YGR238C / KEL2

Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR238C / KEL2

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:4.17|P-value:1.35E-5 ID:SGTC_47|Compound:0149-0135|FD-Score:-4.96|P-value:4.27E-7 ID:SGTC_244|Compound:nsc-207895|FD-Score:-4.86|P-value:6.88E-7 ID:SGTC_247|Compound:mechlorethamine|FD-Score:-3.49|P-value:2.75E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.14|P-value:9.50E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:4.59|P-value:1.91E-6 ID:SGTC_544|Compound:k015-0020|FD-Score:-4.84|P-value:7.92E-7 ID:SGTC_561|Compound:1550-0330|FD-Score:3.28|P-value:4.66E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.67|P-value:1.07E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:4.46|P-value:3.46E-6 ID:SGTC_861|Compound:0443-0273|FD-Score:3.15|P-value:7.18E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.86|P-value:4.93E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:3.15|P-value:7.20E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.60|P-value:1.82E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.24|P-value:5.25E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.78|P-value:7.00E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:-3.16|P-value:8.99E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.37|P-value:3.36E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.83|P-value:5.76E-7 ID:SGTC_1636|Compound:st007707|FD-Score:6.83|P-value:3.36E-12 ID:SGTC_1734|Compound:st037168|FD-Score:-4.31|P-value:9.43E-6 ID:SGTC_1782|Compound:st039423|FD-Score:3.64|P-value:1.20E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.83|P-value:5.58E-5 ID:SGTC_2009|Compound:4012297|FD-Score:-4.21|P-value:1.48E-5 ID:SGTC_2011|Compound:4012611|FD-Score:-4.61|P-value:2.43E-6 ID:SGTC_2012|Compound:4023501|FD-Score:3.10|P-value:8.61E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.14|P-value:7.46E-4 ID:SGTC_2282|Compound:7944268|FD-Score:4.23|P-value:1.02E-5 ID:SGTC_2347|Compound:9049783|FD-Score:4.05|P-value:2.28E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.17|P-value:6.81E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.71|P-value:1.21E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.39|P-value:3.07E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.16|P-value:7.04E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.01|P-value:2.68E-5 ID:SGTC_2623|Compound:humulene|FD-Score:4.00|P-value:2.79E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.20|P-value:6.11E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.11|P-value:8.34E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.82|P-value:5.86E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.13|P-value:7.79E-4 ID:SGTC_2788|Compound:5282734|FD-Score:5.72|P-value:4.51E-9 ID:SGTC_2791|Compound:5663188|FD-Score:3.69|P-value:1.01E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.50|P-value:2.05E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.12|P-value:8.16E-4 ID:SGTC_2959|Compound:9079155|FD-Score:5.12|P-value:1.29E-7 ID:SGTC_3010|Compound:9080089|FD-Score:-3.34|P-value:4.77E-4 ID:SGTC_3012|Compound:9080433|FD-Score:-3.47|P-value:2.97E-4 ID:SGTC_3020|Compound:9089140|FD-Score:-3.15|P-value:9.24E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.93|P-value:3.78E-5 ID:SGTC_3334|Compound:9142812|FD-Score:3.17|P-value:6.89E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:4.17|P-value:1.35E-5 ID:SGTC_47|Compound:0149-0135|FD-Score:-4.96|P-value:4.27E-7 ID:SGTC_244|Compound:nsc-207895|FD-Score:-4.86|P-value:6.88E-7 ID:SGTC_247|Compound:mechlorethamine|FD-Score:-3.49|P-value:2.75E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.14|P-value:9.50E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:4.59|P-value:1.91E-6 ID:SGTC_544|Compound:k015-0020|FD-Score:-4.84|P-value:7.92E-7 ID:SGTC_561|Compound:1550-0330|FD-Score:3.28|P-value:4.66E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.67|P-value:1.07E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:4.46|P-value:3.46E-6 ID:SGTC_861|Compound:0443-0273|FD-Score:3.15|P-value:7.18E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.86|P-value:4.93E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:3.15|P-value:7.20E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.60|P-value:1.82E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.24|P-value:5.25E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.78|P-value:7.00E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:-3.16|P-value:8.99E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.37|P-value:3.36E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.83|P-value:5.76E-7 ID:SGTC_1636|Compound:st007707|FD-Score:6.83|P-value:3.36E-12 ID:SGTC_1734|Compound:st037168|FD-Score:-4.31|P-value:9.43E-6 ID:SGTC_1782|Compound:st039423|FD-Score:3.64|P-value:1.20E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.83|P-value:5.58E-5 ID:SGTC_2009|Compound:4012297|FD-Score:-4.21|P-value:1.48E-5 ID:SGTC_2011|Compound:4012611|FD-Score:-4.61|P-value:2.43E-6 ID:SGTC_2012|Compound:4023501|FD-Score:3.10|P-value:8.61E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.14|P-value:7.46E-4 ID:SGTC_2282|Compound:7944268|FD-Score:4.23|P-value:1.02E-5 ID:SGTC_2347|Compound:9049783|FD-Score:4.05|P-value:2.28E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.17|P-value:6.81E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.71|P-value:1.21E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.39|P-value:3.07E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.16|P-value:7.04E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.01|P-value:2.68E-5 ID:SGTC_2623|Compound:humulene|FD-Score:4.00|P-value:2.79E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.20|P-value:6.11E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.11|P-value:8.34E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.82|P-value:5.86E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.13|P-value:7.79E-4 ID:SGTC_2788|Compound:5282734|FD-Score:5.72|P-value:4.51E-9 ID:SGTC_2791|Compound:5663188|FD-Score:3.69|P-value:1.01E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.50|P-value:2.05E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.12|P-value:8.16E-4 ID:SGTC_2959|Compound:9079155|FD-Score:5.12|P-value:1.29E-7 ID:SGTC_3010|Compound:9080089|FD-Score:-3.34|P-value:4.77E-4 ID:SGTC_3012|Compound:9080433|FD-Score:-3.47|P-value:2.97E-4 ID:SGTC_3020|Compound:9089140|FD-Score:-3.15|P-value:9.24E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.93|P-value:3.78E-5 ID:SGTC_3334|Compound:9142812|FD-Score:3.17|P-value:6.89E-4

Top fitness defect scores for YGR238C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1636 st007707 6.83 68.9 µM 3.36E-12 17 4.18E-12
2 SGTC_2788 5282734 5.72 71.4 µM 4.51E-9 13 5.44E-9
3 SGTC_2959 9079155 5.12 11.0 µM 1.29E-7 11 1.53E-7
4 SGTC_1631 benzylvanillin 4.83 81.9 µM 5.76E-7 Golgi 12 6.77E-7
5 SGTC_1016 4226-1401 4.60 38.0 µM 1.82E-6 RNA pol III & RNase P/MRP 9 2.12E-6
6 SGTC_474 dl-dihydrosphingosine 4.59 5.0 µM 1.91E-6 17 2.23E-6
7 SGTC_740 k014-0057 4.46 261.0 µM 3.46E-6 16 4.02E-6
8 SGTC_2282 7944268 4.23 200.0 µM 1.02E-5 RPP1 & pyrimidine depletion 21 1.18E-5
9 SGTC_44 0929-0055 4.17 61.2 µM 1.35E-5 29 1.56E-5
10 SGTC_2347 9049783 4.05 174.8 µM 2.28E-5 29 2.61E-5
11 SGTC_2572 astragaloside iv 4.01 100.0 µM 2.68E-5 24 3.08E-5
12 SGTC_2623 humulene 4.00 100.0 µM 2.79E-5 18 3.20E-5
13 SGTC_3332 9141069 3.93 11.2 µM 3.78E-5 16 4.33E-5
14 SGTC_967 1306-0166 3.86 352.0 µM 4.93E-5 38 5.62E-5
15 SGTC_1825 st052143 3.83 62.6 µM 5.58E-5 16 6.36E-5
16 SGTC_2649 anisomycin 3.82 9.6 µM 5.86E-5 7 6.68E-5
17 SGTC_1049 3226-0134 3.78 66.0 µM 7.00E-5 32 7.98E-5
18 SGTC_2791 5663188 3.69 71.4 µM 1.01E-4 RPP1 & pyrimidine depletion 27 1.14E-4
19 SGTC_655 k060-0012 3.67 42.0 µM 1.07E-4 19 1.21E-4
20 SGTC_1782 st039423 3.64 80.6 µM 1.20E-4 28 1.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 4.01E-9 YMR140W SIP5 hom Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress
0.099 7.85E-9 YMR253C_p YMR253C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
0.099 9.35E-9 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.087 4.03E-7 YGR234W YHB1 hom Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.083 1.51E-6 YPL223C GRE1 hom Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
0.083 1.54E-6 YGR247W CPD1 hom Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress
0.082 1.74E-6 YJL100W LSB6 hom Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
0.081 2.48E-6 YAL017W PSK1 hom PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication
0.079 5.22E-6 YBR092C PHO3 hom Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
0.078 6.00E-6 YMR152W YIM1 hom Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.076 9.19E-6 YAL046C AIM1 hom Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss
0.075 1.44E-5 YGL122C NAB2 het Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress
0.075 1.49E-5 YAR027W UIP3 hom Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
0.074 1.71E-5 YJL034W KAR2 het ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p
0.074 1.94E-5 YDR258C HSP78 hom Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates