YGR237C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR237C / YGR237C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.03|P-value:2.16E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.27|P-value:5.30E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.36|P-value:3.83E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:4.15|P-value:1.27E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.28|P-value:5.11E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.57|P-value:1.43E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-6.06|P-value:5.52E-10 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.46|P-value:2.21E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.58|P-value:1.39E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.19|P-value:5.94E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:8.89|P-value:1.25E-19 ID:SGTC_547|Compound:1120-0019|FD-Score:5.02|P-value:1.87E-7 ID:SGTC_722|Compound:3534-0461|FD-Score:-4.51|P-value:3.03E-6 ID:SGTC_729|Compound:4092-0585|FD-Score:-5.32|P-value:4.59E-8 ID:SGTC_765|Compound:1319-0117|FD-Score:3.34|P-value:3.45E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.39|P-value:2.91E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:4.46|P-value:3.02E-6 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.07|P-value:9.05E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.70|P-value:8.62E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:-3.92|P-value:4.17E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-4.59|P-value:2.07E-6 ID:SGTC_1678|Compound:st019265|FD-Score:3.11|P-value:7.87E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.72|P-value:3.47E-9 ID:SGTC_1723|Compound:st034307|FD-Score:3.08|P-value:8.77E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.27|P-value:4.54E-4 ID:SGTC_1762|Compound:st045503|FD-Score:-3.53|P-value:2.04E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.47|P-value:2.15E-4 ID:SGTC_1977|Compound:st070720|FD-Score:-3.24|P-value:5.97E-4 ID:SGTC_1978|Compound:st071761|FD-Score:-5.01|P-value:2.41E-7 ID:SGTC_1984|Compound:st072354|FD-Score:3.80|P-value:5.71E-5 ID:SGTC_1993|Compound:st073995|FD-Score:3.81|P-value:5.43E-5 ID:SGTC_1999|Compound:st074831|FD-Score:-3.34|P-value:4.15E-4 ID:SGTC_2015|Compound:5119600|FD-Score:-4.14|P-value:1.68E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.25|P-value:4.77E-4 ID:SGTC_2097|Compound:5376186|FD-Score:-3.23|P-value:6.14E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.88|P-value:4.08E-5 ID:SGTC_2239|Compound:6685329|FD-Score:3.37|P-value:3.06E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.40|P-value:3.30E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.13|P-value:1.76E-5 ID:SGTC_2428|Compound:5615643|FD-Score:-3.12|P-value:9.09E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.91|P-value:4.22E-7 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.19|P-value:6.01E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.46|P-value:5.72E-22 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.53|P-value:1.69E-4 ID:SGTC_2804|Compound:7954240|FD-Score:5.02|P-value:1.78E-7 ID:SGTC_2830|Compound:7992007|FD-Score:-3.17|P-value:7.43E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.23|P-value:6.08E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.61|P-value:1.46E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.17|P-value:6.37E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-4.39|P-value:5.33E-6 ID:SGTC_3104|Compound:9120930|FD-Score:5.16|P-value:8.61E-8 ID:SGTC_3106|Compound:9121286|FD-Score:-6.89|P-value:2.18E-12 ID:SGTC_3117|Compound:9124945|FD-Score:-5.96|P-value:1.07E-9 ID:SGTC_3254|Compound:9136651|FD-Score:-3.11|P-value:9.30E-4 ID:SGTC_3345|Compound:9148410|FD-Score:3.25|P-value:4.89E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:4.03|P-value:2.16E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.27|P-value:5.30E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.36|P-value:3.83E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:4.15|P-value:1.27E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.28|P-value:5.11E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.57|P-value:1.43E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-6.06|P-value:5.52E-10 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.46|P-value:2.21E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.58|P-value:1.39E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.19|P-value:5.94E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:8.89|P-value:1.25E-19 ID:SGTC_547|Compound:1120-0019|FD-Score:5.02|P-value:1.87E-7 ID:SGTC_722|Compound:3534-0461|FD-Score:-4.51|P-value:3.03E-6 ID:SGTC_729|Compound:4092-0585|FD-Score:-5.32|P-value:4.59E-8 ID:SGTC_765|Compound:1319-0117|FD-Score:3.34|P-value:3.45E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.39|P-value:2.91E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:4.46|P-value:3.02E-6 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.07|P-value:9.05E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.70|P-value:8.62E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:-3.92|P-value:4.17E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-4.59|P-value:2.07E-6 ID:SGTC_1678|Compound:st019265|FD-Score:3.11|P-value:7.87E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.72|P-value:3.47E-9 ID:SGTC_1723|Compound:st034307|FD-Score:3.08|P-value:8.77E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.27|P-value:4.54E-4 ID:SGTC_1762|Compound:st045503|FD-Score:-3.53|P-value:2.04E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.47|P-value:2.15E-4 ID:SGTC_1977|Compound:st070720|FD-Score:-3.24|P-value:5.97E-4 ID:SGTC_1978|Compound:st071761|FD-Score:-5.01|P-value:2.41E-7 ID:SGTC_1984|Compound:st072354|FD-Score:3.80|P-value:5.71E-5 ID:SGTC_1993|Compound:st073995|FD-Score:3.81|P-value:5.43E-5 ID:SGTC_1999|Compound:st074831|FD-Score:-3.34|P-value:4.15E-4 ID:SGTC_2015|Compound:5119600|FD-Score:-4.14|P-value:1.68E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.25|P-value:4.77E-4 ID:SGTC_2097|Compound:5376186|FD-Score:-3.23|P-value:6.14E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.88|P-value:4.08E-5 ID:SGTC_2239|Compound:6685329|FD-Score:3.37|P-value:3.06E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.40|P-value:3.30E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.13|P-value:1.76E-5 ID:SGTC_2428|Compound:5615643|FD-Score:-3.12|P-value:9.09E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.91|P-value:4.22E-7 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.19|P-value:6.01E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.46|P-value:5.72E-22 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.53|P-value:1.69E-4 ID:SGTC_2804|Compound:7954240|FD-Score:5.02|P-value:1.78E-7 ID:SGTC_2830|Compound:7992007|FD-Score:-3.17|P-value:7.43E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.23|P-value:6.08E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.61|P-value:1.46E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.17|P-value:6.37E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-4.39|P-value:5.33E-6 ID:SGTC_3104|Compound:9120930|FD-Score:5.16|P-value:8.61E-8 ID:SGTC_3106|Compound:9121286|FD-Score:-6.89|P-value:2.18E-12 ID:SGTC_3117|Compound:9124945|FD-Score:-5.96|P-value:1.07E-9 ID:SGTC_3254|Compound:9136651|FD-Score:-3.11|P-value:9.30E-4 ID:SGTC_3345|Compound:9148410|FD-Score:3.25|P-value:4.89E-4

Top fitness defect scores for YGR237C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 9.46 96.7 µM 5.72E-22 calcium & mitochondrial duress 35 1.56E-21
2 SGTC_528 3492-0019 8.89 172.0 µM 1.25E-19 calcium & mitochondrial duress 55 3.09E-19
3 SGTC_1712 st032288 5.72 53.4 µM 3.47E-9 calcium & mitochondrial duress 85 5.32E-9
4 SGTC_3104 9120930 5.16 49.5 µM 8.61E-8 2 1.24E-7
5 SGTC_2804 7954240 5.02 19.5 µM 1.78E-7 10 2.53E-7
6 SGTC_547 1120-0019 5.02 610.0 nM 1.87E-7 azole & statin 14 2.65E-7
7 SGTC_935 2996-0153 4.46 430.0 µM 3.02E-6 PDR1 12 4.03E-6
8 SGTC_73 0327-0325 4.15 16.2 µM 1.27E-5 DNA damage response 42 1.65E-5
9 SGTC_6 0844-0013 4.03 19.8 µM 2.16E-5 80 2.78E-5
10 SGTC_2117 5521686 3.88 200.0 µM 4.08E-5 14 5.16E-5
11 SGTC_1993 st073995 3.81 70.8 µM 5.43E-5 23 6.83E-5
12 SGTC_1984 st072354 3.80 53.1 µM 5.71E-5 17 7.16E-5
13 SGTC_1143 3454-2408 3.70 5.1 µM 8.62E-5 60S ribosome export 3 1.07E-4
14 SGTC_252 miconazole 3.58 1.3 nM 1.39E-4 ergosterol depletion effects on membrane 42 1.71E-4
15 SGTC_121 0557-0495 3.57 61.3 µM 1.43E-4 calcium & mitochondrial duress 78 1.77E-4
16 SGTC_2770 toltrazuril 3.53 17.5 µM 1.69E-4 39 2.07E-4
17 SGTC_1958 st076513 3.47 41.9 µM 2.15E-4 60S ribosome export 49 2.62E-4
18 SGTC_249 wiskostatin 3.46 11.2 µM 2.21E-4 28 2.70E-4
19 SGTC_815 1582-0027 3.39 36.9 µM 2.91E-4 56 3.53E-4
20 SGTC_2239 6685329 3.37 187.6 µM 3.06E-4 53 3.70E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.340 3.01E-91 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.273 3.41E-58 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.259 2.47E-52 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.245 3.59E-47 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.232 2.86E-42 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.226 5.48E-40 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.212 2.83E-35 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.208 4.90E-34 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.199 4.86E-31 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.198 7.33E-31 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.193 1.41E-29 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.180 6.92E-26 YNL288W CAF40 hom Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
0.171 2.32E-23 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.169 6.27E-23 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.162 4.81E-21 YHL002W HSE1 hom Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes