YGR255C / COQ6

Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR255C / COQ6

Click on Significant Values for Screen Details ID:SGTC_29|Compound:0299-0004|FD-Score:-3.72|P-value:1.51E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:17.60|P-value:4.99E-66 ID:SGTC_58|Compound:0957-0393|FD-Score:4.27|P-value:1.55E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:13.90|P-value:4.33E-42 ID:SGTC_67|Compound:0335-0847|FD-Score:6.59|P-value:6.49E-11 ID:SGTC_86|Compound:0417-1630|FD-Score:12.50|P-value:1.04E-34 ID:SGTC_134|Compound:0269-0018|FD-Score:6.95|P-value:5.85E-12 ID:SGTC_137|Compound:0438-0332|FD-Score:4.76|P-value:1.69E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:9.79|P-value:7.05E-22 ID:SGTC_158|Compound:k038-0087|FD-Score:21.10|P-value:4.27E-94 ID:SGTC_165|Compound:k038-0023|FD-Score:5.36|P-value:8.64E-8 ID:SGTC_168|Compound:3970-0862|FD-Score:3.48|P-value:3.35E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:9.12|P-value:3.04E-19 ID:SGTC_216|Compound:k038-0035|FD-Score:11.20|P-value:2.79E-28 ID:SGTC_236|Compound:1509-0011|FD-Score:13.00|P-value:4.43E-37 ID:SGTC_294|Compound:k038-0071|FD-Score:4.25|P-value:1.70E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:6.50|P-value:1.15E-10 ID:SGTC_386|Compound:1509-0011|FD-Score:9.53|P-value:7.45E-21 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:6.24|P-value:5.57E-10 ID:SGTC_420|Compound:mitomycin C|FD-Score:-3.48|P-value:3.65E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.23|P-value:8.00E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:-4.50|P-value:6.15E-6 ID:SGTC_594|Compound:1487-1584|FD-Score:-3.39|P-value:4.99E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:-4.10|P-value:3.35E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:-3.58|P-value:2.52E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:7.41|P-value:2.43E-13 ID:SGTC_642|Compound:0335-0876|FD-Score:4.39|P-value:9.22E-6 ID:SGTC_709|Compound:3807-1509|FD-Score:3.38|P-value:4.80E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:9.57|P-value:5.03E-21 ID:SGTC_768|Compound:0384-0033|FD-Score:4.00|P-value:4.79E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:4.09|P-value:3.32E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:-4.24|P-value:1.85E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:8.33|P-value:2.18E-16 ID:SGTC_890|Compound:0929-0006|FD-Score:3.47|P-value:3.47E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.20|P-value:8.90E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:7.29|P-value:5.88E-13 ID:SGTC_952|Compound:1185-0122|FD-Score:7.54|P-value:9.95E-14 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.17|P-value:9.65E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:7.91|P-value:5.89E-15 ID:SGTC_1163|Compound:k060-0048|FD-Score:4.08|P-value:3.45E-5 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.35|P-value:1.10E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:4.67|P-value:2.54E-6 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.53|P-value:2.85E-4 ID:SGTC_1605|Compound:st000082|FD-Score:-3.51|P-value:3.25E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.69|P-value:1.56E-4 ID:SGTC_1635|Compound:st007035|FD-Score:12.30|P-value:3.15E-33 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.29|P-value:6.96E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.23|P-value:8.13E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.85|P-value:8.64E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.30|P-value:6.78E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.96|P-value:7.15E-7 ID:SGTC_1800|Compound:st050079|FD-Score:-3.24|P-value:8.07E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.55|P-value:2.77E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-3.34|P-value:5.82E-4 ID:SGTC_2043|Compound:5101342|FD-Score:4.30|P-value:1.38E-5 ID:SGTC_2111|Compound:5486399|FD-Score:4.64|P-value:2.97E-6 ID:SGTC_2159|Compound:5658611|FD-Score:-3.46|P-value:3.80E-4 ID:SGTC_2231|Compound:micatex|FD-Score:3.78|P-value:1.11E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.31|P-value:6.40E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-3.22|P-value:8.63E-4 ID:SGTC_2396|Compound:5342950|FD-Score:5.05|P-value:4.15E-7 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.74|P-value:1.29E-4 ID:SGTC_2459|Compound:5811157|FD-Score:4.96|P-value:6.47E-7 ID:SGTC_2467|Compound:5474540|FD-Score:3.46|P-value:3.67E-4 ID:SGTC_2475|Compound:5812728|FD-Score:4.07|P-value:3.61E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:3.90|P-value:6.94E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.30|P-value:6.25E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.65|P-value:1.85E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-3.32|P-value:6.21E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.42|P-value:6.60E-8 ID:SGTC_2912|Compound:7964298|FD-Score:4.07|P-value:3.53E-5 ID:SGTC_2935|Compound:9038016|FD-Score:4.18|P-value:2.24E-5 ID:SGTC_3330|Compound:9141424|FD-Score:-3.77|P-value:1.25E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.72|P-value:1.51E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:17.60|P-value:4.99E-66 ID:SGTC_58|Compound:0957-0393|FD-Score:4.27|P-value:1.55E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:13.90|P-value:4.33E-42 ID:SGTC_67|Compound:0335-0847|FD-Score:6.59|P-value:6.49E-11 ID:SGTC_86|Compound:0417-1630|FD-Score:12.50|P-value:1.04E-34 ID:SGTC_134|Compound:0269-0018|FD-Score:6.95|P-value:5.85E-12 ID:SGTC_137|Compound:0438-0332|FD-Score:4.76|P-value:1.69E-6 ID:SGTC_142|Compound:0335-0849|FD-Score:9.79|P-value:7.05E-22 ID:SGTC_158|Compound:k038-0087|FD-Score:21.10|P-value:4.27E-94 ID:SGTC_165|Compound:k038-0023|FD-Score:5.36|P-value:8.64E-8 ID:SGTC_168|Compound:3970-0862|FD-Score:3.48|P-value:3.35E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:9.12|P-value:3.04E-19 ID:SGTC_216|Compound:k038-0035|FD-Score:11.20|P-value:2.79E-28 ID:SGTC_236|Compound:1509-0011|FD-Score:13.00|P-value:4.43E-37 ID:SGTC_294|Compound:k038-0071|FD-Score:4.25|P-value:1.70E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:6.50|P-value:1.15E-10 ID:SGTC_386|Compound:1509-0011|FD-Score:9.53|P-value:7.45E-21 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:6.24|P-value:5.57E-10 ID:SGTC_420|Compound:mitomycin C|FD-Score:-3.48|P-value:3.65E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.23|P-value:8.00E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:-4.50|P-value:6.15E-6 ID:SGTC_594|Compound:1487-1584|FD-Score:-3.39|P-value:4.99E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:-4.10|P-value:3.35E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:-3.58|P-value:2.52E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:7.41|P-value:2.43E-13 ID:SGTC_642|Compound:0335-0876|FD-Score:4.39|P-value:9.22E-6 ID:SGTC_709|Compound:3807-1509|FD-Score:3.38|P-value:4.80E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:9.57|P-value:5.03E-21 ID:SGTC_768|Compound:0384-0033|FD-Score:4.00|P-value:4.79E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:4.09|P-value:3.32E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:-4.24|P-value:1.85E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:8.33|P-value:2.18E-16 ID:SGTC_890|Compound:0929-0006|FD-Score:3.47|P-value:3.47E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.20|P-value:8.90E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:7.29|P-value:5.88E-13 ID:SGTC_952|Compound:1185-0122|FD-Score:7.54|P-value:9.95E-14 ID:SGTC_1053|Compound:3366-3204|FD-Score:3.17|P-value:9.65E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:7.91|P-value:5.89E-15 ID:SGTC_1163|Compound:k060-0048|FD-Score:4.08|P-value:3.45E-5 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.35|P-value:1.10E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:4.67|P-value:2.54E-6 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.53|P-value:2.85E-4 ID:SGTC_1605|Compound:st000082|FD-Score:-3.51|P-value:3.25E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.69|P-value:1.56E-4 ID:SGTC_1635|Compound:st007035|FD-Score:12.30|P-value:3.15E-33 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.29|P-value:6.96E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.23|P-value:8.13E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.85|P-value:8.64E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.30|P-value:6.78E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.96|P-value:7.15E-7 ID:SGTC_1800|Compound:st050079|FD-Score:-3.24|P-value:8.07E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.55|P-value:2.77E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-3.34|P-value:5.82E-4 ID:SGTC_2043|Compound:5101342|FD-Score:4.30|P-value:1.38E-5 ID:SGTC_2111|Compound:5486399|FD-Score:4.64|P-value:2.97E-6 ID:SGTC_2159|Compound:5658611|FD-Score:-3.46|P-value:3.80E-4 ID:SGTC_2231|Compound:micatex|FD-Score:3.78|P-value:1.11E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.31|P-value:6.40E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-3.22|P-value:8.63E-4 ID:SGTC_2396|Compound:5342950|FD-Score:5.05|P-value:4.15E-7 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.74|P-value:1.29E-4 ID:SGTC_2459|Compound:5811157|FD-Score:4.96|P-value:6.47E-7 ID:SGTC_2467|Compound:5474540|FD-Score:3.46|P-value:3.67E-4 ID:SGTC_2475|Compound:5812728|FD-Score:4.07|P-value:3.61E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:3.90|P-value:6.94E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.30|P-value:6.25E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.65|P-value:1.85E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-3.32|P-value:6.21E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.42|P-value:6.60E-8 ID:SGTC_2912|Compound:7964298|FD-Score:4.07|P-value:3.53E-5 ID:SGTC_2935|Compound:9038016|FD-Score:4.18|P-value:2.24E-5 ID:SGTC_3330|Compound:9141424|FD-Score:-3.77|P-value:1.25E-4

Top fitness defect scores for YGR255C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_158 k038-0087 21.10 26.4 µM 4.27E-94 ubiquinone biosynthesis & proteasome 4 6.22E-99
2 SGTC_36 0335-0881 17.60 14.2 µM 4.99E-66 ubiquinone biosynthesis & proteasome 9 2.22E-69
3 SGTC_64 000l-0018 13.90 272.1 µM 4.33E-42 ubiquinone biosynthesis & proteasome 23 3.51E-44
4 SGTC_236 1509-0011 13.00 5.3 µM 4.43E-37 134 6.57E-39
5 SGTC_86 0417-1630 12.50 471.9 µM 1.04E-34 ubiquinone biosynthesis & proteasome 26 2.06E-36
6 SGTC_1635 st007035 12.30 42.4 µM 3.15E-33 58 7.44E-35
7 SGTC_216 k038-0035 11.20 28.4 µM 2.79E-28 ubiquinone biosynthesis & proteasome 5 1.20E-29
8 SGTC_142 0335-0849 9.79 62.7 µM 7.05E-22 ubiquinone biosynthesis & proteasome 32 6.52E-23
9 SGTC_767 0929-0023 9.57 86.0 µM 5.03E-21 TRP & mitochondrial translation 5 5.15E-22
10 SGTC_386 1509-0011 9.53 3.1 µM 7.45E-21 49 7.79E-22
11 SGTC_200 k038-0079 9.12 37.5 µM 3.04E-19 ubiquinone biosynthesis & proteasome 12 3.86E-20
12 SGTC_794 k038-0031 8.33 316.0 µM 2.18E-16 ubiquinone biosynthesis & proteasome 27 3.88E-17
13 SGTC_1133 3473-0247 7.91 50.0 µM 5.89E-15 RSC complex & mRNA processing 3 1.24E-15
14 SGTC_952 1185-0122 7.54 232.0 µM 9.95E-14 2 2.43E-14
15 SGTC_635 k038-0028 7.41 24.7 µM 2.43E-13 ubiquinone biosynthesis & proteasome 9 6.23E-14
16 SGTC_944 3370-0224 7.29 231.0 µM 5.88E-13 2 1.58E-13
17 SGTC_134 0269-0018 6.95 6.9 µM 5.85E-12 69 1.76E-12
18 SGTC_67 0335-0847 6.59 266.0 µM 6.49E-11 ubiquinone biosynthesis & proteasome 56 2.21E-11
19 SGTC_340 k038-0059 6.50 454.0 µM 1.15E-10 ubiquinone biosynthesis & proteasome 16 4.04E-11
20 SGTC_414 piperonyl butoxide 6.24 100.0 µM 5.57E-10 1 2.12E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.744 0 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.714 0 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.711 0 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.703 0 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.701 0 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.652 0 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.620 0 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.560 6.85E-277 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.555 4.27E-271 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.532 4.00E-245 YML110C COQ5 hom 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
0.532 6.96E-244 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.499 2.45E-210 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.492 1.93E-204 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.481 4.11E-194 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.480 2.61E-193 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data