HIPHOP chemogenomics database

YGR230W / BNS1

Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR230W / BNS1

Click on Significant Values for Screen Details

Top fitness defect scores for YGR230W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1341	1486-1360	6.44	280.0 µM	1.90E-11		1	5.91E-11
2	SGTC_2569	tetrandrine	5.68	100.0 µM	2.75E-9		4	6.76E-9
3	SGTC_673	1082-0474	5.50	110.0 µM	8.14E-9	RSC complex & mRNA processing	27	1.90E-8
4	SGTC_2698	st077697	4.97	67.5 µM	1.66E-7		9	3.35E-7
5	SGTC_672	1441-0018	4.72	53.7 µM	6.13E-7		8	1.17E-6
6	SGTC_1381	2324-0066	4.41	62.1 µM	2.90E-6		22	5.11E-6
7	SGTC_2617	dihydrotanshinone i	4.41	20.8 µM	2.96E-6	copper-dependent oxidative stress	23	5.22E-6
8	SGTC_2576	guaiol	4.25	23.1 µM	6.35E-6		13	1.08E-5
9	SGTC_1543	azetidyl-2-carboxylic acid	4.19	198.0 µM	8.27E-6		9	1.39E-5
10	SGTC_1809	st050081	4.17	57.6 µM	9.32E-6		15	1.56E-5
11	SGTC_708	3448-5400	3.98	146.0 µM	2.12E-5		41	3.40E-5
12	SGTC_1820	st053765	3.97	18.6 µM	2.29E-5	RPP1 & pyrimidine depletion	16	3.66E-5
13	SGTC_2629	bisabolol	3.75	100.0 µM	5.82E-5		27	8.91E-5
14	SGTC_3118	9124250	3.71	49.5 µM	6.90E-5		15	1.05E-4
15	SGTC_136	0097-0015	3.66	404.5 µM	8.48E-5	60S ribosome export	26	1.27E-4
16	SGTC_1334	1486-0610	3.58	236.0 µM	1.17E-4	60S ribosome export	29	1.73E-4
17	SGTC_2172	5754775	3.56	163.9 µM	1.26E-4		24	1.85E-4
18	SGTC_2176	5809774	3.55	34.0 µM	1.31E-4	mitochondrial processes	22	1.93E-4
19	SGTC_2900	5328528	3.52	85.3 µM	1.49E-4	Golgi	43	2.18E-4
20	SGTC_876	0720-0963	3.48	56.8 µM	1.72E-4		29	2.51E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.108	3.72E-10	YPL033C	SRL4	hom	Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p
0.103	2.31E-9	YKR057W	RPS21A	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication
0.086	5.34E-7	YML010W	SPT5	het	Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair
0.086	5.63E-7	YOR206W	NOC2	het	Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
0.085	7.44E-7	YGL147C	RPL9A	hom	Ribosomal 60S subunit protein L9A; nearly identical to paralog Rpl9Bp; homologous to mammalian ribosomal protein L9 and bacterial L6
0.084	1.27E-6	YPR189W	SKI3	hom	Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
0.080	3.29E-6	YDR449C	UTP6	het	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.077	7.48E-6	YEL035C_p	UTR5_p	het	Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions
0.077	8.33E-6	YDR524W-C_p	YDR524W-C_p	hom	Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin
0.076	1.06E-5	YDL233W_p	MFG1_p	hom	Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene
0.075	1.43E-5	YGL109W_d	YGL109W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C
0.074	1.67E-5	YBL039C	URA7	hom	Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication
0.074	2.02E-5	YOR196C	LIP5	hom	Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase
0.071	3.64E-5	YER022W	SRB4	het	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination
0.071	3.71E-5	YGR264C	MES1	het	Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs