YGR251W / NOP19

Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR251W / NOP19

Click on Significant Values for Screen Details ID:SGTC_324|Compound:1315-0088|FD-Score:3.01|P-value:4.48E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.53|P-value:5.18E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:-4.92|P-value:6.62E-8 ID:SGTC_758|Compound:0868-0029|FD-Score:-6.22|P-value:1.11E-11 ID:SGTC_759|Compound:3486-0358|FD-Score:3.71|P-value:2.27E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:2.88|P-value:7.34E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.14|P-value:2.68E-6 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.06|P-value:3.70E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-3.26|P-value:2.51E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.15|P-value:1.61E-8 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.06|P-value:5.46E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.72|P-value:3.46E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.21|P-value:3.05E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.17|P-value:3.68E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.61|P-value:5.76E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.33|P-value:1.88E-4 ID:SGTC_1614|Compound:st002383|FD-Score:-2.92|P-value:9.50E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.16|P-value:3.78E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.43|P-value:8.06E-5 ID:SGTC_1905|Compound:st060207|FD-Score:2.91|P-value:6.46E-4 ID:SGTC_2013|Compound:4024628|FD-Score:2.87|P-value:7.62E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.75|P-value:3.02E-5 ID:SGTC_2121|Compound:5257820|FD-Score:2.97|P-value:5.16E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:-3.22|P-value:2.97E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-6.05|P-value:3.82E-11 ID:SGTC_2320|Compound:7373003|FD-Score:-4.00|P-value:9.53E-6 ID:SGTC_2324|Compound:6149169|FD-Score:-3.80|P-value:2.37E-5 ID:SGTC_2357|Compound:9067248|FD-Score:-2.93|P-value:8.91E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-2.94|P-value:8.75E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-3.43|P-value:1.26E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.72|P-value:2.11E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.31|P-value:1.30E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.75|P-value:3.08E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-5.66|P-value:5.96E-10 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.19|P-value:3.35E-4 ID:SGTC_2525|Compound:harmine|FD-Score:-2.99|P-value:7.26E-4 ID:SGTC_2551|Compound:apiole|FD-Score:2.97|P-value:5.18E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.96|P-value:6.79E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.19|P-value:3.35E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.74|P-value:1.90E-5 ID:SGTC_2683|Compound:piperine|FD-Score:3.02|P-value:4.37E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-4.69|P-value:2.53E-7 ID:SGTC_2695|Compound:st077686|FD-Score:-4.21|P-value:3.32E-6 ID:SGTC_2696|Compound:st077691|FD-Score:-3.40|P-value:1.43E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.12|P-value:3.08E-6 ID:SGTC_2834|Compound:9001755|FD-Score:-3.01|P-value:6.76E-4 ID:SGTC_2835|Compound:9006588|FD-Score:4.38|P-value:7.54E-7 ID:SGTC_2841|Compound:9004761|FD-Score:-4.10|P-value:5.80E-6 ID:SGTC_2950|Compound:9072895|FD-Score:5.34|P-value:2.42E-9 ID:SGTC_2967|Compound:9089538|FD-Score:4.91|P-value:3.73E-8 ID:SGTC_2973|Compound:9094665|FD-Score:3.48|P-value:6.22E-5 ID:SGTC_3137|Compound:9097352|FD-Score:2.80|P-value:9.92E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.45|P-value:7.23E-5 ID:SGTC_3223|Compound:9129970|FD-Score:3.20|P-value:2.09E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.79|P-value:2.50E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-3.01|P-value:6.82E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.17|P-value:2.34E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.01|P-value:4.48E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.53|P-value:5.18E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:-4.92|P-value:6.62E-8 ID:SGTC_758|Compound:0868-0029|FD-Score:-6.22|P-value:1.11E-11 ID:SGTC_759|Compound:3486-0358|FD-Score:3.71|P-value:2.27E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:2.88|P-value:7.34E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.14|P-value:2.68E-6 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.06|P-value:3.70E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-3.26|P-value:2.51E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.15|P-value:1.61E-8 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.06|P-value:5.46E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.72|P-value:3.46E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.21|P-value:3.05E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.17|P-value:3.68E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.61|P-value:5.76E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.33|P-value:1.88E-4 ID:SGTC_1614|Compound:st002383|FD-Score:-2.92|P-value:9.50E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.16|P-value:3.78E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.43|P-value:8.06E-5 ID:SGTC_1905|Compound:st060207|FD-Score:2.91|P-value:6.46E-4 ID:SGTC_2013|Compound:4024628|FD-Score:2.87|P-value:7.62E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.75|P-value:3.02E-5 ID:SGTC_2121|Compound:5257820|FD-Score:2.97|P-value:5.16E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:-3.22|P-value:2.97E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-6.05|P-value:3.82E-11 ID:SGTC_2320|Compound:7373003|FD-Score:-4.00|P-value:9.53E-6 ID:SGTC_2324|Compound:6149169|FD-Score:-3.80|P-value:2.37E-5 ID:SGTC_2357|Compound:9067248|FD-Score:-2.93|P-value:8.91E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-2.94|P-value:8.75E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-3.43|P-value:1.26E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.72|P-value:2.11E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.31|P-value:1.30E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.75|P-value:3.08E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-5.66|P-value:5.96E-10 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.19|P-value:3.35E-4 ID:SGTC_2525|Compound:harmine|FD-Score:-2.99|P-value:7.26E-4 ID:SGTC_2551|Compound:apiole|FD-Score:2.97|P-value:5.18E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.96|P-value:6.79E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.19|P-value:3.35E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.74|P-value:1.90E-5 ID:SGTC_2683|Compound:piperine|FD-Score:3.02|P-value:4.37E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-4.69|P-value:2.53E-7 ID:SGTC_2695|Compound:st077686|FD-Score:-4.21|P-value:3.32E-6 ID:SGTC_2696|Compound:st077691|FD-Score:-3.40|P-value:1.43E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.12|P-value:3.08E-6 ID:SGTC_2834|Compound:9001755|FD-Score:-3.01|P-value:6.76E-4 ID:SGTC_2835|Compound:9006588|FD-Score:4.38|P-value:7.54E-7 ID:SGTC_2841|Compound:9004761|FD-Score:-4.10|P-value:5.80E-6 ID:SGTC_2950|Compound:9072895|FD-Score:5.34|P-value:2.42E-9 ID:SGTC_2967|Compound:9089538|FD-Score:4.91|P-value:3.73E-8 ID:SGTC_2973|Compound:9094665|FD-Score:3.48|P-value:6.22E-5 ID:SGTC_3137|Compound:9097352|FD-Score:2.80|P-value:9.92E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.45|P-value:7.23E-5 ID:SGTC_3223|Compound:9129970|FD-Score:3.20|P-value:2.09E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.79|P-value:2.50E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-3.01|P-value:6.82E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.17|P-value:2.34E-4

Top fitness defect scores for YGR251W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2950 9072895 5.34 21.5 µM 2.42E-9 4 4.57E-8 0.29
2 SGTC_2967 9089538 4.91 49.9 µM 3.73E-8 5 4.62E-7 0.08
3 SGTC_2835 9006588 4.38 71.4 µM 7.54E-7 8 5.88E-6 0.56
4 SGTC_1008 4106-0037 4.14 6.0 µM 2.68E-6 PDR1 5 1.72E-5 0.49
5 SGTC_2816 7982706 4.12 58.4 µM 3.08E-6 azole & statin 9 1.93E-5 0.07
6 SGTC_2568 diosmetin 3.96 100.0 µM 6.79E-6 8 3.77E-5 0.06
7 SGTC_2657 nystatin 3.74 74.4 µM 1.90E-5 7 9.03E-5 0.02
8 SGTC_2475 5812728 3.72 15.0 µM 2.11E-5 mitochondrial processes 18 9.85E-5 0.16
9 SGTC_759 3486-0358 3.71 89.3 µM 2.27E-5 9 1.05E-4 0.23
10 SGTC_474 dl-dihydrosphingosine 3.53 5.0 µM 5.18E-5 9 2.11E-4 0.03
11 SGTC_2973 9094665 3.48 18.0 µM 6.22E-5 NEO1 21 2.46E-4 0.03
12 SGTC_3143 9086658 3.45 49.5 µM 7.23E-5 20 2.79E-4 0.08
13 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 3.43 14.9 µM 8.06E-5 12 3.06E-4 0.17
14 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.31 3.7 µM 1.30E-4 19 4.60E-4 0.09
15 SGTC_3223 9129970 3.20 49.5 µM 2.09E-4 13 6.87E-4 0.05
16 SGTC_3314 9135860 3.17 59.4 µM 2.34E-4 6 7.55E-4 0.05
17 SGTC_1080 nisoldipine 3.06 24.4 µM 3.70E-4 TSC3-RPN4 15 0.00111 0.01
18 SGTC_2683 piperine 3.02 63.0 µM 4.37E-4 7 0.00128 0.04
19 SGTC_324 1315-0088 3.01 19.6 µM 4.48E-4 RSC & ERG11 21 0.00131 0.02
20 SGTC_2121 5257820 2.97 149.6 µM 5.16E-4 10 0.00148 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.215 2.96E-36 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.191 8.84E-29 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.174 3.26E-24 YGL114W_p YGL114W_p hom Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.173 6.28E-24 YDR242W AMD2 hom Putative amidase
0.153 4.34E-19 YDR056C_p YDR056C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein
0.152 6.62E-19 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.147 1.11E-17 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.140 3.54E-16 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.139 5.51E-16 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.138 9.49E-16 YHR122W CIA2 het Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B
0.136 3.41E-15 YML100W TSL1 hom Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication
0.134 6.26E-15 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.134 6.95E-15 YER172C BRR2 het RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.132 1.39E-14 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.127 1.71E-13 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions