YGR257C / MTM1

Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR257C / MTM1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.80|P-value:1.97E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:4.37|P-value:8.89E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:5.20|P-value:4.15E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:8.92|P-value:1.05E-14 ID:SGTC_70|Compound:0141-0289|FD-Score:5.48|P-value:1.32E-6 ID:SGTC_81|Compound:0411-0046|FD-Score:4.27|P-value:1.26E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.96|P-value:3.47E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:8.13|P-value:1.60E-12 ID:SGTC_127|Compound:0180-0333|FD-Score:4.45|P-value:6.85E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:4.02|P-value:2.86E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:18.60|P-value:8.86E-58 ID:SGTC_141|Compound:0443-0274|FD-Score:7.04|P-value:7.99E-10 ID:SGTC_156|Compound:3474-0145|FD-Score:22.70|P-value:7.56E-85 ID:SGTC_168|Compound:3970-0862|FD-Score:5.70|P-value:5.22E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:5.16|P-value:4.80E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:5.12|P-value:5.76E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:18.40|P-value:3.31E-56 ID:SGTC_275|Compound:trichlorophene|FD-Score:10.00|P-value:4.59E-18 ID:SGTC_279|Compound:1273-0055|FD-Score:6.95|P-value:1.28E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:4.65|P-value:3.39E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:5.66|P-value:6.06E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:13.10|P-value:1.07E-29 ID:SGTC_426|Compound:0988-0037|FD-Score:-6.42|P-value:1.94E-8 ID:SGTC_431|Compound:k089-0097|FD-Score:-7.63|P-value:3.15E-11 ID:SGTC_444|Compound:curcumin|FD-Score:-4.14|P-value:1.95E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.76|P-value:6.46E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:6.81|P-value:2.61E-9 ID:SGTC_485|Compound:niflumic acid|FD-Score:4.04|P-value:2.63E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:4.71|P-value:2.70E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:3.86|P-value:4.69E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.87|P-value:4.60E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:5.88|P-value:2.32E-7 ID:SGTC_649|Compound:1123-0311|FD-Score:-4.04|P-value:2.66E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:4.77|P-value:2.20E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:3.76|P-value:6.38E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:14.90|P-value:1.94E-37 ID:SGTC_824|Compound:1304-0008|FD-Score:4.67|P-value:3.15E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.87|P-value:4.57E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.62|P-value:9.46E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.32|P-value:1.06E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:9.77|P-value:2.88E-17 ID:SGTC_924|Compound:2046-0044|FD-Score:-4.72|P-value:2.65E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:9.22|P-value:1.36E-15 ID:SGTC_1047|Compound:2043-3044|FD-Score:-4.02|P-value:2.84E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:8.28|P-value:6.45E-13 ID:SGTC_1142|Compound:3253-1408|FD-Score:4.08|P-value:2.37E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-4.85|P-value:1.63E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.58|P-value:4.29E-5 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.86|P-value:4.62E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:13.30|P-value:1.80E-30 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.96|P-value:1.61E-7 ID:SGTC_1383|Compound:3049-0032|FD-Score:5.23|P-value:3.75E-6 ID:SGTC_1453|Compound:4237-0541|FD-Score:9.80|P-value:2.29E-17 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.89|P-value:4.31E-4 ID:SGTC_1521|Compound:st012942|FD-Score:9.05|P-value:4.47E-15 ID:SGTC_1554|Compound:st069299|FD-Score:4.11|P-value:2.15E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.25|P-value:1.33E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.10|P-value:2.23E-4 ID:SGTC_1635|Compound:st007035|FD-Score:26.60|P-value:1.48E-115 ID:SGTC_1742|Compound:st038235|FD-Score:6.46|P-value:1.53E-8 ID:SGTC_1786|Compound:berberine|FD-Score:3.84|P-value:4.95E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.31|P-value:1.11E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.61|P-value:9.84E-4 ID:SGTC_1919|Compound:st067113|FD-Score:7.79|P-value:1.23E-11 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-8.11|P-value:1.81E-12 ID:SGTC_1952|Compound:st077036|FD-Score:-5.18|P-value:4.61E-6 ID:SGTC_2089|Compound:5281248|FD-Score:5.04|P-value:7.84E-6 ID:SGTC_2111|Compound:5486399|FD-Score:5.26|P-value:3.27E-6 ID:SGTC_2174|Compound:5790901|FD-Score:-4.64|P-value:3.49E-5 ID:SGTC_2248|Compound:tofa|FD-Score:5.45|P-value:1.53E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:9.24|P-value:1.22E-15 ID:SGTC_2445|Compound:5742597|FD-Score:4.60|P-value:3.97E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:6.87|P-value:1.95E-9 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.12|P-value:2.09E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.22|P-value:1.51E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.62|P-value:9.64E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.20|P-value:1.58E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.69|P-value:7.70E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.24|P-value:1.40E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.64|P-value:9.19E-4 ID:SGTC_2853|Compound:9015042|FD-Score:4.83|P-value:1.75E-5 ID:SGTC_2914|Compound:7968218|FD-Score:-3.92|P-value:3.91E-4 ID:SGTC_2922|Compound:7999257|FD-Score:5.10|P-value:6.22E-6 ID:SGTC_2925|Compound:9010536|FD-Score:5.08|P-value:6.59E-6 ID:SGTC_2928|Compound:9011484|FD-Score:9.35|P-value:5.45E-16 ID:SGTC_2950|Compound:9072895|FD-Score:3.71|P-value:7.33E-4 ID:SGTC_2965|Compound:9082772|FD-Score:5.11|P-value:6.01E-6 ID:SGTC_3037|Compound:9091026|FD-Score:4.08|P-value:2.34E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-6.22|P-value:4.98E-8 ID:SGTC_3143|Compound:9086658|FD-Score:6.48|P-value:1.42E-8 ID:SGTC_3155|Compound:9099265|FD-Score:-3.63|P-value:9.49E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.10|P-value:6.14E-6 ID:SGTC_10|Compound:0279-0212|FD-Score:4.80|P-value:1.97E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:4.37|P-value:8.89E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:5.20|P-value:4.15E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:8.92|P-value:1.05E-14 ID:SGTC_70|Compound:0141-0289|FD-Score:5.48|P-value:1.32E-6 ID:SGTC_81|Compound:0411-0046|FD-Score:4.27|P-value:1.26E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.96|P-value:3.47E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:8.13|P-value:1.60E-12 ID:SGTC_127|Compound:0180-0333|FD-Score:4.45|P-value:6.85E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:4.02|P-value:2.86E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:18.60|P-value:8.86E-58 ID:SGTC_141|Compound:0443-0274|FD-Score:7.04|P-value:7.99E-10 ID:SGTC_156|Compound:3474-0145|FD-Score:22.70|P-value:7.56E-85 ID:SGTC_168|Compound:3970-0862|FD-Score:5.70|P-value:5.22E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:5.16|P-value:4.80E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:5.12|P-value:5.76E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:18.40|P-value:3.31E-56 ID:SGTC_275|Compound:trichlorophene|FD-Score:10.00|P-value:4.59E-18 ID:SGTC_279|Compound:1273-0055|FD-Score:6.95|P-value:1.28E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:4.65|P-value:3.39E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:5.66|P-value:6.06E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:13.10|P-value:1.07E-29 ID:SGTC_426|Compound:0988-0037|FD-Score:-6.42|P-value:1.94E-8 ID:SGTC_431|Compound:k089-0097|FD-Score:-7.63|P-value:3.15E-11 ID:SGTC_444|Compound:curcumin|FD-Score:-4.14|P-value:1.95E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.76|P-value:6.46E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:6.81|P-value:2.61E-9 ID:SGTC_485|Compound:niflumic acid|FD-Score:4.04|P-value:2.63E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:4.71|P-value:2.70E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:3.86|P-value:4.69E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.87|P-value:4.60E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:5.88|P-value:2.32E-7 ID:SGTC_649|Compound:1123-0311|FD-Score:-4.04|P-value:2.66E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:4.77|P-value:2.20E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:3.76|P-value:6.38E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:14.90|P-value:1.94E-37 ID:SGTC_824|Compound:1304-0008|FD-Score:4.67|P-value:3.15E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.87|P-value:4.57E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.62|P-value:9.46E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.32|P-value:1.06E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:9.77|P-value:2.88E-17 ID:SGTC_924|Compound:2046-0044|FD-Score:-4.72|P-value:2.65E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:9.22|P-value:1.36E-15 ID:SGTC_1047|Compound:2043-3044|FD-Score:-4.02|P-value:2.84E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:8.28|P-value:6.45E-13 ID:SGTC_1142|Compound:3253-1408|FD-Score:4.08|P-value:2.37E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-4.85|P-value:1.63E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.58|P-value:4.29E-5 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.86|P-value:4.62E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:13.30|P-value:1.80E-30 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.96|P-value:1.61E-7 ID:SGTC_1383|Compound:3049-0032|FD-Score:5.23|P-value:3.75E-6 ID:SGTC_1453|Compound:4237-0541|FD-Score:9.80|P-value:2.29E-17 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.89|P-value:4.31E-4 ID:SGTC_1521|Compound:st012942|FD-Score:9.05|P-value:4.47E-15 ID:SGTC_1554|Compound:st069299|FD-Score:4.11|P-value:2.15E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.25|P-value:1.33E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.10|P-value:2.23E-4 ID:SGTC_1635|Compound:st007035|FD-Score:26.60|P-value:1.48E-115 ID:SGTC_1742|Compound:st038235|FD-Score:6.46|P-value:1.53E-8 ID:SGTC_1786|Compound:berberine|FD-Score:3.84|P-value:4.95E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.31|P-value:1.11E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.61|P-value:9.84E-4 ID:SGTC_1919|Compound:st067113|FD-Score:7.79|P-value:1.23E-11 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-8.11|P-value:1.81E-12 ID:SGTC_1952|Compound:st077036|FD-Score:-5.18|P-value:4.61E-6 ID:SGTC_2089|Compound:5281248|FD-Score:5.04|P-value:7.84E-6 ID:SGTC_2111|Compound:5486399|FD-Score:5.26|P-value:3.27E-6 ID:SGTC_2174|Compound:5790901|FD-Score:-4.64|P-value:3.49E-5 ID:SGTC_2248|Compound:tofa|FD-Score:5.45|P-value:1.53E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:9.24|P-value:1.22E-15 ID:SGTC_2445|Compound:5742597|FD-Score:4.60|P-value:3.97E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:6.87|P-value:1.95E-9 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.12|P-value:2.09E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.22|P-value:1.51E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.62|P-value:9.64E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.20|P-value:1.58E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.69|P-value:7.70E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.24|P-value:1.40E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.64|P-value:9.19E-4 ID:SGTC_2853|Compound:9015042|FD-Score:4.83|P-value:1.75E-5 ID:SGTC_2914|Compound:7968218|FD-Score:-3.92|P-value:3.91E-4 ID:SGTC_2922|Compound:7999257|FD-Score:5.10|P-value:6.22E-6 ID:SGTC_2925|Compound:9010536|FD-Score:5.08|P-value:6.59E-6 ID:SGTC_2928|Compound:9011484|FD-Score:9.35|P-value:5.45E-16 ID:SGTC_2950|Compound:9072895|FD-Score:3.71|P-value:7.33E-4 ID:SGTC_2965|Compound:9082772|FD-Score:5.11|P-value:6.01E-6 ID:SGTC_3037|Compound:9091026|FD-Score:4.08|P-value:2.34E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-6.22|P-value:4.98E-8 ID:SGTC_3143|Compound:9086658|FD-Score:6.48|P-value:1.42E-8 ID:SGTC_3155|Compound:9099265|FD-Score:-3.63|P-value:9.49E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.10|P-value:6.14E-6

Top fitness defect scores for YGR257C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 26.60 42.4 µM 1.48E-115 10 1.63E-156
2 SGTC_156 3474-0145 22.70 5.6 µM 7.56E-85 endomembrane recycling 1 1.00E-114
3 SGTC_134 0269-0018 18.60 6.9 µM 8.86E-58 10 6.77E-78
4 SGTC_236 1509-0011 18.40 5.3 µM 3.31E-56 63 9.30E-76
5 SGTC_778 3456-2434 14.90 196.0 µM 1.94E-37 mitochondrial response to ROS 1 3.12E-50
6 SGTC_1317 1273-0028 13.30 910.0 nM 1.80E-30 azole & statin 6 9.20E-41
7 SGTC_386 1509-0011 13.10 3.1 µM 1.07E-29 29 1.04E-39
8 SGTC_275 trichlorophene 10.00 5.7 µM 4.59E-18 mitochondrial stress 45 6.49E-24
9 SGTC_1453 4237-0541 9.80 195.0 µM 2.29E-17 heme biosynthesis & mitochondrial translocase 2 5.76E-23
10 SGTC_908 3448-7491 9.77 47.7 µM 2.88E-17 mitochondrial stress 9 7.85E-23
11 SGTC_2928 9011484 9.35 9.8 µM 5.45E-16 heme biosynthesis & mitochondrial translocase 2 4.24E-21
12 SGTC_2250 alverine citrate 9.24 130.0 µM 1.22E-15 13 1.27E-20
13 SGTC_1036 k216-0215 9.22 33.5 µM 1.36E-15 mitochondrial response to ROS 3 1.46E-20
14 SGTC_1521 st012942 9.05 49.4 µM 4.47E-15 1 7.35E-20
15 SGTC_63 0099-0242 8.92 26.7 µM 1.05E-14 mitochondrial stress 3 2.36E-19
16 SGTC_1083 didemethylchlorpromazine sulfoxide 8.28 707.4 nM 6.45E-13 redox potentiating 12 6.21E-17
17 SGTC_116 0155-0182 8.13 31.8 µM 1.60E-12 mitochondrial response to ROS 10 2.13E-16
18 SGTC_1919 st067113 7.79 52.3 µM 1.23E-11 TSC3-RPN4 4 3.36E-15
19 SGTC_141 0443-0274 7.04 32.3 µM 7.99E-10 mitochondrial response to ROS 15 9.58E-13
20 SGTC_279 1273-0055 6.95 2.9 µM 1.28E-9 azole & statin 6 1.81E-12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.483 6.56E-196 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.480 5.38E-193 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.469 1.14E-182 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.464 7.61E-179 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.463 4.02E-178 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.452 2.03E-168 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.452 3.12E-168 YDR533C HSP31 hom Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress
0.451 8.42E-168 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.451 1.73E-167 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.450 1.93E-166 YBR179C FZO1 hom Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
0.449 2.25E-166 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.447 4.00E-164 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.445 4.74E-163 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.439 4.59E-158 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.437 1.65E-156 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain