YGR233C / PHO81

Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR233C / PHO81

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:3.26|P-value:7.28E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:5.50|P-value:3.50E-8 ID:SGTC_161|Compound:4065-0411|FD-Score:3.88|P-value:7.42E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.41|P-value:3.56E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.27|P-value:5.79E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.18|P-value:9.42E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:6.48|P-value:1.05E-10 ID:SGTC_707|Compound:0865-0008|FD-Score:3.55|P-value:2.61E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:5.57|P-value:2.47E-8 ID:SGTC_747|Compound:3448-8087|FD-Score:3.29|P-value:6.56E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.49|P-value:3.27E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:3.60|P-value:2.18E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:5.52|P-value:3.24E-8 ID:SGTC_917|Compound:harmaline|FD-Score:3.97|P-value:5.26E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.45|P-value:3.73E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.51|P-value:3.05E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:5.41|P-value:5.71E-8 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.46|P-value:6.38E-6 ID:SGTC_1246|Compound:0422-0085|FD-Score:5.49|P-value:3.79E-8 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.19|P-value:9.10E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:4.59|P-value:3.48E-6 ID:SGTC_1335|Compound:1486-0900|FD-Score:4.41|P-value:8.09E-6 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.64|P-value:1.86E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:6.33|P-value:2.66E-10 ID:SGTC_1399|Compound:3562-5772|FD-Score:4.30|P-value:1.28E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.50|P-value:3.11E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.38|P-value:4.83E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.30|P-value:6.39E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.38|P-value:4.88E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:4.83|P-value:1.12E-6 ID:SGTC_1936|Compound:st074407|FD-Score:3.74|P-value:1.30E-4 ID:SGTC_1967|Compound:st070177|FD-Score:-3.19|P-value:7.76E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.35|P-value:5.36E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.35|P-value:5.40E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.21|P-value:8.50E-4 ID:SGTC_2195|Compound:6536160|FD-Score:4.68|P-value:2.26E-6 ID:SGTC_2288|Compound:7946289|FD-Score:-3.98|P-value:3.96E-5 ID:SGTC_2361|Compound:9034121|FD-Score:-7.05|P-value:1.61E-12 ID:SGTC_2362|Compound:9071156|FD-Score:3.98|P-value:4.91E-5 ID:SGTC_2366|Compound:9070441|FD-Score:4.13|P-value:2.62E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.50|P-value:3.13E-4 ID:SGTC_2368|Compound:9071271|FD-Score:-3.53|P-value:2.33E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.97|P-value:4.14E-5 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.23|P-value:8.16E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.24|P-value:1.67E-5 ID:SGTC_2625|Compound:euphol|FD-Score:4.86|P-value:9.98E-7 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.21|P-value:8.62E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.23|P-value:7.95E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.28|P-value:6.81E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.22|P-value:7.05E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.23|P-value:8.18E-4 ID:SGTC_3102|Compound:9121669|FD-Score:3.79|P-value:1.05E-4 ID:SGTC_3119|Compound:9125183|FD-Score:5.90|P-value:3.73E-9 ID:SGTC_3132|Compound:9126706|FD-Score:3.75|P-value:1.22E-4 ID:SGTC_3248|Compound:9135562|FD-Score:5.29|P-value:1.11E-7 ID:SGTC_3348|Compound:9149464|FD-Score:3.73|P-value:1.32E-4 ID:SGTC_3354|Compound:9151612|FD-Score:4.14|P-value:2.58E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:3.26|P-value:7.28E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:5.50|P-value:3.50E-8 ID:SGTC_161|Compound:4065-0411|FD-Score:3.88|P-value:7.42E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.41|P-value:3.56E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.27|P-value:5.79E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.18|P-value:9.42E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:6.48|P-value:1.05E-10 ID:SGTC_707|Compound:0865-0008|FD-Score:3.55|P-value:2.61E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:5.57|P-value:2.47E-8 ID:SGTC_747|Compound:3448-8087|FD-Score:3.29|P-value:6.56E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.49|P-value:3.27E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:3.60|P-value:2.18E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:5.52|P-value:3.24E-8 ID:SGTC_917|Compound:harmaline|FD-Score:3.97|P-value:5.26E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.45|P-value:3.73E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.51|P-value:3.05E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:5.41|P-value:5.71E-8 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.46|P-value:6.38E-6 ID:SGTC_1246|Compound:0422-0085|FD-Score:5.49|P-value:3.79E-8 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.19|P-value:9.10E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:4.59|P-value:3.48E-6 ID:SGTC_1335|Compound:1486-0900|FD-Score:4.41|P-value:8.09E-6 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.64|P-value:1.86E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:6.33|P-value:2.66E-10 ID:SGTC_1399|Compound:3562-5772|FD-Score:4.30|P-value:1.28E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.50|P-value:3.11E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.38|P-value:4.83E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.30|P-value:6.39E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.38|P-value:4.88E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:4.83|P-value:1.12E-6 ID:SGTC_1936|Compound:st074407|FD-Score:3.74|P-value:1.30E-4 ID:SGTC_1967|Compound:st070177|FD-Score:-3.19|P-value:7.76E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.35|P-value:5.36E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.35|P-value:5.40E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.21|P-value:8.50E-4 ID:SGTC_2195|Compound:6536160|FD-Score:4.68|P-value:2.26E-6 ID:SGTC_2288|Compound:7946289|FD-Score:-3.98|P-value:3.96E-5 ID:SGTC_2361|Compound:9034121|FD-Score:-7.05|P-value:1.61E-12 ID:SGTC_2362|Compound:9071156|FD-Score:3.98|P-value:4.91E-5 ID:SGTC_2366|Compound:9070441|FD-Score:4.13|P-value:2.62E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.50|P-value:3.13E-4 ID:SGTC_2368|Compound:9071271|FD-Score:-3.53|P-value:2.33E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.97|P-value:4.14E-5 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.23|P-value:8.16E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.24|P-value:1.67E-5 ID:SGTC_2625|Compound:euphol|FD-Score:4.86|P-value:9.98E-7 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:3.21|P-value:8.62E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.23|P-value:7.95E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.28|P-value:6.81E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.22|P-value:7.05E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.23|P-value:8.18E-4 ID:SGTC_3102|Compound:9121669|FD-Score:3.79|P-value:1.05E-4 ID:SGTC_3119|Compound:9125183|FD-Score:5.90|P-value:3.73E-9 ID:SGTC_3132|Compound:9126706|FD-Score:3.75|P-value:1.22E-4 ID:SGTC_3248|Compound:9135562|FD-Score:5.29|P-value:1.11E-7 ID:SGTC_3348|Compound:9149464|FD-Score:3.73|P-value:1.32E-4 ID:SGTC_3354|Compound:9151612|FD-Score:4.14|P-value:2.58E-5

Top fitness defect scores for YGR233C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_622 1348-1566 6.48 26.3 µM 1.05E-10 2 4.60E-11
2 SGTC_1369 1866-0067 6.33 208.0 µM 2.66E-10 RPP1 & pyrimidine depletion 9 1.20E-10
3 SGTC_3119 9125183 5.90 49.5 µM 3.73E-9 3 1.84E-9
4 SGTC_727 3032-0951 5.57 202.0 µM 2.47E-8 12 1.31E-8
5 SGTC_912 3474-0017 5.52 2.2 µM 3.24E-8 5 1.73E-8
6 SGTC_160 3453-0671 5.50 289.7 µM 3.50E-8 15 1.87E-8
7 SGTC_1246 0422-0085 5.49 105.0 µM 3.79E-8 6 2.03E-8
8 SGTC_1076 itraconazole 5.41 331.0 nM 5.71E-8 13 3.11E-8
9 SGTC_3248 9135562 5.29 49.5 µM 1.11E-7 1 6.17E-8
10 SGTC_2625 euphol 4.86 100.0 µM 9.98E-7 17 6.02E-7
11 SGTC_1929 genistein trimethyl ether 4.83 50.5 µM 1.12E-6 7 6.77E-7
12 SGTC_2195 6536160 4.68 144.2 µM 2.26E-6 60S ribosome export 3 1.40E-6
13 SGTC_1296 1068-0102 4.59 11.9 µM 3.48E-6 6 2.19E-6
14 SGTC_1179 1021-1431 4.46 9.3 µM 6.38E-6 27 4.11E-6
15 SGTC_1335 1486-0900 4.41 202.0 µM 8.09E-6 18 5.26E-6
16 SGTC_1399 3562-5772 4.30 25.0 µM 1.28E-5 RPP1 & pyrimidine depletion 13 8.49E-6
17 SGTC_2613 3',4'-dimethoxydalbergione 4.24 24.6 µM 1.67E-5 15 1.11E-5
18 SGTC_3354 9151612 4.14 71.4 µM 2.58E-5 4 1.75E-5
19 SGTC_2366 9070441 4.13 60.6 µM 2.62E-5 24 1.78E-5
20 SGTC_2362 9071156 3.98 126.0 µM 4.91E-5 9 3.41E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.092 1.02E-7 YOR214C_p YOR214C_p hom Putative protein of unknown function; YOR214C is not an essential gene
0.084 1.15E-6 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.083 1.50E-6 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.078 6.35E-6 YOR376W_d YOR376W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
0.077 7.60E-6 YCL043C PDI1 het Protein disulfide isomerase; multifunctional protein of ER lumen, essential for formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response; PDI1 has a paralog, EUG1, that arose from the whole genome duplication
0.073 2.28E-5 YLR066W SPC3 het Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23
0.071 3.84E-5 YBR264C YPT10 hom Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles
0.071 4.17E-5 YNL075W IMP4 het Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
0.070 4.81E-5 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.070 4.97E-5 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.068 7.64E-5 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.066 1.25E-4 YER073W ALD5 hom Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
0.065 1.73E-4 YGR234W YHB1 hom Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.065 1.76E-4 YOR108W LEU9 hom Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication
0.064 1.91E-4 YDR491C_d YDR491C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data