YGR229C / SMI1

Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR229C / SMI1

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:3.67|P-value:4.02E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:4.29|P-value:4.19E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:3.50|P-value:6.94E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.86|P-value:4.00E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:5.29|P-value:5.89E-7 ID:SGTC_67|Compound:0335-0847|FD-Score:5.10|P-value:1.37E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:3.80|P-value:2.60E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:4.93|P-value:2.92E-6 ID:SGTC_91|Compound:0417-1751|FD-Score:5.01|P-value:2.08E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:7.32|P-value:7.00E-12 ID:SGTC_138|Compound:0850-0259|FD-Score:3.53|P-value:6.38E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.98|P-value:2.35E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:3.72|P-value:3.42E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:3.49|P-value:7.32E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:4.29|P-value:4.25E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:8.26|P-value:1.13E-14 ID:SGTC_208|Compound:k072-0098|FD-Score:4.08|P-value:9.54E-5 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.56|P-value:5.78E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.69|P-value:8.26E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.25|P-value:9.43E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.58|P-value:5.39E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.09|P-value:8.90E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:4.02|P-value:1.16E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.58|P-value:5.51E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:4.49|P-value:1.89E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.47|P-value:7.84E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.47|P-value:4.64E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-4.04|P-value:5.98E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:3.78|P-value:2.77E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:5.22|P-value:8.11E-7 ID:SGTC_706|Compound:4262-0057|FD-Score:4.80|P-value:5.32E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:3.46|P-value:8.10E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:5.02|P-value:2.01E-6 ID:SGTC_728|Compound:3030-5151|FD-Score:4.69|P-value:8.44E-6 ID:SGTC_735|Compound:3076-0345|FD-Score:4.25|P-value:4.93E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.94|P-value:1.56E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:7.56|P-value:1.48E-12 ID:SGTC_761|Compound:k216-0224|FD-Score:3.43|P-value:8.94E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.80|P-value:2.54E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.93|P-value:1.65E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:5.24|P-value:7.16E-7 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.01|P-value:1.02E-6 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:4.65|P-value:9.87E-6 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.11|P-value:8.35E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:3.71|P-value:3.51E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:7.05|P-value:3.81E-11 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.24|P-value:5.20E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.72|P-value:3.34E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.41|P-value:9.49E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.69|P-value:3.79E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.64|P-value:4.37E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.00|P-value:1.25E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:-3.78|P-value:1.60E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:-3.35|P-value:6.80E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.74|P-value:3.21E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:4.30|P-value:4.00E-5 ID:SGTC_1685|Compound:st024049|FD-Score:3.60|P-value:5.10E-4 ID:SGTC_1729|Compound:st035615|FD-Score:4.13|P-value:7.84E-5 ID:SGTC_1759|Compound:st043059|FD-Score:4.07|P-value:9.84E-5 ID:SGTC_1847|Compound:st056231|FD-Score:4.36|P-value:3.22E-5 ID:SGTC_1920|Compound:st075728|FD-Score:-4.17|P-value:3.68E-5 ID:SGTC_2089|Compound:5281248|FD-Score:3.84|P-value:2.26E-4 ID:SGTC_2146|Compound:5545642|FD-Score:6.21|P-value:5.27E-9 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.07|P-value:9.75E-5 ID:SGTC_2254|Compound:7938975|FD-Score:5.12|P-value:1.27E-6 ID:SGTC_2289|Compound:7946404|FD-Score:8.34|P-value:6.14E-15 ID:SGTC_2342|Compound:7990637|FD-Score:4.30|P-value:4.11E-5 ID:SGTC_2354|Compound:9060492|FD-Score:3.56|P-value:5.83E-4 ID:SGTC_2387|Compound:9077560|FD-Score:4.02|P-value:1.16E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.77|P-value:2.86E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.70|P-value:3.68E-4 ID:SGTC_2448|Compound:5185112|FD-Score:3.40|P-value:9.76E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.84|P-value:2.21E-4 ID:SGTC_2585|Compound:alliin|FD-Score:6.23|P-value:4.63E-9 ID:SGTC_2623|Compound:humulene|FD-Score:3.68|P-value:3.86E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.47|P-value:7.75E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.63|P-value:4.66E-4 ID:SGTC_2900|Compound:5328528|FD-Score:4.50|P-value:1.87E-5 ID:SGTC_3078|Compound:9116413|FD-Score:4.34|P-value:3.55E-5 ID:SGTC_3113|Compound:9123498|FD-Score:5.17|P-value:9.85E-7 ID:SGTC_3175|Compound:9106517|FD-Score:3.89|P-value:1.84E-4 ID:SGTC_3229|Compound:9132204|FD-Score:4.05|P-value:1.05E-4 ID:SGTC_3244|Compound:9134489|FD-Score:4.01|P-value:1.20E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.92|P-value:1.71E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.70|P-value:3.59E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.67|P-value:4.02E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:4.29|P-value:4.19E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:3.50|P-value:6.94E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.86|P-value:4.00E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:5.29|P-value:5.89E-7 ID:SGTC_67|Compound:0335-0847|FD-Score:5.10|P-value:1.37E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:3.80|P-value:2.60E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:4.93|P-value:2.92E-6 ID:SGTC_91|Compound:0417-1751|FD-Score:5.01|P-value:2.08E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:7.32|P-value:7.00E-12 ID:SGTC_138|Compound:0850-0259|FD-Score:3.53|P-value:6.38E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.98|P-value:2.35E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:3.72|P-value:3.42E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:3.49|P-value:7.32E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:4.29|P-value:4.25E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:8.26|P-value:1.13E-14 ID:SGTC_208|Compound:k072-0098|FD-Score:4.08|P-value:9.54E-5 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.56|P-value:5.78E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.69|P-value:8.26E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.25|P-value:9.43E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.58|P-value:5.39E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.09|P-value:8.90E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:4.02|P-value:1.16E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.58|P-value:5.51E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:4.49|P-value:1.89E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.47|P-value:7.84E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.47|P-value:4.64E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-4.04|P-value:5.98E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:3.78|P-value:2.77E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:5.22|P-value:8.11E-7 ID:SGTC_706|Compound:4262-0057|FD-Score:4.80|P-value:5.32E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:3.46|P-value:8.10E-4 ID:SGTC_715|Compound:0868-0130|FD-Score:5.02|P-value:2.01E-6 ID:SGTC_728|Compound:3030-5151|FD-Score:4.69|P-value:8.44E-6 ID:SGTC_735|Compound:3076-0345|FD-Score:4.25|P-value:4.93E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.94|P-value:1.56E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:7.56|P-value:1.48E-12 ID:SGTC_761|Compound:k216-0224|FD-Score:3.43|P-value:8.94E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:3.80|P-value:2.54E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.93|P-value:1.65E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:5.24|P-value:7.16E-7 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.01|P-value:1.02E-6 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:4.65|P-value:9.87E-6 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.11|P-value:8.35E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:3.71|P-value:3.51E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:7.05|P-value:3.81E-11 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.24|P-value:5.20E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.72|P-value:3.34E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.41|P-value:9.49E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.69|P-value:3.79E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.64|P-value:4.37E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.00|P-value:1.25E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:-3.78|P-value:1.60E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:-3.35|P-value:6.80E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.74|P-value:3.21E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:4.30|P-value:4.00E-5 ID:SGTC_1685|Compound:st024049|FD-Score:3.60|P-value:5.10E-4 ID:SGTC_1729|Compound:st035615|FD-Score:4.13|P-value:7.84E-5 ID:SGTC_1759|Compound:st043059|FD-Score:4.07|P-value:9.84E-5 ID:SGTC_1847|Compound:st056231|FD-Score:4.36|P-value:3.22E-5 ID:SGTC_1920|Compound:st075728|FD-Score:-4.17|P-value:3.68E-5 ID:SGTC_2089|Compound:5281248|FD-Score:3.84|P-value:2.26E-4 ID:SGTC_2146|Compound:5545642|FD-Score:6.21|P-value:5.27E-9 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.07|P-value:9.75E-5 ID:SGTC_2254|Compound:7938975|FD-Score:5.12|P-value:1.27E-6 ID:SGTC_2289|Compound:7946404|FD-Score:8.34|P-value:6.14E-15 ID:SGTC_2342|Compound:7990637|FD-Score:4.30|P-value:4.11E-5 ID:SGTC_2354|Compound:9060492|FD-Score:3.56|P-value:5.83E-4 ID:SGTC_2387|Compound:9077560|FD-Score:4.02|P-value:1.16E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.77|P-value:2.86E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.70|P-value:3.68E-4 ID:SGTC_2448|Compound:5185112|FD-Score:3.40|P-value:9.76E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.84|P-value:2.21E-4 ID:SGTC_2585|Compound:alliin|FD-Score:6.23|P-value:4.63E-9 ID:SGTC_2623|Compound:humulene|FD-Score:3.68|P-value:3.86E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.47|P-value:7.75E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.63|P-value:4.66E-4 ID:SGTC_2900|Compound:5328528|FD-Score:4.50|P-value:1.87E-5 ID:SGTC_3078|Compound:9116413|FD-Score:4.34|P-value:3.55E-5 ID:SGTC_3113|Compound:9123498|FD-Score:5.17|P-value:9.85E-7 ID:SGTC_3175|Compound:9106517|FD-Score:3.89|P-value:1.84E-4 ID:SGTC_3229|Compound:9132204|FD-Score:4.05|P-value:1.05E-4 ID:SGTC_3244|Compound:9134489|FD-Score:4.01|P-value:1.20E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.92|P-value:1.71E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.70|P-value:3.59E-4

Top fitness defect scores for YGR229C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2289 7946404 8.34 165.1 µM 6.14E-15 13 3.63E-17
2 SGTC_206 4546-0025 8.26 72.0 µM 1.13E-14 NEO1 19 7.38E-17
3 SGTC_759 3486-0358 7.56 89.3 µM 1.48E-12 1 2.07E-14
4 SGTC_137 0438-0332 7.32 85.4 µM 7.00E-12 ubiquinone biosynthesis & proteasome 45 1.25E-13
5 SGTC_1105 epirubicin 7.05 18.1 µM 3.81E-11 anthracycline transcription coupled DNA repair 2 8.86E-13
6 SGTC_2585 alliin 6.23 100.0 µM 4.63E-9 4 2.29E-10
7 SGTC_2146 5545642 6.21 200.0 µM 5.27E-9 2 2.66E-10
8 SGTC_59 0330-0160 5.29 1.3 µM 5.89E-7 52 6.27E-8
9 SGTC_887 0885-0007 5.24 9.6 µM 7.16E-7 endomembrane recycling 20 7.88E-8
10 SGTC_685 1278-0033 5.22 54.9 µM 8.11E-7 60S ribosome export 5 9.09E-8
11 SGTC_3113 9123498 5.17 49.5 µM 9.85E-7 3 1.14E-7
12 SGTC_2254 7938975 5.12 95.2 µM 1.27E-6 30 1.53E-7
13 SGTC_67 0335-0847 5.10 266.0 µM 1.37E-6 ubiquinone biosynthesis & proteasome 84 1.67E-7
14 SGTC_715 0868-0130 5.02 184.0 µM 2.01E-6 6 2.61E-7
15 SGTC_91 0417-1751 5.01 58.4 µM 2.08E-6 Golgi 24 2.71E-7
16 SGTC_142 0335-0849 4.98 62.7 µM 2.35E-6 ubiquinone biosynthesis & proteasome 84 3.12E-7
17 SGTC_90 0870-0863 4.93 4.6 µM 2.92E-6 23 4.02E-7
18 SGTC_58 0957-0393 4.86 9.0 µM 4.00E-6 cell wall 299 5.79E-7
19 SGTC_706 4262-0057 4.80 46.9 µM 5.32E-6 fatty acid desaturase (OLE1) 13 8.06E-7
20 SGTC_270 tamoxifen 4.69 5.5 µM 8.26E-6 NEO1 14 1.34E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.170 3.88E-23 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.147 1.12E-17 YMR316W DIA1 hom Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.140 4.40E-16 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.139 6.03E-16 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.131 2.41E-14 YDR086C SSS1 het Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
0.129 5.93E-14 YCR094W CDC50 hom Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication
0.127 1.68E-13 YJR073C OPI3 hom Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis
0.121 1.89E-12 YOR165W SEY1 hom Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
0.121 2.36E-12 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.121 2.36E-12 YDR363W-A SEM1 hom Component of lid subcomplex of the 26S proteasome regulatory subunit; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1; protein abundance increases in response to DNA replication stress
0.116 1.63E-11 YBR275C RIF1 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.115 2.46E-11 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.114 3.59E-11 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.114 4.22E-11 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.113 6.06E-11 YJR118C ILM1 hom Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth