTC_2812|Compound:7970281|FD-Score:5.28|P-value:3.61E-6 ID:SGTC_2814|Compound:7977482|FD-Score:4.59|P-value:4.63E-5 ID:SGTC_2848|Compound:9016370|FD-Score:6.39|P-value:2.81E-8 ID:SGTC_2893|Compound:9048488|FD-Score:4.75|P-value:2.67E-5 ID:SGTC_2895|Compound:9054447|FD-Score:4.41|P-value:8.54E-5 ID:SGTC_2970|Compound:9090938|FD-Score:4.05|P-value:2.74E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.80|P-value:6.03E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.68|P-value:8.33E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.64|P-value:3.93E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:4.64|P-value:3.88E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:3.77|P-value:6.47E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:8.50|P-value:2.92E-13 ID:SGTC_75|Compound:0159-0059|FD-Score:3.97|P-value:3.53E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:4.23|P-value:1.57E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-4.55|P-value:7.02E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:6.02|P-value:1.59E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:4.56|P-value:5.24E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:6.83|P-value:3.28E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.06|P-value:3.52E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:5.40|P-value:2.24E-6 ID:SGTC_553|Compound:k007-0256|FD-Score:3.67|P-value:8.65E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.75|P-value:6.97E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:4.77|P-value:2.43E-5 ID:SGTC_595|Compound:3909-8003|FD-Score:4.75|P-value:2.63E-5 ID:SGTC_645|Compound:0845-0943|FD-Score:4.02|P-value:3.01E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.57|P-value:4.96E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:3.83|P-value:5.37E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:4.10|P-value:2.34E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.69|P-value:3.26E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:-5.47|P-value:2.33E-6 ID:SGTC_923|Compound:1900-2434|FD-Score:3.83|P-value:5.51E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:4.36|P-value:1.03E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:5.99|P-value:1.82E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:6.51|P-value:1.62E-8 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.19|P-value:1.75E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.06|P-value:2.71E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.62|P-value:9.88E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.68|P-value:8.50E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.66|P-value:8.98E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:4.50|P-value:6.37E-5 ID:SGTC_1407|Compound:3909-7909|FD-Score:4.08|P-value:2.51E-4 ID:SGTC_1760|Compound:st045453|FD-Score:3.69|P-value:8.18E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.80|P-value:5.92E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.70|P-value:3.17E-5 ID:SGTC_1927|Compound:st060202|FD-Score:3.78|P-value:6.26E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.57|P-value:5.00E-5 ID:SGTC_1943|Compound:st076331|FD-Score:3.84|P-value:5.29E-4 ID:SGTC_1996|Compound:st072960|FD-Score:9.59|P-value:2.18E-16 ID:SGTC_2054|Compound:5233173|FD-Score:4.06|P-value:2.69E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.28|P-value:1.32E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.85|P-value:5.07E-4 ID:SGTC_2177|Compound:5811945|FD-Score:-6.04|P-value:2.08E-7 ID:SGTC_2178|Compound:5812956|FD-Score:5.58|P-value:1.05E-6 ID:SGTC_2254|Compound:7938975|FD-Score:5.28|P-value:3.62E-6 ID:SGTC_2260|Compound:7964312|FD-Score:3.73|P-value:7.36E-4 ID:SGTC_2289|Compound:7946404|FD-Score:6.13|P-value:9.56E-8 ID:SGTC_2302|Compound:7771753|FD-Score:3.69|P-value:8.17E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.90|P-value:4.45E-4 ID:SGTC_2413|Compound:inermin|FD-Score:5.36|P-value:2.57E-6 ID:SGTC_2476|Compound:5806916|FD-Score:4.10|P-value:2.34E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.61|P-value:4.38E-5 ID:SGTC_2785|Compound:7756463|FD-Score:6.19|P-value:7.38E-8 ID:SGTC_2812|Compound:7970281|FD-Score:5.28|P-value:3.61E-6 ID:SGTC_2814|Compound:7977482|FD-Score:4.59|P-value:4.63E-5 ID:SGTC_2848|Compound:9016370|FD-Score:6.39|P-value:2.81E-8 ID:SGTC_2893|Compound:9048488|FD-Score:4.75|P-value:2.67E-5 ID:SGTC_2895|Compound:9054447|FD-Score:4.41|P-value:8.54E-5 ID:SGTC_2970|Compound:9090938|FD-Score:4.05|P-value:2.74E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.80|P-value:6.03E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.68|P-value:8.33E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.64|P-value:3.93E-5

Top fitness defect scores for YGR228W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1996 st072960 9.59 66.8 µM 2.18E-16 1 4.31E-22
2 SGTC_66 0109-0187 8.50 42.4 µM 2.92E-13 1 9.74E-18
3 SGTC_138 0850-0259 6.83 40.9 µM 3.28E-9 cell wall 81 4.10E-12
4 SGTC_1098 clofazimine 6.51 15.1 µM 1.62E-8 heme biosynthesis & mitochondrial translocase 3 3.75E-11
5 SGTC_2848 9016370 6.39 26.0 µM 2.81E-8 3 8.03E-11
6 SGTC_2785 7756463 6.19 72.7 µM 7.38E-8 2 3.06E-10
7 SGTC_2289 7946404 6.13 165.1 µM 9.56E-8 34 4.38E-10
8 SGTC_131 0141-0277 6.02 33.9 µM 1.59E-7 5 8.83E-10
9 SGTC_1014 4130-3005 5.99 69.3 µM 1.82E-7 2 1.06E-9
10 SGTC_2178 5812956 5.58 200.0 µM 1.05E-6 2 1.20E-8
11 SGTC_351 caspofungin 5.40 25.0 nM 2.24E-6 cell wall 49 3.40E-8
12 SGTC_2413 inermin 5.36 26.1 µM 2.57E-6 26 4.11E-8
13 SGTC_2812 7970281 5.28 58.4 µM 3.61E-6 5 6.57E-8
14 SGTC_2254 7938975 5.28 95.2 µM 3.62E-6 27 6.61E-8
15 SGTC_591 4299-0174 4.77 154.0 µM 2.43E-5 4 9.05E-7
16 SGTC_595 3909-8003 4.75 73.7 µM 2.63E-5 5 1.01E-6
17 SGTC_2893 9048488 4.75 26.0 µM 2.67E-5 fatty acid desaturase (OLE1) 11 1.03E-6
18 SGTC_1926 methyl fluorone black 4.70 53.6 µM 3.17E-5 DNA intercalators 41 1.31E-6
19 SGTC_768 0384-0033 4.69 77.3 µM 3.26E-5 fatty acid desaturase (OLE1) 59 1.36E-6
20 SGTC_36 0335-0881 4.64 14.2 µM 3.88E-5 ubiquinone biosynthesis & proteasome 90 1.73E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 4.81E-13 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.112 9.12E-11 YLL021W SPA2 hom Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
0.105 1.11E-9 YCL040W GLK1 hom Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication
0.098 1.48E-8 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.097 1.70E-8 YPR033C HTS1 het Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome
0.096 2.58E-8 YGR229C SMI1 hom Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity
0.095 3.01E-8 YOR026W BUB3 hom Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p
0.095 3.07E-8 YNL233W BNI4 hom Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p
0.093 7.09E-8 YJL065C DLS1 hom Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication
0.093 7.48E-8 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
0.092 9.13E-8 YDR389W SAC7 hom GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate
0.091 1.14E-7 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.091 1.29E-7 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
0.091 1.46E-7 YDL147W RPN5 het Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein
0.090 1.77E-7 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases