YGR260W / TNA1

High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR260W / TNA1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.42|P-value:7.00E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.37|P-value:8.11E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.60|P-value:3.85E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.46|P-value:6.01E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-3.64|P-value:3.12E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:4.43|P-value:1.67E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:3.90|P-value:1.31E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.88|P-value:1.39E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.67|P-value:3.03E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:5.30|P-value:3.43E-7 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.63|P-value:3.36E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.33|P-value:9.30E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.38|P-value:7.90E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.32|P-value:9.42E-4 ID:SGTC_1822|Compound:st052468|FD-Score:4.54|P-value:1.06E-5 ID:SGTC_1834|Compound:st055981|FD-Score:3.79|P-value:1.95E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.71|P-value:2.62E-4 ID:SGTC_1966|Compound:st070145|FD-Score:4.56|P-value:9.95E-6 ID:SGTC_1972|Compound:st070201|FD-Score:-4.32|P-value:2.50E-5 ID:SGTC_1975|Compound:st070967|FD-Score:-4.00|P-value:8.71E-5 ID:SGTC_1980|Compound:st071811|FD-Score:4.01|P-value:8.61E-5 ID:SGTC_1981|Compound:st071826|FD-Score:3.47|P-value:5.94E-4 ID:SGTC_2678|Compound:equilin|FD-Score:-4.24|P-value:3.48E-5 ID:SGTC_2695|Compound:st077686|FD-Score:4.34|P-value:2.44E-5 ID:SGTC_2783|Compound:7738165|FD-Score:3.70|P-value:2.73E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.50|P-value:5.38E-4 ID:SGTC_2892|Compound:9047358|FD-Score:5.22|P-value:5.21E-7 ID:SGTC_2893|Compound:9048488|FD-Score:4.34|P-value:2.45E-5 ID:SGTC_3026|Compound:9090633|FD-Score:3.90|P-value:1.31E-4 ID:SGTC_3116|Compound:9124943|FD-Score:-3.32|P-value:9.04E-4 ID:SGTC_3186|Compound:9110464|FD-Score:-3.74|P-value:2.23E-4 ID:SGTC_3187|Compound:9109394|FD-Score:-3.57|P-value:3.94E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.44|P-value:6.37E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:3.42|P-value:7.00E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.37|P-value:8.11E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.60|P-value:3.85E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.46|P-value:6.01E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-3.64|P-value:3.12E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:4.43|P-value:1.67E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:3.90|P-value:1.31E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.88|P-value:1.39E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.67|P-value:3.03E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:5.30|P-value:3.43E-7 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.63|P-value:3.36E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.33|P-value:9.30E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.38|P-value:7.90E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.32|P-value:9.42E-4 ID:SGTC_1822|Compound:st052468|FD-Score:4.54|P-value:1.06E-5 ID:SGTC_1834|Compound:st055981|FD-Score:3.79|P-value:1.95E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.71|P-value:2.62E-4 ID:SGTC_1966|Compound:st070145|FD-Score:4.56|P-value:9.95E-6 ID:SGTC_1972|Compound:st070201|FD-Score:-4.32|P-value:2.50E-5 ID:SGTC_1975|Compound:st070967|FD-Score:-4.00|P-value:8.71E-5 ID:SGTC_1980|Compound:st071811|FD-Score:4.01|P-value:8.61E-5 ID:SGTC_1981|Compound:st071826|FD-Score:3.47|P-value:5.94E-4 ID:SGTC_2678|Compound:equilin|FD-Score:-4.24|P-value:3.48E-5 ID:SGTC_2695|Compound:st077686|FD-Score:4.34|P-value:2.44E-5 ID:SGTC_2783|Compound:7738165|FD-Score:3.70|P-value:2.73E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.50|P-value:5.38E-4 ID:SGTC_2892|Compound:9047358|FD-Score:5.22|P-value:5.21E-7 ID:SGTC_2893|Compound:9048488|FD-Score:4.34|P-value:2.45E-5 ID:SGTC_3026|Compound:9090633|FD-Score:3.90|P-value:1.31E-4 ID:SGTC_3116|Compound:9124943|FD-Score:-3.32|P-value:9.04E-4 ID:SGTC_3186|Compound:9110464|FD-Score:-3.74|P-value:2.23E-4 ID:SGTC_3187|Compound:9109394|FD-Score:-3.57|P-value:3.94E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.44|P-value:6.37E-4

Top fitness defect scores for YGR260W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1510 1123-0200 5.30 71.5 µM 3.43E-7 22 5.67E-8
2 SGTC_2892 9047358 5.22 58.4 µM 5.21E-7 1 9.11E-8
3 SGTC_1966 st070145 4.56 16.1 µM 9.95E-6 16 2.59E-6
4 SGTC_1822 st052468 4.54 42.0 µM 1.06E-5 6 2.78E-6
5 SGTC_839 0122-0028 4.43 230.0 µM 1.67E-5 RSC complex & mRNA processing 26 4.66E-6
6 SGTC_2695 st077686 4.34 52.0 µM 2.44E-5 27 7.16E-6
7 SGTC_2893 9048488 4.34 26.0 µM 2.45E-5 fatty acid desaturase (OLE1) 17 7.18E-6
8 SGTC_1980 st071811 4.01 45.7 µM 8.61E-5 RPP1 & pyrimidine depletion 15 2.98E-5
9 SGTC_962 1254-0300 3.90 21.5 µM 1.31E-4 24 4.79E-5
10 SGTC_3026 9090633 3.90 49.5 µM 1.31E-4 22 4.80E-5
11 SGTC_1017 4239-0030 3.88 168.0 µM 1.39E-4 29 5.14E-5
12 SGTC_1834 st055981 3.79 52.8 µM 1.95E-4 RPP1 & pyrimidine depletion 38 7.52E-5
13 SGTC_1930 st074634 3.71 34.3 µM 2.62E-4 RNA pol III & RNase P/MRP 46 1.05E-4
14 SGTC_2783 7738165 3.70 71.4 µM 2.73E-4 38 1.10E-4
15 SGTC_1105 epirubicin 3.67 18.1 µM 3.03E-4 anthracycline transcription coupled DNA repair 26 1.24E-4
16 SGTC_1537 2',6'-dihydroxyflavanone 3.63 78.0 µM 3.36E-4 25 1.39E-4
17 SGTC_277 nystatin 3.60 15.5 µM 3.85E-4 20 1.62E-4
18 SGTC_2789 5281112 3.50 71.4 µM 5.38E-4 59 2.37E-4
19 SGTC_1981 st071826 3.47 47.0 µM 5.94E-4 25 2.65E-4
20 SGTC_355 1311-2252 3.46 105.0 µM 6.01E-4 34 2.68E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 3.89E-12 YNL150W_d YNL150W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking
0.090 1.95E-7 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.087 4.25E-7 YGR012W YGR012W hom Putative cysteine synthase, localized to the mitochondrial outer membrane
0.086 5.22E-7 YLR287C-A RPS30A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication
0.086 6.89E-7 YLR318W EST2 hom Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia
0.084 1.27E-6 YOR210W RPB10 het RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III
0.082 1.97E-6 YMR002W MIC17 hom Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.082 2.09E-6 YLR274W MCM5 het Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
0.079 5.09E-6 YOL122C SMF1 hom Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
0.076 9.49E-6 YPR032W SRO7 hom Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication
0.075 1.34E-5 YEL020C_p YEL020C_p hom Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data
0.074 1.70E-5 YER004W FMP52 hom Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.072 3.38E-5 YPL004C LSP1 hom Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family
0.071 3.68E-5 YDR514C YDR514C hom Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication
0.071 4.11E-5 YOR116C RPO31 het RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21