YGR243W / FMP43

Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR243W / FMP43

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-5.87|P-value:2.11E-9 ID:SGTC_51|Compound:1013-0126|FD-Score:3.81|P-value:6.75E-5 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.81|P-value:6.75E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:4.10|P-value:2.00E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:4.60|P-value:2.06E-6 ID:SGTC_623|Compound:k072-0108|FD-Score:3.65|P-value:1.27E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.18|P-value:7.24E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:3.79|P-value:7.33E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-7.30|P-value:1.40E-13 ID:SGTC_787|Compound:4152-0075|FD-Score:3.52|P-value:2.08E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:5.36|P-value:4.02E-8 ID:SGTC_965|Compound:1291-5240|FD-Score:6.12|P-value:4.40E-10 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.38|P-value:3.51E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.40|P-value:3.31E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.72|P-value:9.75E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:4.26|P-value:9.80E-6 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.26|P-value:5.50E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:4.67|P-value:1.48E-6 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.14|P-value:8.19E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.41|P-value:3.16E-4 ID:SGTC_1777|Compound:st045864|FD-Score:3.53|P-value:2.03E-4 ID:SGTC_1835|Compound:st008666|FD-Score:4.42|P-value:4.86E-6 ID:SGTC_2156|Compound:5649887|FD-Score:3.66|P-value:1.24E-4 ID:SGTC_2190|Compound:6049624|FD-Score:3.18|P-value:7.36E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.22|P-value:6.39E-4 ID:SGTC_2201|Compound:6605497|FD-Score:4.40|P-value:5.26E-6 ID:SGTC_2237|Compound:6667747|FD-Score:3.15|P-value:8.15E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.32|P-value:7.53E-6 ID:SGTC_2266|Compound:7929956|FD-Score:7.31|P-value:1.26E-13 ID:SGTC_2269|Compound:7935389|FD-Score:4.89|P-value:4.93E-7 ID:SGTC_2296|Compound:7971656|FD-Score:3.23|P-value:6.06E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.17|P-value:7.45E-4 ID:SGTC_2340|Compound:7987427|FD-Score:5.12|P-value:1.46E-7 ID:SGTC_2387|Compound:9077560|FD-Score:4.50|P-value:3.25E-6 ID:SGTC_2452|Compound:5863136|FD-Score:3.53|P-value:2.02E-4 ID:SGTC_2469|Compound:5655019|FD-Score:5.48|P-value:2.04E-8 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.43|P-value:2.94E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.26|P-value:5.53E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.76|P-value:8.43E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.19|P-value:6.95E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.33|P-value:4.34E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.34|P-value:4.12E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.39|P-value:3.50E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-5.87|P-value:2.11E-9 ID:SGTC_51|Compound:1013-0126|FD-Score:3.81|P-value:6.75E-5 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.81|P-value:6.75E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:4.10|P-value:2.00E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:4.60|P-value:2.06E-6 ID:SGTC_623|Compound:k072-0108|FD-Score:3.65|P-value:1.27E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.18|P-value:7.24E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:3.79|P-value:7.33E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-7.30|P-value:1.40E-13 ID:SGTC_787|Compound:4152-0075|FD-Score:3.52|P-value:2.08E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:5.36|P-value:4.02E-8 ID:SGTC_965|Compound:1291-5240|FD-Score:6.12|P-value:4.40E-10 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.38|P-value:3.51E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.40|P-value:3.31E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.72|P-value:9.75E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:4.26|P-value:9.80E-6 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.26|P-value:5.50E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:4.67|P-value:1.48E-6 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.14|P-value:8.19E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.41|P-value:3.16E-4 ID:SGTC_1777|Compound:st045864|FD-Score:3.53|P-value:2.03E-4 ID:SGTC_1835|Compound:st008666|FD-Score:4.42|P-value:4.86E-6 ID:SGTC_2156|Compound:5649887|FD-Score:3.66|P-value:1.24E-4 ID:SGTC_2190|Compound:6049624|FD-Score:3.18|P-value:7.36E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.22|P-value:6.39E-4 ID:SGTC_2201|Compound:6605497|FD-Score:4.40|P-value:5.26E-6 ID:SGTC_2237|Compound:6667747|FD-Score:3.15|P-value:8.15E-4 ID:SGTC_2239|Compound:6685329|FD-Score:4.32|P-value:7.53E-6 ID:SGTC_2266|Compound:7929956|FD-Score:7.31|P-value:1.26E-13 ID:SGTC_2269|Compound:7935389|FD-Score:4.89|P-value:4.93E-7 ID:SGTC_2296|Compound:7971656|FD-Score:3.23|P-value:6.06E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.17|P-value:7.45E-4 ID:SGTC_2340|Compound:7987427|FD-Score:5.12|P-value:1.46E-7 ID:SGTC_2387|Compound:9077560|FD-Score:4.50|P-value:3.25E-6 ID:SGTC_2452|Compound:5863136|FD-Score:3.53|P-value:2.02E-4 ID:SGTC_2469|Compound:5655019|FD-Score:5.48|P-value:2.04E-8 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.43|P-value:2.94E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.26|P-value:5.53E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.76|P-value:8.43E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.19|P-value:6.95E-4 ID:SGTC_2913|Compound:7966556|FD-Score:3.33|P-value:4.34E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.34|P-value:4.12E-4 ID:SGTC_3341|Compound:9147222|FD-Score:3.39|P-value:3.50E-4

Top fitness defect scores for YGR243W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2266 7929956 7.31 200.0 µM 1.26E-13 6 1.33E-13
2 SGTC_965 1291-5240 6.12 308.0 µM 4.40E-10 3 4.58E-10
3 SGTC_2469 5655019 5.48 90.8 µM 2.04E-8 6 2.11E-8
4 SGTC_964 1287-0107 5.36 19.4 µM 4.02E-8 cell wall 18 4.15E-8
5 SGTC_2340 7987427 5.12 183.4 µM 1.46E-7 13 1.51E-7
6 SGTC_2269 7935389 4.89 174.4 µM 4.93E-7 tubulin folding & SWR complex 15 5.07E-7
7 SGTC_1358 1509-0022 4.67 2.5 µM 1.48E-6 5 1.52E-6
8 SGTC_557 1315-0110 4.60 16.2 µM 2.06E-6 Golgi 12 2.11E-6
9 SGTC_2387 9077560 4.50 195.1 µM 3.25E-6 10 3.33E-6
10 SGTC_1835 st008666 4.42 49.2 µM 4.86E-6 18 4.98E-6
11 SGTC_2201 6605497 4.40 169.9 µM 5.26E-6 ergosterol biosynthesis 4 5.39E-6
12 SGTC_2239 6685329 4.32 187.6 µM 7.53E-6 20 7.71E-6
13 SGTC_1175 0741-0056 4.26 27.6 µM 9.80E-6 10 1.00E-5
14 SGTC_551 k048-0028 4.10 34.9 µM 2.00E-5 11 2.04E-5
15 SGTC_416 estradiol valerate 3.81 100.0 µM 6.75E-5 15 6.88E-5
16 SGTC_51 1013-0126 3.81 23.4 µM 6.75E-5 31 6.89E-5
17 SGTC_728 3030-5151 3.79 22.5 µM 7.33E-5 18 7.48E-5
18 SGTC_2718 lomofungin 3.76 53.0 µM 8.43E-5 mitochondrial processes 12 8.59E-5
19 SGTC_1091 telmisartan 3.72 47.6 µM 9.75E-5 21 9.94E-5
20 SGTC_2156 5649887 3.66 115.0 µM 1.24E-4 RPP1 & pyrimidine depletion 20 1.26E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.222 6.96E-39 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.204 7.24E-33 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.183 1.23E-26 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.177 4.00E-25 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.177 5.25E-25 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.174 3.66E-24 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.162 3.42E-21 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.159 2.37E-20 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.152 9.81E-19 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.149 3.92E-18 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.145 3.66E-17 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.137 1.57E-15 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.134 5.91E-15 YLR034C SMF3 hom Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress
0.134 7.04E-15 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.133 9.12E-15 YKL034W TUL1 hom Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1