YGR247W / CPD1

Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR247W / CPD1

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:-3.18|P-value:4.38E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.18|P-value:4.72E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.29|P-value:2.83E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:4.10|P-value:1.01E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:3.79|P-value:3.99E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:-3.36|P-value:2.17E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.39|P-value:2.11E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.75|P-value:4.85E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.04|P-value:8.03E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.44|P-value:1.74E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.60|P-value:9.20E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:3.05|P-value:7.58E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:5.42|P-value:8.19E-9 ID:SGTC_784|Compound:4579-0127|FD-Score:-4.07|P-value:1.03E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:3.09|P-value:6.68E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:3.12|P-value:5.88E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:4.37|P-value:2.75E-6 ID:SGTC_971|Compound:1315-0384|FD-Score:3.68|P-value:6.35E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:-3.01|P-value:7.97E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.57|P-value:1.01E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.50|P-value:1.38E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.25|P-value:3.57E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.29|P-value:3.10E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.44|P-value:1.55E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.13|P-value:5.61E-4 ID:SGTC_1636|Compound:st007707|FD-Score:6.34|P-value:1.96E-11 ID:SGTC_1806|Compound:st050005|FD-Score:3.27|P-value:3.41E-4 ID:SGTC_1845|Compound:st056753|FD-Score:5.73|P-value:1.21E-9 ID:SGTC_1917|Compound:st066507|FD-Score:3.33|P-value:2.71E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.39|P-value:2.14E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.54|P-value:1.17E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.13|P-value:5.71E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.54|P-value:1.15E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.20|P-value:4.40E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-4.64|P-value:6.00E-7 ID:SGTC_2412|Compound:st077135|FD-Score:3.18|P-value:4.66E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.13|P-value:5.76E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:4.05|P-value:1.27E-5 ID:SGTC_2696|Compound:st077691|FD-Score:4.38|P-value:2.54E-6 ID:SGTC_2817|Compound:7995342|FD-Score:-4.27|P-value:3.94E-6 ID:SGTC_2819|Compound:7996655|FD-Score:-3.53|P-value:1.10E-4 ID:SGTC_2857|Compound:9024691|FD-Score:4.49|P-value:1.45E-6 ID:SGTC_2888|Compound:9058547|FD-Score:-3.87|P-value:2.53E-5 ID:SGTC_2899|Compound:9053889|FD-Score:3.35|P-value:2.47E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.05|P-value:7.62E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.44|P-value:1.72E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.65|P-value:6.61E-7 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.18|P-value:4.38E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.18|P-value:4.72E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.29|P-value:2.83E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:4.10|P-value:1.01E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:3.79|P-value:3.99E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:-3.36|P-value:2.17E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.39|P-value:2.11E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.75|P-value:4.85E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:3.04|P-value:8.03E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.44|P-value:1.74E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.60|P-value:9.20E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:3.05|P-value:7.58E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:5.42|P-value:8.19E-9 ID:SGTC_784|Compound:4579-0127|FD-Score:-4.07|P-value:1.03E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:3.09|P-value:6.68E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:3.12|P-value:5.88E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:4.37|P-value:2.75E-6 ID:SGTC_971|Compound:1315-0384|FD-Score:3.68|P-value:6.35E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:-3.01|P-value:7.97E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.57|P-value:1.01E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.50|P-value:1.38E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.25|P-value:3.57E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.29|P-value:3.10E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.44|P-value:1.55E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.13|P-value:5.61E-4 ID:SGTC_1636|Compound:st007707|FD-Score:6.34|P-value:1.96E-11 ID:SGTC_1806|Compound:st050005|FD-Score:3.27|P-value:3.41E-4 ID:SGTC_1845|Compound:st056753|FD-Score:5.73|P-value:1.21E-9 ID:SGTC_1917|Compound:st066507|FD-Score:3.33|P-value:2.71E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.39|P-value:2.14E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.54|P-value:1.17E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.13|P-value:5.71E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.54|P-value:1.15E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.20|P-value:4.40E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-4.64|P-value:6.00E-7 ID:SGTC_2412|Compound:st077135|FD-Score:3.18|P-value:4.66E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.13|P-value:5.76E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:4.05|P-value:1.27E-5 ID:SGTC_2696|Compound:st077691|FD-Score:4.38|P-value:2.54E-6 ID:SGTC_2817|Compound:7995342|FD-Score:-4.27|P-value:3.94E-6 ID:SGTC_2819|Compound:7996655|FD-Score:-3.53|P-value:1.10E-4 ID:SGTC_2857|Compound:9024691|FD-Score:4.49|P-value:1.45E-6 ID:SGTC_2888|Compound:9058547|FD-Score:-3.87|P-value:2.53E-5 ID:SGTC_2899|Compound:9053889|FD-Score:3.35|P-value:2.47E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.05|P-value:7.62E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.44|P-value:1.72E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.65|P-value:6.61E-7

Top fitness defect scores for YGR247W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1636 st007707 6.34 68.9 µM 1.96E-11 19 1.13E-10
2 SGTC_1845 st056753 5.73 3.0 µM 1.21E-9 TSC3-RPN4 11 5.05E-9
3 SGTC_770 0389-1121 5.42 67.2 µM 8.19E-9 RPP1 & pyrimidine depletion 4 2.94E-8
4 SGTC_3217 9129673 4.65 49.5 µM 6.61E-7 16 1.69E-6
5 SGTC_2857 9024691 4.49 58.4 µM 1.45E-6 12 3.48E-6
6 SGTC_2696 st077691 4.38 74.3 µM 2.54E-6 19 5.86E-6
7 SGTC_884 0851-0618 4.37 334.0 µM 2.75E-6 10 6.30E-6
8 SGTC_416 estradiol valerate 4.10 100.0 µM 1.01E-5 6 2.10E-5
9 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 4.05 100.0 µM 1.27E-5 20 2.60E-5
10 SGTC_617 3770-0098 3.79 35.0 µM 3.99E-5 exosome 18 7.46E-5
11 SGTC_680 0417-1641 3.75 114.0 µM 4.85E-5 RPP1 & pyrimidine depletion 20 8.94E-5
12 SGTC_971 1315-0384 3.68 26.7 µM 6.35E-5 cell wall signaling 31 1.15E-4
13 SGTC_736 0958-0254 3.60 92.6 µM 9.20E-5 Golgi 43 1.62E-4
14 SGTC_1015 4130-4525 3.57 82.0 µM 1.01E-4 60S ribosome export 33 1.77E-4
15 SGTC_2182 6325192 3.54 200.0 µM 1.15E-4 Golgi 22 1.98E-4
16 SGTC_2111 5486399 3.54 200.0 µM 1.17E-4 66 2.02E-4
17 SGTC_1043 0916-0009 3.50 19.3 µM 1.38E-4 37 2.35E-4
18 SGTC_3212 9128307 3.44 49.5 µM 1.72E-4 70 2.88E-4
19 SGTC_701 4424-0219 3.44 185.0 µM 1.74E-4 calcium & mitochondrial duress 28 2.91E-4
20 SGTC_676 falcarinol 3.39 140.0 µM 2.11E-4 74 3.48E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 2.77E-12 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.114 4.31E-11 YMR283C RIT1 hom 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA
0.102 3.43E-9 YMR253C_p YMR253C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
0.100 6.72E-9 YGR256W GND2 hom 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication
0.098 1.40E-8 YBL043W ECM13 hom Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication
0.097 2.03E-8 YPR013C_p CMR3_p hom Putative zinc finger protein; YPR013C is not an essential gene
0.093 5.98E-8 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.093 7.93E-8 YLR320W MMS22 hom Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork, such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; required for accurate meiotic chromosome segregation
0.089 2.15E-7 YOR032C HMS1 hom Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
0.085 7.41E-7 YHR154W RTT107 hom Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress
0.083 1.54E-6 YGR238C KEL2 hom Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
0.081 2.51E-6 YNL232W CSL4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)
0.081 2.72E-6 YGR235C MOS2 hom Mitochondrial inner membrane protein; non-essential component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.079 5.02E-6 YDR352W YPQ2 hom Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter
0.078 5.42E-6 YJL034W KAR2 het ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p