YGR230W / BNS1

Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR230W / BNS1

Click on Significant Values for Screen Details ID:SGTC_135|Compound:0933-0004|FD-Score:3.01|P-value:9.69E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.66|P-value:8.48E-5 ID:SGTC_237|Compound:nikkomycin|FD-Score:-3.46|P-value:2.07E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:-3.43|P-value:2.39E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:4.72|P-value:6.13E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:5.50|P-value:8.14E-9 ID:SGTC_708|Compound:3448-5400|FD-Score:3.98|P-value:2.12E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:3.43|P-value:2.12E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.48|P-value:1.72E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:-3.50|P-value:1.79E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.10|P-value:7.12E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.58|P-value:1.17E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:6.44|P-value:1.90E-11 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.04|P-value:8.74E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.41|P-value:2.90E-6 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:4.19|P-value:8.27E-6 ID:SGTC_1652|Compound:st011932|FD-Score:-3.05|P-value:9.47E-4 ID:SGTC_1669|Compound:st015249|FD-Score:3.33|P-value:3.03E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.41|P-value:2.31E-4 ID:SGTC_1809|Compound:st050081|FD-Score:4.17|P-value:9.32E-6 ID:SGTC_1820|Compound:st053765|FD-Score:3.97|P-value:2.29E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-4.18|P-value:9.86E-6 ID:SGTC_2011|Compound:4012611|FD-Score:-3.49|P-value:1.89E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.56|P-value:1.26E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.55|P-value:1.31E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:5.68|P-value:2.75E-9 ID:SGTC_2576|Compound:guaiol|FD-Score:4.25|P-value:6.35E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.41|P-value:2.96E-6 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.75|P-value:5.82E-5 ID:SGTC_2698|Compound:st077697|FD-Score:4.97|P-value:1.66E-7 ID:SGTC_2790|Compound:5423970|FD-Score:-3.21|P-value:5.31E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.55|P-value:1.45E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.52|P-value:1.49E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.15|P-value:6.04E-4 ID:SGTC_3118|Compound:9124250|FD-Score:3.71|P-value:6.90E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:3.01|P-value:9.69E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.66|P-value:8.48E-5 ID:SGTC_237|Compound:nikkomycin|FD-Score:-3.46|P-value:2.07E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:-3.43|P-value:2.39E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:4.72|P-value:6.13E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:5.50|P-value:8.14E-9 ID:SGTC_708|Compound:3448-5400|FD-Score:3.98|P-value:2.12E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:3.43|P-value:2.12E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.48|P-value:1.72E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:-3.50|P-value:1.79E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.10|P-value:7.12E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.58|P-value:1.17E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:6.44|P-value:1.90E-11 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.04|P-value:8.74E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.41|P-value:2.90E-6 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:4.19|P-value:8.27E-6 ID:SGTC_1652|Compound:st011932|FD-Score:-3.05|P-value:9.47E-4 ID:SGTC_1669|Compound:st015249|FD-Score:3.33|P-value:3.03E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.41|P-value:2.31E-4 ID:SGTC_1809|Compound:st050081|FD-Score:4.17|P-value:9.32E-6 ID:SGTC_1820|Compound:st053765|FD-Score:3.97|P-value:2.29E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-4.18|P-value:9.86E-6 ID:SGTC_2011|Compound:4012611|FD-Score:-3.49|P-value:1.89E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.56|P-value:1.26E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.55|P-value:1.31E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:5.68|P-value:2.75E-9 ID:SGTC_2576|Compound:guaiol|FD-Score:4.25|P-value:6.35E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.41|P-value:2.96E-6 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.75|P-value:5.82E-5 ID:SGTC_2698|Compound:st077697|FD-Score:4.97|P-value:1.66E-7 ID:SGTC_2790|Compound:5423970|FD-Score:-3.21|P-value:5.31E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.55|P-value:1.45E-4 ID:SGTC_2900|Compound:5328528|FD-Score:3.52|P-value:1.49E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.15|P-value:6.04E-4 ID:SGTC_3118|Compound:9124250|FD-Score:3.71|P-value:6.90E-5

Top fitness defect scores for YGR230W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1341 1486-1360 6.44 280.0 µM 1.90E-11 1 5.91E-11
2 SGTC_2569 tetrandrine 5.68 100.0 µM 2.75E-9 4 6.76E-9
3 SGTC_673 1082-0474 5.50 110.0 µM 8.14E-9 RSC complex & mRNA processing 27 1.90E-8
4 SGTC_2698 st077697 4.97 67.5 µM 1.66E-7 9 3.35E-7
5 SGTC_672 1441-0018 4.72 53.7 µM 6.13E-7 8 1.17E-6
6 SGTC_1381 2324-0066 4.41 62.1 µM 2.90E-6 22 5.11E-6
7 SGTC_2617 dihydrotanshinone i 4.41 20.8 µM 2.96E-6 copper-dependent oxidative stress 23 5.22E-6
8 SGTC_2576 guaiol 4.25 23.1 µM 6.35E-6 13 1.08E-5
9 SGTC_1543 azetidyl-2-carboxylic acid 4.19 198.0 µM 8.27E-6 9 1.39E-5
10 SGTC_1809 st050081 4.17 57.6 µM 9.32E-6 15 1.56E-5
11 SGTC_708 3448-5400 3.98 146.0 µM 2.12E-5 41 3.40E-5
12 SGTC_1820 st053765 3.97 18.6 µM 2.29E-5 RPP1 & pyrimidine depletion 16 3.66E-5
13 SGTC_2629 bisabolol 3.75 100.0 µM 5.82E-5 27 8.91E-5
14 SGTC_3118 9124250 3.71 49.5 µM 6.90E-5 15 1.05E-4
15 SGTC_136 0097-0015 3.66 404.5 µM 8.48E-5 60S ribosome export 26 1.27E-4
16 SGTC_1334 1486-0610 3.58 236.0 µM 1.17E-4 60S ribosome export 29 1.73E-4
17 SGTC_2172 5754775 3.56 163.9 µM 1.26E-4 24 1.85E-4
18 SGTC_2176 5809774 3.55 34.0 µM 1.31E-4 mitochondrial processes 22 1.93E-4
19 SGTC_2900 5328528 3.52 85.3 µM 1.49E-4 Golgi 43 2.18E-4
20 SGTC_876 0720-0963 3.48 56.8 µM 1.72E-4 29 2.51E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 3.72E-10 YPL033C SRL4 hom Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p
0.103 2.31E-9 YKR057W RPS21A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication
0.086 5.34E-7 YML010W SPT5 het Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair
0.086 5.63E-7 YOR206W NOC2 het Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
0.085 7.44E-7 YGL147C RPL9A hom Ribosomal 60S subunit protein L9A; nearly identical to paralog Rpl9Bp; homologous to mammalian ribosomal protein L9 and bacterial L6
0.084 1.27E-6 YPR189W SKI3 hom Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
0.080 3.29E-6 YDR449C UTP6 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.077 7.48E-6 YEL035C_p UTR5_p het Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions
0.077 8.33E-6 YDR524W-C_p YDR524W-C_p hom Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin
0.076 1.06E-5 YDL233W_p MFG1_p hom Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene
0.075 1.43E-5 YGL109W_d YGL109W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C
0.074 1.67E-5 YBL039C URA7 hom Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication
0.074 2.02E-5 YOR196C LIP5 hom Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase
0.071 3.64E-5 YER022W SRB4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination
0.071 3.71E-5 YGR264C MES1 het Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs