YGR249W / MGA1

Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR249W / MGA1

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:4.04|P-value:4.02E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.20|P-value:9.25E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:6.41|P-value:1.95E-10 ID:SGTC_160|Compound:3453-0671|FD-Score:3.18|P-value:9.28E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:4.67|P-value:2.51E-6 ID:SGTC_481|Compound:bay k-8644|FD-Score:5.81|P-value:7.14E-9 ID:SGTC_555|Compound:4296-0685|FD-Score:3.19|P-value:9.24E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:4.80|P-value:1.39E-6 ID:SGTC_628|Compound:1636-0253|FD-Score:3.93|P-value:6.10E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:3.38|P-value:4.71E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.69|P-value:1.56E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.56|P-value:2.47E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:4.27|P-value:1.53E-5 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.27|P-value:7.06E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.74|P-value:1.79E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.82|P-value:9.38E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.52|P-value:3.06E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:4.77|P-value:1.61E-6 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.18|P-value:9.54E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.68|P-value:1.59E-4 ID:SGTC_1594|Compound:piperine|FD-Score:4.10|P-value:3.04E-5 ID:SGTC_1622|Compound:st003707|FD-Score:3.78|P-value:1.12E-4 ID:SGTC_1691|Compound:st019933|FD-Score:-3.41|P-value:4.54E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-3.33|P-value:5.88E-4 ID:SGTC_1728|Compound:st035614|FD-Score:7.33|P-value:4.25E-13 ID:SGTC_1730|Compound:st033808|FD-Score:-3.48|P-value:3.51E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-5.22|P-value:1.80E-7 ID:SGTC_1732|Compound:st034308|FD-Score:-5.16|P-value:2.52E-7 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.45|P-value:3.80E-4 ID:SGTC_2024|Compound:5144227|FD-Score:-3.82|P-value:9.97E-5 ID:SGTC_2086|Compound:5274770|FD-Score:3.49|P-value:3.20E-4 ID:SGTC_2784|Compound:7567673|FD-Score:4.05|P-value:3.87E-5 ID:SGTC_2801|Compound:7907800|FD-Score:5.54|P-value:3.15E-8 ID:SGTC_2844|Compound:9010103|FD-Score:3.63|P-value:1.96E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.19|P-value:9.08E-4 ID:SGTC_2958|Compound:9077254|FD-Score:4.59|P-value:3.73E-6 ID:SGTC_3054|Compound:9094397|FD-Score:3.39|P-value:4.62E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.72|P-value:1.48E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.71|P-value:1.44E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.47|P-value:3.52E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.25|P-value:7.57E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:4.04|P-value:4.02E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.20|P-value:9.25E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:6.41|P-value:1.95E-10 ID:SGTC_160|Compound:3453-0671|FD-Score:3.18|P-value:9.28E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:4.67|P-value:2.51E-6 ID:SGTC_481|Compound:bay k-8644|FD-Score:5.81|P-value:7.14E-9 ID:SGTC_555|Compound:4296-0685|FD-Score:3.19|P-value:9.24E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:4.80|P-value:1.39E-6 ID:SGTC_628|Compound:1636-0253|FD-Score:3.93|P-value:6.10E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:3.38|P-value:4.71E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.69|P-value:1.56E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.56|P-value:2.47E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:4.27|P-value:1.53E-5 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.27|P-value:7.06E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.74|P-value:1.79E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.82|P-value:9.38E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.52|P-value:3.06E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:4.77|P-value:1.61E-6 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.18|P-value:9.54E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.68|P-value:1.59E-4 ID:SGTC_1594|Compound:piperine|FD-Score:4.10|P-value:3.04E-5 ID:SGTC_1622|Compound:st003707|FD-Score:3.78|P-value:1.12E-4 ID:SGTC_1691|Compound:st019933|FD-Score:-3.41|P-value:4.54E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-3.33|P-value:5.88E-4 ID:SGTC_1728|Compound:st035614|FD-Score:7.33|P-value:4.25E-13 ID:SGTC_1730|Compound:st033808|FD-Score:-3.48|P-value:3.51E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-5.22|P-value:1.80E-7 ID:SGTC_1732|Compound:st034308|FD-Score:-5.16|P-value:2.52E-7 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.45|P-value:3.80E-4 ID:SGTC_2024|Compound:5144227|FD-Score:-3.82|P-value:9.97E-5 ID:SGTC_2086|Compound:5274770|FD-Score:3.49|P-value:3.20E-4 ID:SGTC_2784|Compound:7567673|FD-Score:4.05|P-value:3.87E-5 ID:SGTC_2801|Compound:7907800|FD-Score:5.54|P-value:3.15E-8 ID:SGTC_2844|Compound:9010103|FD-Score:3.63|P-value:1.96E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.19|P-value:9.08E-4 ID:SGTC_2958|Compound:9077254|FD-Score:4.59|P-value:3.73E-6 ID:SGTC_3054|Compound:9094397|FD-Score:3.39|P-value:4.62E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.72|P-value:1.48E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.71|P-value:1.44E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.47|P-value:3.52E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.25|P-value:7.57E-4

Top fitness defect scores for YGR249W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1728 st035614 7.33 33.8 µM 4.25E-13 5 1.18E-13
2 SGTC_82 0054-0107 6.41 293.8 µM 1.95E-10 1 7.32E-11
3 SGTC_481 bay k-8644 5.81 50.0 µM 7.14E-9 9 3.20E-9
4 SGTC_2801 7907800 5.54 81.8 µM 3.15E-8 8 1.51E-8
5 SGTC_557 1315-0110 4.80 16.2 µM 1.39E-6 Golgi 8 8.02E-7
6 SGTC_1513 0337-0559 4.77 19.0 µM 1.61E-6 7 9.38E-7
7 SGTC_1195 1502-0147 4.74 41.1 µM 1.79E-6 10 1.04E-6
8 SGTC_388 3',4'-dichloroisocoumarin 4.67 16.7 µM 2.51E-6 6 1.49E-6
9 SGTC_2958 9077254 4.59 16.7 µM 3.73E-6 13 2.25E-6
10 SGTC_1108 betulinic acid 4.27 729.1 nM 1.53E-5 11 9.91E-6
11 SGTC_1594 piperine 4.10 70.1 µM 3.04E-5 10 2.03E-5
12 SGTC_2784 7567673 4.05 72.7 µM 3.87E-5 iron homeostasis 27 2.61E-5
13 SGTC_37 0566-0070 4.04 1.6 µM 4.02E-5 25 2.72E-5
14 SGTC_628 1636-0253 3.93 16.0 µM 6.10E-5 sphingolipid biosynthesis & PDR1 34 4.21E-5
15 SGTC_1239 0337-0584 3.82 35.4 µM 9.38E-5 unfolded protein response 63 6.60E-5
16 SGTC_1622 st003707 3.78 19.4 µM 1.12E-4 calcium & mitochondrial duress 46 7.97E-5
17 SGTC_3165 9101544 3.71 49.5 µM 1.44E-4 14 1.03E-4
18 SGTC_1092 toremifene 3.69 6.3 µM 1.56E-4 29 1.12E-4
19 SGTC_1592 4',5'-dihydroxyflavone 3.68 8.8 µM 1.59E-4 60S ribosome export 20 1.15E-4
20 SGTC_2844 9010103 3.63 26.0 µM 1.96E-4 41 1.43E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 3.42E-25 YGR067C_p YGR067C_p hom Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
0.101 4.14E-9 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.096 2.38E-8 YNR032W PPG1 hom Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases
0.096 2.83E-8 YPR073C LTP1 hom Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine
0.094 4.68E-8 YGL151W NUT1 hom Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
0.088 2.95E-7 YDR171W HSP42 hom Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.087 4.20E-7 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.086 6.00E-7 YKL188C PXA2 hom Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder
0.086 6.70E-7 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.085 7.41E-7 YBR222C PCS60 hom Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase
0.084 1.27E-6 YDL129W YDL129W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress
0.080 3.26E-6 YGR099W TEL2 het Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1
0.079 4.79E-6 YJL211C_d YJL211C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2
0.077 7.42E-6 YDR464W SPP41 het Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
0.075 1.27E-5 YGL085W_p LCL3_p hom Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS