YGR265W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase

Zygosity: Heterozygous strain
fixedexpanded
Profile for YGR265W / YGR265W

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.85|P-value:3.18E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:5.15|P-value:2.27E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.68|P-value:5.63E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.58|P-value:7.55E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.43|P-value:7.53E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.55|P-value:5.11E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:6.67|P-value:1.21E-9 ID:SGTC_210|Compound:3551-0445|FD-Score:4.76|P-value:1.14E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.91|P-value:2.66E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.92|P-value:3.11E-6 ID:SGTC_341|Compound:1486-1430|FD-Score:5.70|P-value:1.84E-7 ID:SGTC_342|Compound:k048-0088|FD-Score:4.06|P-value:1.57E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.48|P-value:1.84E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.58|P-value:4.68E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.54|P-value:8.77E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.37|P-value:2.88E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.27|P-value:4.19E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:3.67|P-value:5.71E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:4.62|P-value:1.98E-5 ID:SGTC_835|Compound:0312-0010|FD-Score:4.79|P-value:1.01E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:3.51|P-value:9.56E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:4.15|P-value:1.14E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.12|P-value:1.27E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.86|P-value:3.08E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:5.19|P-value:1.91E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:-4.58|P-value:1.23E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:5.72|P-value:1.64E-7 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.98|P-value:2.10E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:4.16|P-value:1.10E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-3.55|P-value:5.14E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.54|P-value:5.30E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:-4.96|P-value:2.58E-6 ID:SGTC_1518|Compound:st038567|FD-Score:3.52|P-value:9.16E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.68|P-value:5.51E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.53|P-value:9.04E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:4.30|P-value:6.64E-5 ID:SGTC_1866|Compound:st057638|FD-Score:3.71|P-value:5.12E-4 ID:SGTC_1868|Compound:st057644|FD-Score:6.00|P-value:4.13E-8 ID:SGTC_1880|Compound:MG-132|FD-Score:-5.28|P-value:6.22E-7 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:-4.00|P-value:1.11E-4 ID:SGTC_1884|Compound:5633444|FD-Score:-3.88|P-value:1.69E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-3.71|P-value:3.05E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.93|P-value:1.42E-4 ID:SGTC_2041|Compound:5107442|FD-Score:7.27|P-value:3.87E-11 ID:SGTC_2186|Compound:6124449|FD-Score:4.09|P-value:1.43E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.71|P-value:5.09E-4 ID:SGTC_2301|Compound:7769476|FD-Score:3.89|P-value:2.79E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.84|P-value:3.38E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.57|P-value:7.86E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.95|P-value:2.26E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.94|P-value:1.41E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.80|P-value:3.77E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:5.78|P-value:1.23E-7 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.66|P-value:5.89E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.87|P-value:2.97E-4 ID:SGTC_2795|Compound:7780010|FD-Score:4.99|P-value:4.39E-6 ID:SGTC_2817|Compound:7995342|FD-Score:3.77|P-value:4.15E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-3.34|P-value:9.80E-4 ID:SGTC_2910|Compound:7948405|FD-Score:-3.45|P-value:7.17E-4 ID:SGTC_2937|Compound:9044753|FD-Score:5.37|P-value:8.42E-7 ID:SGTC_2989|Compound:9073649|FD-Score:-4.48|P-value:1.85E-5 ID:SGTC_3026|Compound:9090633|FD-Score:3.99|P-value:1.97E-4 ID:SGTC_3224|Compound:9130643|FD-Score:5.46|P-value:5.49E-7 ID:SGTC_3265|Compound:9137266|FD-Score:5.03|P-value:3.77E-6 ID:SGTC_3272|Compound:9137413|FD-Score:-3.71|P-value:3.05E-4 ID:SGTC_3283|Compound:9109332|FD-Score:4.11|P-value:1.34E-4 ID:SGTC_3341|Compound:9147222|FD-Score:4.04|P-value:1.71E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:3.85|P-value:3.18E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:5.15|P-value:2.27E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.68|P-value:5.63E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.58|P-value:7.55E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.43|P-value:7.53E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.55|P-value:5.11E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:6.67|P-value:1.21E-9 ID:SGTC_210|Compound:3551-0445|FD-Score:4.76|P-value:1.14E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.91|P-value:2.66E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.92|P-value:3.11E-6 ID:SGTC_341|Compound:1486-1430|FD-Score:5.70|P-value:1.84E-7 ID:SGTC_342|Compound:k048-0088|FD-Score:4.06|P-value:1.57E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.48|P-value:1.84E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.58|P-value:4.68E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.54|P-value:8.77E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.37|P-value:2.88E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.27|P-value:4.19E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:3.67|P-value:5.71E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:4.62|P-value:1.98E-5 ID:SGTC_835|Compound:0312-0010|FD-Score:4.79|P-value:1.01E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:3.51|P-value:9.56E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:4.15|P-value:1.14E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.12|P-value:1.27E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.86|P-value:3.08E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:5.19|P-value:1.91E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:-4.58|P-value:1.23E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:5.72|P-value:1.64E-7 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.98|P-value:2.10E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:4.16|P-value:1.10E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-3.55|P-value:5.14E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-3.54|P-value:5.30E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:-4.96|P-value:2.58E-6 ID:SGTC_1518|Compound:st038567|FD-Score:3.52|P-value:9.16E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.68|P-value:5.51E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.53|P-value:9.04E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:4.30|P-value:6.64E-5 ID:SGTC_1866|Compound:st057638|FD-Score:3.71|P-value:5.12E-4 ID:SGTC_1868|Compound:st057644|FD-Score:6.00|P-value:4.13E-8 ID:SGTC_1880|Compound:MG-132|FD-Score:-5.28|P-value:6.22E-7 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:-4.00|P-value:1.11E-4 ID:SGTC_1884|Compound:5633444|FD-Score:-3.88|P-value:1.69E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-3.71|P-value:3.05E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.93|P-value:1.42E-4 ID:SGTC_2041|Compound:5107442|FD-Score:7.27|P-value:3.87E-11 ID:SGTC_2186|Compound:6124449|FD-Score:4.09|P-value:1.43E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.71|P-value:5.09E-4 ID:SGTC_2301|Compound:7769476|FD-Score:3.89|P-value:2.79E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.84|P-value:3.38E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.57|P-value:7.86E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.95|P-value:2.26E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.94|P-value:1.41E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.80|P-value:3.77E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:5.78|P-value:1.23E-7 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.66|P-value:5.89E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.87|P-value:2.97E-4 ID:SGTC_2795|Compound:7780010|FD-Score:4.99|P-value:4.39E-6 ID:SGTC_2817|Compound:7995342|FD-Score:3.77|P-value:4.15E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-3.34|P-value:9.80E-4 ID:SGTC_2910|Compound:7948405|FD-Score:-3.45|P-value:7.17E-4 ID:SGTC_2937|Compound:9044753|FD-Score:5.37|P-value:8.42E-7 ID:SGTC_2989|Compound:9073649|FD-Score:-4.48|P-value:1.85E-5 ID:SGTC_3026|Compound:9090633|FD-Score:3.99|P-value:1.97E-4 ID:SGTC_3224|Compound:9130643|FD-Score:5.46|P-value:5.49E-7 ID:SGTC_3265|Compound:9137266|FD-Score:5.03|P-value:3.77E-6 ID:SGTC_3272|Compound:9137413|FD-Score:-3.71|P-value:3.05E-4 ID:SGTC_3283|Compound:9109332|FD-Score:4.11|P-value:1.34E-4 ID:SGTC_3341|Compound:9147222|FD-Score:4.04|P-value:1.71E-4

Top fitness defect scores for YGR265W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2041 5107442 7.27 45.3 µM 3.87E-11 RSC complex & mRNA processing 12 1.82E-13 0.35
2 SGTC_188 3229-0966 6.67 278.5 µM 1.21E-9 4 1.26E-11 0.82
3 SGTC_1868 st057644 6.00 42.7 µM 4.13E-8 1 9.64E-10 0.91
4 SGTC_2621 lithochol-11-enic acid 5.78 100.0 µM 1.23E-7 2 3.69E-9 0.91
5 SGTC_1166 k206-0078 5.72 225.0 µM 1.64E-7 1 5.26E-9 1.58
6 SGTC_341 1486-1430 5.70 230.0 µM 1.84E-7 7 6.07E-9 0.04
7 SGTC_3224 9130643 5.46 49.5 µM 5.49E-7 RPP1 & pyrimidine depletion 3 2.32E-8 0.44
8 SGTC_2937 9044753 5.37 11.3 µM 8.42E-7 60S ribosome export 4 3.94E-8 0.24
9 SGTC_1058 3448-5425 5.19 97.3 µM 1.91E-6 3 1.08E-7 0.25
10 SGTC_41 0478-0632 5.15 82.6 µM 2.27E-6 6 1.33E-7 0.02
11 SGTC_3265 9137266 5.03 49.5 µM 3.77E-6 2 2.49E-7 1.05
12 SGTC_2795 7780010 4.99 54.5 µM 4.39E-6 3 3.01E-7 0.43
13 SGTC_835 0312-0010 4.79 67.2 µM 1.01E-5 1 8.37E-7 0.92
14 SGTC_210 3551-0445 4.76 56.8 µM 1.14E-5 9 9.74E-7 0.28
15 SGTC_519 k048-0011 4.62 62.8 µM 1.98E-5 5 1.91E-6 0.13
16 SGTC_1575 cyproterone acetate 4.30 48.0 µM 6.64E-5 5 8.49E-6 0.38
17 SGTC_1356 1502-0781 4.16 85.8 µM 1.10E-4 fatty acid desaturase (OLE1) 2 1.58E-5 0.15
18 SGTC_954 1189-0853 4.15 2.9 µM 1.14E-4 endomembrane recycling 2 1.64E-5 0.55
19 SGTC_1000 4048-0884 4.12 8.7 µM 1.27E-4 copper-dependent oxidative stress 5 1.89E-5 0.11
20 SGTC_3283 9109332 4.11 35.8 µM 1.34E-4 DNA intercalators 4 2.01E-5 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 4.85E-17 YGR115C_d YGR115C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C
0.106 7.19E-10 YFL002C SPB4 het Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
0.087 4.10E-7 YNL289W PCL1 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth
0.084 9.99E-7 YGR078C PAC10 hom Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
0.083 1.39E-6 YKL069W YKL069W hom Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress
0.082 1.92E-6 YNL114C_d YNL114C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit
0.082 2.06E-6 YPL005W AEP3 hom Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA
0.081 2.66E-6 YFL023W BUD27 hom Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP
0.078 5.56E-6 YLR300W EXG1 hom Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
0.078 6.06E-6 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.078 6.78E-6 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.077 7.40E-6 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.077 7.84E-6 YLR418C CDC73 hom Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress
0.076 9.88E-6 YOL005C RPB11 het RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
0.076 1.01E-5 YAL041W CDC24 het Guanine nucleotide exchange factor for Cdc42p; also known as a GEF or GDP-release factor; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress