YGR236C / SPG1

Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR236C / SPG1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:5.45|P-value:1.42E-8 ID:SGTC_130|Compound:0136-0219|FD-Score:3.24|P-value:4.82E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.07|P-value:8.47E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.44|P-value:2.29E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.60|P-value:1.22E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.35|P-value:3.24E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.88|P-value:3.83E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:3.21|P-value:5.43E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.57|P-value:1.38E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.29|P-value:3.88E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.87|P-value:4.05E-5 ID:SGTC_812|Compound:4251-0442|FD-Score:3.49|P-value:1.88E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.09|P-value:8.28E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.48|P-value:1.98E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.91|P-value:3.42E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.55|P-value:1.44E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:4.13|P-value:1.30E-5 ID:SGTC_1114|Compound:scopoletin|FD-Score:5.32|P-value:2.90E-8 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.46|P-value:2.79E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.08|P-value:8.16E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.14|P-value:6.69E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.76|P-value:6.13E-7 ID:SGTC_1164|Compound:k060-0068|FD-Score:5.12|P-value:9.18E-8 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.04|P-value:9.32E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.50|P-value:1.80E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.29|P-value:4.10E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.08|P-value:8.50E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:6.38|P-value:4.00E-11 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.50|P-value:1.80E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.44|P-value:2.29E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:-3.08|P-value:8.09E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.11|P-value:7.84E-4 ID:SGTC_1777|Compound:st045864|FD-Score:4.35|P-value:4.62E-6 ID:SGTC_1935|Compound:st074532|FD-Score:-3.14|P-value:6.69E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.96|P-value:2.70E-5 ID:SGTC_2256|Compound:7954252|FD-Score:4.00|P-value:2.29E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-3.67|P-value:8.99E-5 ID:SGTC_2289|Compound:7946404|FD-Score:-3.27|P-value:4.16E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-3.52|P-value:1.63E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.40|P-value:2.67E-4 ID:SGTC_2380|Compound:9035439|FD-Score:-5.21|P-value:5.12E-8 ID:SGTC_2381|Compound:9035592|FD-Score:3.66|P-value:9.77E-5 ID:SGTC_2435|Compound:5706476|FD-Score:-3.33|P-value:3.28E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.32|P-value:3.64E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:6.02|P-value:4.35E-10 ID:SGTC_2861|Compound:9024595|FD-Score:-4.80|P-value:4.78E-7 ID:SGTC_2862|Compound:9027634|FD-Score:-3.55|P-value:1.45E-4 ID:SGTC_2871|Compound:9038510|FD-Score:5.88|P-value:1.06E-9 ID:SGTC_2879|Compound:9041815|FD-Score:-3.97|P-value:2.47E-5 ID:SGTC_2946|Compound:9065502|FD-Score:-3.36|P-value:3.03E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.22|P-value:5.18E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.59|P-value:1.29E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:5.45|P-value:1.42E-8 ID:SGTC_130|Compound:0136-0219|FD-Score:3.24|P-value:4.82E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.07|P-value:8.47E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.44|P-value:2.29E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.60|P-value:1.22E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.35|P-value:3.24E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.88|P-value:3.83E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:3.21|P-value:5.43E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.57|P-value:1.38E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.29|P-value:3.88E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.87|P-value:4.05E-5 ID:SGTC_812|Compound:4251-0442|FD-Score:3.49|P-value:1.88E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.09|P-value:8.28E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.48|P-value:1.98E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.91|P-value:3.42E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.55|P-value:1.44E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:4.13|P-value:1.30E-5 ID:SGTC_1114|Compound:scopoletin|FD-Score:5.32|P-value:2.90E-8 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.46|P-value:2.79E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.08|P-value:8.16E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.14|P-value:6.69E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:4.76|P-value:6.13E-7 ID:SGTC_1164|Compound:k060-0068|FD-Score:5.12|P-value:9.18E-8 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.04|P-value:9.32E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.50|P-value:1.80E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.29|P-value:4.10E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.08|P-value:8.50E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:6.38|P-value:4.00E-11 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.50|P-value:1.80E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.44|P-value:2.29E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:-3.08|P-value:8.09E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.11|P-value:7.84E-4 ID:SGTC_1777|Compound:st045864|FD-Score:4.35|P-value:4.62E-6 ID:SGTC_1935|Compound:st074532|FD-Score:-3.14|P-value:6.69E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.96|P-value:2.70E-5 ID:SGTC_2256|Compound:7954252|FD-Score:4.00|P-value:2.29E-5 ID:SGTC_2285|Compound:7945142|FD-Score:-3.67|P-value:8.99E-5 ID:SGTC_2289|Compound:7946404|FD-Score:-3.27|P-value:4.16E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-3.52|P-value:1.63E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.40|P-value:2.67E-4 ID:SGTC_2380|Compound:9035439|FD-Score:-5.21|P-value:5.12E-8 ID:SGTC_2381|Compound:9035592|FD-Score:3.66|P-value:9.77E-5 ID:SGTC_2435|Compound:5706476|FD-Score:-3.33|P-value:3.28E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.32|P-value:3.64E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:6.02|P-value:4.35E-10 ID:SGTC_2861|Compound:9024595|FD-Score:-4.80|P-value:4.78E-7 ID:SGTC_2862|Compound:9027634|FD-Score:-3.55|P-value:1.45E-4 ID:SGTC_2871|Compound:9038510|FD-Score:5.88|P-value:1.06E-9 ID:SGTC_2879|Compound:9041815|FD-Score:-3.97|P-value:2.47E-5 ID:SGTC_2946|Compound:9065502|FD-Score:-3.36|P-value:3.03E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.22|P-value:5.18E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.59|P-value:1.29E-4

Top fitness defect scores for YGR236C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1244 0416-0015 6.38 52.5 µM 4.00E-11 ERG2 4 8.95E-11
2 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 6.02 3.7 µM 4.35E-10 12 8.91E-10
3 SGTC_2871 9038510 5.88 13.0 µM 1.06E-9 1 2.10E-9
4 SGTC_6 0844-0013 5.45 19.8 µM 1.42E-8 24 2.56E-8
5 SGTC_1114 scopoletin 5.32 1.7 µM 2.90E-8 8 5.08E-8
6 SGTC_1164 k060-0068 5.12 93.7 µM 9.18E-8 10 1.54E-7
7 SGTC_1144 3486-0183 4.76 12.5 µM 6.13E-7 13 9.60E-7
8 SGTC_1122 capsaicin 4.46 818.6 nM 2.79E-6 17 4.13E-6
9 SGTC_1777 st045864 4.35 34.8 µM 4.62E-6 6 6.72E-6
10 SGTC_1109 tnp00067 4.13 928.3 nM 1.30E-5 14 1.83E-5
11 SGTC_2256 7954252 4.00 200.0 µM 2.29E-5 mitochondrial processes 7 3.15E-5
12 SGTC_2119 5528445 3.96 120.6 µM 2.70E-5 18 3.69E-5
13 SGTC_1102 cgs 12066b 3.91 26.1 µM 3.42E-5 endomembrane recycling 10 4.63E-5
14 SGTC_583 1488-1091 3.88 88.9 µM 3.83E-5 20 5.16E-5
15 SGTC_795 0685-0265 3.87 78.0 µM 4.05E-5 excess fatty acid 29 5.46E-5
16 SGTC_2381 9035592 3.66 200.0 µM 9.77E-5 26 1.27E-4
17 SGTC_354 2783-3500 3.60 4.9 µM 1.22E-4 cell wall 60 1.58E-4
18 SGTC_3294 9122953 3.59 26.3 µM 1.29E-4 tubulin folding & SWR complex 41 1.67E-4
19 SGTC_771 0250-0039 3.57 27.3 µM 1.38E-4 22 1.78E-4
20 SGTC_1170 0310-0127 3.50 64.8 µM 1.80E-4 41 2.30E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.205 3.11E-33 YDR068W DOS2 hom Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.184 5.16E-27 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.160 9.64E-21 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.152 7.90E-19 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.151 1.28E-18 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.144 6.44E-17 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.142 1.13E-16 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.138 8.28E-16 YFL046W_p FMP32_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.136 2.46E-15 YNL242W ATG2 hom Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress
0.134 7.72E-15 YOR113W AZF1 hom Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity
0.130 4.80E-14 YML067C ERV41 hom Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein
0.126 1.97E-13 YNL176C_p TDA7_p hom Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele
0.122 1.16E-12 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.122 1.35E-12 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.118 6.01E-12 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel