YGR266W

Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR266W / YGR266W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.88|P-value:6.56E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:3.96|P-value:3.58E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:-4.82|P-value:9.69E-7 ID:SGTC_154|Compound:3389-1638|FD-Score:6.34|P-value:1.21E-10 ID:SGTC_156|Compound:3474-0145|FD-Score:-4.12|P-value:2.43E-5 ID:SGTC_215|Compound:1287-0124|FD-Score:-3.38|P-value:4.42E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.48|P-value:2.42E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:4.08|P-value:2.16E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.15|P-value:7.83E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:3.46|P-value:2.56E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:-4.84|P-value:9.03E-7 ID:SGTC_679|Compound:0422-0091|FD-Score:3.76|P-value:8.21E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:3.67|P-value:1.14E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:-3.74|P-value:1.14E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.58|P-value:1.65E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.96|P-value:4.75E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:3.64|P-value:1.33E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:-3.25|P-value:6.86E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.20|P-value:6.51E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.27|P-value:9.28E-6 ID:SGTC_974|Compound:1326-0144|FD-Score:3.58|P-value:1.62E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.18|P-value:6.99E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:-3.84|P-value:7.87E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.24|P-value:5.77E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.21|P-value:1.22E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.27|P-value:9.42E-6 ID:SGTC_1514|Compound:1189-1591|FD-Score:8.02|P-value:5.98E-16 ID:SGTC_1523|Compound:st012844|FD-Score:3.21|P-value:6.20E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.39|P-value:3.36E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.24|P-value:5.72E-4 ID:SGTC_1843|Compound:st055809|FD-Score:-3.38|P-value:4.41E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.83|P-value:6.20E-5 ID:SGTC_1954|Compound:st077032|FD-Score:3.16|P-value:7.44E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.25|P-value:5.43E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.90|P-value:4.63E-5 ID:SGTC_2118|Compound:5526350|FD-Score:4.30|P-value:8.33E-6 ID:SGTC_2173|Compound:5763948|FD-Score:3.20|P-value:6.53E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.49|P-value:2.96E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.23|P-value:5.81E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.11|P-value:8.82E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.85|P-value:7.51E-5 ID:SGTC_2785|Compound:7756463|FD-Score:3.83|P-value:6.22E-5 ID:SGTC_2797|Compound:7859098|FD-Score:-4.64|P-value:2.38E-6 ID:SGTC_2801|Compound:7907800|FD-Score:-3.26|P-value:6.65E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-3.49|P-value:2.97E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.30|P-value:4.67E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.20|P-value:6.50E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.11|P-value:9.03E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.18|P-value:8.92E-4 ID:SGTC_3346|Compound:9158254|FD-Score:5.56|P-value:1.34E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.88|P-value:6.56E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:3.96|P-value:3.58E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:-4.82|P-value:9.69E-7 ID:SGTC_154|Compound:3389-1638|FD-Score:6.34|P-value:1.21E-10 ID:SGTC_156|Compound:3474-0145|FD-Score:-4.12|P-value:2.43E-5 ID:SGTC_215|Compound:1287-0124|FD-Score:-3.38|P-value:4.42E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.48|P-value:2.42E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:4.08|P-value:2.16E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.15|P-value:7.83E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:3.46|P-value:2.56E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:-4.84|P-value:9.03E-7 ID:SGTC_679|Compound:0422-0091|FD-Score:3.76|P-value:8.21E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:3.67|P-value:1.14E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:-3.74|P-value:1.14E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:3.58|P-value:1.65E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.96|P-value:4.75E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:3.64|P-value:1.33E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:-3.25|P-value:6.86E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.20|P-value:6.51E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.27|P-value:9.28E-6 ID:SGTC_974|Compound:1326-0144|FD-Score:3.58|P-value:1.62E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:3.18|P-value:6.99E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:-3.84|P-value:7.87E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.24|P-value:5.77E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.21|P-value:1.22E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.27|P-value:9.42E-6 ID:SGTC_1514|Compound:1189-1591|FD-Score:8.02|P-value:5.98E-16 ID:SGTC_1523|Compound:st012844|FD-Score:3.21|P-value:6.20E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.39|P-value:3.36E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.24|P-value:5.72E-4 ID:SGTC_1843|Compound:st055809|FD-Score:-3.38|P-value:4.41E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.83|P-value:6.20E-5 ID:SGTC_1954|Compound:st077032|FD-Score:3.16|P-value:7.44E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.25|P-value:5.43E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.90|P-value:4.63E-5 ID:SGTC_2118|Compound:5526350|FD-Score:4.30|P-value:8.33E-6 ID:SGTC_2173|Compound:5763948|FD-Score:3.20|P-value:6.53E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.49|P-value:2.96E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.23|P-value:5.81E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.11|P-value:8.82E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.85|P-value:7.51E-5 ID:SGTC_2785|Compound:7756463|FD-Score:3.83|P-value:6.22E-5 ID:SGTC_2797|Compound:7859098|FD-Score:-4.64|P-value:2.38E-6 ID:SGTC_2801|Compound:7907800|FD-Score:-3.26|P-value:6.65E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-3.49|P-value:2.97E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.30|P-value:4.67E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.20|P-value:6.50E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.11|P-value:9.03E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.18|P-value:8.92E-4 ID:SGTC_3346|Compound:9158254|FD-Score:5.56|P-value:1.34E-8

Top fitness defect scores for YGR266W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1514 1189-1591 8.02 158.0 µM 5.98E-16 4 5.28E-16
2 SGTC_154 3389-1638 6.34 511.1 µM 1.21E-10 1 1.17E-10
3 SGTC_3346 9158254 5.56 43.6 µM 1.34E-8 2 1.33E-8
4 SGTC_2118 5526350 4.30 200.0 µM 8.33E-6 10 8.62E-6
5 SGTC_967 1306-0166 4.27 352.0 µM 9.28E-6 23 9.61E-6
6 SGTC_1510 1123-0200 4.27 71.5 µM 9.42E-6 35 9.76E-6
7 SGTC_1500 4488-1866 4.21 171.0 µM 1.22E-5 RPP1 & pyrimidine depletion 12 1.27E-5
8 SGTC_574 1315-0397 4.08 40.0 µM 2.16E-5 34 2.25E-5
9 SGTC_60 0986-0278 3.96 202.0 µM 3.58E-5 15 3.73E-5
10 SGTC_2115 tiliquinol 3.90 12.8 µM 4.63E-5 10 4.83E-5
11 SGTC_1910 st062352 3.83 60.4 µM 6.20E-5 41 6.47E-5
12 SGTC_2785 7756463 3.83 72.7 µM 6.22E-5 33 6.49E-5
13 SGTC_679 0422-0091 3.76 41.4 µM 8.21E-5 Golgi 36 8.58E-5
14 SGTC_695 3505-6186 3.67 243.0 µM 1.14E-4 31 1.19E-4
15 SGTC_754 3474-0146 3.64 171.0 µM 1.33E-4 copper-dependent oxidative stress 36 1.39E-4
16 SGTC_974 1326-0144 3.58 138.0 µM 1.62E-4 ERG2 59 1.70E-4
17 SGTC_746 1095-0025 3.58 46.6 µM 1.65E-4 RSC & ERG11 20 1.73E-4
18 SGTC_310 1273-0058 3.48 1.1 µM 2.42E-4 mitochondrial stress 291 2.53E-4
19 SGTC_619 1652-1634 3.46 108.0 µM 2.56E-4 PDR1 33 2.68E-4
20 SGTC_1747 st037496 3.39 66.6 µM 3.36E-4 33 3.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 7.10E-11 YFR041C ERJ5 hom Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response
0.108 3.32E-10 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.096 2.88E-8 YCR023C YCR023C hom Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene
0.090 1.77E-7 YOR080W DIA2 hom Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.089 2.64E-7 YJR034W PET191 hom Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery
0.087 4.38E-7 YGR206W MVB12 hom ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.087 4.48E-7 YER139C RTR1 hom CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication
0.086 5.63E-7 YJL093C TOK1 hom Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
0.082 2.10E-6 YNL194C YNL194C hom Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate
0.080 3.86E-6 YDR399W HPT1 hom Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
0.078 5.93E-6 YMR119W-A_d YMR119W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.076 1.06E-5 YPL270W MDL2 hom Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis
0.075 1.39E-5 YOR211C MGM1 hom Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy
0.073 2.43E-5 YDR003W RCR2 hom Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication
0.072 3.16E-5 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis