YGR259C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR259C / YGR259C

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:2.98|P-value:8.01E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.13|P-value:2.69E-8 ID:SGTC_137|Compound:0438-0332|FD-Score:3.70|P-value:4.41E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.71|P-value:3.74E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.33|P-value:1.93E-4 ID:SGTC_215|Compound:1287-0124|FD-Score:3.80|P-value:2.83E-5 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.54|P-value:7.87E-5 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.04|P-value:6.51E-4 ID:SGTC_433|Compound:pimozide|FD-Score:3.29|P-value:2.43E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-2.93|P-value:8.80E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-3.03|P-value:6.15E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.51|P-value:9.85E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:4.71|P-value:2.95E-7 ID:SGTC_550|Compound:4123-0385|FD-Score:3.80|P-value:2.77E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:3.75|P-value:3.46E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:-3.76|P-value:3.06E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:3.09|P-value:5.32E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.14|P-value:4.45E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.36|P-value:1.67E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.05|P-value:5.60E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.58|P-value:6.02E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.81|P-value:2.65E-5 ID:SGTC_1297|Compound:1068-0111|FD-Score:2.94|P-value:9.13E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.39|P-value:1.64E-4 ID:SGTC_1642|Compound:st009582|FD-Score:7.95|P-value:1.60E-17 ID:SGTC_1671|Compound:st016596|FD-Score:3.76|P-value:3.32E-5 ID:SGTC_1704|Compound:st028805|FD-Score:3.12|P-value:4.85E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.20|P-value:3.50E-4 ID:SGTC_2205|Compound:7238770|FD-Score:2.97|P-value:8.45E-4 ID:SGTC_2335|Compound:9018011|FD-Score:-3.67|P-value:4.45E-5 ID:SGTC_2381|Compound:9035592|FD-Score:4.15|P-value:5.47E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:6.72|P-value:4.87E-13 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.39|P-value:1.51E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.31|P-value:2.31E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.52|P-value:9.44E-5 ID:SGTC_2712|Compound:st079126|FD-Score:3.14|P-value:4.43E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.29|P-value:2.42E-4 ID:SGTC_2780|Compound:5215298|FD-Score:2.93|P-value:9.70E-4 ID:SGTC_2792|Compound:7535235|FD-Score:6.27|P-value:1.39E-11 ID:SGTC_2799|Compound:7812892|FD-Score:4.83|P-value:1.55E-7 ID:SGTC_2814|Compound:7977482|FD-Score:3.13|P-value:4.57E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-4.12|P-value:5.64E-6 ID:SGTC_2944|Compound:9067346|FD-Score:3.23|P-value:3.15E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.01|P-value:7.10E-4 ID:SGTC_3057|Compound:9095946|FD-Score:-2.98|P-value:7.43E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.13|P-value:4.51E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.11|P-value:4.86E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.14|P-value:4.44E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.35|P-value:1.90E-4 ID:SGTC_3197|Compound:9113331|FD-Score:2.95|P-value:8.91E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.52|P-value:9.48E-5 ID:SGTC_3278|Compound:9139605|FD-Score:4.06|P-value:8.32E-6 ID:SGTC_3331|Compound:9141060|FD-Score:2.95|P-value:9.04E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:2.98|P-value:8.01E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:5.13|P-value:2.69E-8 ID:SGTC_137|Compound:0438-0332|FD-Score:3.70|P-value:4.41E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.71|P-value:3.74E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.33|P-value:1.93E-4 ID:SGTC_215|Compound:1287-0124|FD-Score:3.80|P-value:2.83E-5 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.54|P-value:7.87E-5 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.04|P-value:6.51E-4 ID:SGTC_433|Compound:pimozide|FD-Score:3.29|P-value:2.43E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-2.93|P-value:8.80E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-3.03|P-value:6.15E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.51|P-value:9.85E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:4.71|P-value:2.95E-7 ID:SGTC_550|Compound:4123-0385|FD-Score:3.80|P-value:2.77E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:3.75|P-value:3.46E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:-3.76|P-value:3.06E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:3.09|P-value:5.32E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.14|P-value:4.45E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.36|P-value:1.67E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.05|P-value:5.60E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.58|P-value:6.02E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.81|P-value:2.65E-5 ID:SGTC_1297|Compound:1068-0111|FD-Score:2.94|P-value:9.13E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.39|P-value:1.64E-4 ID:SGTC_1642|Compound:st009582|FD-Score:7.95|P-value:1.60E-17 ID:SGTC_1671|Compound:st016596|FD-Score:3.76|P-value:3.32E-5 ID:SGTC_1704|Compound:st028805|FD-Score:3.12|P-value:4.85E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.20|P-value:3.50E-4 ID:SGTC_2205|Compound:7238770|FD-Score:2.97|P-value:8.45E-4 ID:SGTC_2335|Compound:9018011|FD-Score:-3.67|P-value:4.45E-5 ID:SGTC_2381|Compound:9035592|FD-Score:4.15|P-value:5.47E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:6.72|P-value:4.87E-13 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.39|P-value:1.51E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.31|P-value:2.31E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.52|P-value:9.44E-5 ID:SGTC_2712|Compound:st079126|FD-Score:3.14|P-value:4.43E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.29|P-value:2.42E-4 ID:SGTC_2780|Compound:5215298|FD-Score:2.93|P-value:9.70E-4 ID:SGTC_2792|Compound:7535235|FD-Score:6.27|P-value:1.39E-11 ID:SGTC_2799|Compound:7812892|FD-Score:4.83|P-value:1.55E-7 ID:SGTC_2814|Compound:7977482|FD-Score:3.13|P-value:4.57E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-4.12|P-value:5.64E-6 ID:SGTC_2944|Compound:9067346|FD-Score:3.23|P-value:3.15E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.01|P-value:7.10E-4 ID:SGTC_3057|Compound:9095946|FD-Score:-2.98|P-value:7.43E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.13|P-value:4.51E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.11|P-value:4.86E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.14|P-value:4.44E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.35|P-value:1.90E-4 ID:SGTC_3197|Compound:9113331|FD-Score:2.95|P-value:8.91E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.52|P-value:9.48E-5 ID:SGTC_3278|Compound:9139605|FD-Score:4.06|P-value:8.32E-6 ID:SGTC_3331|Compound:9141060|FD-Score:2.95|P-value:9.04E-4

Top fitness defect scores for YGR259C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1642 st009582 7.95 77.7 µM 1.60E-17 RPP1 & pyrimidine depletion 1 9.27E-16
2 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 6.72 3.7 µM 4.87E-13 6 8.89E-12
3 SGTC_2792 7535235 6.27 81.8 µM 1.39E-11 fatty acid desaturase (OLE1) 9 1.75E-10
4 SGTC_103 0844-0104 5.13 51.8 µM 2.69E-8 ERAD & cell cycle 97 1.47E-7
5 SGTC_2799 7812892 4.83 81.8 µM 1.55E-7 superoxide 18 6.96E-7
6 SGTC_533 1222-0222 4.71 6.7 µM 2.95E-7 PDR1 15 1.24E-6
7 SGTC_1055 3448-0672 4.58 86.0 µM 6.02E-7 17 2.34E-6
8 SGTC_2381 9035592 4.15 200.0 µM 5.47E-6 15 1.67E-5
9 SGTC_3278 9139605 4.06 49.5 µM 8.32E-6 13 2.43E-5
10 SGTC_1107 amlodipine 3.81 47.0 µM 2.65E-5 39 6.84E-5
11 SGTC_550 4123-0385 3.80 25.7 µM 2.77E-5 TSC3-RPN4 30 7.10E-5
12 SGTC_215 1287-0124 3.80 461.5 µM 2.83E-5 1 7.24E-5
13 SGTC_1671 st016596 3.76 74.5 µM 3.32E-5 18 8.35E-5
14 SGTC_553 k007-0256 3.75 45.7 µM 3.46E-5 heme biosynthesis & mitochondrial translocase 24 8.68E-5
15 SGTC_137 0438-0332 3.70 85.4 µM 4.41E-5 ubiquinone biosynthesis & proteasome 139 1.08E-4
16 SGTC_2651 1327-0036 3.52 5.0 µM 9.44E-5 194 2.13E-4
17 SGTC_3267 9137951 3.52 49.5 µM 9.48E-5 14 2.13E-4
18 SGTC_524 r073-0010 3.51 27.8 µM 9.85E-5 67 2.21E-4
19 SGTC_1349 flufenamic acid 3.39 69.0 µM 1.64E-4 32 3.49E-4
20 SGTC_3185 9108267 3.35 49.5 µM 1.90E-4 60S ribosome export 40 3.98E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 9.63E-19 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.139 5.16E-16 YNL043C_d YNL043C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
0.122 1.38E-12 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.120 3.24E-12 YOR165W SEY1 hom Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
0.114 3.35E-11 YKL018W SWD2 het Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination
0.113 5.67E-11 YOR113W AZF1 hom Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity
0.112 7.76E-11 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.109 2.47E-10 YPL117C IDI1 het Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability
0.105 1.02E-9 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.105 1.26E-9 YOR363C PIP2 hom Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication
0.104 1.53E-9 YMR180C CTL1 hom RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm
0.096 2.65E-8 YLR065C ENV10 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene
0.094 4.84E-8 YKL149C DBR1 hom RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition
0.092 1.04E-7 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.090 1.90E-7 YKL091C YKL091C hom Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study