Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YGR230W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.108 | 3.72E-10 | YPL033C | SRL4 | hom | Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p |
0.103 | 2.31E-9 | YKR057W | RPS21A | hom | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication |
0.086 | 5.34E-7 | YML010W | SPT5 | het | Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair |
0.086 | 5.63E-7 | YOR206W | NOC2 | het | Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors |
0.085 | 7.44E-7 | YGL147C | RPL9A | hom | Ribosomal 60S subunit protein L9A; nearly identical to paralog Rpl9Bp; homologous to mammalian ribosomal protein L9 and bacterial L6 |
0.084 | 1.27E-6 | YPR189W | SKI3 | hom | Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay |
0.080 | 3.29E-6 | YDR449C | UTP6 | het | Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA |
0.077 | 7.48E-6 | YEL035C_p | UTR5_p | het | Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions |
0.077 | 8.33E-6 | YDR524W-C_p | YDR524W-C_p | hom | Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin |
0.076 | 1.06E-5 | YDL233W_p | MFG1_p | hom | Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene |
0.075 | 1.43E-5 | YGL109W_d | YGL109W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C |
0.074 | 1.67E-5 | YBL039C | URA7 | hom | Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication |
0.074 | 2.02E-5 | YOR196C | LIP5 | hom | Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase |
0.071 | 3.64E-5 | YER022W | SRB4 | het | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination |
0.071 | 3.71E-5 | YGR264C | MES1 | het | Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs |