YGR231C / PHB2

Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR231C / PHB2

Click on Significant Values for Screen Details ID:SGTC_133|Compound:0724-0033|FD-Score:-4.83|P-value:4.13E-6 ID:SGTC_545|Compound:4218-0007|FD-Score:6.81|P-value:1.40E-10 ID:SGTC_550|Compound:4123-0385|FD-Score:3.41|P-value:7.72E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:-3.76|P-value:2.59E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:5.80|P-value:3.90E-8 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.34|P-value:9.55E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.51|P-value:5.58E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.92|P-value:1.36E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.51|P-value:5.66E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.96|P-value:1.21E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.64|P-value:3.63E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.53|P-value:5.21E-4 ID:SGTC_1986|Compound:st071812|FD-Score:3.82|P-value:1.95E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.47|P-value:6.50E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.40|P-value:8.03E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:5.52|P-value:1.52E-7 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.54|P-value:5.47E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-3.72|P-value:3.00E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.71|P-value:2.89E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.76|P-value:2.45E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-3.56|P-value:5.15E-4 ID:SGTC_2918|Compound:7977171|FD-Score:-3.59|P-value:4.71E-4 ID:SGTC_2986|Compound:9022445|FD-Score:-3.49|P-value:6.39E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-5.18|P-value:8.81E-7 ID:SGTC_133|Compound:0724-0033|FD-Score:-4.83|P-value:4.13E-6 ID:SGTC_545|Compound:4218-0007|FD-Score:6.81|P-value:1.40E-10 ID:SGTC_550|Compound:4123-0385|FD-Score:3.41|P-value:7.72E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:-3.76|P-value:2.59E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:5.80|P-value:3.90E-8 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.34|P-value:9.55E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.51|P-value:5.58E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.92|P-value:1.36E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.51|P-value:5.66E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.96|P-value:1.21E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.64|P-value:3.63E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.53|P-value:5.21E-4 ID:SGTC_1986|Compound:st071812|FD-Score:3.82|P-value:1.95E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.47|P-value:6.50E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.40|P-value:8.03E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:5.52|P-value:1.52E-7 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.54|P-value:5.47E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-3.72|P-value:3.00E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.71|P-value:2.89E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.76|P-value:2.45E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-3.56|P-value:5.15E-4 ID:SGTC_2918|Compound:7977171|FD-Score:-3.59|P-value:4.71E-4 ID:SGTC_2986|Compound:9022445|FD-Score:-3.49|P-value:6.39E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-5.18|P-value:8.81E-7

Top fitness defect scores for YGR231C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_545 4218-0007 6.81 221.0 µM 1.40E-10 4 4.88E-12
2 SGTC_852 0418-0143 5.80 439.0 µM 3.90E-8 calcium & mitochondrial duress 32 3.40E-9
3 SGTC_2566 crystal violet carbinol 5.52 226.0 nM 1.52E-7 14 1.65E-8
4 SGTC_1648 st011736 3.96 69.8 µM 1.21E-4 PDR1 13 3.80E-5
5 SGTC_1380 2291-0730 3.92 164.0 µM 1.36E-4 26 4.34E-5
6 SGTC_1986 st071812 3.82 45.0 µM 1.95E-4 9 6.58E-5
7 SGTC_2783 7738165 3.76 71.4 µM 2.45E-4 36 8.57E-5
8 SGTC_2782 7736369 3.71 71.4 µM 2.89E-4 51 1.04E-4
9 SGTC_1675 st018485 3.64 24.5 µM 3.63E-4 60S ribosome export 37 1.35E-4
10 SGTC_1728 st035614 3.53 33.8 µM 5.21E-4 74 2.05E-4
11 SGTC_1223 0764-0573 3.51 147.0 µM 5.58E-4 34 2.22E-4
12 SGTC_1596 piperlongumine 3.51 63.0 µM 5.66E-4 28 2.26E-4
13 SGTC_2367 9070478 3.47 135.4 µM 6.50E-4 cell wall 56 2.65E-4
14 SGTC_550 4123-0385 3.41 25.7 µM 7.72E-4 TSC3-RPN4 50 3.23E-4
15 SGTC_2564 betulinic acid 3.40 100.0 µM 8.03E-4 53 3.38E-4
16 SGTC_1022 4477-0945 3.34 21.3 µM 9.55E-4 47 4.12E-4
17 SGTC_1963 st076565 3.30 50.3 µM 0.00108 31 4.77E-4
18 SGTC_1503 4585-0012 3.21 61.3 µM 0.00146 43 6.75E-4
19 SGTC_2787 5284540 3.21 71.4 µM 0.00146 54 6.75E-4
20 SGTC_331 k048-0133 3.20 24.5 µM 0.00151 RSC & ERG11 33 6.99E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.173 6.88E-24 YGR132C PHB1 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
0.141 2.12E-16 YER053C-A YER053C-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.107 4.27E-10 YBL070C_d YBL070C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.094 4.31E-8 YNR029C_p YNR029C_p hom Putative protein of unknown function, deletion confers reduced fitness in saline
0.091 1.41E-7 YDR362C TFC6 het One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110
0.088 3.53E-7 YFL028C CAF16 hom Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator
0.084 1.23E-6 YJL051W IRC8 hom Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc
0.084 1.26E-6 YJR055W HIT1 hom Protein of unknown function, required for growth at high temperature
0.083 1.61E-6 YDL169C UGX2 hom Protein of unknown function, transcript accumulates in response to any combination of stress conditions
0.082 2.02E-6 YPL274W SAM3 hom High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
0.080 3.42E-6 YBR103W SIF2 hom WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus
0.079 4.66E-6 YNL046W_p YNL046W_p hom Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.078 6.68E-6 YJR023C_d YJR023C_d het Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing
0.077 8.15E-6 YPR133W-A TOM5 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore
0.077 8.30E-6 YPR045C THP3 hom Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes